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Conserved domains on  [gi|755519394|ref|XP_011248812|]
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zinc finger and SCAN domain-containing protein 18 isoform X5 [Mus musculus]

Protein Classification

SCAN domain-containing protein( domain architecture ID 10488381)

SCAN domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 452-540 4.00e-34

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


:

Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 124.91  E-value: 4.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394  452 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLRPEACSKEQILELLVLEQFLGILPDRVRPWVVAQYPENCKKAASLV 531
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 755519394  532 EGISDILEE 540
Cdd:pfam02023  81 EDLLLERGE 89
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 98-201 4.69e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 40.36  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394    98 QEGLIKQQEPSQQEECRRQDELIRKEEPIQLLETSQREELSEQQEPSQQDEPSQEEESVQLQEPSQWGEPGQKDVPMQQE 177
Cdd:TIGR00927  794 DEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEE 873

                           90       100
                   ....*....|....*....|....
gi 755519394   178 EPMQQDEPSQWEEPMQQDEPMQQE 201
Cdd:TIGR00927  874 EEEEEEEEEEEEEEEENEEPLSLE 897
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 452-540 4.00e-34

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 124.91  E-value: 4.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394  452 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLRPEACSKEQILELLVLEQFLGILPDRVRPWVVAQYPENCKKAASLV 531
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 755519394  532 EGISDILEE 540
Cdd:pfam02023  81 EDLLLERGE 89
SCAN smart00431
leucine rich region;
453-542 1.79e-29

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 112.78  E-value: 1.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394   453 EFSRLRFREFVYQEAAGPHQTLARLHELCRQWLRPEACSKEQILELLVLEQFLGILPDRVRPWVVAQYPENCKKAASLVE 532
Cdd:smart00431   2 EIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLE 81

                           90
                   ....*....|
gi 755519394   533 GISDILEEPG 542
Cdd:smart00431  82 DLERELDEPG 91
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 452-532 2.67e-28

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 108.50  E-value: 2.67e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394 452 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLRPEACSKEQILELLVLEQFLGILPDRVRPWVVAQYPENCKKAASLV 531
Cdd:cd07936    1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                 .
gi 755519394 532 E 532
Cdd:cd07936   81 E 81
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 98-201 4.69e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 40.36  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394    98 QEGLIKQQEPSQQEECRRQDELIRKEEPIQLLETSQREELSEQQEPSQQDEPSQEEESVQLQEPSQWGEPGQKDVPMQQE 177
Cdd:TIGR00927  794 DEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEE 873

                           90       100
                   ....*....|....*....|....
gi 755519394   178 EPMQQDEPSQWEEPMQQDEPMQQE 201
Cdd:TIGR00927  874 EEEEEEEEEEEEEEEENEEPLSLE 897
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 452-540 4.00e-34

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 124.91  E-value: 4.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394  452 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLRPEACSKEQILELLVLEQFLGILPDRVRPWVVAQYPENCKKAASLV 531
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 755519394  532 EGISDILEE 540
Cdd:pfam02023  81 EDLLLERGE 89
SCAN smart00431
leucine rich region;
453-542 1.79e-29

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 112.78  E-value: 1.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394   453 EFSRLRFREFVYQEAAGPHQTLARLHELCRQWLRPEACSKEQILELLVLEQFLGILPDRVRPWVVAQYPENCKKAASLVE 532
Cdd:smart00431   2 EIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLE 81

                           90
                   ....*....|
gi 755519394   533 GISDILEEPG 542
Cdd:smart00431  82 DLERELDEPG 91
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 452-532 2.67e-28

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 108.50  E-value: 2.67e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394 452 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLRPEACSKEQILELLVLEQFLGILPDRVRPWVVAQYPENCKKAASLV 531
Cdd:cd07936    1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                 .
gi 755519394 532 E 532
Cdd:cd07936   81 E 81
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 98-201 4.69e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 40.36  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519394    98 QEGLIKQQEPSQQEECRRQDELIRKEEPIQLLETSQREELSEQQEPSQQDEPSQEEESVQLQEPSQWGEPGQKDVPMQQE 177
Cdd:TIGR00927  794 DEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEE 873

                           90       100
                   ....*....|....*....|....
gi 755519394   178 EPMQQDEPSQWEEPMQQDEPMQQE 201
Cdd:TIGR00927  874 EEEEEEEEEEEEEEEENEEPLSLE 897
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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