protein spinster homolog 3 isoform X2 [Mus musculus]
spinster family MFS transporter( domain architecture ID 13023647)
spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
MFS_spinster_like | cd17328 | Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-257 | 1.13e-80 | |||||
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. : Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 249.85 E-value: 1.13e-80
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Name | Accession | Description | Interval | E-value | |||||
MFS_spinster_like | cd17328 | Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-257 | 1.13e-80 | |||||
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 249.85 E-value: 1.13e-80
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UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
50-265 | 1.47e-07 | |||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.18 E-value: 1.47e-07
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OATP | pfam03137 | Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
43-176 | 9.71e-03 | |||||
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters. Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 37.57 E-value: 9.71e-03
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Name | Accession | Description | Interval | E-value | |||||
MFS_spinster_like | cd17328 | Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-257 | 1.13e-80 | |||||
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 249.85 E-value: 1.13e-80
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UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
50-265 | 1.47e-07 | |||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.18 E-value: 1.47e-07
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MFS_ExuT_GudP_like | cd17319 | Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
50-258 | 9.73e-06 | |||||
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.41 E-value: 9.73e-06
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MFS_SLCO4_OATP4 | cd17403 | Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ... |
50-182 | 2.02e-03 | |||||
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340961 [Multi-domain] Cd Length: 420 Bit Score: 39.54 E-value: 2.02e-03
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OATP | pfam03137 | Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
43-176 | 9.71e-03 | |||||
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters. Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 37.57 E-value: 9.71e-03
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Blast search parameters | ||||
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