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Conserved domains on  [gi|755523932|ref|XP_011248151|]
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p53-induced death domain-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
125-300 2.31e-38

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 2.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 125 GLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRL 204
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 205 DLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPtGLVHLPLITRLDLRDNRLRDLP 284
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP 266

                        170
                 ....*....|....*...
gi 755523932 285 --AELLDAPFVRLQGNPL 300
Cdd:COG4886  267 plANLTNLKTLDLSNNQL 284
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 426-458 6.74e-12

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


:

Pssm-ID: 463098  Cd Length: 34  Bit Score: 60.24  E-value: 6.74e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755523932  426 WNDLETQLEEEAPKRL-WARCQVPHFSWFLVVLR 458
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
ZU5 super family cl02517
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 330-403 7.11e-08

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


The actual alignment was detected with superfamily member pfam00791:

Pssm-ID: 470600  Cd Length: 97  Bit Score: 50.60  E-value: 7.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755523932  330 SFLVTPHGCSVTLA-CGVRLQFPAGATTTPVTIHYRLWLP--EPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWL 403
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGTRIECYLAVNrdESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEV 78
ZU5 super family cl02517
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 469-542 3.09e-05

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


The actual alignment was detected with superfamily member pfam00791:

Pssm-ID: 470600  Cd Length: 97  Bit Score: 42.90  E-value: 3.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755523932  469 EGALLCSSgHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLsqsGPP--SFLQPVTVQLP 542
Cdd:pfam00791   8 RGGRLVLP-NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
125-300 2.31e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 2.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 125 GLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRL 204
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 205 DLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPtGLVHLPLITRLDLRDNRLRDLP 284
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP 266

                        170
                 ....*....|....*...
gi 755523932 285 --AELLDAPFVRLQGNPL 300
Cdd:COG4886  267 plANLTNLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-287 9.70e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 9.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 119 LTTLPAGLSDlaCLAHLDLSFNRLETLPTCVPElhGLDALLLSHNHLSELPEALgalP-ALTFLTVTHNRLERLPLTLGS 197
Cdd:PRK15370 232 LTSIPATLPD--TIQEMELSINRITELPERLPS--ALQSLDLFHNKISCLPENL---PeELRYLSVYDNSIRTLPAHLPS 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 198 lsTLQRLDLSENLLDTIPSEIGnlRSLSELNLASNRLQSLPASLAglRSLRLLVLHSNLLTSVPTGLVhlPLITRLDLRD 277
Cdd:PRK15370 305 --GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSR 376

                        170
                 ....*....|
gi 755523932 278 NRLRDLPAEL 287
Cdd:PRK15370 377 NALTNLPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 134-300 2.65e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 134 HLDLS---FNRLETLPTCvpelHGLDALLLSHNHLSELpEALGALPALTFLTVTHNRLERLPlTLGSLSTLQRLDLSENL 210
Cdd:cd21340    6 HLYLNdknITKIDNLSLC----KNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 211 LDTIpSEIGNLRSLSELNLASNRL---QSL---PASLAGL-RSLRLLVLHSNLLTSVpTGLVHLPLITRLDLRDNRLRDL 283
Cdd:cd21340   80 ISVV-EGLENLTNLEELHIENQRLppgEKLtfdPRSLAALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL 157

                        170       180
                 ....*....|....*....|....
gi 755523932 284 pAELLDA----PFVR---LQGNPL 300
Cdd:cd21340  158 -EELLDLlsswPSLReldLTGNPV 180
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 426-458 6.74e-12

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


Pssm-ID: 463098  Cd Length: 34  Bit Score: 60.24  E-value: 6.74e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755523932  426 WNDLETQLEEEAPKRL-WARCQVPHFSWFLVVLR 458
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
LRR_8 pfam13855
Leucine rich repeat;
222-280 8.07e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 8.07e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755523932  222 RSLSELNLASNRLQSL-PASLAGLRSLRLLVLHSNLLTSV-PTGLVHLPLITRLDLRDNRL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 330-403 7.11e-08

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 50.60  E-value: 7.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755523932  330 SFLVTPHGCSVTLA-CGVRLQFPAGATTTPVTIHYRLWLP--EPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWL 403
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGTRIECYLAVNrdESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEV 78
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 469-542 3.09e-05

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 42.90  E-value: 3.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755523932  469 EGALLCSSgHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLsqsGPP--SFLQPVTVQLP 542
Cdd:pfam00791   8 RGGRLVLP-NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 480-542 2.11e-04

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 40.80  E-value: 2.11e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755523932   480 GVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQSGpPSFLQPVTVQLP 542
Cdd:smart00218  22 GVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHG-ALFLRPVILEVP 83
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
125-300 2.31e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 2.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 125 GLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRL 204
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 205 DLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPtGLVHLPLITRLDLRDNRLRDLP 284
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP 266

                        170
                 ....*....|....*...
gi 755523932 285 --AELLDAPFVRLQGNPL 300
Cdd:COG4886  267 plANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
119-289 4.40e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.24  E-value: 4.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 119 LTTLPAGLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPlTLGSL 198
Cdd:COG4886  171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNL 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 199 STLQRLDLSENLLDTIPSEiGNLRSLSELNLASNRLQSLP----ASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLD 274
Cdd:COG4886  250 TNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                        170
                 ....*....|....*
gi 755523932 275 LRDNRLRDLPAELLD 289
Cdd:COG4886  329 LLKGLLVTLTTLALS 343
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-287 9.47e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 9.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 135 LDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRLDLSENL---- 210
Cdd:COG4886   32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEelsn 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 211 -------------LDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDLRD 277
Cdd:COG4886  112 ltnlesldlsgnqLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                        170
                 ....*....|
gi 755523932 278 NRLRDLPAEL 287
Cdd:COG4886  192 NQITDLPEPL 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-287 9.70e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 9.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 119 LTTLPAGLSDlaCLAHLDLSFNRLETLPTCVPElhGLDALLLSHNHLSELPEALgalP-ALTFLTVTHNRLERLPLTLGS 197
Cdd:PRK15370 232 LTSIPATLPD--TIQEMELSINRITELPERLPS--ALQSLDLFHNKISCLPENL---PeELRYLSVYDNSIRTLPAHLPS 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 198 lsTLQRLDLSENLLDTIPSEIGnlRSLSELNLASNRLQSLPASLAglRSLRLLVLHSNLLTSVPTGLVhlPLITRLDLRD 277
Cdd:PRK15370 305 --GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSR 376

                        170
                 ....*....|
gi 755523932 278 NRLRDLPAEL 287
Cdd:PRK15370 377 NALTNLPENL 386
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-280 1.62e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 122 LPAGLSDLACLAHLDLSFNRLE-TLPTCVPELHGLDALLLSHNHLS-ELPEALGALPALTFLTVTHNRLE-RLPLTLGSL 198
Cdd:PLN00113 276 IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 199 STLQRLDLSEN-LLDTIPSEIGNLRSLSELNLASNRLQS-LPASLAGLRSLRLLVLHSNLLT-SVPTGLVHLPLITRLDL 275
Cdd:PLN00113 356 NNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDI 435


                 ....*
gi 755523932 276 RDNRL 280
Cdd:PLN00113 436 SNNNL 440
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 134-300 2.65e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 134 HLDLS---FNRLETLPTCvpelHGLDALLLSHNHLSELpEALGALPALTFLTVTHNRLERLPlTLGSLSTLQRLDLSENL 210
Cdd:cd21340    6 HLYLNdknITKIDNLSLC----KNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 211 LDTIpSEIGNLRSLSELNLASNRL---QSL---PASLAGL-RSLRLLVLHSNLLTSVpTGLVHLPLITRLDLRDNRLRDL 283
Cdd:cd21340   80 ISVV-EGLENLTNLEELHIENQRLppgEKLtfdPRSLAALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL 157

                        170       180
                 ....*....|....*....|....
gi 755523932 284 pAELLDA----PFVR---LQGNPL 300
Cdd:cd21340  158 -EELLDLlsswPSLReldLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 125-261 3.33e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 3.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 125 GLSDLACLAHLDLSFNRLETLPtcvpELHGLDAL---LLSHNHLSELpEALGALPALTFLTVTHNRL---ERL---PLTL 195
Cdd:cd21340   41 NLEFLTNLTHLYLQNNQIEKIE----NLENLVNLkklYLGGNRISVV-EGLENLTNLEELHIENQRLppgEKLtfdPRSL 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 196 GSLS-TLQRLDLSENLLDTIpSEIGNLRSLSELNLASNRLQSLPA---SLAGLRSLRLLVLHSNLLTSVP 261
Cdd:cd21340  116 AALSnSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
118-254 3.90e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 3.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 118 TLTTLPAGLSdlACLAHLDLSFNRLETLPTCVPElhGLDALLLSHNHLSELPEALGalPALTFLTVTHNRLERLPLTLGS 197
Cdd:PRK15370 294 SIRTLPAHLP--SGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPP 367

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755523932 198 lsTLQRLDLSENLLDTIPSeigNL-RSLSELNLASNRLQSLPASLAGLRS-----LRLLVLHS 254
Cdd:PRK15370 368 --TITTLDVSRNALTNLPE---NLpAALQIMQASRNNLVRLPESLPHFRGegpqpTRIIVEYN 425
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 129-288 9.62e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 9.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 129 LACLAHLDLSFNRLE-TLPTCVPELHGLDALLLSHNHLS-ELPEALGALPALTFLTVTHNRLE-RLPLTLGSLSTLQRLD 205
Cdd:PLN00113 139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIY 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 206 LS-ENLLDTIPSEIGNLRSLSELNLASNRLQ-SLPASLAGLRSLRLLVLHSNLLT-SVPTGLVHLPLITRLDLRDNRLRD 282
Cdd:PLN00113 219 LGyNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG 298


                 ....*.
gi 755523932 283 LPAELL 288
Cdd:PLN00113 299 EIPELV 304
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 426-458 6.74e-12

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


Pssm-ID: 463098  Cd Length: 34  Bit Score: 60.24  E-value: 6.74e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755523932  426 WNDLETQLEEEAPKRL-WARCQVPHFSWFLVVLR 458
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-280 1.10e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 122 LPAGLSDLACLAHLDLSFNRLE-TLPTCVPELHGLDALLLSHNHLS-ELPEALGAlPALTFLTVTHNRL-ERLPLTLGSL 198
Cdd:PLN00113 420 LPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSRNQFsGAVPRKLGSL 498

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 199 STLQRLDLSENLLD-TIPSEIGNLRSLSELNLASNRLQ-SLPASLAGLRSLRLLVLHSNLLT-SVPTGLVHLPLITRLDL 275
Cdd:PLN00113 499 SELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNI 578


                 ....*
gi 755523932 276 RDNRL 280
Cdd:PLN00113 579 SHNHL 583
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
119-302 6.86e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.02  E-value: 6.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 119 LTTLPAGLSDLACLAhldlsfNRLETLPTCVPelhGLDALLLSHNHLSELPealgALPA-LTFLTVTHNRLERLPlTLGS 197
Cdd:PRK15387 277 LPALPSGLCKLWIFG------NQLTSLPVLPP---GLQELSVSDNQLASLP----ALPSeLCKLWAYNNQLTSLP-TLPS 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 198 lsTLQRLDLSENLL---DTIPSEIGNL--------------RSLSELNLASNRLQSLPASLAGLRSlrlLVLHSNLLTSV 260
Cdd:PRK15387 343 --GLQELSVSDNQLaslPTLPSELYKLwaynnrltslpalpSGLKELIVSGNRLTSLPVLPSELKE---LMVSGNRLTSL 417

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755523932 261 PTglvhLPL-ITRLDLRDNRLRDLPAELL---DAPFVRLQGNPLGE 302
Cdd:PRK15387 418 PM----LPSgLLSLSVYRNQLTRLPESLIhlsSETTVNLEGNPLSE 459
LRR_8 pfam13855
Leucine rich repeat;
222-280 8.07e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 8.07e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755523932  222 RSLSELNLASNRLQSL-PASLAGLRSLRLLVLHSNLLTSV-PTGLVHLPLITRLDLRDNRL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 160-264 2.80e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 160 LSHNHLS-ELPEALGALP-ALTFLTVTHNRLERlPLTLGSLSTLQRLDLSENLLD-TIPSEIGNLRSLSELNLASNRLQS 236
Cdd:PLN00113 100 LSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVG 178

                         90       100       110
                 ....*....|....*....|....*....|
gi 755523932 237 -LPASLAGLRSLRLLVLHSNLLT-SVPTGL 264
Cdd:PLN00113 179 kIPNSLTNLTSLEFLTLASNQLVgQIPREL 208
PLN03150 PLN03150
hypothetical protein; Provisional
 148-244 3.46e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 56.36  E-value: 3.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 148 CVPELHG----------------LDALLLSHNHL-SELPEALGALPALTFLTVTHNRLE-RLPLTLGSLSTLQRLDLSEN 209
Cdd:PLN03150 397 CVPQQHPwsgadcqfdstkgkwfIDGLGLDNQGLrGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYN 476

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755523932 210 LLD-TIPSEIGNLRSLSELNLASNRLQS-LPASLAGL 244
Cdd:PLN03150 477 SFNgSIPESLGQLTSLRILNLNGNSLSGrVPAALGGR 513
LRR_8 pfam13855
Leucine rich repeat;
199-257 4.57e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.57e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755523932  199 STLQRLDLSENLLDTIPSEI-GNLRSLSELNLASNRLQSL-PASLAGLRSLRLLVLHSNLL 257
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 191-278 6.06e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.59  E-value: 6.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 191 LPLTLGSLSTLQRLDLSENLLD-TIPSEIGNLRSLSELNLASNRLQ-SLPASLAGLRSLRLLVLHSNLLTS-VPTGLVHL 267
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAALGGR 513

                         90
                 ....*....|..
gi 755523932 268 PLI-TRLDLRDN 278
Cdd:PLN03150 514 LLHrASFNFTDN 525
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 330-403 7.11e-08

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 50.60  E-value: 7.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755523932  330 SFLVTPHGCSVTLA-CGVRLQFPAGATTTPVTIHYRLWLP--EPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWL 403
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGTRIECYLAVNrdESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEV 78
LRR_8 pfam13855
Leucine rich repeat;
176-234 4.71e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.71e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755523932  176 PALTFLTVTHNRLERL-PLTLGSLSTLQRLDLSENLLDTI-PSEIGNLRSLSELNLASNRL 234
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 132-295 1.63e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 132 LAHLDLSFNRLE-----TLPTCVPEL-HGLDALLLSHNHLS-----ELPEALGALPALTFLTVTHNRL-----ERLPLTL 195
Cdd:cd00116  110 LQELKLNNNGLGdrglrLLAKGLKDLpPALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGIgdagiRALAEGL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 196 GSLSTLQRLDLSEN---------LLDTIPSeignLRSLSELNLASNRLQS------LPASLAGLRSLRLLVLHSNLLT-- 258
Cdd:cd00116  190 KANCNLEVLDLNNNgltdegasaLAETLAS----LKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDITdd 265

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755523932 259 ---SVPTGLVHLPLITRLDLRDNRL----RDLPAELLDAPFVRL 295
Cdd:cd00116  266 gakDLAEVLAEKESLLELDLRGNKFgeegAQLLAESLLEPGNEL 309
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 469-542 3.09e-05

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 42.90  E-value: 3.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755523932  469 EGALLCSSgHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLsqsGPP--SFLQPVTVQLP 542
Cdd:pfam00791   8 RGGRLVLP-NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
PLN03150 PLN03150
hypothetical protein; Provisional
 208-287 4.33e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 46.73  E-value: 4.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932 208 ENLLDTIPSEIGNLRSLSELNLASNRLQ-SLPASLAGLRSLRLLVLHSNLLT-SVPTGLVHLPLITRLDLRDNRLR-DLP 284
Cdd:PLN03150 428 QGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVP 507


                 ...
gi 755523932 285 AEL 287
Cdd:PLN03150 508 AAL 510
LRR_8 pfam13855
Leucine rich repeat;
132-188 4.98e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755523932  132 LAHLDLSFNRLETLPTCVPE-LHGLDALLLSHNHLSEL-PEALGALPALTFLTVTHNRL 188
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 480-542 2.11e-04

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 40.80  E-value: 2.11e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755523932   480 GVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQSGpPSFLQPVTVQLP 542
Cdd:smart00218  22 GVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHG-ALFLRPVILEVP 83
PLN03150 PLN03150
hypothetical protein; Provisional
 122-176 2.87e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 2.87e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755523932 122 LPAGLSDLACLAHLDLSFNRLE-TLPTCVPELHGLDALLLSHNHLS-ELPEALGALP 176
Cdd:PLN03150 458 IPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 114-284 4.51e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932  114 CLHgtLTTLPAGLsDLACLAHLDLS-FNRLETLPTCVPELHGLDallLSHNHLSELPEALgALPALTFLTVTHNRLERL- 191
Cdd:PLN03210  691 CEN--LEILPTGI-NLKSLYRLNLSgCSRLKSFPDISTNISWLD---LDETAIEEFPSNL-RLENLDELILCEMKSEKLw 763

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932  192 ----PLT--LGSLS-TLQRLDLSEN-LLDTIPSEIGNLRSLSELNLASNRlqslpaslaglrslrllvlhsNLLTsVPTG 263
Cdd:PLN03210  764 ervqPLTplMTMLSpSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCI---------------------NLET-LPTG 821

                         170       180
                  ....*....|....*....|..
gi 755523932  264 lVHLPLITRLDLRD-NRLRDLP 284
Cdd:PLN03210  822 -INLESLESLDLSGcSRLRTFP 842
LRR_9 pfam14580
Leucine-rich repeat;
135-215 9.92e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.44  E-value: 9.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755523932  135 LDLSFNRLETLPTcVPELHGLDALLLSHNHLSELPEALG-ALPALTFLTVTHNRLERL--PLTLGSLSTLQRLDLSENLL 211
Cdd:pfam14580  47 IDFSDNEIRKLDG-FPLLRRLKTLLLNNNRICRIGEGLGeALPNLTELILTNNNLQELgdLDPLASLKKLTFLSLLRNPV 125


                  ....
gi 755523932  212 DTIP 215
Cdd:pfam14580 126 TNKP 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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