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Conserved domains on  [gi|767934338|ref|XP_011512305|]
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tetratricopeptide repeat protein 33 isoform X1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708416)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 20-185 9.99e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.41  E-value: 9.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  20 QQFEAEAADEKDVVDNDEGNWLHAIKRRKEILLEgcaekskQLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMK 99
Cdd:COG3914   46 LLLAALAEAAAAALLALAAGEAAAAAAALLLLAA-------LLELAALLLQALGRYEEALALYRRALALNPDNAEALFNL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338 100 SQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWkedLSWARTLQEQQK 179
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL---NNLGNALQDLGR 195


                 ....*.
gi 767934338 180 VAQRIK 185
Cdd:COG3914  196 LEEAIA 201
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 20-185 9.99e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.41  E-value: 9.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  20 QQFEAEAADEKDVVDNDEGNWLHAIKRRKEILLEgcaekskQLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMK 99
Cdd:COG3914   46 LLLAALAEAAAAALLALAAGEAAAAAAALLLLAA-------LLELAALLLQALGRYEEALALYRRALALNPDNAEALFNL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338 100 SQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWkedLSWARTLQEQQK 179
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL---NNLGNALQDLGR 195


                 ....*.
gi 767934338 180 VAQRIK 185
Cdd:COG3914  196 LEEAIA 201
TPR_11 pfam13414
TPR repeat;
66-96 6.20e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 33.98  E-value: 6.20e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767934338   66 GASLAENKRYREAIQKWDEALQLTPNDATLY 96
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAY 31
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-187 6.72e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 37.76  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338   33 VDNDEGNWLHAIKRRKEILLEgcAEKSKQLKDEGASLAENK-RYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFP 111
Cdd:TIGR02917 508 IDIQEGNPDDAIQRFEKVLTI--DPKNLRAILALAGLYLRTgNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKK 585

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767934338  112 AVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWKEDLSWARTLQEQQKVAQRIKKS 187
Cdd:TIGR02917 586 ALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRA 661
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 20-185 9.99e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.41  E-value: 9.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  20 QQFEAEAADEKDVVDNDEGNWLHAIKRRKEILLEgcaekskQLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMK 99
Cdd:COG3914   46 LLLAALAEAAAAALLALAAGEAAAAAAALLLLAA-------LLELAALLLQALGRYEEALALYRRALALNPDNAEALFNL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338 100 SQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWkedLSWARTLQEQQK 179
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL---NNLGNALQDLGR 195


                 ....*.
gi 767934338 180 VAQRIK 185
Cdd:COG3914  196 LEEAIA 201
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 56-185 1.97e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.60  E-value: 1.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  56 AEKSKQLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGR 135
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767934338 136 AQLGLGEIILAIRSFQVALHIYPMNPEIWkedLSWARTLQEQQKVAQRIK 185
Cdd:COG4783   81 ALLKAGDYDEALALLEKALKLDPEHPEAY---LRLARAYRALGRPDEAIA 127
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 66-221 4.21e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.78  E-value: 4.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338 146 AIRSFQVALHIYPMNPEIWkedLSWARTLQEQ------QKVAQRIKKSEA-PAEVTHFSPKSIPDYDfeSDEIVAVCAAI 218
Cdd:COG3914  199 AIAAYRRALELDPDNADAH---SNLLFALRQAcdwevyDRFEELLAALARgPSELSPFALLYLPDDD--PAELLALARAW 273


                 ...
gi 767934338 219 AEK 221
Cdd:COG3914  274 AQL 276
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-182 1.08e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG0457   15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767934338 146 AIRSFQVALHIYPMNPEIWkedLSWARTLQEQQKVAQ 182
Cdd:COG0457   95 ALEDYDKALELDPDDAEAL---YNLGLALLELGRYDE 128
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-164 1.30e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG0457   49 GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                         90
                 ....*....|....*....
gi 767934338 146 AIRSFQVALHIYPMNPEIW 164
Cdd:COG0457  129 AIEAYERALELDPDDADAL 147
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 66-160 5.99e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.97  E-value: 5.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG4783   45 GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124

                         90
                 ....*....|....*
gi 767934338 146 AIRSFQVALHIYPMN 160
Cdd:COG4783  125 AIAALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 66-162 5.77e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 5.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAE 103

                         90
                 ....*....|....*..
gi 767934338 146 AIRSFQVALHIYPMNPE 162
Cdd:COG4235  104 AIAAWQKLLALLPADAP 120
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 20-159 5.86e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.81  E-value: 5.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  20 QQFEAEAADEKDVVDNDEGNWLHAIKRRKEILLEGCAEKSKQLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMK 99
Cdd:COG5010   15 LLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNL 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338 100 SQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPM 159
Cdd:COG5010   95 ALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPL 154
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
69-158 2.66e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.47  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  69 LAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEmFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIR 148
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGR-YDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                         90
                 ....*....|
gi 767934338 149 SFQVALHIYP 158
Cdd:COG3063   81 YLERALELDP 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 77-182 3.14e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.46  E-value: 3.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  77 EAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHI 156
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100
                 ....*....|....*....|....*.
gi 767934338 157 YPMNPEIWkedLSWARTLQEQQKVAQ 182
Cdd:COG4235   81 DPDNPEAL---YLLGLAAFQQGDYAE 103
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 36-185 6.56e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 6.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  36 DEGNWLHAIKRRKEILLEGcaEKSKQLKDEGASLA-ENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVH 114
Cdd:COG2956  122 QEGDWEKAIEVLERLLKLG--PENAHAYCELAELYlEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIA 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767934338 115 AAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIwkedLSWARTLQEQQKVAQRIK 185
Cdd:COG2956  200 ALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL----LALADLLERKEGLEAALA 266
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 74-184 1.14e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.26  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  74 RYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVA 153
Cdd:COG5010   35 NNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKA 114

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767934338 154 LHIYPMNPEIWkEDLSWARTLQEQQKVAQRI 184
Cdd:COG5010  115 LALSPDNPNAY-SNLAALLLSLGQDDEAKAA 144
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
62-162 1.32e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  62 LKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLG 141
Cdd:COG4785   76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLG 155

                         90       100
                 ....*....|....*....|.
gi 767934338 142 EIILAIRSFQVALHIYPMNPE 162
Cdd:COG4785  156 RYELAIADLEKALELDPNDPE 176
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
86-179 1.93e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  86 LQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWk 165
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL- 79

                         90
                 ....*....|....
gi 767934338 166 edLSWARTLQEQQK 179
Cdd:COG0457   80 --NNLGLALQALGR 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 65-185 9.25e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  65 EGASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEII 144
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767934338 145 LAIRSFQVALHIYPMNPEIWkedLSWARTLQEQQKVAQRIK 185
Cdd:COG2956   94 RAEELLEKLLELDPDDAEAL---RLLAEIYEQEGDWEKAIE 131
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 66-163 9.96e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 9.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG2956  117 AEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196

                         90
                 ....*....|....*...
gi 767934338 146 AIRSFQVALHIYPMNPEI 163
Cdd:COG2956  197 AIAALERALEQDPDYLPA 214
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
102-182 4.24e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.53  E-value: 4.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338 102 VLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRsFQVALHIYPMNPEIWkedLSWARTLQEQQKVA 181
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEAL---LNLAELLLELGDYD 76


                 .
gi 767934338 182 Q 182
Cdd:COG3063   77 E 77
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
66-128 4.24e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.53  E-value: 4.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934338  66 GASLAENKRYREAIQkWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWE 128
Cdd:COG3063   33 GLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSALR 94
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 66-185 4.51e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 4.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG2956   49 GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767934338 146 AIRSFQVALHIYPMNPEIWKEdlsWARTLQEQQKVAQRIK 185
Cdd:COG2956  129 AIEVLERLLKLGPENAHAYCE---LAELYLEQGDYDEAIE 165
TPR_11 pfam13414
TPR repeat;
66-96 6.20e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 33.98  E-value: 6.20e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767934338   66 GASLAENKRYREAIQKWDEALQLTPNDATLY 96
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAY 31
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-187 6.72e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 37.76  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338   33 VDNDEGNWLHAIKRRKEILLEgcAEKSKQLKDEGASLAENK-RYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFP 111
Cdd:TIGR02917 508 IDIQEGNPDDAIQRFEKVLTI--DPKNLRAILALAGLYLRTgNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKK 585

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767934338  112 AVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWKEDLSWARTLQEQQKVAQRIKKS 187
Cdd:TIGR02917 586 ALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRA 661
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-189 7.15e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 36.91  E-value: 7.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934338  66 GASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWESWQTLGRAQLGLGEIIL 145
Cdd:COG0457  117 GLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVL 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767934338 146 AIRSFQVALHIYPMNPEIWKEDLSWARTLQEQQKVAQRIKKSEA 189
Cdd:COG0457  197 LALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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