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Conserved domains on  [gi|755556562|ref|XP_011244720|]
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zinc finger protein 101 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
6-46 8.47e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 8.47e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755556562    6 PVTFEDVAVNFTSGEWTLLDSSQKKLYRDVMKENFLNLISI 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-609 3.07e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 187 HDGNKNNENTFMKCTSDQIDEKLHseVKPFVCKQCGEAFVNSSHLISHERIHIVEKCYIC--KQCGKTFRYLSCFQKHER 264
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTLKSLSNA--PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 265 IHSGERPYVCEQCGKGFIQLKYLLMHQRSHGENSYECKHCEKVFTISSVHNVHEDIQDGDKPYSCTHCGKAFSSPSDYNS 344
Cdd:COG5048   85 THHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 345 CERIHTGENPFVCKKCGKAFKRLghfmNHERIHTGEKPYACKHCGKAFTSSSDRNSHERIHTGEKPFVCKTCGKAFSRSD 424
Cdd:COG5048  165 NSLHPPLPANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 425 YLINHKRIHTGEKPYPCKYCGKAFATSSDRNSHERIHTGER-------SFLCKKCGKVFILSGDLIKHER--IHTGE--K 493
Cdd:COG5048  241 LSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 494 PYACKH--CGKAFTTSSARNSHERIHTGEKPYTCK--HCTKTFTTSSTRNSHEKTH-----TAEKHFAC--NLCGKTFNS 562
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 755556562 563 QSSYYTHKKIH-SMKEKLYVCKHCGKEFTYCGNFLKHERSHTMETLSI 609
Cdd:COG5048  401 DSNLSLHIITHlSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
6-46 8.47e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 8.47e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755556562    6 PVTFEDVAVNFTSGEWTLLDSSQKKLYRDVMKENFLNLISI 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
7-47 9.33e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 77.25  E-value: 9.33e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 755556562     7 VTFEDVAVNFTSGEWTLLDSSQKKLYRDVMKENFLNLISIE 47
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
7-46 2.97e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.97e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 755556562   7 VTFEDVAVNFTSGEWTLLDSSQKKLYRDVMKENFLNLISI 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-609 3.07e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 187 HDGNKNNENTFMKCTSDQIDEKLHseVKPFVCKQCGEAFVNSSHLISHERIHIVEKCYIC--KQCGKTFRYLSCFQKHER 264
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTLKSLSNA--PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 265 IHSGERPYVCEQCGKGFIQLKYLLMHQRSHGENSYECKHCEKVFTISSVHNVHEDIQDGDKPYSCTHCGKAFSSPSDYNS 344
Cdd:COG5048   85 THHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 345 CERIHTGENPFVCKKCGKAFKRLghfmNHERIHTGEKPYACKHCGKAFTSSSDRNSHERIHTGEKPFVCKTCGKAFSRSD 424
Cdd:COG5048  165 NSLHPPLPANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 425 YLINHKRIHTGEKPYPCKYCGKAFATSSDRNSHERIHTGER-------SFLCKKCGKVFILSGDLIKHER--IHTGE--K 493
Cdd:COG5048  241 LSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 494 PYACKH--CGKAFTTSSARNSHERIHTGEKPYTCK--HCTKTFTTSSTRNSHEKTH-----TAEKHFAC--NLCGKTFNS 562
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 755556562 563 QSSYYTHKKIH-SMKEKLYVCKHCGKEFTYCGNFLKHERSHTMETLSI 609
Cdd:COG5048  401 DSNLSLHIITHlSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 6.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 755556562  425 YLINHKRIHTGEKPYPCKYCGKAFAT 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
6-46 8.47e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 8.47e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755556562    6 PVTFEDVAVNFTSGEWTLLDSSQKKLYRDVMKENFLNLISI 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
7-47 9.33e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 77.25  E-value: 9.33e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 755556562     7 VTFEDVAVNFTSGEWTLLDSSQKKLYRDVMKENFLNLISIE 47
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
7-46 2.97e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.97e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 755556562   7 VTFEDVAVNFTSGEWTLLDSSQKKLYRDVMKENFLNLISI 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-609 3.07e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 187 HDGNKNNENTFMKCTSDQIDEKLHseVKPFVCKQCGEAFVNSSHLISHERIHIVEKCYIC--KQCGKTFRYLSCFQKHER 264
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTLKSLSNA--PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 265 IHSGERPYVCEQCGKGFIQLKYLLMHQRSHGENSYECKHCEKVFTISSVHNVHEDIQDGDKPYSCTHCGKAFSSPSDYNS 344
Cdd:COG5048   85 THHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 345 CERIHTGENPFVCKKCGKAFKRLghfmNHERIHTGEKPYACKHCGKAFTSSSDRNSHERIHTGEKPFVCKTCGKAFSRSD 424
Cdd:COG5048  165 NSLHPPLPANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 425 YLINHKRIHTGEKPYPCKYCGKAFATSSDRNSHERIHTGER-------SFLCKKCGKVFILSGDLIKHER--IHTGE--K 493
Cdd:COG5048  241 LSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 494 PYACKH--CGKAFTTSSARNSHERIHTGEKPYTCK--HCTKTFTTSSTRNSHEKTH-----TAEKHFAC--NLCGKTFNS 562
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 755556562 563 QSSYYTHKKIH-SMKEKLYVCKHCGKEFTYCGNFLKHERSHTMETLSI 609
Cdd:COG5048  401 DSNLSLHIITHlSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-514 2.02e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 302 KHCEKVFTISSVHNVHEDIQdgdkpYSCTHCGKAFSSPSDYNSCERIHTG-ENPFVCKKCGKAFKRLGHFMNHER--IHT 378
Cdd:COG5048  241 LSQSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHS 315
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 379 GE--KPYACKH--CGKAFTSSSDRNSHERIHTGEKPFVCKT--CGKAFSRSDY-----LINHKRIHTGEKPYPCKYCGKA 447
Cdd:COG5048  316 GEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSNSCI 395
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755556562 448 FATSSDRNSHERIHT----GERSFLCKKCGKVFILSGDLIKHERIHTGEKPYACKHCGKAFTTSSARNSHE 514
Cdd:COG5048  396 RNFKRDSNLSLHIIThlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-458 2.04e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 170 CDAAHRNLHCDPHHERTHDGNKNNENTFMKCTSDQIDEKLHSEVKPFVCKqcgEAFVNSSHLISHERIHIVEKCYICKQC 249
Cdd:COG5048  129 PPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSK---DPSSNLSLLISSNVSTSIPSSSENSPL 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 250 GKTFRYLSCFQKHERIHSGErPYVCEQCGkgFIQLKYLLMHQRSHGENSYECKHCEKV--------FTISSVHNVH--ED 319
Cdd:COG5048  206 SSSYSIPSSSSDQNLENSSS-SLPLTTNS--QLSPKSLLSQSPSSLSSSDSSSSASESprsslptaSSQSSSPNESdsSS 282
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 320 IQDGDKPYSCTHCGKAFSSPSDYNSCER--IHTGEN--PFVCKK--CGKAFKRLGHFMNHERIHTGEKPYACK--HCGKA 391
Cdd:COG5048  283 EKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSK 362
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556562 392 FTSSSDRNSHERIH----------------TGEKPFV---------------------CKTCGKAFSRSDYLINHKRIHT 434
Cdd:COG5048  363 FSPLLNNEPPQSLQqykdlkndkksetlsnSCIRNFKrdsnlslhiithlsfrpynckNPPCSKSFNRHYNLIPHKKIHT 442
                        330       340
                 ....*....|....*....|....
gi 755556562 435 GEKPYPCKYCGKAFATSSDRNSHE 458
Cdd:COG5048  443 NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 6.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 755556562  425 YLINHKRIHTGEKPYPCKYCGKAFAT 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 755556562  369 HFMNHERIHTGEKPYACKHCGKAFTS 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 755556562  481 DLIKHERIHTGEKPYACKHCGKAFTT 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-422 5.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.43e-03
                          10        20
                  ....*....|....*....|....
gi 755556562  399 NSHERIHTGEKPFVCKTCGKAFSR 422
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-534 7.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|....
gi 755556562  511 NSHERIHTGEKPYTCKHCTKTFTT 534
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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