Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155 2996 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3030
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155   2142 TCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2174
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155   2871 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 2903
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155  346 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 380
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767918155   2595 VIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 2636
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155 2230 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 2264
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767918155   3378 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYR 3413
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767918155  3434 GLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDY 3475
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155 2312 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 2346
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155   1936 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 1968
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767918155  2570 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 2611
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|...
gi 767918155 2831 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDED 2863
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155  263 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 297
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155   2749 CSSTQFLCANNeKCIPIWWKCDGQKDCSDGSDE 2781
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767918155   2499 ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHR 2541
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767918155  1120 GKLYWsdqgTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1165
Cdd:pfam00058    1 GRLYW----TDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1328 AGQGRNALHVDVDVSSGFIYWCDfsssvASDNAIRRIKPDGSSLMNIVTHGigeNGVRGIAVDWVAGNLYFTNAFVSEtl 1407
Cdd:COG3391    64 AAAVADADGADAGADGRRLYVAN-----SGSGRVSVIDLATGKVVATIPVG---GGPRGLAVDPDGGRLYVADSGNGR-- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1408 ieVLRINTTYRRVLLKVTV-DMPRHIVVDPKNRYLFWADYGQrPKIER--SFLDCTNRTVL--VSEGiVTPRGLAVDRSD 1482
Cdd:COG3391   134 --VSVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVatIPVG-GGPVGVAVSPDG 209

                  ....*..
gi 767918155 1483 GYVYWVD 1489
Cdd:COG3391   210 RRLYVAN 216

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767918155  424 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDEAGC 459
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155  467 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDEHN 501
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEEN 34

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|...
gi 767918155 2919 TEFSCKtNYRCIPKWAVCNGVDDCRDNSDEQGC 2951
Cdd:cd00112     4 NEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|.
gi 767918155   3122 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3152
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767918155  2519 RKLYWLDARLD-GLFVSDLNGGHRRMLAQHcvdanntfCFDNPRGLALHP 2567
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTD--------DLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767918155   1148 KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDR 1190
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767918155  1259 CSNNMNACQQICLPVPGGlFSCACATGFKLNPDNRSC 1295
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....
gi 767918155   2058 TCQSGYTKCHNSNiCIPRVYLCDGDNDCGDNSDE 2091
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33

Streptogramin lyase [Defense mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1473 PRGLAVDRsDGYVYWVDDSLDIIARIRINGENSEVIRYGSRyPTPYGITVFENSIIWV-DRNLKKIFQaskepenteppt 1551
Cdd:COG4257    19 PRDVAVDP-DGAVWFTDQGGGRIGRLDPATGEFTEYPLGGG-SGPHGIAVDPDGNLWFtDNGNNRIGR------------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1552 virdninwlrdVTIFDKQVQprspaevnnnpclennggcshlCFALPGLHTPKCDCAFGtlqSDGKncaistenfLIFAL 1631
Cdd:COG4257    85 -----------IDPKTGEIT----------------------TFALPGGGSNPHGIAFD---PDGN---------LWFTD 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1632 SNSLRSLHLDPENHSppFQTINVERTV---MSLDYDSvSDRIYFTQNLASGVGQISYATLSSGIHT-PTVIA--SGIG-T 1704
Cdd:COG4257   120 QGGNRIGRLDPATGE--VTEFPLPTGGagpYGIAVDP-DGNLWVTDFGANAIGRIDPDTGTLTEYAlPTPGAgpRGLAvD 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1705 ADGiafdwitrRIYYSDYLN---QMINsmAEDGSNRTVI--ARVPKPRAIVLDPcQGYLYWADWDTH--AKIERATLGGN 1777
Cdd:COG4257   197 PDG--------NLWVADTGSgriGRFD--PKTGTVTEYPlpGGGARPYGVAVDG-DGRVWFAESGANriVRFDPDTELTE 265

                  ....
gi 767918155 1778 FRVP 1781
Cdd:COG4257   266 YVLP 269

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767918155 2384 KRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKT 2427
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 767918155   2790 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDE 2821
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|
gi 767918155  2706 CGTNNGGCSHLCLIKPGgkGFTCECPDDFR 2735
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYE 28

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 767918155   218 NGDCSHFCFPVPNfQRVCGCPYGMRLASNHLTC 250
Cdd:pfam14670    5 NGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1024 DAEQYIYWVENP-GEIHRVKTDGTNRTVFASISmvGPSMNLALD-----WI---SRNLYSTNPRTQSIEVLTLHGDIRYR 1094
Cdd:COG3386    16 DPDGRLYWVDIPgGRIHRYDPDGGAVEVFAEPS--GRPNGLAFDpdgrlLVadhGRGLVRFDPADGEVTVLADEYGKPLN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918155 1095 ktlIANDGtalgvgfpigiTVDPArGKLYWSDQGTDSGvPAKIASANMDGtSVKTLFTG----N-LehleCVTLDieEQK 1169
Cdd:COG3386    94 ---RPNDG-----------VVDPD-GRLYFTDMGEYLP-TGALYRVDPDG-SLRVLADGltfpNgI----AFSPD--GRT 150

                         170
                  ....*....|....*....
gi 767918155 1170 LYWAVTGRGVIERGNVDGT 1188
Cdd:COG3386   151 LYVADTGAGRIYRFDLDAD 169

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10
                   ....*....|....*....
gi 767918155  3575 CSHLCLLRPGGYSCACPQG 3593
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEG 26

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155 2996 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3030
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155   2142 TCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2174
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155   2871 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 2903
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155  346 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 380
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767918155   2595 VIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 2636
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|...
gi 767918155 2143 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDED 2175
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155 2230 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 2264
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 767918155    782 VLISKNLTNPRGLALDPRmnEHLLFWSDWGhHPRIERASMDGSMR 826
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWI--EGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767918155   3378 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYR 3413
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 767918155  2141 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2174
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155   2268 TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 2300
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155    507 TCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDE 539
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155 2312 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 2346
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767918155 1978 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2012
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767918155   3459 ILVFEDLGWPTGLSIDYLNnDRIYWSDFKEDVIETIKYDGTDR 3501
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIE-GRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767918155  2570 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 2611
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767918155   385 TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 420
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767918155   303 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 338
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 767918155    303 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 335
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33