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MORC family CW-type zinc finger protein 1 isoform X7 [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
Morc6_S5 super family | cl39387 | Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ... |
139-340 | 8.28e-12 | ||||
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway. The actual alignment was detected with superfamily member pfam17942: Pssm-ID: 465579 Cd Length: 139 Bit Score: 63.72 E-value: 8.28e-12
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zf-CW | pfam07496 | CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ... |
415-460 | 1.73e-11 | ||||
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found. : Pssm-ID: 462181 Cd Length: 46 Bit Score: 59.63 E-value: 1.73e-11
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HATPase super family | cl00075 | Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
7-35 | 4.51e-11 | ||||
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains. The actual alignment was detected with superfamily member cd16931: Pssm-ID: 469604 [Multi-domain] Cd Length: 118 Bit Score: 60.89 E-value: 4.51e-11
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Name | Accession | Description | Interval | E-value | ||||
Morc6_S5 | pfam17942 | Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ... |
139-340 | 8.28e-12 | ||||
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway. Pssm-ID: 465579 Cd Length: 139 Bit Score: 63.72 E-value: 8.28e-12
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zf-CW | pfam07496 | CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ... |
415-460 | 1.73e-11 | ||||
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found. Pssm-ID: 462181 Cd Length: 46 Bit Score: 59.63 E-value: 1.73e-11
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HATPase_MORC-like | cd16931 | Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ... |
7-35 | 4.51e-11 | ||||
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker. Pssm-ID: 340408 [Multi-domain] Cd Length: 118 Bit Score: 60.89 E-value: 4.51e-11
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HATPase_c_3 | pfam13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ... |
7-61 | 3.85e-04 | ||||
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 433332 [Multi-domain] Cd Length: 135 Bit Score: 41.55 E-value: 3.85e-04
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KpsE | COG3524 | Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; |
195-254 | 3.33e-03 | ||||
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442746 [Multi-domain] Cd Length: 370 Bit Score: 40.60 E-value: 3.33e-03
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Name | Accession | Description | Interval | E-value | ||||
Morc6_S5 | pfam17942 | Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ... |
139-340 | 8.28e-12 | ||||
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway. Pssm-ID: 465579 Cd Length: 139 Bit Score: 63.72 E-value: 8.28e-12
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zf-CW | pfam07496 | CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ... |
415-460 | 1.73e-11 | ||||
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found. Pssm-ID: 462181 Cd Length: 46 Bit Score: 59.63 E-value: 1.73e-11
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HATPase_MORC-like | cd16931 | Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ... |
7-35 | 4.51e-11 | ||||
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker. Pssm-ID: 340408 [Multi-domain] Cd Length: 118 Bit Score: 60.89 E-value: 4.51e-11
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HATPase_c_3 | pfam13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ... |
7-61 | 3.85e-04 | ||||
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 433332 [Multi-domain] Cd Length: 135 Bit Score: 41.55 E-value: 3.85e-04
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KpsE | COG3524 | Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; |
195-254 | 3.33e-03 | ||||
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442746 [Multi-domain] Cd Length: 370 Bit Score: 40.60 E-value: 3.33e-03
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Blast search parameters | ||||
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