NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1370486722|ref|XP_011511982|]
View 

protein furry homolog-like isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2390-3119 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1056.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2390 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 2469
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2470 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDINQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 2549
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2550 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtiPDHPD 2629
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2630 LLLQSEDSTGSitTEEVLqiRDETPTLEASLdnansrlPEDTtsvlkeehvttfedegsyiiqeqqeslvcqgildleet 2709
Cdd:pfam19421  236 SLSQSQDSSSA--DEESL--RAETPSLEVSL-------PEDA-------------------------------------- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2710 empeplapesypesvceedvtlalkelderceeeeadfsglssqdeeEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 2789
Cdd:pfam19421  267 -----------------------------------------------SARGFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2790 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDA 2869
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2870 ETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAKED--MYRINTDAQQMeilAELELCRRLYKLHFQ 2947
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGSGdgVITCQPADQEE---KQLELCQRLYKLHFQ 456

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2948 LLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKE-----AESASENEEIDISKAAQTTIETAIHSLIETLKNKE 3022
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 3023 FISAVAQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSY 3102
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616

                          730
                   ....*....|....*..
gi 1370486722 3103 QLLAQAKPMGNMVSTGF 3119
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 209-756 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 621.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  209 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 288
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  289 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 368
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  369 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLkmpsnnsirkqi 448
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKL------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  449 etlqnKDPKMSRVALESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDF 528
Cdd:pfam14222  229 -----KDKTTRPVALQGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDF 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  529 AMKEIIFDLLSVG--KSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGN--TLRVKKIFLNKTlTDE 604
Cdd:pfam14222  303 CFENIIFPLLNADlfNGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDT 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  605 EAKVIGMSVYYPQVRKALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAA 670
Cdd:pfam14222  382 LALSEGIKDYYERFCKILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQA 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  671 IPRLIPDGMSRTDLIELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLL 741
Cdd:pfam14222  462 IPRCLPSSIPFNSLIELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHI 539

                          570
                   ....*....|....*
gi 1370486722  742 DNAVKMLVQLINQWK 756
Cdd:pfam14222  540 ESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2107-2360 1.74e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 252.01  E-value: 1.74e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2107 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 2185
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2186 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2263
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2264 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 2342
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1370486722 2343 PYWKEALNILKLVVSRSA 2360
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 788-1965 5.05e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 157.49  E-value: 5.05e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  788 SNVFHV--VEGFALVILCSSRPATRRLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLY 865
Cdd:pfam14228    1 TNEFRPsgLDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  866 CPSSIDLQTLAEWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSP 945
Cdd:pfam14228   81 WDSGRPYDMRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  946 qVDINSpinakKVNTTTSSDSYIGLWRNYLILCCSaatsssstsagsvrCsPPETlasTPDSGYSidskiigipSPSSLF 1025
Cdd:pfam14228  150 -VELGG-----KAHQSQDADNKLDQWLLYSMFACS--------------C-PPDD---VEDTKSH---------SAKELY 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1026 KHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD--- 1099
Cdd:pfam14228  197 HLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfw 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1100 AGVISHSASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHS 1179
Cdd:pfam14228  277 PGMLIRKPVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKR 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1180 LFMLFSHWAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNV 1232
Cdd:pfam14228  346 LFDLLASWCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDN 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1233 GLSSDGYLYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqsn 1275
Cdd:pfam14228  425 ARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD--- 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1276 LMYWAVDRCYTGSGRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEV 1354
Cdd:pfam14228  502 LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEE 579

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1355 QRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA--HPAGRQVmLHYLLPWMNNIELVDLKplp 1432
Cdd:pfam14228  580 GTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDAvdIIAQHQV-LTCMAPWIENLNFLKLW--- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1433 tarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILH 1512
Cdd:pfam14228  656 ----------ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLD 701

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1513 FLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL------QLTDPVSSGVTHMDnppyyrIT 1575
Cdd:pfam14228  702 FLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrmleESVEPSRPSDGAFD------LE 775

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1576 SSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLNSHLNRQHHRLesryssssGGSYEEEKSDSM 1655
Cdd:pfam14228  776 SSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLEGPLRNASGSL--------SWRTVTGRSMSG 833

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1656 PLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV-------------------DYVPETSSPG------------ 1697
Cdd:pfam14228  834 PLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTPNSVeeiritpvvnas 910

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1698 -----LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLivmgpnsnir 1767
Cdd:pfam14228  911 elqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLL---------- 978

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1768 tvasvllrnkefneprvltvkqvahldYNFTGindfipdyqpspmtdsglsssstsssislgnnsaaiSHLHttiLNEVD 1847
Cdd:pfam14228  979 ---------------------------YSLAG------------------------------------RHLE---LYDVE 992

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1848 IS-VEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVV-SVFKQSSsegihLEHHLSEVALQTALS 1925
Cdd:pfam14228  993 HGdGEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAME 1067

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|
gi 1370486722 1926 CSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 1965
Cdd:pfam14228 1068 CTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2390-3119 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1056.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2390 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 2469
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2470 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDINQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 2549
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2550 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtiPDHPD 2629
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2630 LLLQSEDSTGSitTEEVLqiRDETPTLEASLdnansrlPEDTtsvlkeehvttfedegsyiiqeqqeslvcqgildleet 2709
Cdd:pfam19421  236 SLSQSQDSSSA--DEESL--RAETPSLEVSL-------PEDA-------------------------------------- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2710 empeplapesypesvceedvtlalkelderceeeeadfsglssqdeeEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 2789
Cdd:pfam19421  267 -----------------------------------------------SARGFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2790 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDA 2869
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2870 ETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAKED--MYRINTDAQQMeilAELELCRRLYKLHFQ 2947
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGSGdgVITCQPADQEE---KQLELCQRLYKLHFQ 456

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2948 LLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKE-----AESASENEEIDISKAAQTTIETAIHSLIETLKNKE 3022
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 3023 FISAVAQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSY 3102
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616

                          730
                   ....*....|....*..
gi 1370486722 3103 QLLAQAKPMGNMVSTGF 3119
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 209-756 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 621.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  209 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 288
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  289 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 368
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  369 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLkmpsnnsirkqi 448
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKL------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  449 etlqnKDPKMSRVALESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDF 528
Cdd:pfam14222  229 -----KDKTTRPVALQGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDF 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  529 AMKEIIFDLLSVG--KSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGN--TLRVKKIFLNKTlTDE 604
Cdd:pfam14222  303 CFENIIFPLLNADlfNGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDT 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  605 EAKVIGMSVYYPQVRKALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAA 670
Cdd:pfam14222  382 LALSEGIKDYYERFCKILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQA 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  671 IPRLIPDGMSRTDLIELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLL 741
Cdd:pfam14222  462 IPRCLPSSIPFNSLIELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHI 539

                          570
                   ....*....|....*
gi 1370486722  742 DNAVKMLVQLINQWK 756
Cdd:pfam14222  540 ESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2107-2360 1.74e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 252.01  E-value: 1.74e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2107 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 2185
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2186 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2263
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2264 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 2342
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1370486722 2343 PYWKEALNILKLVVSRSA 2360
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 788-1965 5.05e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 157.49  E-value: 5.05e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  788 SNVFHV--VEGFALVILCSSRPATRRLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLY 865
Cdd:pfam14228    1 TNEFRPsgLDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  866 CPSSIDLQTLAEWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSP 945
Cdd:pfam14228   81 WDSGRPYDMRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  946 qVDINSpinakKVNTTTSSDSYIGLWRNYLILCCSaatsssstsagsvrCsPPETlasTPDSGYSidskiigipSPSSLF 1025
Cdd:pfam14228  150 -VELGG-----KAHQSQDADNKLDQWLLYSMFACS--------------C-PPDD---VEDTKSH---------SAKELY 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1026 KHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD--- 1099
Cdd:pfam14228  197 HLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfw 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1100 AGVISHSASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHS 1179
Cdd:pfam14228  277 PGMLIRKPVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKR 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1180 LFMLFSHWAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNV 1232
Cdd:pfam14228  346 LFDLLASWCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDN 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1233 GLSSDGYLYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqsn 1275
Cdd:pfam14228  425 ARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD--- 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1276 LMYWAVDRCYTGSGRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEV 1354
Cdd:pfam14228  502 LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEE 579

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1355 QRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA--HPAGRQVmLHYLLPWMNNIELVDLKplp 1432
Cdd:pfam14228  580 GTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDAvdIIAQHQV-LTCMAPWIENLNFLKLW--- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1433 tarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILH 1512
Cdd:pfam14228  656 ----------ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLD 701

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1513 FLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL------QLTDPVSSGVTHMDnppyyrIT 1575
Cdd:pfam14228  702 FLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrmleESVEPSRPSDGAFD------LE 775

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1576 SSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLNSHLNRQHHRLesryssssGGSYEEEKSDSM 1655
Cdd:pfam14228  776 SSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLEGPLRNASGSL--------SWRTVTGRSMSG 833

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1656 PLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV-------------------DYVPETSSPG------------ 1697
Cdd:pfam14228  834 PLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTPNSVeeiritpvvnas 910

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1698 -----LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLivmgpnsnir 1767
Cdd:pfam14228  911 elqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLL---------- 978

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1768 tvasvllrnkefneprvltvkqvahldYNFTGindfipdyqpspmtdsglsssstsssislgnnsaaiSHLHttiLNEVD 1847
Cdd:pfam14228  979 ---------------------------YSLAG------------------------------------RHLE---LYDVE 992

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1848 IS-VEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVV-SVFKQSSsegihLEHHLSEVALQTALS 1925
Cdd:pfam14228  993 HGdGEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAME 1067

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|
gi 1370486722 1926 CSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 1965
Cdd:pfam14228 1068 CTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2390-3119 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1056.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2390 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 2469
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2470 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDINQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 2549
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2550 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtiPDHPD 2629
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2630 LLLQSEDSTGSitTEEVLqiRDETPTLEASLdnansrlPEDTtsvlkeehvttfedegsyiiqeqqeslvcqgildleet 2709
Cdd:pfam19421  236 SLSQSQDSSSA--DEESL--RAETPSLEVSL-------PEDA-------------------------------------- 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2710 empeplapesypesvceedvtlalkelderceeeeadfsglssqdeeEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 2789
Cdd:pfam19421  267 -----------------------------------------------SARGFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2790 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDA 2869
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2870 ETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAKED--MYRINTDAQQMeilAELELCRRLYKLHFQ 2947
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGSGdgVITCQPADQEE---KQLELCQRLYKLHFQ 456

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2948 LLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKE-----AESASENEEIDISKAAQTTIETAIHSLIETLKNKE 3022
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 3023 FISAVAQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSY 3102
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616

                          730
                   ....*....|....*..
gi 1370486722 3103 QLLAQAKPMGNMVSTGF 3119
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 209-756 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 621.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  209 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 288
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  289 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 368
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  369 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLkmpsnnsirkqi 448
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKL------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  449 etlqnKDPKMSRVALESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDF 528
Cdd:pfam14222  229 -----KDKTTRPVALQGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDF 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  529 AMKEIIFDLLSVG--KSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGN--TLRVKKIFLNKTlTDE 604
Cdd:pfam14222  303 CFENIIFPLLNADlfNGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDT 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  605 EAKVIGMSVYYPQVRKALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAA 670
Cdd:pfam14222  382 LALSEGIKDYYERFCKILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQA 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  671 IPRLIPDGMSRTDLIELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLL 741
Cdd:pfam14222  462 IPRCLPSSIPFNSLIELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHI 539

                          570
                   ....*....|....*
gi 1370486722  742 DNAVKMLVQLINQWK 756
Cdd:pfam14222  540 ESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2107-2360 1.74e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 252.01  E-value: 1.74e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2107 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 2185
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2186 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2263
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 2264 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 2342
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1370486722 2343 PYWKEALNILKLVVSRSA 2360
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 788-1965 5.05e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 157.49  E-value: 5.05e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  788 SNVFHV--VEGFALVILCSSRPATRRLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLY 865
Cdd:pfam14228    1 TNEFRPsgLDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  866 CPSSIDLQTLAEWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSP 945
Cdd:pfam14228   81 WDSGRPYDMRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722  946 qVDINSpinakKVNTTTSSDSYIGLWRNYLILCCSaatsssstsagsvrCsPPETlasTPDSGYSidskiigipSPSSLF 1025
Cdd:pfam14228  150 -VELGG-----KAHQSQDADNKLDQWLLYSMFACS--------------C-PPDD---VEDTKSH---------SAKELY 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1026 KHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD--- 1099
Cdd:pfam14228  197 HLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfw 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1100 AGVISHSASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHS 1179
Cdd:pfam14228  277 PGMLIRKPVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKR 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1180 LFMLFSHWAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNV 1232
Cdd:pfam14228  346 LFDLLASWCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDN 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1233 GLSSDGYLYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqsn 1275
Cdd:pfam14228  425 ARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD--- 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1276 LMYWAVDRCYTGSGRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEV 1354
Cdd:pfam14228  502 LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEE 579

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1355 QRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA--HPAGRQVmLHYLLPWMNNIELVDLKplp 1432
Cdd:pfam14228  580 GTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDAvdIIAQHQV-LTCMAPWIENLNFLKLW--- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1433 tarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILH 1512
Cdd:pfam14228  656 ----------ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLD 701

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1513 FLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL------QLTDPVSSGVTHMDnppyyrIT 1575
Cdd:pfam14228  702 FLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrmleESVEPSRPSDGAFD------LE 775

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1576 SSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLNSHLNRQHHRLesryssssGGSYEEEKSDSM 1655
Cdd:pfam14228  776 SSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLEGPLRNASGSL--------SWRTVTGRSMSG 833

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1656 PLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV-------------------DYVPETSSPG------------ 1697
Cdd:pfam14228  834 PLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTPNSVeeiritpvvnas 910

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1698 -----LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLivmgpnsnir 1767
Cdd:pfam14228  911 elqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLL---------- 978

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1768 tvasvllrnkefneprvltvkqvahldYNFTGindfipdyqpspmtdsglsssstsssislgnnsaaiSHLHttiLNEVD 1847
Cdd:pfam14228  979 ---------------------------YSLAG------------------------------------RHLE---LYDVE 992

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486722 1848 IS-VEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVV-SVFKQSSsegihLEHHLSEVALQTALS 1925
Cdd:pfam14228  993 HGdGEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAME 1067

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|
gi 1370486722 1926 CSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 1965
Cdd:pfam14228 1068 CTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH