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Conserved domains on  [gi|767953028|ref|XP_011515352|]
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tonsoku-like protein isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
517-635 9.77e-30

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 9.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGC 596
Cdd:COG0666  108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNA---RDN 184

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767953028 597 EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
Cdd:COG0666  185 DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 43-355 5.16e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.01  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  43 YAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYD 122
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 123 HCQsRDALLQAQAAFEKSLAIVDEELEgtlaqgeLNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEqnhlyeDLF 202
Cdd:COG3914   81 LEL-AALLLQALGRYEEALALYRRALA-------LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP------DFA 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 203 RARYNLGTIHWRAGQHSQAMRCLEGARECAHTMrkrfmeSECCVVIAQVLQDLGDFLAAKRALKKAYRLgsqKPvQRAAI 282
Cdd:COG3914  147 EAYLNLGEALRRLGRLEEAIAALRRALELDPDN------AEALNNLGNALQDLGRLEEAIAAYRRALEL---DP-DNADA 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028 283 CQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFSKAGDFPrAAEAYQKQLRFAELLDRPGAERAIIH 355
Cdd:COG3914  217 HSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDD-PAELLALARAWAQLVAAAAAPELPPP 288
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 668-931 1.06e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  668 ASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSPgQAAPAMARPRRSRHGPASSSSSSEGE 747
Cdd:PHA03247 2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERP-RDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  748 DSAGPARPSQKRPRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPE 827
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  828 EECLAGDWLELDMPLTRSRRPRPRGTgdnrRPSSTSGSDSEESRPRAR----------AKQVRLTCMQSCSAPVNAGPSS 897
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPRRLT----RPAVASLSESRESLPSPWdpadppaavlAPAAALPPAASPAGPLPPPTSA 2834

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767953028  898 LASEPPGSPSTPRVSEPSGDSSAAGQPLVGSGPA 931
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS 2868
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
517-635 9.77e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 9.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGC 596
Cdd:COG0666  108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNA---RDN 184

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767953028 597 EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
Cdd:COG0666  185 DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
Ank_2 pfam12796
Ankyrin repeats (3 copies);
533-627 5.49e-23

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 94.03  E-value: 5.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  533 LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggqgCEGITPLHDALNCGHFE 612
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*
gi 767953028  613 VAELLLERGASVTLR 627
Cdd:pfam12796  76 IVKLLLEKGADINVK 90
PHA03095 PHA03095
ankyrin-like protein; Provisional
 517-653 3.23e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 3.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 517 RKGSKWNRRNDMGETLLH---RACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLH-EACNYGHLEIVRFLLDHGAAVDDPG 592
Cdd:PHA03095  35 AAGADVNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKD 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028 593 GQGcegITPLHDALN--CGHFEVAELLLERGASVTLRTRKGLSPLETLqqwvkLYRRDLDLET 653
Cdd:PHA03095 115 KVG---RTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPLAVL-----LKSRNANVEL 169
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 43-355 5.16e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.01  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  43 YAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYD 122
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 123 HCQsRDALLQAQAAFEKSLAIVDEELEgtlaqgeLNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEqnhlyeDLF 202
Cdd:COG3914   81 LEL-AALLLQALGRYEEALALYRRALA-------LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP------DFA 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 203 RARYNLGTIHWRAGQHSQAMRCLEGARECAHTMrkrfmeSECCVVIAQVLQDLGDFLAAKRALKKAYRLgsqKPvQRAAI 282
Cdd:COG3914  147 EAYLNLGEALRRLGRLEEAIAALRRALELDPDN------AEALNNLGNALQDLGRLEEAIAAYRRALEL---DP-DNADA 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028 283 CQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFSKAGDFPrAAEAYQKQLRFAELLDRPGAERAIIH 355
Cdd:COG3914  217 HSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDD-PAELLALARAWAQLVAAAAAPELPPP 288
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 562-590 3.49e-07

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 47.20  E-value: 3.49e-07
                           10        20
                   ....*....|....*....|....*....
gi 767953028   562 GWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 529-635 6.78e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 529 GETLLHRACIEGQLRRVQDLVRQG-HPLNPRD-------------YCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQ 594
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGaDVVSPRAtgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGA---DIRAQ 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767953028 595 GCEGITPLH-------DALNCghfEVAELLL-----ERGASV-TLRTRKGLSPL 635
Cdd:cd22192  166 DSLGNTVLHilvlqpnKTFAC---QMYDLILsydkeDDLQPLdLVPNNQGLTPF 216
PHA03247 PHA03247
large tegument protein UL36; Provisional
 668-931 1.06e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  668 ASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSPgQAAPAMARPRRSRHGPASSSSSSEGE 747
Cdd:PHA03247 2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERP-RDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  748 DSAGPARPSQKRPRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPE 827
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  828 EECLAGDWLELDMPLTRSRRPRPRGTgdnrRPSSTSGSDSEESRPRAR----------AKQVRLTCMQSCSAPVNAGPSS 897
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPRRLT----RPAVASLSESRESLPSPWdpadppaavlAPAAALPPAASPAGPLPPPTSA 2834

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767953028  898 LASEPPGSPSTPRVSEPSGDSSAAGQPLVGSGPA 931
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS 2868
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 523-627 2.01e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.99  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  523 NRRNDMGETLLHRACIEgqlrrvqdlvrqghplnprdycgwtpLHEACNyghlEIVRFLLDHGA-------AVDDPGGQG 595
Cdd:TIGR00870  76 SCRGAVGDTLLHAISLE--------------------------YVDAVE----AILLHLLAAFRksgplelANDQYTSEF 125

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767953028  596 CEGITPLHDALNCGHFEVAELLLERGASVTLR 627
Cdd:TIGR00870 126 TPGITALHLAAHRQNYEIVKLLLERGASVPAR 157
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
517-635 9.77e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 9.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggQGC 596
Cdd:COG0666  108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNA---RDN 184

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767953028 597 EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
Cdd:COG0666  185 DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
494-635 1.66e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.59  E-value: 1.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 494 EDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYG 573
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767953028 574 HLEIVRFLLDHGAAVDDpggQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
Cdd:COG0666  132 NLEIVKLLLEAGADVNA---QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-659 2.33e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.27  E-value: 2.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCEGITPL 602
Cdd:COG0666  147 NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA---DVNAKDNDGKTAL 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767953028 603 HDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARA 659
Cdd:COG0666  224 DLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280
Ank_2 pfam12796
Ankyrin repeats (3 copies);
533-627 5.49e-23

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 94.03  E-value: 5.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  533 LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDpggqgCEGITPLHDALNCGHFE 612
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*
gi 767953028  613 VAELLLERGASVTLR 627
Cdd:pfam12796  76 IVKLLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
518-586 3.99e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 3.99e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767953028  518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHpLNPRDYcGWTPLHEACNYGHLEIVRFLLDHGA 586
Cdd:pfam12796  19 NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD-VNLKDN-GRTALHYAARSGHLEIVKLLLEKGA 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-635 4.94e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.67  E-value: 4.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGqgcEGITPL 602
Cdd:COG0666  180 NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDK---DGLTAL 256

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767953028 603 HDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
Cdd:COG0666  257 LLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 517-653 3.23e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 3.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 517 RKGSKWNRRNDMGETLLH---RACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLH-EACNYGHLEIVRFLLDHGAAVDDPG 592
Cdd:PHA03095  35 AAGADVNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKD 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028 593 GQGcegITPLHDALN--CGHFEVAELLLERGASVTLRTRKGLSPLETLqqwvkLYRRDLDLET 653
Cdd:PHA03095 115 KVG---RTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPLAVL-----LKSRNANVEL 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
562-618 3.52e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.13  E-value: 3.52e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767953028  562 GWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCegiTPLHDALNCGHFEVAELLL 618
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE---TALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
531-582 4.96e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 4.96e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767953028  531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 519-637 1.01e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.90  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA--AVDDPGGQgc 596
Cdd:PHA02874 114 GIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVKDNNGE-- 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767953028 597 egiTPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLET 637
Cdd:PHA02874 192 ---SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHN 229
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 544-624 2.23e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.83  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 544 RVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCEGITPLHDALNCGHFEVAELLLERGAS 623
Cdd:PHA03100 174 RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGA---NPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250


                 .
gi 767953028 624 V 624
Cdd:PHA03100 251 I 251
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 43-355 5.16e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.01  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  43 YAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYD 122
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 123 HCQsRDALLQAQAAFEKSLAIVDEELEgtlaqgeLNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEqnhlyeDLF 202
Cdd:COG3914   81 LEL-AALLLQALGRYEEALALYRRALA-------LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP------DFA 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 203 RARYNLGTIHWRAGQHSQAMRCLEGARECAHTMrkrfmeSECCVVIAQVLQDLGDFLAAKRALKKAYRLgsqKPvQRAAI 282
Cdd:COG3914  147 EAYLNLGEALRRLGRLEEAIAALRRALELDPDN------AEALNNLGNALQDLGRLEEAIAAYRRALEL---DP-DNADA 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028 283 CQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFSKAGDFPrAAEAYQKQLRFAELLDRPGAERAIIH 355
Cdd:COG3914  217 HSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDD-PAELLALARAWAQLVAAAAAPELPPP 288
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 531-628 7.68e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 7.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCegITPLHDALNCGH 610
Cdd:PHA02875 137 SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGC--VAALCYAIENNK 214

                         90
                 ....*....|....*...
gi 767953028 611 FEVAELLLERGASVTLRT 628
Cdd:PHA02875 215 IDIVRLFIKRGADCNIMF 232
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 561-589 1.35e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 48.41  E-value: 1.35e-07
                          10        20
                  ....*....|....*....|....*....
gi 767953028  561 CGWTPLHEACNYGHLEIVRFLLDHGAAVD 589
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 519-618 1.37e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.29  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 519 GSKWNR--RNDMGETLLHRACIE-------GQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavd 589
Cdd:PTZ00322  63 TPDHNLttEEVIDPVVAHMLTVElcqlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA--- 139

                         90       100
                 ....*....|....*....|....*....
gi 767953028 590 DPGGQGCEGITPLHDALNCGHFEVAELLL 618
Cdd:PTZ00322 140 DPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 527-635 1.93e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.89  E-value: 1.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 527 DMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDdpgGQGCEGITPLHDAL 606
Cdd:PHA02878 166 HKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD---ARDKCGNTPLHISV 242

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767953028 607 N-CGHFEVAELLLERGASVTLR-TRKGLSPL 635
Cdd:PHA02878 243 GyCKDYDILKLLLEHGVDVNAKsYILGLTAL 273
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 518-636 2.01e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 518 KGSKWNRRNDMGETLLHRACIE--GQLRRVQDLVRQGHPLNPRDYCGWTPLHEA--CNYGHLEIVRFLLDHGAAVDdpgg 593
Cdd:PHA03100  95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVDIN---- 170

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 594 QGCE-----------------GITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
Cdd:PHA03100 171 AKNRvnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLH 230
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 519-642 3.34e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQG--- 595
Cdd:PHA02874 147 GADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGftp 226

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767953028 596 -------------------------CEGITPLHDALN--CGhFEVAELLLERGASVTLRTRKGLSPLETLQQWV 642
Cdd:PHA02874 227 lhnaiihnrsaiellinnasindqdIDGSTPLHHAINppCD-IDIIDILLYHKADISIKDNKGENPIDTAFKYI 299
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 562-590 3.49e-07

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 47.20  E-value: 3.49e-07
                           10        20
                   ....*....|....*....|....*....
gi 767953028   562 GWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 518-635 3.85e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 3.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNY-GHLEIVRFLLDHGAAVDdpGGQGC 596
Cdd:PHA02878 190 YGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVN--AKSYI 267

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767953028 597 EGITPLHDALNCGhfEVAELLLERGASVTLRTRKGLSPL 635
Cdd:PHA02878 268 LGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPL 304
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
156-411 4.36e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 4.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 156 ELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIflaeqnHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTM 235
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKAL------ELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 236 rkrfmeSECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKP---VQRAAICQNLQHVLAVVRLqqqLEEAEGRDPQGAMV 312
Cdd:COG0457   76 ------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAealYNLGLALLELGRYDEAIEA---YERALELDPDDADA 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 313 ICEqLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKT 392
Cdd:COG0457  147 LYN-LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLL 225

                        250
                 ....*....|....*....
gi 767953028 393 WLNIALSREEAGDAYELLA 411
Cdd:COG0457  226 ALALLLALRLAALALYQYR 244
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 530-635 5.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 5.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 530 ETLLHRACIEGQLRRVQDLVRQGHPLNPRDYC-GWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCEGITPLHDALNC 608
Cdd:PHA02875  69 ESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLDIMKLLIARGA---DPDIPNTDKFSPLHLAVMM 145

                         90       100
                 ....*....|....*....|....*..
gi 767953028 609 GHFEVAELLLERGASVTLRTRKGLSPL 635
Cdd:PHA02875 146 GDIKGIELLIDHKACLDIEDCCGCTPL 172
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 562-589 5.98e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 46.51  E-value: 5.98e-07
                          10        20
                  ....*....|....*....|....*....
gi 767953028  562 GWTPLHEAC-NYGHLEIVRFLLDHGAAVD 589
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
581-636 8.67e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 8.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767953028  581 LLDHGAAvdDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
Cdd:pfam13857   1 LLEHGPI--DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
25-230 8.74e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 8.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  25 EEAALCHQLGELLAGHGRYAEALEQHWQELQLreradDPlGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHslrnht 104
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL-----DP-DDAEALYNLGLAYLRLGRYEEALADYEQALELDP------ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 105 ELQRAWATIGRTHLDIYDHcqsrdalLQAQAAFEKSLaivdeelegtlaqgELNEMRTRLYLNLGLTFESLQQTALCNDY 184
Cdd:COG0457   74 DDAEALNNLGLALQALGRY-------EEALEDYDKAL--------------ELDPDDAEALYNLGLALLELGRYDEAIEA 132

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767953028 185 FRKSIFLAeqnhlyEDLFRARYNLGTIHWRAGQHSQAMRCLEGARE 230
Cdd:COG0457  133 YERALELD------PDDADALYNLGIALEKLGRYEEALELLEKLEA 172
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 526-635 3.99e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 3.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 526 NDMGETLLHRACIEGQLrrVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCegiTPLHDA 605
Cdd:PHA02874  90 NGVDTSILPIPCIEKDM--IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGC---YPIHIA 164

                         90       100       110
                 ....*....|....*....|....*....|
gi 767953028 606 LNCGHFEVAELLLERGASVTLRTRKGLSPL 635
Cdd:PHA02874 165 IKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
Ank_5 pfam13857
Ankyrin repeats (many copies);
548-603 1.37e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 1.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767953028  548 LVRQGHP-LNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCegiTPLH 603
Cdd:pfam13857   1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL---TALD 54
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 197-416 2.62e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 2.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 197 LYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMEseccvvIAQVLQDLGDFLAAKRALKKAYRLGSQKP 276
Cdd:COG2956   37 LDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLE------LAQDYLKAGLLDRAEELLEKLLELDPDDA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 277 VQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEqLGDLFSKAGDFPRAAEAYQKQLRFAelldrPGAERAiiHV 356
Cdd:COG2956  111 EALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCE-LAELYLEQGDYDEAIEALEKALKLD-----PDCARA--LL 182

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 357 SLATTLGDMKDHHGAVRHYEEELRLRSGNVleeaktwlnialsreeagDAYELLAPCFQK 416
Cdd:COG2956  183 LLAELYLEQGDYEEAIAALERALEQDPDYL------------------PALPRLAELYEK 224
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 578-636 2.89e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 2.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767953028 578 VRFLLDHGAavdDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
Cdd:PTZ00322  98 ARILLTGGA---DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLE 153
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 529-631 3.29e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.29  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCegiTPLHDALNC 608
Cdd:PHA02875 102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGC---TPLIIAMAK 178

                         90       100
                 ....*....|....*....|...
gi 767953028 609 GHFEVAELLLERGASVTLRTRKG 631
Cdd:PHA02875 179 GDIAICKMLLDSGANIDYFGKNG 201
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 518-635 3.57e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 3.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 518 KGSKWNRRNDMGETLLHRAcieGQLRRVQD----LVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGG 593
Cdd:PHA02876 330 LGADVNAADRLYITPLHQA---STLDRNKDivitLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767953028 594 Q-GcegiTPLHDALnCGH--FEVAELLLERGASVTLRTRKGLSPL 635
Cdd:PHA02876 407 KiG----TALHFAL-CGTnpYMSVKTLIDRGANVNSKNKDLSTPL 446
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 8-339 4.32e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028   8 RQLSKAKAKAQRAGQRREEAALCH-QLGELLAGHGRYAEALEQHwqeLQLRERADDPlgcAVAHRKIGERLAEMEDYPAA 86
Cdd:COG2956   22 GQPDKAIDLLEEALELDPETVEAHlALGNLYRRRGEYDRAIRIH---QKLLERDPDR---AEALLELAQDYLKAGLLDRA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  87 LQHqhqYLELAHSLRNHTELQRAWATIgrthldiydhcqsrdalLQAQAAFEKSLAIVDEELEgtlaqgeLNEMRTRLYL 166
Cdd:COG2956   96 EEL---LEKLLELDPDDAEALRLLAEI-----------------YEQEGDWEKAIEVLERLLK-------LGPENAHAYC 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 167 NLGLTFESLQQTALCNDYFRKSIFLAEQNhlyedlFRARYNLGTIHWRAGQHSQAMRCLEgarecahtmrkrfmeseccv 246
Cdd:COG2956  149 ELAELYLEQGDYDEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALE-------------------- 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 247 viaQVLQDLGDFLAAKRALKKAYRLGSQKPvqraaicqnlqhvlavvRLQQQLEEAEGRDPQGAMVIceQLGDLFSKAGD 326
Cdd:COG2956  203 ---RALEQDPDYLPALPRLAELYEKLGDPE-----------------EALELLRKALELDPSDDLLL--ALADLLERKEG 260

                        330
                 ....*....|...
gi 767953028 327 FPRAAEAYQKQLR 339
Cdd:COG2956  261 LEAALALLERQLR 273
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 247-438 4.67e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.30  E-value: 4.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 247 VIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQG-AMVICEQLGDLFSKAG 325
Cdd:COG3914   13 AAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLlLAALLELAALLLQALG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 326 DFPRAAEAYQKQLRFAElldrpgaERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNvleeAKTWLNIALSREEAGD 405
Cdd:COG3914   93 RYEEALALYRRALALNP-------DNAEALFNLGNLLLALGRLEEALAALRRALALNPDF----AEAYLNLGEALRRLGR 161

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767953028 406 AYELLApCFQKALscAQQAQRPQLQRQ---VLQHLH 438
Cdd:COG3914  162 LEEAIA-ALRRAL--ELDPDNAEALNNlgnALQDLG 194
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 517-590 5.11e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 5.11e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767953028 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
Cdd:PHA03100 180 SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 529-635 6.78e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 529 GETLLHRACIEGQLRRVQDLVRQG-HPLNPRD-------------YCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQ 594
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGaDVVSPRAtgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGA---DIRAQ 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767953028 595 GCEGITPLH-------DALNCghfEVAELLL-----ERGASV-TLRTRKGLSPL 635
Cdd:cd22192  166 DSLGNTVLHilvlqpnKTFAC---QMYDLILsydkeDDLQPLdLVPNNQGLTPF 216
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 3-232 8.06e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.52  E-value: 8.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028   3 LERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALE--QHWQELqlreradDPLgCAVAHRKIGERLAEM 80
Cdd:COG3914   54 AAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALAlyRRALAL-------NPD-NAEALFNLGNLLLAL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  81 EDYPAALQHQHQYLELAHslrnhtELQRAWATIGRTHldiydhcQSRDALLQAQAAFEKSLAIVDEELEgtlaqgelnem 160
Cdd:COG3914  126 GRLEEALAALRRALALNP------DFAEAYLNLGEAL-------RRLGRLEEAIAALRRALELDPDNAE----------- 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028 161 rtrLYLNLGLTFESLQQTALCNDYFRKSIFLA-EQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECA 232
Cdd:COG3914  182 ---ALNNLGNALQDLGRLEEAIAAYRRALELDpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELS 251
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 597-629 8.56e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 8.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767953028  597 EGITPLHDA-LNCGHFEVAELLLERGASVTLRTR 629
Cdd:pfam00023   1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 525-638 9.15e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.16  E-value: 9.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 525 RNDMGETLLHRACIEGQ-------LRRVQDLVRQghPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDP------ 591
Cdd:cd22192   47 RGALGETALHVAALYDNleaavvlMEAAPELVNE--PMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPratgtf 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767953028 592 --GGQGCE---GITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
Cdd:cd22192  125 frPGPKNLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHIL 176
PHA03247 PHA03247
large tegument protein UL36; Provisional
 668-931 1.06e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  668 ASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSPgQAAPAMARPRRSRHGPASSSSSSEGE 747
Cdd:PHA03247 2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERP-RDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  748 DSAGPARPSQKRPRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPE 827
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  828 EECLAGDWLELDMPLTRSRRPRPRGTgdnrRPSSTSGSDSEESRPRAR----------AKQVRLTCMQSCSAPVNAGPSS 897
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPRRLT----RPAVASLSESRESLPSPWdpadppaavlAPAAALPPAASPAGPLPPPTSA 2834

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767953028  898 LASEPPGSPSTPRVSEPSGDSSAAGQPLVGSGPA 931
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS 2868
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 530-624 1.32e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.77  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 530 ETLLHRACIEGQLRRVQDLVRQGH-PLNPRDYCGWTPLHEACNYGHLEIVRFLLDhgAA---VDDP-GGQGCEGITPLHD 604
Cdd:cd22192   18 ESPLLLAAKENDVQAIKKLLKCPScDLFQRGALGETALHVAALYDNLEAAVVLME--AApelVNEPmTSDLYQGETALHI 95

                         90       100
                 ....*....|....*....|
gi 767953028 605 ALNCGHFEVAELLLERGASV 624
Cdd:cd22192   96 AVVNQNLNLVRELIARGADV 115
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 666-930 1.41e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  666 AAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSPGQAAPAMARPRRSRHGPasSSSSSE 745
Cdd:PHA03307  213 ISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP--ASSSSS 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  746 GEDSAGPARPSQKR-PRCSATAQRVAAWTPGPASNreaatastsraayQAAIRGVGSAQSRLGPGPPRGHSKALAPQAal 824
Cdd:PHA03307  291 PRERSPSPSPSSPGsGPAPSSPRASSSSSSSRESS-------------SSSTSSSSESSRGAAVSPGPSPSRSPSPSR-- 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  825 ipeeeclagdwlelDMPLTRSRRPRPRGTGdNRRPSSTSGSDSEESRPRARAKQVRLTCMQSCSAPVNAG-PSSLASEPP 903
Cdd:PHA03307  356 --------------PPPPADPSSPRKRPRP-SRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGrPRPSPLDAG 420

                         250       260
                  ....*....|....*....|....*..
gi 767953028  904 GSPSTPRVSEPSGDSSaaGQPLVGSGP 930
Cdd:PHA03307  421 AASGAFYARYPLLTPS--GEPWPGSPP 445
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 709-930 1.42e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  709 PEASQAHVrVSPGQAAPAMARPRRSRHGPASSSSSSEGE-DSAGPARPSQKRPRCSATAQRVAAWTPGPASNREAATAST 787
Cdd:PHA03307  159 PAAVASDA-ASSRQAALPLSSPEETARAPSSPPAEPPPStPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSS 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  788 SRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPEEECLAGDWLELDMPLTRSRRPRPRGTGDNRRPSSTSGSDS 867
Cdd:PHA03307  238 DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSS 317

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028  868 EESRPRARAKQVRLTCMQSCSAPVNAGPSSlasEPPGSPSTPRVSEPSGDSSAAGQPLVGSGP 930
Cdd:PHA03307  318 SSSSRESSSSSTSSSSESSRGAAVSPGPSP---SRSPSPSRPPPPADPSSPRKRPRPSRAPSS 377
PHA03247 PHA03247
large tegument protein UL36; Provisional
 746-930 3.64e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  746 GEDSAGPARPSQKR--PRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPrghskalaPQAA 823
Cdd:PHA03247  250 GDIAAPAPPPVVGEgaDRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPP--------PAPA 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  824 LIPEEECLAGDWLELDMPLTRSRRPRPRGTGDNRRPSSTSGSDSEE------SRPRARAKQVRLTCMQSCSAPVNAGPSS 897
Cdd:PHA03247  322 GDAEEEDDEDGAMEVVSPLPRPRQHYPLGFPKRRRPTWTPPSSLEDlsagrhHPKRASLPTRKRRSARHAATPFARGPGG 401

                         170       180       190
                  ....*....|....*....|....*....|...
gi 767953028  898 LASEPPGSPSTPRVSEPSGDSSAAGQPLVGSGP 930
Cdd:PHA03247  402 DDQTRPAAPVPASVPTPAPTPVPASAPPPPATP 434
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 597-626 3.72e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 3.72e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 767953028   597 EGITPLHDALNCGHFEVAELLLERGASVTL 626
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
5-230 8.00e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028   5 RELRQLSKAKAKAQRAGQ-RREEAALCHQLGELLAGHGRYAEALEQHWQELQLreradDPlGCAVAHRKIGERLAEMEDY 83
Cdd:COG0457   19 RRLGRYEEAIEDYEKALElDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL-----DP-DDAEALNNLGLALQALGRY 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  84 PAALQHQHQYLELAHslrnhtELQRAWATIGRTHLDIYDHcqsrdalLQAQAAFEKSLaivdeelegtlaqgELNEMRTR 163
Cdd:COG0457   93 EEALEDYDKALELDP------DDAEALYNLGLALLELGRY-------DEAIEAYERAL--------------ELDPDDAD 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767953028 164 LYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARE 230
Cdd:COG0457  146 ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLA 212
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 291-419 9.30e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.37  E-value: 9.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 291 AVVRLQQQLEeAEGRDPQGAMviceQLGDLFSKAGDFPRAAEAYQKQLRFAelldrpgAERAIIHVSLATTLGDMKDHHG 370
Cdd:COG4235    2 AIARLRQALA-ANPNDAEGWL----LLGRAYLRLGRYDEALAAYEKALRLD-------PDNADALLDLAEALLAAGDTEE 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767953028 371 AVRHYEEELRLRSGNvleeAKTWLNIALSREEAGDaYELLAPCFQKALS 419
Cdd:COG4235   70 AEELLERALALDPDN----PEALYLLGLAAFQQGD-YAEAIAAWQKLLA 113
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
518-590 9.91e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 42.25  E-value: 9.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953028 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
Cdd:COG0666  208 AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 249-354 1.71e-03

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 40.61  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 249 AQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAicqNLQhvLAVVRLQQ-QLEEA----EGRDPQG--AMVIcEQLGDLF 321
Cdd:COG2976   97 AKAAVDAGDLDKAAAQLQWVLDNAKDPALKALA---RLR--LARVLLAQkKYDEAlatlDAVKPEAfaALYA-ELRGDIL 170

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767953028 322 SKAGDFPRAAEAYQKQLrfaELLDRPGAERAII 354
Cdd:COG2976  171 LAQGDKAEARAAYQKAL---AALPEDAPLRQLL 200
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 523-627 2.01e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.99  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  523 NRRNDMGETLLHRACIEgqlrrvqdlvrqghplnprdycgwtpLHEACNyghlEIVRFLLDHGA-------AVDDPGGQG 595
Cdd:TIGR00870  76 SCRGAVGDTLLHAISLE--------------------------YVDAVE----AILLHLLAAFRksgplelANDQYTSEF 125

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767953028  596 CEGITPLHDALNCGHFEVAELLLERGASVTLR 627
Cdd:TIGR00870 126 TPGITALHLAAHRQNYEIVKLLLERGASVPAR 157
COG3899 COG3899
Predicted ATPase [General function prediction only];
3-459 2.31e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 41.77  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028    3 LERELRQLSKAKAKAQRAGQRREEAALCHQLGELLagHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMED 82
Cdd:COG3899   768 LERALAARALAALAALRHGNPPASARAYANLGLLL--LGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGP 845

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028   83 YPAALQHQHQYLEL-------AHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQG 155
Cdd:COG3899   846 LREALELLREALEAgletgdaALALLALAAAAAAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAA 925

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  156 ELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTM 235
Cdd:COG3899   926 AAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAA 1005

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  236 RKRFMESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICE 315
Cdd:COG3899  1006 AAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAA 1085

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  316 QLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLN 395
Cdd:COG3899  1086 AALAAALAAAALAAAAAAALALAAALAALALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLA 1165

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767953028  396 IALSREEAGDAYELLAPCFQKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLREL 459
Cdd:COG3899  1166 LAALALAAALAALAAALLAAAAAAAAAAALLAALLALAARLAALLALALLALEAAALLLLLLLA 1229
COG3899 COG3899
Predicted ATPase [General function prediction only];
3-449 2.67e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 41.77  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028    3 LERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMED 82
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028   83 YPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAfekslaivdEELEGTLAQGELNEMRT 162
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAA---------AAAAALAAAAAAAALAA 956

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  163 RLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMES 242
Cdd:COG3899   957 ALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAAL 1036

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  243 ECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFS 322
Cdd:COG3899  1037 LAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALAL 1116

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  323 KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSREE 402
Cdd:COG3899  1117 AAALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALL 1196

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 767953028  403 AGDAYELLAPCFQKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQEA 449
Cdd:COG3899  1197 AALLALAARLAALLALALLALEAAALLLLLLLAALALAAALLALRLL 1243
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 548-635 3.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028 548 LVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAavdDPGGQGCEGITPLHDALNCGH-----FEVAELLLERGA 622
Cdd:PHA03100  21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGA---DINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGA 97

                         90
                 ....*....|...
gi 767953028 623 SVTLRTRKGLSPL 635
Cdd:PHA03100  98 NVNAPDNNGITPL 110
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
5-168 5.87e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 5.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028   5 RELRQLSKAKAKAQRAGQRR-EEAALCHQLGELLAGHGRYAEALEQHWQELQLreradDPlGCAVAHRKIGERLAEMEDY 83
Cdd:COG0457   87 QALGRYEEALEDYDKALELDpDDAEALYNLGLALLELGRYDEAIEAYERALEL-----DP-DDADALYNLGIALEKLGRY 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  84 PAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTR 163
Cdd:COG0457  161 EEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240


                 ....*
gi 767953028 164 LYLNL 168
Cdd:COG0457  241 YQYRA 245
COG3899 COG3899
Predicted ATPase [General function prediction only];
34-517 8.82e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 40.23  E-value: 8.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028   34 GELLAGHGRYAEALEQHWQELQLR---------ERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHT 104
Cdd:COG3899   663 EERRALHRRIARALEARGPEPLEErlfelahhlNRAGERDRAARLLLRAARRALARGAYAEALRYLERALELLPPDPEEE 742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  105 ELQRAWATIGRTHLDIYDHCQSRDALLQAQAAfekslaivdeELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDY 184
Cdd:COG3899   743 YRLALLLELAEALYLAGRFEEAEALLERALAA----------RALAALAALRHGNPPASARAYANLGLLLLGDYEEAYEF 812

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  185 FRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLGDFLAAKRA 264
Cdd:COG3899   813 GELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAALAAAAAA 892

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  265 LKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQL---------EEAEGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQ 335
Cdd:COG3899   893 AARLLAAAAAALAAAAAAAALAAAELARLAAAAAAaaalalaaaAAAAAAAALAAAAAAAALAAALALAAAAAAAAAAAL 972

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  336 KQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQ 415
Cdd:COG3899   973 AAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALLAALAAA 1052

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953028  416 KALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED 495
Cdd:COG3899  1053 AAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALAAALAALALAAAARAA 1132

                         490       500
                  ....*....|....*....|..
gi 767953028  496 DTDGLTPQLEEDEELQGHLGRR 517
Cdd:COG3899  1133 AALLLLAAALALALAALLLLAA 1154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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