NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767948481|ref|XP_011514781|]
View 

sonic hedgehog protein isoform X1 [Homo sapiens]

Protein Classification

HH_signal and Hint domain-containing protein( domain architecture ID 11645567)

HH_signal and Hint domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
99-361 1.02e-93

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


:

Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 279.14  E-value: 1.02e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   99 KAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPrERLL 178
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481  179 LTAAHLLFVAPHNDSATGEpeassgsgppsggalgPRALFASRVRPGQRVYVvaERDGDRRLLPAAVHSVTLsEEAAGAY 258
Cdd:pfam01079  80 LTPAHLVFVADCERSSSAL----------------ERAVFASRVRPGDCVLV--PDTGGGELRPVRVVSVST-VEATGVY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481  259 APLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRlahallaalapartdrggdsgggdrgggggrVALTAPGAADAPG 338
Cdd:pfam01079 141 APLTSHGTIVVNRVLASCYAVIDSHSLAHWAFAPVR-------------------------------LLHSLSSLFWPNA 189
                         250       260
                  ....*....|....*....|...
gi 767948481  339 AGATAGIHWYSQLLYQIGTWLLD 361
Cdd:pfam01079 190 ASQTEGIHWYSNLLYGLGSLLLD 212
HH_signal super family cl03090
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
12-97 7.03e-66

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


The actual alignment was detected with superfamily member pfam01085:

Pssm-ID: 460055  Cd Length: 161  Bit Score: 206.07  E-value: 7.03e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   12 SSRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 91
Cdd:pfam01085  76 TKRCKDKLNILAILVMNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESR 155

                  ....*.
gi 767948481   92 AHIHCS 97
Cdd:pfam01085 156 AHIHCS 161
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
99-361 1.02e-93

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 279.14  E-value: 1.02e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   99 KAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPrERLL 178
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481  179 LTAAHLLFVAPHNDSATGEpeassgsgppsggalgPRALFASRVRPGQRVYVvaERDGDRRLLPAAVHSVTLsEEAAGAY 258
Cdd:pfam01079  80 LTPAHLVFVADCERSSSAL----------------ERAVFASRVRPGDCVLV--PDTGGGELRPVRVVSVST-VEATGVY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481  259 APLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRlahallaalapartdrggdsgggdrgggggrVALTAPGAADAPG 338
Cdd:pfam01079 141 APLTSHGTIVVNRVLASCYAVIDSHSLAHWAFAPVR-------------------------------LLHSLSSLFWPNA 189
                         250       260
                  ....*....|....*....|...
gi 767948481  339 AGATAGIHWYSQLLYQIGTWLLD 361
Cdd:pfam01079 190 ASQTEGIHWYSNLLYGLGSLLLD 212
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
12-97 7.03e-66

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 206.07  E-value: 7.03e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   12 SSRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 91
Cdd:pfam01085  76 TKRCKDKLNILAILVMNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESR 155

                  ....*.
gi 767948481   92 AHIHCS 97
Cdd:pfam01085 156 AHIHCS 161
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
111-276 1.90e-30

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 113.13  E-value: 1.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481 111 CFPGSATVHLEQGGTKLVKDLSP--GDRVLAADDQGRLLYSDFLTFLDRDdgAKKVFYVIETREPRErLLLTAAHLLFVA 188
Cdd:cd00081    1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTESGRE-ITLTPDHLLFVL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481 189 PHNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVVaerdgdrrlLPAAVHSVTLSEEAAGAYAPLTA-QGTI 267
Cdd:cd00081   78 EDG---------------------ELKWVFASDLKPGDYVLVP---------VLEKVKEIEEIEYTGGVYDLTVEdNHNF 127

                 ....*....
gi 767948481 268 LINRVLASC 276
Cdd:cd00081  128 IANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
110-231 1.47e-24

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 96.19  E-value: 1.47e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   110 GCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDqGRLLYSDFLTFLDRDDGAKKVFYVIETREPRErLLLTAAHLLFVAP 189
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALDE-GTLKYSPVKVFLVREPKGEKKFYRIKTENGRE-ITLTPDHLLLVRD 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 767948481   190 HNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVV 231
Cdd:smart00306  79 GG---------------------KLVWVFASELKPGDYVLVP 99
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
99-361 1.02e-93

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 279.14  E-value: 1.02e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   99 KAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPrERLL 178
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481  179 LTAAHLLFVAPHNDSATGEpeassgsgppsggalgPRALFASRVRPGQRVYVvaERDGDRRLLPAAVHSVTLsEEAAGAY 258
Cdd:pfam01079  80 LTPAHLVFVADCERSSSAL----------------ERAVFASRVRPGDCVLV--PDTGGGELRPVRVVSVST-VEATGVY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481  259 APLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRlahallaalapartdrggdsgggdrgggggrVALTAPGAADAPG 338
Cdd:pfam01079 141 APLTSHGTIVVNRVLASCYAVIDSHSLAHWAFAPVR-------------------------------LLHSLSSLFWPNA 189
                         250       260
                  ....*....|....*....|...
gi 767948481  339 AGATAGIHWYSQLLYQIGTWLLD 361
Cdd:pfam01079 190 ASQTEGIHWYSNLLYGLGSLLLD 212
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
12-97 7.03e-66

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 206.07  E-value: 7.03e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   12 SSRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 91
Cdd:pfam01085  76 TKRCKDKLNILAILVMNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESR 155

                  ....*.
gi 767948481   92 AHIHCS 97
Cdd:pfam01085 156 AHIHCS 161
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
111-276 1.90e-30

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 113.13  E-value: 1.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481 111 CFPGSATVHLEQGGTKLVKDLSP--GDRVLAADDQGRLLYSDFLTFLDRDdgAKKVFYVIETREPRErLLLTAAHLLFVA 188
Cdd:cd00081    1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTESGRE-ITLTPDHLLFVL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481 189 PHNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVVaerdgdrrlLPAAVHSVTLSEEAAGAYAPLTA-QGTI 267
Cdd:cd00081   78 EDG---------------------ELKWVFASDLKPGDYVLVP---------VLEKVKEIEEIEYTGGVYDLTVEdNHNF 127

                 ....*....
gi 767948481 268 LINRVLASC 276
Cdd:cd00081  128 IANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
110-231 1.47e-24

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 96.19  E-value: 1.47e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948481   110 GCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDqGRLLYSDFLTFLDRDDGAKKVFYVIETREPRErLLLTAAHLLFVAP 189
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALDE-GTLKYSPVKVFLVREPKGEKKFYRIKTENGRE-ITLTPDHLLLVRD 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 767948481   190 HNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVV 231
Cdd:smart00306  79 GG---------------------KLVWVFASELKPGDYVLVP 99
HintC smart00305
Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. ...
237-281 8.37e-05

Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197641  Cd Length: 46  Bit Score: 39.46  E-value: 8.37e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767948481   237 DRRLLPAAVHSVTlSEEAAGAYAP-LTAQGTILINRVLASCYAVIE 281
Cdd:smart00305   1 EGDFRFVRVKSIE-ETEYTGVYDPtVTENHNFIANGILVHNCAEIE 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH