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Conserved domains on  [gi|767919700|ref|XP_011510120|]
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sperm-associated antigen 16 protein isoform X6 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 348-551 1.14e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.86  E-value: 1.14e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 348 FRLHELPVSCVSMQPHKDILVSCGED---RLWKvLGLPKCNVLLTGfgHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLC 424
Cdd:cd00200   47 LKGHTGPVRDVAASADGTYLASGSSDktiRLWD-LETGECVRTLTG--HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 425 KGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSI 504
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767919700 505 WDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 348-551 1.14e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.86  E-value: 1.14e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 348 FRLHELPVSCVSMQPHKDILVSCGED---RLWKvLGLPKCNVLLTGfgHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLC 424
Cdd:cd00200   47 LKGHTGPVRDVAASADGTYLASGSSDktiRLWD-LETGECVRTLTG--HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 425 KGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSI 504
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767919700 505 WDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
343-548 3.14e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.57  E-value: 3.14e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGED---RLWKVLGLPKCNVLLtgfGHTDWLSDCCFHPSGDKLATSSGDTTVK 419
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDgtvRLWDLATGKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 420 LWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSAD 499
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767919700 500 KTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
PTZ00421 PTZ00421
coronin; Provisional
 399-563 1.03e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.06  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 399 DCCFHPSGD-KLATSSGDTTVKLWDLCK-------GDCILTFEGHSRAVWSCTWH-SCGNFVASSSLDKTSKIWDVNSER 469
Cdd:PTZ00421  80 DVAFNPFDPqKLFTASEDGTIMGWGIPEegltqniSDPIVHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 470 CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIND-AIFDPRGHMIAScdaCGVTK--- 545
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIIT---LGCSKsqq 236

                        170       180
                 ....*....|....*....|...
gi 767919700 546 ----LWDFRKLL-PIVSIDIGPS 563
Cdd:PTZ00421 237 rqimLWDTRKMAsPYSTVDLDQS 259
WD40 pfam00400
WD domain, G-beta repeat;
426-464 1.77e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767919700  426 GDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD 464
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 425-464 3.20e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 3.20e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767919700   425 KGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD 464
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 348-551 1.14e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.86  E-value: 1.14e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 348 FRLHELPVSCVSMQPHKDILVSCGED---RLWKvLGLPKCNVLLTGfgHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLC 424
Cdd:cd00200   47 LKGHTGPVRDVAASADGTYLASGSSDktiRLWD-LETGECVRTLTG--HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 425 KGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSI 504
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767919700 505 WDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-551 2.41e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.39  E-value: 2.41e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 344 LKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDL 423
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 424 CKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLS 503
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767919700 504 IWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 343-548 1.22e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.77  E-value: 1.22e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWD 422
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 423 LCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767919700 503 SIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 392-555 1.27e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 178.68  E-value: 1.27e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCR 471
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 472 CTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166


                 ....
gi 767919700 552 LLPI 555
Cdd:cd00200  167 GKCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
343-548 3.14e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.57  E-value: 3.14e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGED---RLWKVLGLPKCNVLLtgfGHTDWLSDCCFHPSGDKLATSSGDTTVK 419
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDgtvRLWDLATGKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 420 LWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSAD 499
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767919700 500 KTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
343-570 4.36e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 4.36e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGED---RLWKVLGLPKCNVLLtgfGHTDWLSDCCFHPSGDKLATSSGDTTVK 419
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADgtvRLWDLATGKLLRTLT---GHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 420 LWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSAD 499
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767919700 500 KTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
343-570 7.90e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 7.90e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWD 422
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 423 LCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767919700 503 SIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
343-548 4.45e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 4.45e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWD 422
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 423 LCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
Cdd:COG2319  275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767919700 503 SIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:COG2319  355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
348-548 6.52e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.54  E-value: 6.52e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGD 427
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 428 CILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767919700 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
343-509 1.10e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 1.10e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGED---RLWKVLGlPKCNVLLTGfgHTDWLSDCCFHPSGDKLATSSGDTTVK 419
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADgtvRLWDLAT-GELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 420 LWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSAD 499
Cdd:COG2319  314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                        170
                 ....*....|
gi 767919700 500 KTLSIWDART 509
Cdd:COG2319  394 GTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
367-570 2.53e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 2.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 367 LVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHS 446
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 447 CGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDA 526
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767919700 527 IFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 212
WD40 COG2319
WD40 repeat [General function prediction only];
402-548 1.71e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 1.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 402 FHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSV 481
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767919700 482 NSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148
PTZ00421 PTZ00421
coronin; Provisional
 399-563 1.03e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.06  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 399 DCCFHPSGD-KLATSSGDTTVKLWDLCK-------GDCILTFEGHSRAVWSCTWH-SCGNFVASSSLDKTSKIWDVNSER 469
Cdd:PTZ00421  80 DVAFNPFDPqKLFTASEDGTIMGWGIPEegltqniSDPIVHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 470 CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIND-AIFDPRGHMIAScdaCGVTK--- 545
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIIT---LGCSKsqq 236

                        170       180
                 ....*....|....*....|...
gi 767919700 546 ----LWDFRKLL-PIVSIDIGPS 563
Cdd:PTZ00421 237 rqimLWDTRKMAsPYSTVDLDQS 259
WD40 pfam00400
WD domain, G-beta repeat;
426-464 1.77e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767919700  426 GDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD 464
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 397-524 2.21e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.49  E-value: 2.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 397 LSDCCFHPS-GDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCG-NFVASSSLDKTSKIWDVN-------- 466
Cdd:PLN00181 535 LSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINqgvsigti 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 467 ------------SERCR-----------------------CTLYGHTDSVNSIEFFPfSNTLLTSSADKTLSIWD---AR 508
Cdd:PLN00181 615 ktkaniccvqfpSESGRslafgsadhkvyyydlrnpklplCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDlsmSI 693

                        170
                 ....*....|....*.
gi 767919700 509 TGICEQSLYGHMHSIN 524
Cdd:PLN00181 694 SGINETPLHSFMGHTN 709
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 425-464 3.20e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 3.20e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767919700   425 KGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD 464
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 467-506 1.47e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.47e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767919700   467 SERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
469-506 1.02e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767919700  469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
448-570 1.19e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 448 GNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAI 527
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767919700 528 FDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNF 570
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 392-422 1.50e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.50e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767919700   392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD 422
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
392-422 2.96e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.96e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767919700  392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD 422
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 509-548 1.41e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.41e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767919700   509 TGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 392-508 7.66e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 7.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 392 GHTDWLSDCCFHPSGDKLATSSG-DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI 202

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767919700 471 RCTLYGH--TDSVNSIeFFPFSNTLLT----SSADKTLSIWDAR 508
Cdd:PTZ00421 203 VSSVEAHasAKSQRCL-WAKRKDLIITlgcsKSQQRQIMLWDTR 245
PTZ00420 PTZ00420
coronin; Provisional
 392-469 9.34e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 9.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 392 GHTDWLSDCCFHPS-GDKLATSSGDTTVKLWDLCKGD----------CILtfEGHSRAVWSCTWHSCGNFV-ASSSLDKT 459
Cdd:PTZ00420  72 GHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCIL--KGHKKKISIIDWNPMNYYImCSSGFDSF 149

                         90
                 ....*....|
gi 767919700 460 SKIWDVNSER 469
Cdd:PTZ00420 150 VNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
510-548 8.28e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.28e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767919700  510 GICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 429-537 1.02e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767919700 429 ILTFEGHSRAVWSCTWHSC-GNFVASSSLDKTSKIWDV--NSERCR------CTLYGHTDSVNSIEFFPFSNTLLTSSA- 498
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIphNDESVKeikdpqCILKGHKKKISIIDWNPMNYYIMCSSGf 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767919700 499 DKTLSIWDAR--------------------------TGICEQSlygHMHsindaIFDPRGHMIAS 537
Cdd:PTZ00420 147 DSFVNIWDIEnekrafqinmpkklsslkwnikgnllSGTCVGK---HMH-----IIDPRKQEIAS 203
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 343-378 3.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 3.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767919700   343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKV 378
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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