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Conserved domains on  [gi|767918132|ref|XP_011509476|]
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AF4/FMR2 family member 3 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
45-498 1.54e-131

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 412.98  E-value: 1.54e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132    45 YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQsHLVGVPKPG 124
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQ-HLVGIPKNS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   125 VPQTPVNKIDEHFVADSRAQNQPSSICSTTTST---PAAVPV-------QQSKRGTMGWQKAGHPPSDGQ---------- 184
Cdd:pfam05110   80 VPQTPQEKPDQPFFPDKTSGLPPSFHTSSHSQPmgpPSSSSPsvsssqsQKKSQARTEPAHGGHSSSGSQssqrsqgqsr 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   185 ---------------------------------------------------QRATQQGSLRTL-LGDGVGRQQPRAKQVC 212
Cdd:pfam05110  160 skggqeshssshhkrqerredlfscaslshsleelspllsslsspvkplspSHSRQHTGSKAQnSSDHHGKEYSHSKSPR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   213 NVEVGLQTQERPPAMAAKHSSsGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSEtSVHCTSYRGV 292
Cdd:pfam05110  240 DSEAGSHGPESPSTSLLASSS-QLSSQTFPPSLPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPE-DYHGQSYGKL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   293 PASKPEparAKAKLSKFSIPKQ-GEESRSGEtNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHN 369
Cdd:pfam05110  318 SDLKAN---AKAKLSKLKIPSQpLEQSLSND-VHCVEEILKEMThsWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQ 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   370 NPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSS 449
Cdd:pfam05110  394 NQKQYDAPSKTLPTSQQGTSMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGS 465
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 767918132   450 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 498
Cdd:pfam05110  466 SSDSESSSESDSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
990-1250 1.95e-128

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 394.81  E-value: 1.95e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   990 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 1069
Cdd:pfam18876    5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132  1070 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGAsgKSTGTPSPMSPNP 1149
Cdd:pfam18876   85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVA--KSTGTPSPLSPMP 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132  1150 SPASSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS 1229
Cdd:pfam18876  163 SPASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSS 240
                          250       260
                   ....*....|....*....|.
gi 767918132  1230 MEHLVQYSQQGLHWLRNSAHL 1250
Cdd:pfam18876  241 MTELVRYTRQGLHWLRLDAKL 261
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
791-804 1.65e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


:

Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.65e-03
                           10
                   ....*....|....
gi 767918132   791 LWVKIDLTLLSRIP 804
Cdd:pfam18875    1 LVVKIDLSLLSRVP 14
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
45-498 1.54e-131

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 412.98  E-value: 1.54e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132    45 YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQsHLVGVPKPG 124
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQ-HLVGIPKNS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   125 VPQTPVNKIDEHFVADSRAQNQPSSICSTTTST---PAAVPV-------QQSKRGTMGWQKAGHPPSDGQ---------- 184
Cdd:pfam05110   80 VPQTPQEKPDQPFFPDKTSGLPPSFHTSSHSQPmgpPSSSSPsvsssqsQKKSQARTEPAHGGHSSSGSQssqrsqgqsr 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   185 ---------------------------------------------------QRATQQGSLRTL-LGDGVGRQQPRAKQVC 212
Cdd:pfam05110  160 skggqeshssshhkrqerredlfscaslshsleelspllsslsspvkplspSHSRQHTGSKAQnSSDHHGKEYSHSKSPR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   213 NVEVGLQTQERPPAMAAKHSSsGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSEtSVHCTSYRGV 292
Cdd:pfam05110  240 DSEAGSHGPESPSTSLLASSS-QLSSQTFPPSLPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPE-DYHGQSYGKL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   293 PASKPEparAKAKLSKFSIPKQ-GEESRSGEtNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHN 369
Cdd:pfam05110  318 SDLKAN---AKAKLSKLKIPSQpLEQSLSND-VHCVEEILKEMThsWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQ 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   370 NPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSS 449
Cdd:pfam05110  394 NQKQYDAPSKTLPTSQQGTSMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGS 465
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 767918132   450 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 498
Cdd:pfam05110  466 SSDSESSSESDSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
990-1250 1.95e-128

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 394.81  E-value: 1.95e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   990 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 1069
Cdd:pfam18876    5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132  1070 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGAsgKSTGTPSPMSPNP 1149
Cdd:pfam18876   85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVA--KSTGTPSPLSPMP 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132  1150 SPASSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS 1229
Cdd:pfam18876  163 SPASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSS 240
                          250       260
                   ....*....|....*....|.
gi 767918132  1230 MEHLVQYSQQGLHWLRNSAHL 1250
Cdd:pfam18876  241 MTELVRYTRQGLHWLRLDAKL 261
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
791-804 1.65e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.65e-03
                           10
                   ....*....|....
gi 767918132   791 LWVKIDLTLLSRIP 804
Cdd:pfam18875    1 LVVKIDLSLLSRVP 14
 
Name Accession Description Interval E-value
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
45-498 1.54e-131

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 412.98  E-value: 1.54e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132    45 YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQsHLVGVPKPG 124
Cdd:pfam05110    1 YNEDRNLLRIREWERRNQEVQQEKDLFPENFPLFGEPYKTNKGDELSSRIQNMLGNYEEMKELITNKSNQ-HLVGIPKNS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   125 VPQTPVNKIDEHFVADSRAQNQPSSICSTTTST---PAAVPV-------QQSKRGTMGWQKAGHPPSDGQ---------- 184
Cdd:pfam05110   80 VPQTPQEKPDQPFFPDKTSGLPPSFHTSSHSQPmgpPSSSSPsvsssqsQKKSQARTEPAHGGHSSSGSQssqrsqgqsr 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   185 ---------------------------------------------------QRATQQGSLRTL-LGDGVGRQQPRAKQVC 212
Cdd:pfam05110  160 skggqeshssshhkrqerredlfscaslshsleelspllsslsspvkplspSHSRQHTGSKAQnSSDHHGKEYSHSKSPR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   213 NVEVGLQTQERPPAMAAKHSSsGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSEtSVHCTSYRGV 292
Cdd:pfam05110  240 DSEAGSHGPESPSTSLLASSS-QLSSQTFPPSLPSKTSAMQQKPTAYVRPMDGQDQAPSESPELKPSPE-DYHGQSYGKL 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   293 PASKPEparAKAKLSKFSIPKQ-GEESRSGEtNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHN 369
Cdd:pfam05110  318 SDLKAN---AKAKLSKLKIPSQpLEQSLSND-VHCVEEILKEMThsWPPPLTAIHTPSTAEPSKFPFPTKESQHVTSGYQ 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   370 NPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSS 449
Cdd:pfam05110  394 NQKQYDAPSKTLPTSQQGTSMLEDDLKLSSSEDSDDDQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGS 465
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 767918132   450 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 498
Cdd:pfam05110  466 SSDSESSSESDSESESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
990-1250 1.95e-128

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 394.81  E-value: 1.95e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132   990 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 1069
Cdd:pfam18876    5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132  1070 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGAsgKSTGTPSPMSPNP 1149
Cdd:pfam18876   85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVA--KSTGTPSPLSPMP 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918132  1150 SPASSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS 1229
Cdd:pfam18876  163 SPASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSS 240
                          250       260
                   ....*....|....*....|.
gi 767918132  1230 MEHLVQYSQQGLHWLRNSAHL 1250
Cdd:pfam18876  241 MTELVRYTRQGLHWLRLDAKL 261
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
791-804 1.65e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.65e-03
                           10
                   ....*....|....
gi 767918132   791 LWVKIDLTLLSRIP 804
Cdd:pfam18875    1 LVVKIDLSLLSRVP 14
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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