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Conserved domains on  [gi|755494273|ref|XP_011246300|]
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potassium channel subfamily T member 2 isoform X13 [Mus musculus]

Protein Classification

potassium channel family protein( domain architecture ID 13585923)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium translocate across cell membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BK_channel_a super family cl47822
Calcium-activated BK potassium channel alpha subunit;
432-468 5.30e-14

Calcium-activated BK potassium channel alpha subunit;


The actual alignment was detected with superfamily member pfam03493:

Pssm-ID: 460947  Cd Length: 90  Bit Score: 68.35  E-value: 5.30e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755494273   432 DHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQ 468
Cdd:pfam03493    1 DHVICIEELKLGLLAQSCLCPGLSTLITNLLHTRSGE 37
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
206-272 4.01e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 4.01e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755494273   206 LLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPI 272
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAI 67
Ion_trans super family cl37996
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
63-270 1.30e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


The actual alignment was detected with superfamily member pfam00520:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 44.57  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273    63 RLFNFSLkLLSCLLYIIRVLLEKPSQGSEWSHIFWvnrslplwgLQVSVALISLF--ETIL----LGY-LSYKGNIWeqi 135
Cdd:pfam00520    2 RYFELFI-LLLILLNTIFLALETYFQPEEPLTTVL---------EILDYVFTGIFtlEMLLkiiaAGFkKRYFRSPW--- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273   136 lripFILEIINAVPFIISIFWPTLRNLFVPVFLNCW-------LAKHA--LENMINDLHRAIQrtqsAMFNqvLILISTL 206
Cdd:pfam00520   69 ----NILDFVVVLPSLISLVLSSVGSLSGLRVLRLLrllrllrLIRRLegLRTLVNSLIRSLK----SLGN--LLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273   207 LCLIFTCIcGIQHLERIGKKL-----------NLFDSLYFCIVTFSTVGFGDVTPETWSSK-------LFVVAMICVALV 268
Cdd:pfam00520  139 FLFIFAII-GYQLFGGKLKTWenpdngrtnfdNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFL 217

                   ..
gi 755494273   269 VL 270
Cdd:pfam00520  218 LL 219
TrkA super family cl33955
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
227-499 1.38e-04

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0569:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 45.06  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  227 LNLFDSLYFCIVTFSTVGF---GDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYL-----WMERQKSGgnysRHRAQT 298
Cdd:COG0569    19 LVLLDALYGLLITLTTVTTlggGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFgglleALRRRRME----RGIKKL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  299 EKHVVLC-----VSSLkIDLLMDFLNEfyahprlqdyYVVIlcptEMDVQVRRVLQipmwSQRVIYLQGSALKDQDLLRA 373
Cdd:COG0569    95 KMHVIIIgagrvGRSL-ARELEEEGHD----------VVVI----DKDPERVERLA----EEDVLVIVGDATDEEVLEEA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  374 KMDNAEACFILssrcevdrTSSDHQTILRAWAVKDFAP-------NCPLYVQILKpenKFHIkfaDHVVCEEEFKYAMLA 446
Cdd:COG0569   156 GIEDADAVIAA--------TGDDEANILACLLAKELGVpriiaraNDPEYADLLE---RLGA---DVVISPERLAARRIA 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755494273  447 LNCICPATSTLITL-----------------LVHTS------RGQFGVCLVGVRREDNkniLLNPGPRYIMNASDI 499
Cdd:COG0569   222 RLLLRPGVLDVLELadgdaeivevtvpegspLVGKTlkeldlRERYGVTVVAIKRGGE---VIIPSGDTVLEAGDE 294
 
Name Accession Description Interval E-value
BK_channel_a pfam03493
Calcium-activated BK potassium channel alpha subunit;
432-468 5.30e-14

Calcium-activated BK potassium channel alpha subunit;


Pssm-ID: 460947  Cd Length: 90  Bit Score: 68.35  E-value: 5.30e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755494273   432 DHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQ 468
Cdd:pfam03493    1 DHVICIEELKLGLLAQSCLCPGLSTLITNLLHTRSGE 37
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
206-272 4.01e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 4.01e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755494273   206 LLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPI 272
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAI 67
PRK10537 PRK10537
voltage-gated potassium channel protein;
227-269 3.50e-06

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 50.79  E-value: 3.50e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755494273  227 LNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVV 269
Cdd:PRK10537  167 ESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITV 209
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
63-270 1.30e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 44.57  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273    63 RLFNFSLkLLSCLLYIIRVLLEKPSQGSEWSHIFWvnrslplwgLQVSVALISLF--ETIL----LGY-LSYKGNIWeqi 135
Cdd:pfam00520    2 RYFELFI-LLLILLNTIFLALETYFQPEEPLTTVL---------EILDYVFTGIFtlEMLLkiiaAGFkKRYFRSPW--- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273   136 lripFILEIINAVPFIISIFWPTLRNLFVPVFLNCW-------LAKHA--LENMINDLHRAIQrtqsAMFNqvLILISTL 206
Cdd:pfam00520   69 ----NILDFVVVLPSLISLVLSSVGSLSGLRVLRLLrllrllrLIRRLegLRTLVNSLIRSLK----SLGN--LLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273   207 LCLIFTCIcGIQHLERIGKKL-----------NLFDSLYFCIVTFSTVGFGDVTPETWSSK-------LFVVAMICVALV 268
Cdd:pfam00520  139 FLFIFAII-GYQLFGGKLKTWenpdngrtnfdNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFL 217

                   ..
gi 755494273   269 VL 270
Cdd:pfam00520  218 LL 219
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
227-499 1.38e-04

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 45.06  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  227 LNLFDSLYFCIVTFSTVGF---GDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYL-----WMERQKSGgnysRHRAQT 298
Cdd:COG0569    19 LVLLDALYGLLITLTTVTTlggGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFgglleALRRRRME----RGIKKL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  299 EKHVVLC-----VSSLkIDLLMDFLNEfyahprlqdyYVVIlcptEMDVQVRRVLQipmwSQRVIYLQGSALKDQDLLRA 373
Cdd:COG0569    95 KMHVIIIgagrvGRSL-ARELEEEGHD----------VVVI----DKDPERVERLA----EEDVLVIVGDATDEEVLEEA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  374 KMDNAEACFILssrcevdrTSSDHQTILRAWAVKDFAP-------NCPLYVQILKpenKFHIkfaDHVVCEEEFKYAMLA 446
Cdd:COG0569   156 GIEDADAVIAA--------TGDDEANILACLLAKELGVpriiaraNDPEYADLLE---RLGA---DVVISPERLAARRIA 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755494273  447 LNCICPATSTLITL-----------------LVHTS------RGQFGVCLVGVRREDNkniLLNPGPRYIMNASDI 499
Cdd:COG0569   222 RLLLRPGVLDVLELadgdaeivevtvpegspLVGKTlkeldlRERYGVTVVAIKRGGE---VIIPSGDTVLEAGDE 294
 
Name Accession Description Interval E-value
BK_channel_a pfam03493
Calcium-activated BK potassium channel alpha subunit;
432-468 5.30e-14

Calcium-activated BK potassium channel alpha subunit;


Pssm-ID: 460947  Cd Length: 90  Bit Score: 68.35  E-value: 5.30e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755494273   432 DHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQ 468
Cdd:pfam03493    1 DHVICIEELKLGLLAQSCLCPGLSTLITNLLHTRSGE 37
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
206-272 4.01e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 4.01e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755494273   206 LLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPI 272
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAI 67
PRK10537 PRK10537
voltage-gated potassium channel protein;
227-269 3.50e-06

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 50.79  E-value: 3.50e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755494273  227 LNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVV 269
Cdd:PRK10537  167 ESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITV 209
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
63-270 1.30e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 44.57  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273    63 RLFNFSLkLLSCLLYIIRVLLEKPSQGSEWSHIFWvnrslplwgLQVSVALISLF--ETIL----LGY-LSYKGNIWeqi 135
Cdd:pfam00520    2 RYFELFI-LLLILLNTIFLALETYFQPEEPLTTVL---------EILDYVFTGIFtlEMLLkiiaAGFkKRYFRSPW--- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273   136 lripFILEIINAVPFIISIFWPTLRNLFVPVFLNCW-------LAKHA--LENMINDLHRAIQrtqsAMFNqvLILISTL 206
Cdd:pfam00520   69 ----NILDFVVVLPSLISLVLSSVGSLSGLRVLRLLrllrllrLIRRLegLRTLVNSLIRSLK----SLGN--LLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273   207 LCLIFTCIcGIQHLERIGKKL-----------NLFDSLYFCIVTFSTVGFGDVTPETWSSK-------LFVVAMICVALV 268
Cdd:pfam00520  139 FLFIFAII-GYQLFGGKLKTWenpdngrtnfdNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFL 217

                   ..
gi 755494273   269 VL 270
Cdd:pfam00520  218 LL 219
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
227-499 1.38e-04

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 45.06  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  227 LNLFDSLYFCIVTFSTVGF---GDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYL-----WMERQKSGgnysRHRAQT 298
Cdd:COG0569    19 LVLLDALYGLLITLTTVTTlggGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFgglleALRRRRME----RGIKKL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  299 EKHVVLC-----VSSLkIDLLMDFLNEfyahprlqdyYVVIlcptEMDVQVRRVLQipmwSQRVIYLQGSALKDQDLLRA 373
Cdd:COG0569    95 KMHVIIIgagrvGRSL-ARELEEEGHD----------VVVI----DKDPERVERLA----EEDVLVIVGDATDEEVLEEA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494273  374 KMDNAEACFILssrcevdrTSSDHQTILRAWAVKDFAP-------NCPLYVQILKpenKFHIkfaDHVVCEEEFKYAMLA 446
Cdd:COG0569   156 GIEDADAVIAA--------TGDDEANILACLLAKELGVpriiaraNDPEYADLLE---RLGA---DVVISPERLAARRIA 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755494273  447 LNCICPATSTLITL-----------------LVHTS------RGQFGVCLVGVRREDNkniLLNPGPRYIMNASDI 499
Cdd:COG0569   222 RLLLRPGVLDVLELadgdaeivevtvpegspLVGKTlkeldlRERYGVTVVAIKRGGE---VIIPSGDTVLEAGDE 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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