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Conserved domains on  [gi|767909587|ref|XP_011507953|]
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ADAMTS-like protein 4 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
45-158 3.21e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 111.90  E-value: 3.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909587   45 LVSGNLTdRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREe 123
Cdd:pfam05986   1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767909587  124 gkGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 158
Cdd:pfam05986  79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
286-342 3.86e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.79  E-value: 3.86e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  286 WEAGEWTSCSRSCGPGTQHRQLQCRQEfgGGGSSVPPERCGHLPRPNITQSCQLRLC 342
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
473-529 1.08e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 1.08e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  473 WYTGPWGECSSECGSGTQRRDIICVSKLGteFNVTSPSNCSHLPRPPALQPCQGQAC 529
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
533-584 1.58e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767909587  533 WFSTPWSPCSRSCQGGTQTREVQCLSTN---QTLSTRCPPQLRPSRKRPCNSQPC 584
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
592-621 1.02e-09

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 53.69  E-value: 1.02e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 767909587  592 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 621
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
345-400 1.24e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 1.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  345 WEVGsPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECaSGPPQPPSREACDMGPC 400
Cdd:pfam19030   1 WVAG-PWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
404-467 3.14e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.45  E-value: 3.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909587  404 WFHSDWSSkCSAECGTGIQRRSVVCLGSGaalgpGQGEAGagtGQSCPTGSRPPDMRACSLGPC 467
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKG-----GGSIVP---DSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
233-282 5.90e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.51  E-value: 5.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767909587  233 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASpEPCHGTPC 282
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
45-158 3.21e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 111.90  E-value: 3.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909587   45 LVSGNLTdRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREe 123
Cdd:pfam05986   1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767909587  124 gkGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 158
Cdd:pfam05986  79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
286-342 3.86e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.79  E-value: 3.86e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  286 WEAGEWTSCSRSCGPGTQHRQLQCRQEfgGGGSSVPPERCGHLPRPNITQSCQLRLC 342
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
473-529 1.08e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 1.08e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  473 WYTGPWGECSSECGSGTQRRDIICVSKLGteFNVTSPSNCSHLPRPPALQPCQGQAC 529
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
533-584 1.58e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767909587  533 WFSTPWSPCSRSCQGGTQTREVQCLSTN---QTLSTRCPPQLRPSRKRPCNSQPC 584
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
592-621 1.02e-09

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 53.69  E-value: 1.02e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 767909587  592 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 621
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
345-400 1.24e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 1.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  345 WEVGsPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECaSGPPQPPSREACDMGPC 400
Cdd:pfam19030   1 WVAG-PWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
404-467 3.14e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.45  E-value: 3.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909587  404 WFHSDWSSkCSAECGTGIQRRSVVCLGSGaalgpGQGEAGagtGQSCPTGSRPPDMRACSLGPC 467
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKG-----GGSIVP---DSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
536-585 1.33e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 1.33e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767909587   536 TPWSPCSRSCQGGTQTREVQCLSTNQTLS-TRCPPQLRpsRKRPCNSQPCS 585
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
345-400 9.58e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 9.58e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767909587   345 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDeVSEQECasgPPQPPSREACDMGPC 400
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
342-389 6.18e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 6.18e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767909587 342 CGHWEvgsPWSQCSVRCGRGQRSRQ-----VRCVGNNGDEVSEQECasgPPQP 389
Cdd:PTZ00441 240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEEC---PVEP 286
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
233-282 5.90e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.51  E-value: 5.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767909587  233 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASpEPCHGTPC 282
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
45-158 3.21e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 111.90  E-value: 3.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909587   45 LVSGNLTdRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREe 123
Cdd:pfam05986   1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767909587  124 gkGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 158
Cdd:pfam05986  79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
286-342 3.86e-15

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.79  E-value: 3.86e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  286 WEAGEWTSCSRSCGPGTQHRQLQCRQEfgGGGSSVPPERCGHLPRPNITQSCQLRLC 342
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
473-529 1.08e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 1.08e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  473 WYTGPWGECSSECGSGTQRRDIICVSKLGteFNVTSPSNCSHLPRPPALQPCQGQAC 529
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
533-584 1.58e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767909587  533 WFSTPWSPCSRSCQGGTQTREVQCLSTN---QTLSTRCPPQLRPSRKRPCNSQPC 584
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
592-621 1.02e-09

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 53.69  E-value: 1.02e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 767909587  592 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 621
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
345-400 1.24e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 1.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909587  345 WEVGsPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECaSGPPQPPSREACDMGPC 400
Cdd:pfam19030   1 WVAG-PWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
404-467 3.14e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 47.45  E-value: 3.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909587  404 WFHSDWSSkCSAECGTGIQRRSVVCLGSGaalgpGQGEAGagtGQSCPTGSRPPDMRACSLGPC 467
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKG-----GGSIVP---DSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
536-585 1.33e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 1.33e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767909587   536 TPWSPCSRSCQGGTQTREVQCLSTNQTLS-TRCPPQLRpsRKRPCNSQPCS 585
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
345-400 9.58e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 9.58e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767909587   345 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDeVSEQECasgPPQPPSREACDMGPC 400
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
536-584 1.68e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.57  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767909587  536 TPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLrpsRKRPCNSQPC 584
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELL---ERRPCNLPPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
342-389 6.18e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 6.18e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767909587 342 CGHWEvgsPWSQCSVRCGRGQRSRQ-----VRCVGNNGDEVSEQECasgPPQP 389
Cdd:PTZ00441 240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEEC---PVEP 286
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
233-282 5.90e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.51  E-value: 5.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767909587  233 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASpEPCHGTPC 282
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
536-584 9.25e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 34.70  E-value: 9.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767909587  536 TPWSPCSRSCQGGTQTREVQCLStNQTLSTRCPPQLRpsRKRPCNSQPC 584
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTCKS-PFPGGEPCTGDDI--ETQACKMDKC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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