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Conserved domains on  [gi|767945337|ref|XP_011513628|]
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NPC1-like intracellular cholesterol transporter 1 isoform X1 [Homo sapiens]

Protein Classification

Niemann-Pick C type protein family( domain architecture ID 1003172)

Niemann-Pick C (NPC) type protein family is essential for sterol homeostasis that drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes

Gene Ontology:  GO:0015485|GO:0030301

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
2A060601 super family cl36767
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 33-1201 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00917:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 736.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337    33 CAFYDECGKNPELSGslmtlsnVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTR 112
Cdd:TIGR00917    1 CAMYDICGARSDGKV-------LNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   113 CPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQlpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVY 192
Cdd:TIGR00917   74 CPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKTNS--TVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   193 GSAlCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAvgSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQAL 272
Cdd:TIGR00917  152 KNF-KEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVS--SGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKK 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   273 DS-TFYLGQMPGSLVLIIILcsvFAVVTILLVGFRVAPARDKSK------------------MVDPKKGTSLSDKLSFST 333
Cdd:TIGR00917  229 HScSIKLGVKCVDFILAILY---IVLVSVFLGGGLLHPVRGKKKtsqmgtlseadgeinsvnQQKDQNTPQRNWGQLSTV 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILT 413
Cdd:TIGR00917  306 QGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIA 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   414 APNRSSYrydslllgpKNFSGILDLDLLLELLELQERLrhLQVWSPEAQRNISLQDICYAPLNPdntslYDCCINSLLQY 493
Cdd:TIGR00917  386 TVQTSSH---------EKAPEILTDDNLKLLFDIQKKV--SQLFANYEGELITLDSPCFKPNHP-----YNCFIYSTCKK 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   494 FQNNRTLLLLTANQTLMGqtsqVDWKDHFLYCANAPLtfkdgtalalSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMT 573
Cdd:TIGR00917  450 LQNMYSKLKPENYDDYGG----VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVT 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   574 FSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAgMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGS 653
Cdd:TIGR00917  516 FPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMV-QATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGD 594

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   654 YSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEY------------ 721
Cdd:TIGR00917  595 SPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgv 674

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   722 --------------------------------------------------------------QMSAFVALLSLDSKRQEA 739
Cdd:TIGR00917  675 dneqeltlerrlsralmevgpsitlaslseilafalgalikmpavrvfsmfavlavfldfllQITAFVALLVLDFKRTED 754

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   740 SRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALP 813
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   814 KDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFI 893
Cdd:TIGR00917  835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYL 908

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   894 DWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN 972
Cdd:TIGR00917  909 VWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVD 983

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   973 LT-SDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLrkvpgtdpAFEVFPYTITNVFYEQYLTILPEGLFML 1051
Cdd:TIGR00917  984 LQgYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS--------KMEVYPYSVFYVFFEQYLTIWKTAIINL 1055

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1052 SLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPT 1131
Cdd:TIGR00917 1056 SIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFS 1135

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1132 WLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVG 1201
Cdd:TIGR00917 1136 RNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 33-1201 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 736.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337    33 CAFYDECGKNPELSGslmtlsnVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTR 112
Cdd:TIGR00917    1 CAMYDICGARSDGKV-------LNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   113 CPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQlpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVY 192
Cdd:TIGR00917   74 CPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKTNS--TVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   193 GSAlCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAvgSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQAL 272
Cdd:TIGR00917  152 KNF-KEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVS--SGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKK 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   273 DS-TFYLGQMPGSLVLIIILcsvFAVVTILLVGFRVAPARDKSK------------------MVDPKKGTSLSDKLSFST 333
Cdd:TIGR00917  229 HScSIKLGVKCVDFILAILY---IVLVSVFLGGGLLHPVRGKKKtsqmgtlseadgeinsvnQQKDQNTPQRNWGQLSTV 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILT 413
Cdd:TIGR00917  306 QGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIA 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   414 APNRSSYrydslllgpKNFSGILDLDLLLELLELQERLrhLQVWSPEAQRNISLQDICYAPLNPdntslYDCCINSLLQY 493
Cdd:TIGR00917  386 TVQTSSH---------EKAPEILTDDNLKLLFDIQKKV--SQLFANYEGELITLDSPCFKPNHP-----YNCFIYSTCKK 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   494 FQNNRTLLLLTANQTLMGqtsqVDWKDHFLYCANAPLtfkdgtalalSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMT 573
Cdd:TIGR00917  450 LQNMYSKLKPENYDDYGG----VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVT 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   574 FSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAgMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGS 653
Cdd:TIGR00917  516 FPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMV-QATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGD 594

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   654 YSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEY------------ 721
Cdd:TIGR00917  595 SPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgv 674

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   722 --------------------------------------------------------------QMSAFVALLSLDSKRQEA 739
Cdd:TIGR00917  675 dneqeltlerrlsralmevgpsitlaslseilafalgalikmpavrvfsmfavlavfldfllQITAFVALLVLDFKRTED 754

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   740 SRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALP 813
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   814 KDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFI 893
Cdd:TIGR00917  835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYL 908

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   894 DWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN 972
Cdd:TIGR00917  909 VWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVD 983

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   973 LT-SDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLrkvpgtdpAFEVFPYTITNVFYEQYLTILPEGLFML 1051
Cdd:TIGR00917  984 LQgYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS--------KMEVYPYSVFYVFFEQYLTIWKTAIINL 1055

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1052 SLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPT 1131
Cdd:TIGR00917 1056 SIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFS 1135

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1132 WLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVG 1201
Cdd:TIGR00917 1136 RNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 31-283 4.21e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 301.83  E-value: 4.21e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337    31 GYCAFYDECGKNPELSGSLmtlsnvSCLSNTPARKITGDHLILLQKICPRLYTGpNTQACCSAKQLVSLEASLSITKALL 110
Cdd:pfam16414    1 GRCAWYGECGKKSLFGKDL------PCPYNGPAKPLDDEVRDLLAELCPLLFAD-ETPVCCDADQLNTLRSNLKLAEGLL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   111 TRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCG 190
Cdd:pfam16414   74 SRCPACKKNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKE-YVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   191 VYgsalCNAQRWLNFQGDTGNGLAPLDITFHLlePGQAVGSGIQPLNEGVARCNESQGDDVAtCSCQDCAASCPAIARPQ 270
Cdd:pfam16414  153 GA----CNYTRWLKFMGDKKNGGSPFQINFPD--PPEEDPSGMVPLNPNTKDCNESYDASYA-CSCVDCPLSCPPPPQLP 225

                          250
                   ....*....|....
gi 767945337   271 ALDS-TFYLGQMPG 283
Cdd:pfam16414  226 PPPHgPCKVGGLDG 239
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
558-718 1.24e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 46.39  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  558 GYKGKDYSE-AEALIMTFSLNNYPAGDPrLAQAKLWE--EAFLEEMRA--FQRRMAGMFQVTfmaersleDEINRTTAED 632
Cdd:COG1033   149 LYVGRLVSPdGKATLIVVTLDPDPLSSD-LDRKEVVAeiRAIIAKYEDpgVEVYLTGFPVLR--------GDIAEAIQSD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  633 LPIF-ATSYIVIFLYISLALGSYSSWsrvmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSlVILQVVPFLVLSVG- 710
Cdd:COG1033   220 LAIFfPLALLLILLLLFLFFRSLRGV------------LLPLLVVLLAVIWTLGLMGLLGIPLS-PLTILVPPLLLAIGi 286


                  ....*...
gi 767945337  711 ADNIFIFV 718
Cdd:COG1033   287 DYGIHLLN 294
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 33-1201 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 736.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337    33 CAFYDECGKNPELSGslmtlsnVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTR 112
Cdd:TIGR00917    1 CAMYDICGARSDGKV-------LNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   113 CPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQlpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVY 192
Cdd:TIGR00917   74 CPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKTNS--TVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   193 GSAlCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAvgSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQAL 272
Cdd:TIGR00917  152 KNF-KEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVS--SGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKK 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   273 DS-TFYLGQMPGSLVLIIILcsvFAVVTILLVGFRVAPARDKSK------------------MVDPKKGTSLSDKLSFST 333
Cdd:TIGR00917  229 HScSIKLGVKCVDFILAILY---IVLVSVFLGGGLLHPVRGKKKtsqmgtlseadgeinsvnQQKDQNTPQRNWGQLSTV 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILT 413
Cdd:TIGR00917  306 QGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIA 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   414 APNRSSYrydslllgpKNFSGILDLDLLLELLELQERLrhLQVWSPEAQRNISLQDICYAPLNPdntslYDCCINSLLQY 493
Cdd:TIGR00917  386 TVQTSSH---------EKAPEILTDDNLKLLFDIQKKV--SQLFANYEGELITLDSPCFKPNHP-----YNCFIYSTCKK 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   494 FQNNRTLLLLTANQTLMGqtsqVDWKDHFLYCANAPLtfkdgtalalSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMT 573
Cdd:TIGR00917  450 LQNMYSKLKPENYDDYGG----VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVT 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   574 FSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAgMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGS 653
Cdd:TIGR00917  516 FPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMV-QATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGD 594

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   654 YSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEY------------ 721
Cdd:TIGR00917  595 SPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgv 674

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   722 --------------------------------------------------------------QMSAFVALLSLDSKRQEA 739
Cdd:TIGR00917  675 dneqeltlerrlsralmevgpsitlaslseilafalgalikmpavrvfsmfavlavfldfllQITAFVALLVLDFKRTED 754

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   740 SRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALP 813
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   814 KDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFI 893
Cdd:TIGR00917  835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYL 908

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   894 DWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN 972
Cdd:TIGR00917  909 VWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVD 983

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   973 LT-SDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLrkvpgtdpAFEVFPYTITNVFYEQYLTILPEGLFML 1051
Cdd:TIGR00917  984 LQgYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS--------KMEVYPYSVFYVFFEQYLTIWKTAIINL 1055

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1052 SLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPT 1131
Cdd:TIGR00917 1056 SIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFS 1135

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1132 WLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVG 1201
Cdd:TIGR00917 1136 RNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 31-283 4.21e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 301.83  E-value: 4.21e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337    31 GYCAFYDECGKNPELSGSLmtlsnvSCLSNTPARKITGDHLILLQKICPRLYTGpNTQACCSAKQLVSLEASLSITKALL 110
Cdd:pfam16414    1 GRCAWYGECGKKSLFGKDL------PCPYNGPAKPLDDEVRDLLAELCPLLFAD-ETPVCCDADQLNTLRSNLKLAEGLL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   111 TRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCG 190
Cdd:pfam16414   74 SRCPACKKNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKE-YVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   191 VYgsalCNAQRWLNFQGDTGNGLAPLDITFHLlePGQAVGSGIQPLNEGVARCNESQGDDVAtCSCQDCAASCPAIARPQ 270
Cdd:pfam16414  153 GA----CNYTRWLKFMGDKKNGGSPFQINFPD--PPEEDPSGMVPLNPNTKDCNESYDASYA-CSCVDCPLSCPPPPQLP 225

                          250
                   ....*....|....
gi 767945337   271 ALDS-TFYLGQMPG 283
Cdd:pfam16414  226 PPPHgPCKVGGLDG 239
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 598-1174 2.78e-34

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 142.11  E-value: 2.78e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   598 EEMRAFQRRMAGMF----------QVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKAT 667
Cdd:pfam02460  171 EEDSKEWEDELSQLlhnkyasehiQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPI 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   668 LGLGGVAVVLGAVMAAMGFFSYLGIRSSlVILQVVPFLVLSVGADNIFIFVLE--------------------------- 720
Cdd:pfam02460  251 LAALGLLSPVMAIVSSFGLLFWMGFPFN-SIVCVTPFLVLAIGVDDMFLMVAAwqrttatlsvkkrmgealseagvsiti 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   721 ------------------------------------YQMSAFVALLSLDSKRQEASR--LDVCCCVKPQEL------PPP 756
Cdd:pfam02460  330 tsltdvlsfgigtytptpaiqlfcaytavaiffdfiYQITFFAAIMAICAKPEAEGRhcLFVWATSSPQRIdsegsePDK 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   757 GQG-EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFevgapv 835
Cdd:pfam02460  410 SHNiEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHF------ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   836 yfvttlgynfsseagmnaicssagcnnFSFTQKIQYATEFPEQsyLAIPAS-----SWVDDFIDwlTPssccrlYISGPN 910
Cdd:pfam02460  484 ---------------------------WPEGLQIQVAVNNPPN--LTIPESrdrmnEMVDEFEN--TP------YSLGPN 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   911 kdkfcpSTVNSLNCLKNCMSITMGSVRPSVEQFHKY--LPWFLndrpniKCPKGGLAAYSTSVNlTSDGQVLASRFMAYH 988
Cdd:pfam02460  527 ------STLFWLREYENFLSTLNMEEEEDEEKEWSYgnLPSFL------KAPGNSHWAGDLVWD-DNTTMVTKFRFTLAG 593

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   989 KPLKNSQDYTEalraarelaanITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVsCLLLGL 1068
Cdd:pfam02460  594 KGLSTWNDRTR-----------ALQEWRSIADQYPEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIV-CFLFIP 661

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1069 DLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVF 1148
Cdd:pfam02460  662 NPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVF 741

                          650       660
                   ....*....|....*....|....*.
gi 767945337  1149 AGvAMTNLPGILVLGLAKAQLIQIFF 1174
Cdd:pfam02460  742 QG-GLSTILGVLVLLFVPSYMVVVFF 766
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 661-749 2.74e-23

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 97.27  E-value: 2.74e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   661 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE-------------------- 720
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAvvrtprsldvseriaealge 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767945337   721 -------------------------------------------YQMSAFVALLSLDSKRQEASRLDVCCCVK 749
Cdd:pfam12349   81 vgpsitltslteilafllgaltdmpavqefclfaavavlfdflLQMTFFVAVLSLDIRRLESNRLDVACCIR 152
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
592-1207 1.89e-16

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 85.32  E-value: 1.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   592 WEEAFLEEMRAFQRRMAGmFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSwsrvmVDSKATLGLG 671
Cdd:TIGR00918  359 WQRNFSEEVQQSLPKNSS-QKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTMLRWDC-----AKSQGSVGLA 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   672 GVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQ----------------------------- 722
Cdd:TIGR00918  433 GVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSetgqnipfeertgeclkrtgasvvltsis 512

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   723 ------MSAFV----------------------------ALLSLDSKRQEASRLDV-CCCVKP------QELP------- 754
Cdd:TIGR00918  513 nvtaffMAALIpipalrafslqaaivvvfnfaavllvfpAILSLDLRRREDRRLDIfCCFFSPcsarviQIEPqayadgs 592

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   755 --------------------------------------------------PPGQGEGL--------------------LL 764
Cdd:TIGR00918  593 appvysshmqstvqlrteydpgtqhyyttneprshlsvqpsdplscqspdIAGSTRDLlsqfedskaaclslpcarwtLA 672

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   765 GFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVgAPVYFVTTLGYN 844
Cdd:TIGR00918  673 TFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSF-YNMYAVTQGNFD 751

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   845 FSSeagmnaicssagcnnfsftqkIQYATEFPEQSYLAIPA----------SSWVDDFIDWL---------------TPS 899
Cdd:TIGR00918  752 YPT---------------------QQQLLYDLHQSFSSVKYvlkedngqlpRMWLHYFRDWLqglqkafdedwrdgrITK 810

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   900 SCCR-----------LYISGPNKDKfcpsTVNSLNCLKNCMSITMGSVRPsvEQFHKYLP-WFLNDRPNIKCPKGGLAAY 967
Cdd:TIGR00918  811 ENYRngsddavlaykLLVQTGHRDK----PVDKEQLTTQRLVNADGIINP--NAFYIYLSaWVSNDPVAYAASQANIYPH 884

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337   968 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITAdlRKVPGtdpafevFPYTITNV 1035
Cdd:TIGR00918  885 ppewlhdkndydPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEG--FGLPS-------YPSGYPFL 955

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1036 FYEQYLTILPEGLFMLSLCLVPTFAVSCLLLgLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVE 1115
Cdd:TIGR00918  956 FWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVE 1034

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1116 FVSHITRSFAISTKptwlERAKEATISMgSAVFAGV---AMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVF 1192
Cdd:TIGR00918 1035 FTVHIALGFLTAIG----DRNRRAVLAL-EHMFAPVldgALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVL 1109

                          810
                   ....*....|....*..
gi 767945337  1193 LPVILSYVGP--DVNPA 1207
Cdd:TIGR00918 1110 LPVLLSMFGPepEVSPA 1126
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
558-718 1.24e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 46.39  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  558 GYKGKDYSE-AEALIMTFSLNNYPAGDPrLAQAKLWE--EAFLEEMRA--FQRRMAGMFQVTfmaersleDEINRTTAED 632
Cdd:COG1033   149 LYVGRLVSPdGKATLIVVTLDPDPLSSD-LDRKEVVAeiRAIIAKYEDpgVEVYLTGFPVLR--------GDIAEAIQSD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  633 LPIF-ATSYIVIFLYISLALGSYSSWsrvmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSlVILQVVPFLVLSVG- 710
Cdd:COG1033   220 LAIFfPLALLLILLLLFLFFRSLRGV------------LLPLLVVLLAVIWTLGLMGLLGIPLS-PLTILVPPLLLAIGi 286


                  ....*...
gi 767945337  711 ADNIFIFV 718
Cdd:COG1033   287 DYGIHLLN 294
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1058-1173 5.45e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 44.47  E-value: 5.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337 1058 TFAVSCLLLGL---DLRSGLLNLLSIVMILVDTVGFMALWGISYNAVS--LINLVSAVGMS--VEFVSHITRSFAISTKP 1130
Cdd:COG1033   227 ALLLILLLLFLffrSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIGIDygIHLLNRYREERRKGLDK 306

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767945337 1131 TwlERAKEATISMGSAVFAgVAMTNLPGILVLGLAKAQLIQIF 1173
Cdd:COG1033   307 R--EALREALRKLGPPVLL-TSLTTAIGFLSLLFSDIPPIRDF 346
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1064-1174 6.75e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.06  E-value: 6.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  1064 LLLGLDLRS---GLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF------------AIST 1128
Cdd:TIGR00921  208 LVLLLDFKRwwrPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYeeerdigrakgeAIVT 287

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767945337  1129 KPTWLERAKEATISMGSAVFAGVAMTNLPGI------LVLGLAKAQLIQIFF 1174
Cdd:TIGR00921  288 AVRRTGRAVLIALLTTSAGFAALALSEFPMVsefglgLVAGLITAYLLTLLV 339
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 288-415 1.21e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 43.22  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337  288 IIILCSVFAVVTIL-----LVGFRV-APARDKSKMVDPKKGTslsdklsfsthtllgqFFQGWGTWVASWPLTILVLSVI 361
Cdd:COG2409   306 IGVAVAVLAALTLLpallaLLGRRVfWPRRPRRRRAAAPESG----------------FWRRLARAVVRRPVPVLVAAVA 369

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767945337  362 PVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFhDQHFGPFFrTNQVILTAP 415
Cdd:COG2409   370 VLLALALPALGLRLGLPDADSLPADSPSRQGYDAL-AEHFPPGS-NGPLTVVVE 421
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1058-1173 1.59e-03

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 42.92  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945337 1058 TFAVSCLLLGLDLRS---GLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVE----FVSHITRsfAISTKP 1130
Cdd:COG1033   614 ALLLIFLLLLLAFRSlrlGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDytihFLSRYRE--ERRKGG 691

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767945337 1131 TWLERAKEATISMGSAVFaGVAMTNLPGILVLGLAKAQLIQIF 1173
Cdd:COG1033   692 DLEEAIRRALRTTGKAIL-FTSLTLAAGFGVLLFSSFPPLADF 733
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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