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Conserved domains on  [gi|767910633|ref|XP_011508359|]
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mitochondrial import receptor subunit TOM40B isoform X3 [Homo sapiens]

Protein Classification

mitochondrial import receptor subunit TOM40 family protein( domain architecture ID 10163980)

mitochondrial import receptor subunit TOM40 family protein is a porin similar to translocase of outer mitochondrial membrane 40 (Tom40) which forms channels in the mitochondrial outer membrane and functions as a transport channel for unfolded protein chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
 24-243 2.51e-93

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


:

Pssm-ID: 132766 [Multi-domain]  Cd Length: 279  Bit Score: 275.24  E-value: 2.51e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  24 LPNPGSFDELHRLCKDVFPAQME-GVKLVVNKVLSSHFQ----------------------------------------- 61
Cdd:cd07305    1 LPNPGTFEELHREVKEVFPLDFFdGFRLDVNKGLSPHFQvshslhlgsssltssyqfgatyvgdkqypflqgdidndgnl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  62 -------------------TQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRR 122
Cdd:cd07305   81 nariihqlgdrlrsklqaqLQDSKFNMSQLELDYRGDDFTASLKLANPDILNETGIYVASYLQSVTPKLALGGELVYQRV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633 123 PGEEGAILTLAGKYSAVHWVATLNVGS-GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQAnmVFRGLVD 201
Cdd:cd07305  161 PGNGISVLSYAARYTAGNWIASGQLGAqGGLHLSYYRKLSDKLQLGVELELNLRTRESTATLGYQYDFRQS--RFRGSID 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767910633 202 SNWCVGAVLEKKMPPlPVTLALGAFLNHWRNRFHCGFSITVG 243
Cdd:cd07305  239 SNGKVSAVLEKRLPL-PLSLLLSGELNHVKNDYKFGFGLTIG 279
 
Name Accession Description Interval E-value
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
 24-243 2.51e-93

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


Pssm-ID: 132766 [Multi-domain]  Cd Length: 279  Bit Score: 275.24  E-value: 2.51e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  24 LPNPGSFDELHRLCKDVFPAQME-GVKLVVNKVLSSHFQ----------------------------------------- 61
Cdd:cd07305    1 LPNPGTFEELHREVKEVFPLDFFdGFRLDVNKGLSPHFQvshslhlgsssltssyqfgatyvgdkqypflqgdidndgnl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  62 -------------------TQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRR 122
Cdd:cd07305   81 nariihqlgdrlrsklqaqLQDSKFNMSQLELDYRGDDFTASLKLANPDILNETGIYVASYLQSVTPKLALGGELVYQRV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633 123 PGEEGAILTLAGKYSAVHWVATLNVGS-GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQAnmVFRGLVD 201
Cdd:cd07305  161 PGNGISVLSYAARYTAGNWIASGQLGAqGGLHLSYYRKLSDKLQLGVELELNLRTRESTATLGYQYDFRQS--RFRGSID 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767910633 202 SNWCVGAVLEKKMPPlPVTLALGAFLNHWRNRFHCGFSITVG 243
Cdd:cd07305  239 SNGKVSAVLEKRLPL-PLSLLLSGELNHVKNDYKFGFGLTIG 279
Porin_3 pfam01459
Eukaryotic porin;
26-232 4.25e-49

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 162.00  E-value: 4.25e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633   26 NPGSFDELHRLCKDVFPAQ--MEGVKLVVNKV--LSSHFQTQ--------------QAKF--------LTW--------- 70
Cdd:pfam01459   1 NPGTYEDIGKEAKDLLNKDyhFDGAKLDVTTKsgLGVAFQVSgsfslgsglssgdfEAKYkdkgltltLKGdtdndlstt 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633   71 --------------------------QFDGEYRGDDYTATLTLGNpdliGESVIMVAHFLQSLTHrLVLGGELVYHRRPG 124
Cdd:pfam01459  81 atvneqltpglktklstqfvpgkksgKLELDYKGDDFTASLKVGL----LAGPVVVGSYLQGVTG-LALGAEASYDTASG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  125 EEGAIlTLAGKYSAVHWVATLNVGS--GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVfRGLVDS 202
Cdd:pfam01459 156 KLTKY-NAALGYTARDYIASLTLVNngGVLTASYYHKVSEKLEVGAELTLNFSSNENTVTIGYKYDLDKSTTV-KAKVNS 233

                         250       260       270
                  ....*....|....*....|....*....|
gi 767910633  203 NWCVGAVLEKKMPPlPVTLALGAFLNHWRN 232
Cdd:pfam01459 234 NGKVGLLYEQKLRP-GVTLTLSAEVDHKKL 262
3a0801s07tom40 TIGR00989
mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) ...
 71-119 4.29e-04

mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tom40 proteins. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130062  Cd Length: 161  Bit Score: 39.87  E-value: 4.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767910633   71 QFDGEYRGDDYTATLTLGNPDLI--GESVIMVAHFLQSLTHRLVLGGELVY 119
Cdd:TIGR00989 110 QFEHDHLGDDFSASLKAINPSFLekGLTGIFVGSYLQSVTPRLGLGLEALW 160
 
Name Accession Description Interval E-value
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
 24-243 2.51e-93

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


Pssm-ID: 132766 [Multi-domain]  Cd Length: 279  Bit Score: 275.24  E-value: 2.51e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  24 LPNPGSFDELHRLCKDVFPAQME-GVKLVVNKVLSSHFQ----------------------------------------- 61
Cdd:cd07305    1 LPNPGTFEELHREVKEVFPLDFFdGFRLDVNKGLSPHFQvshslhlgsssltssyqfgatyvgdkqypflqgdidndgnl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  62 -------------------TQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRR 122
Cdd:cd07305   81 nariihqlgdrlrsklqaqLQDSKFNMSQLELDYRGDDFTASLKLANPDILNETGIYVASYLQSVTPKLALGGELVYQRV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633 123 PGEEGAILTLAGKYSAVHWVATLNVGS-GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQAnmVFRGLVD 201
Cdd:cd07305  161 PGNGISVLSYAARYTAGNWIASGQLGAqGGLHLSYYRKLSDKLQLGVELELNLRTRESTATLGYQYDFRQS--RFRGSID 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767910633 202 SNWCVGAVLEKKMPPlPVTLALGAFLNHWRNRFHCGFSITVG 243
Cdd:cd07305  239 SNGKVSAVLEKRLPL-PLSLLLSGELNHVKNDYKFGFGLTIG 279
Porin_3 pfam01459
Eukaryotic porin;
26-232 4.25e-49

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 162.00  E-value: 4.25e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633   26 NPGSFDELHRLCKDVFPAQ--MEGVKLVVNKV--LSSHFQTQ--------------QAKF--------LTW--------- 70
Cdd:pfam01459   1 NPGTYEDIGKEAKDLLNKDyhFDGAKLDVTTKsgLGVAFQVSgsfslgsglssgdfEAKYkdkgltltLKGdtdndlstt 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633   71 --------------------------QFDGEYRGDDYTATLTLGNpdliGESVIMVAHFLQSLTHrLVLGGELVYHRRPG 124
Cdd:pfam01459  81 atvneqltpglktklstqfvpgkksgKLELDYKGDDFTASLKVGL----LAGPVVVGSYLQGVTG-LALGAEASYDTASG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  125 EEGAIlTLAGKYSAVHWVATLNVGS--GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVfRGLVDS 202
Cdd:pfam01459 156 KLTKY-NAALGYTARDYIASLTLVNngGVLTASYYHKVSEKLEVGAELTLNFSSNENTVTIGYKYDLDKSTTV-KAKVNS 233

                         250       260       270
                  ....*....|....*....|....*....|
gi 767910633  203 NWCVGAVLEKKMPPlPVTLALGAFLNHWRN 232
Cdd:pfam01459 234 NGKVGLLYEQKLRP-GVTLTLSAEVDHKKL 262
Porin3 cd07303
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ...
 29-243 9.14e-49

Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane.


Pssm-ID: 132765 [Multi-domain]  Cd Length: 274  Bit Score: 161.67  E-value: 9.14e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  29 SFDELHRLCKDVFPAQME-GVKLVVNKVLSSHFQT--------------------------------------------- 62
Cdd:cd07303    1 TYAELGKSARDLFTKGYGgGIKLDVKTKSELEFTSsgsantetiesttkvggsletkyrwspygltftekwntdntlgle 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  63 --------------------QQAKFLTWQFDGEYRGDDYTATLTLGNpdligeSVIMVAHFLQSLTHRLVLGGELVYHR- 121
Cdd:cd07303   81 itvedqlsrglkstfdssfsPNTGKKNAKIKTGYKRINLGCDVDFDI------AGPLIRGALVLGYEGWLAGYQMVFETv 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633 122 -RPGEEGAILTLAGKYSavHWVATLNVGSG-GAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQaNMVFRGL 199
Cdd:cd07303  155 sRVTQSNFAVGYKTDYN--EFQAHTNVNDGtEFGGSIYHKVNDKLEVGVNLAATAGNSNTRFGIAAKYQVDP-DACFSAS 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767910633 200 VDSNWCVGAVLEKKMPPlPVTLALGAFLNHWRNRFHCGFSITVG 243
Cdd:cd07303  232 VNNSSLVGLGYTQTLKP-GIKLTLSALLDHKAGGHKLGLGLEFQ 274
3a0801s07tom40 TIGR00989
mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) ...
 71-119 4.29e-04

mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tom40 proteins. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130062  Cd Length: 161  Bit Score: 39.87  E-value: 4.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767910633   71 QFDGEYRGDDYTATLTLGNPDLI--GESVIMVAHFLQSLTHRLVLGGELVY 119
Cdd:TIGR00989 110 QFEHDHLGDDFSASLKAINPSFLekGLTGIFVGSYLQSVTPRLGLGLEALW 160
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
 154-228 2.66e-03

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 38.34  E-value: 2.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910633 154 ASYYHRANEQVQVGVEFEANTRLQDTTFSFG--YHLtlpQANMVFRGLVDSNWCVGAVLEKKMPPLpVTLALGAFLN 228
Cdd:cd07306  186 GSYFHKVSPRLAVGAKVTWYSGTNETTFAVGgqYAL---DPDALVKAKVNNDGQLGLSYQHKLRPG-VTLTLSAGFD 258
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
 60-189 3.79e-03

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 37.57  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910633  60 FQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESvimvahFLQSLTHRLVLGGELvyHRRPGEEGAILTLAGKYsAV 139
Cdd:cd07306  151 YDTAKSKFTKYNFALGYTNGDFELSLKLNNGKTLRGS------YFHKVSPRLAVGAKV--TWYSGTNETTFAVGGQY-AL 221

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767910633 140 HWVATLNV---GSGGAHASYYHRANEQVQVGVEFEANTR-LQDTTFSFGYHLTL 189
Cdd:cd07306  222 DPDALVKAkvnNDGQLGLSYQHKLRPGVTLTLSAGFDAKnLNQGGHKFGLSLSL 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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