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Conserved domains on  [gi|767926413|ref|XP_011510996|]
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MORC family CW-type zinc finger protein 1 isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 139-340 8.28e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 63.72  E-value: 8.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926413  139 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 216
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926413  217 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 296
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767926413  297 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 340
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 415-460 1.73e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 59.63  E-value: 1.73e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767926413  415 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 460
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 7-35 4.51e-11

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16931:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 118  Bit Score: 60.89  E-value: 4.51e-11
                         10        20
                 ....*....|....*....|....*....
gi 767926413   7 GSMRIGKDFILFTKKEETMTCVFFSQTFC 35
Cdd:cd16931   90 GSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 139-340 8.28e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 63.72  E-value: 8.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926413  139 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 216
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926413  217 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 296
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767926413  297 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 340
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 415-460 1.73e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 59.63  E-value: 1.73e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767926413  415 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 460
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 7-35 4.51e-11

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 60.89  E-value: 4.51e-11
                         10        20
                 ....*....|....*....|....*....
gi 767926413   7 GSMRIGKDFILFTKKEETMTCVFFSQTFC 35
Cdd:cd16931   90 GSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 7-61 3.85e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 41.55  E-value: 3.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767926413    7 GSMRIGKDFILFTKKEETMTCVFFSQTFCEEESlSEVVVPMPSWLIRTRESVTDD 61
Cdd:pfam13589  78 ASLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPAPIENFDELDKD 131
KpsE COG3524
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
195-254 3.33e-03

Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442746 [Multi-domain]  Cd Length: 370  Bit Score: 40.60  E-value: 3.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926413 195 AEEAVKIAESILKEAQIKVNQcdrtsLS--SAKDVLQRALEDVEAKQKNLKEKQRELKTART 254
Cdd:COG3524  149 PEDAQAIAEALLAESEELVNQ-----LSerAREDAVRFAEEEVERAEERLRDAREALLAFRN 205
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 139-340 8.28e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 63.72  E-value: 8.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926413  139 SFRAYTSVLYFN--PWMRIFIQAKRVKTKHLCYCLYRPRKYLYVTSSFKGAfkdevkkaEEAVKIAESILKEAqikvnqc 216
Cdd:pfam17942   2 SLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVGGGK--------EVVVITTIGFLKEA------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926413  217 drtslssakdvlqraledveaKQKNLkekqrelktartlslfYGVNVenrsqagmfiYSNNRLIKMHEKVGSQLKLKsll 296
Cdd:pfam17942  67 ---------------------PHINV----------------HGFNV----------YHKNRLIKPFWRVGNQAGSK--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767926413  297 GAGVVGIvnipLEV--MEPSHNKQEFLNVQEYNHLLKVMGQYLVQY 340
Cdd:pfam17942  97 GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 415-460 1.73e-11

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 59.63  E-value: 1.73e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767926413  415 FIIQCDLCLKWRVLPSSTNyqEKEFFDIWICANNPNRLENSCHQVE 460
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 7-35 4.51e-11

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 60.89  E-value: 4.51e-11
                         10        20
                 ....*....|....*....|....*....
gi 767926413   7 GSMRIGKDFILFTKKEETMTCVFFSQTFC 35
Cdd:cd16931   90 GSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 7-61 3.85e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 41.55  E-value: 3.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767926413    7 GSMRIGKDFILFTKKEETMTCVFFSQTFCEEESlSEVVVPMPSWLIRTRESVTDD 61
Cdd:pfam13589  78 ASLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPAPIENFDELDKD 131
KpsE COG3524
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
195-254 3.33e-03

Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442746 [Multi-domain]  Cd Length: 370  Bit Score: 40.60  E-value: 3.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926413 195 AEEAVKIAESILKEAQIKVNQcdrtsLS--SAKDVLQRALEDVEAKQKNLKEKQRELKTART 254
Cdd:COG3524  149 PEDAQAIAEALLAESEELVNQ-----LSerAREDAVRFAEEEVERAEERLRDAREALLAFRN 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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