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Conserved domains on  [gi|767953316|ref|XP_011515473|]
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solute carrier family 45 member 4 isoform X2 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 52-270 3.35e-80

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 264.10  E-value: 3.35e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  52 WVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVL 131
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 132 FGVALFLNGSAIGLALGDvpNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 211
Cdd:cd17313   81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767953316 212 VLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 270
Cdd:cd17313  159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 497-709 8.04e-54

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 192.46  E-value: 8.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 497 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 576
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 577 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 656
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767953316 657 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 709
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 52-270 3.35e-80

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 264.10  E-value: 3.35e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  52 WVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVL 131
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 132 FGVALFLNGSAIGLALGDvpNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 211
Cdd:cd17313   81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767953316 212 VLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 270
Cdd:cd17313  159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 497-709 8.04e-54

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 192.46  E-value: 8.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 497 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 576
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 577 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 656
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767953316 657 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 709
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 47-214 1.75e-23

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 104.89  E-value: 1.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316   47 IPMRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILAL 126
Cdd:TIGR01301   1 VPLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  127 CVGVLFGVALFLNGSAIGLALGDVPNR--QPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDM--ALNIHAFS 202
Cdd:TIGR01301  81 AALVAFAVILIGFAADIGHLFGDNLDKktKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSFF 160

                         170
                  ....*....|..
gi 767953316  203 AGLGGAIGYVLG 214
Cdd:TIGR01301 161 MAIGNVLGYAAG 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-265 1.58e-13

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 73.40  E-value: 1.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  45 DRIPMRLWVMHGAVMFGREFCYAMETALVTPILLQI-GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFI 123
Cdd:COG2211    5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 124 LALcvGVLFGVALFLNGSAIGLAlgdvpnrQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALN-IHAFS 202
Cdd:COG2211   85 LIG--AIPLALSFVLLFTAPDLS-------PTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRFAF 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953316 203 AGLGGAIGYVLGGLdwTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERS 265
Cdd:COG2211  156 AGLGGLLASVLPPP--LVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS 216
MFS_1 pfam07690
Major Facilitator Superfamily;
64-271 5.49e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 55.50  E-value: 5.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316   64 FCYAMETALVTPILLQI-----GLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFL 138
Cdd:pfam07690   6 FLAALGRSLLGPALPLLlaedlGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  139 NGSAIGLALGdvpnRQPIGIvltvlgvvvldFSAdATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldw 218
Cdd:pfam07690  82 ASSLWLLLVL----RVLQGL-----------GAG-ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG--- 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767953316  219 tqtFLGSWFRTqnQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGA 271
Cdd:pfam07690 143 ---LLASLFGW--RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
499-726 1.56e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.36  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 499 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 578
Cdd:COG2211  221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 579 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALLGqyhDIKQYIHHSPGns 656
Cdd:COG2211  284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 657 KRGFGIDCAILSCQVYISQILVASALGGVVDAVG----------TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEE 726
Cdd:COG2211  357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 499-719 5.05e-04

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 43.25  E-value: 5.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  499 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 578
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  579 LQKYLDNYDLSVR---VIYVLGTLGFSVGTAVMAMFPN-----------------VYVAMVTISTMGIvSMSISYC-PYA 637
Cdd:TIGR01301 325 MEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgiKASALIVFAILGI-PLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  638 LLGQYHDikqyihhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVGTVRVIP--MVASVGSFLGFLTATFLVI 715
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 767953316  716 YPNV 719
Cdd:TIGR01301 473 RPRV 476
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 52-270 3.35e-80

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 264.10  E-value: 3.35e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  52 WVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVL 131
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 132 FGVALFLNGSAIGLALGDvpNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 211
Cdd:cd17313   81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767953316 212 VLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 270
Cdd:cd17313  159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 497-709 8.04e-54

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 192.46  E-value: 8.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 497 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 576
Cdd:cd17313  225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 577 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDikqyihhspgNS 656
Cdd:cd17313  299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHS----------ES 366

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767953316 657 KRGFGIDCAILSCQVYISQILVASALGGV--VDAVGTVRVIPMVASVGSFLGFLT 709
Cdd:cd17313  367 GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 47-214 1.75e-23

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 104.89  E-value: 1.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316   47 IPMRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILAL 126
Cdd:TIGR01301   1 VPLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  127 CVGVLFGVALFLNGSAIGLALGDVPNR--QPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDM--ALNIHAFS 202
Cdd:TIGR01301  81 AALVAFAVILIGFAADIGHLFGDNLDKktKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSFF 160

                         170
                  ....*....|..
gi 767953316  203 AGLGGAIGYVLG 214
Cdd:TIGR01301 161 MAIGNVLGYAAG 172
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 58-270 5.58e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 74.39  E-value: 5.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  58 VMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALF 137
Cdd:cd06174    4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADR----FGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 138 LNGSAIGLALGDVpnrqpigivltvlgvvVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGld 217
Cdd:cd06174   80 FAPSFWLLLLGRF----------------LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG-- 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767953316 218 wtqtFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 270
Cdd:cd06174  142 ----ILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK 190
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-265 1.58e-13

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 73.40  E-value: 1.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  45 DRIPMRLWVMHGAVMFGREFCYAMETALVTPILLQI-GLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFI 123
Cdd:COG2211    5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 124 LALcvGVLFGVALFLNGSAIGLAlgdvpnrQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALN-IHAFS 202
Cdd:COG2211   85 LIG--AIPLALSFVLLFTAPDLS-------PTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRFAF 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767953316 203 AGLGGAIGYVLGGLdwTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERS 265
Cdd:COG2211  156 AGLGGLLASVLPPP--LVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS 216
MFS_1 pfam07690
Major Facilitator Superfamily;
64-271 5.49e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 55.50  E-value: 5.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316   64 FCYAMETALVTPILLQI-----GLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFL 138
Cdd:pfam07690   6 FLAALGRSLLGPALPLLlaedlGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  139 NGSAIGLALGdvpnRQPIGIvltvlgvvvldFSAdATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldw 218
Cdd:pfam07690  82 ASSLWLLLVL----RVLQGL-----------GAG-ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG--- 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767953316  219 tqtFLGSWFRTqnQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGA 271
Cdd:pfam07690 143 ---LLASLFGW--RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
51-272 6.84e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.37  E-value: 6.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  51 LWVMHGAVMFGRefcyAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGV 130
Cdd:COG2814   15 LALGAFLSGLGI----GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 131 LFGVALFLNGSAIGLALGdvpnRQPIGIvltvlgvvvldfSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIG 210
Cdd:COG2814   87 LGSLLCALAPSLWLLLAA----RFLQGL------------GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767953316 211 YVLGGLdWTQTFlgSWfrtqnQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGAL 272
Cdd:COG2814  151 PLLGGL-LADLF--GW-----RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL 204
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 51-248 5.68e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.58  E-value: 5.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  51 LWVMHGAVMFGRefcYAMETALvtPILLQ--IGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCV 128
Cdd:cd17325  204 LFLAIFVLAFAF---GALEPFL--PLYAAelGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR----IGRKPLILIGLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 129 GVLFGVALFLNGSAIGLALGdvpnrqpigivltvlgVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGA 208
Cdd:cd17325  275 SAVALLLLPLATSFWLLLLL----------------LALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMV 338

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767953316 209 IGYVLGGLdWTQTFLGSWfrtqnqvLFFFAAIIFTVSVAL 248
Cdd:cd17325  339 LGPLLGGF-LYDAFGFAT-------PFLAAAALLLLAAVL 370
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 64-251 1.28e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 51.42  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  64 FCYAMETALVTPILLQIGLPEQYYSLTWFLS-------PILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVAL 136
Cdd:cd17330    6 FLDALGFGIVFPVLPFYVREFNKLGASGYYVgllqssySLGQFLASPLWGRLSDR----YGRKPVLLLSLAGSAVSYVLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 137 FLNGSAIGLALGdvpnRQPIGIVLtvlgvvvldfsadATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGl 216
Cdd:cd17330   82 GLSRNLWLLFLA----RFLDGLTG-------------GNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGG- 143

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767953316 217 dwtqtFLGSWFrtQNQVLFFFAAIIFTVSVALHLF 251
Cdd:cd17330  144 -----FLSTPY--GYALPFLVAAALALLNLVLVLF 171
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 51-272 3.41e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.92  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  51 LWVMHGAVMFGReFCYAMETALVTPILLQiglpEQYYSLTW-----FLSPILGLIFTPLIGSASDRctlsWGRRrPFILA 125
Cdd:cd17329    1 LWVLLIGSFLNR-LGFFMVWPFMAIYLHQ----QLGLSASIvglvlALSAVAGIVASLIGGRLADR----FGRK-PVMLA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 126 LCVGVLFGVALF-----LNGSAIGLALgdvpnrqpIGivltvlgvvvldFSADATEGPIRAYLLDVVDSEEQDMALNIHA 200
Cdd:cd17329   71 GLLLRALGFALLgfahsPWLFAIALVL--------TG------------FGGGLFEPASEAMIADVTTPENRTRAFSLLY 130

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767953316 201 FSAGLGGAIGYVLGGLdwtqtFLGSWFRTqnqvLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGAL 272
Cdd:cd17329  131 WAINLGVAIGPLLGGL-----LLLYSFRL----LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY 193
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 57-256 1.40e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.34  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  57 AVMFGREFCYAMetalVTPIL----LQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLF 132
Cdd:cd17325    3 LALFLDMLGYGI----IIPILplyaESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR----FGRKRLLLLGLLLLAVS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 133 GVALFLNGSAIGLALGdvpnRQPIGIvltvlgvvvldfsADATEGPIR-AYLLDVVDSEEQDMALNIHAFSAGLGGAIGY 211
Cdd:cd17325   75 TLLFAFATSYWQLLLA----RFLQGL-------------ASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGP 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767953316 212 VLGGldwtqtFLGSWFRTqnQVLFFFAAIIFTVSVALHLFSIDEE 256
Cdd:cd17325  138 LLGG------LLADALGY--RAPFLVCAALALLALVLALLLLPEP 174
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
499-726 1.56e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.36  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 499 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 578
Cdd:COG2211  221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 579 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALLGqyhDIKQYIHHSPGns 656
Cdd:COG2211  284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA---DVVDYDEWKTG-- 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 657 KRGFGIDCAILSCQVYISQILVASALGGVVDAVG----------TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEE 726
Cdd:COG2211  357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
MFS_1 pfam07690
Major Facilitator Superfamily;
18-210 2.27e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.33  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316   18 LSVPLPDPQKAGGAEAENCETISEGSIDRIPMRLWVMHGAVMFGreFCYAMETALVTPILLQIGLPEQYYSLTWFLSPIL 97
Cdd:pfam07690 170 LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG--FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316   98 GLIFTPLIGSASDRctLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGdvpnrqpigivltvlGVVVLDFSADATEG 177
Cdd:pfam07690 248 GAIGRLLLGRLSDR--LGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLL---------------ALLLLGFGFGLVFP 310

                         170       180       190
                  ....*....|....*....|....*....|...
gi 767953316  178 PIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIG 210
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 66-248 3.10e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.72  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  66 YAMETALVTPIL------LQIGLPEQYYSLTWFLspILGLIFTPLIGSASDRctlsWGRRRPFILALcvgVLFGVALFLN 139
Cdd:cd17504    8 VMLVETMLSPALptiqreFGTSAAAVSWVLTAYL--LVGAVSTPILGRLGDL----YGRKKVLLIVL---AIYTAGSLLA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 140 GSA-------IGLALgdvpnrQPIGIVLTvlgvvvldfsadategPIrAYLL--DVVDSEEQDMALNIHAFSAGLGGAIG 210
Cdd:cd17504   79 AFApnlpvliAGRAL------QGIGGAVF----------------PL-AFALvrEEFPPERVPVAQGILSATFGIGAGIG 135

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 767953316 211 YVLGGldWTQTFLGsWfrtqnQVLFFFAAIIFTVSVAL 248
Cdd:cd17504  136 LPLGG--WIVQHLG-W-----RWIFWTAAPVAVLLAAL 165
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
45-209 3.49e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  45 DRIPMRLWVMHGAVMFGrefCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFIL 124
Cdd:COG2814  206 RPRLLLLLLLAFLLGFG---FFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR----FGRRRLLLI 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 125 ALCVGVLFGVALFLNGSAIGLALGdvpnrqpigivltvlgVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAG 204
Cdd:COG2814  279 GLLLLALGLLLLALAGSLWLLLLA----------------LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342


                 ....*
gi 767953316 205 LGGAI 209
Cdd:COG2814  343 LGGPL 347
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 91-139 3.84e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 43.75  E-value: 3.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767953316  91 WFLSPILGLIFTPLIGSASDRCTLSWGRRRPFIL--ALCVGVLFgVALFLN 139
Cdd:cd17332   41 FLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLwgAIPLALLF-VLLFTT 90
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 499-719 5.05e-04

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 43.25  E-value: 5.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  499 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 578
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  579 LQKYLDNYDLSVR---VIYVLGTLGFSVGTAVMAMFPN-----------------VYVAMVTISTMGIvSMSISYC-PYA 637
Cdd:TIGR01301 325 MEKLCRGWGAGKRlwgIVNIILAICLAATVLVTYVAKNsryydgdgeslppptgiKASALIVFAILGI-PLAITYSiPFA 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  638 LLGQYHDikqyihhspgNSKRGFGIDCAILSCQVYISQILVaSALGGVVDAVGTVRVIP--MVASVGSFLGFLTATFLVI 715
Cdd:TIGR01301 404 LASIRSS----------NLGAGQGLSMGVLNLAIVIPQIIV-SLGSGPWDQLFGGGNLPafVVGAVAAFVSGLLALILLP 472


                  ....
gi 767953316  716 YPNV 719
Cdd:TIGR01301 473 RPRV 476
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 48-251 5.29e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.88  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  48 PMRLWVMHGAVMFGReFCYAMETALVTPILLQI----GLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFI 123
Cdd:COG0477    9 TRRRRRALLALALGT-FLEGLDFTIVNVALPSIaadlGASSAQLGWIVSAYLLGRAIGLLLFGRLGDR----YGRKRVLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 124 LALcvgVLFGVALFLNG---SAIGLALGdvpnR--QPIGIvltvlgvvvldfsadATEGPI-RAYLLDVVDSEEQDMALN 197
Cdd:COG0477   84 IGL---LLFGLASLLCGlapSPELLIAA----RalQGIGA---------------GGLMPGaLALIAELFPARERGRALG 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767953316 198 IHAFSAGLGGAIGYVLGGLDWTqtfLGSWfrtqnQVLFFFAAIIFTVSVALHLF 251
Cdd:COG0477  142 LWGAAIGLGLALGPLLGGLLVA---ALGW-----RWIFLINAPLGLLALVLRLR 187
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 37-250 5.83e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 5.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  37 ETISEGSIDRIPMRLWVMHGAVMFGrEFCYAMETALVTpILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsW 116
Cdd:cd17370  188 KKSKKTSLKKLPKAFWLYLLAVALF-ALGNFSFAFLIL-RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR----I 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 117 GRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPnrqpIGIVLTvlgvvvldfsadATEGPIRAYLLDVVDSEEQDMAL 196
Cdd:cd17370  262 GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFIL----WGLYMG------------AQESIERAAVADLVPAELRGTAY 325

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767953316 197 NIHAFSAGLGGAIGYVLGGLDWTQTFLgswfrtqnQVLFFFAAIIFTVSVALHL 250
Cdd:cd17370  326 GLFNTVVGIGWLLASLIAGYLWDLISP--------SAAFLFSAVLALIALLLLL 371
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 80-139 9.00e-04

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 42.68  E-value: 9.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316   80 IGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLN 139
Cdd:pfam13347  28 LGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFT 87
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
50-271 9.00e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 9.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  50 RLWVMHGAVMFGREFCYAMETALVTPILLQ-IGLPEQYYSLTWFLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCV 128
Cdd:COG2211  228 RPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKR----FGKKKAFIIGLLL 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 129 GVLFGVAL-FLNGSAIGLALGdvpnrqPIGIVLtvlgvvvldFSADATEGPIRAYLLDVVDSEEQD-------MALNIHA 200
Cdd:COG2211  304 AALGLLLLfFLGPGNLWLLLV------LAALAG---------IGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFT 368

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 201 FSAGLGGAIGYVLGG--LDWTQTFLGSwfrTQNQ--------VLFFFAAIIFTVS-VALHLFSIDEEQYSPQQERSAEEP 269
Cdd:COG2211  369 FAIKLGQALAGALAGllLALFGYVAGA---AQSPsaltgirlLFFLLPAVLLLLAaLLLLFYPLTRERHAEIRAELAARR 445


                 ..
gi 767953316 270 GA 271
Cdd:COG2211  446 AA 447
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 83-216 9.33e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.45  E-value: 9.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  83 PEQYYSLTWFLSPILGLIFTPLIGSASDRCtlswGRRRPFILALC-VGVLFGVALFLNG------SAIGLALGDVpnrqp 155
Cdd:COG2270   50 ATALWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFFTlLGVLATAALFFVApgglwlGLLLFVLANI----- 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767953316 156 igivltvlgvvvldfSADATEGPIRAYLLDVVDSEEQDMAlnihafsAGLGGAIGYVLGGL 216
Cdd:COG2270  121 ---------------GFEGSLVFYNAFLPDIATPEEIGRV-------SGLGWALGYLGGVL 159
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 511-736 1.33e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 511 LCLCHLLTWFSVIAEAVFYTDFMGQVIFegdpkapsnSTAWQAYNAGVKMGcwglvIYAATGAICSALLQKYldnydlSV 590
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGL---------SASQLGLLFALFSL-----GYALLQPLAGLLADRF------GR 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 591 RVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQyihhspgnskrgFGIDCAILSCQ 670
Cdd:cd06174   61 RPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERE------------RGRALGLLQAF 128

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767953316 671 VYISQILVASALGGVVDAVG-TVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAG 736
Cdd:cd06174  129 GSVGGILGPLLGGILASSLGfGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 96-248 2.93e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.67  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  96 ILGLIFTPLIGSASDRctlsWGRRrpFILALCVgVLFGVALFLNGSAIGLALGdVPNRQPIGIVLTvlgvvvldfsadaT 175
Cdd:cd17390   42 ALQLFSSPLVGSWSDV----VGRR--PVLLICL-LLTALGYVLLGFSTSLALL-FLSRIPLGIFKH-------------T 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767953316 176 EGPIRAYLLDVVDSEEQDMAL-NIHAFSaGLGGAIGYVLGGldwtqtFLGSWFRTQnQVLFFFAAIIFTVSVAL 248
Cdd:cd17390  101 QSLCKAYLSDLVSEQERSRVLgRFNAAS-SLGFILGPVVGG------HLAETDGGF-YYVALLCSAIFILNAGL 166
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 50-248 4.46e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.10  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  50 RLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCtlsWGRRRPFILALCVG 129
Cdd:cd06174  204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL---IGRKPLLLIGLLLM 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 130 VLFGVALFLNGSAIGLALGDVpnrqPIGivltvlgvvvldFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAI 209
Cdd:cd06174  281 ALGLALLLLAPSLLLLLLLLL----LLG------------FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAI 344

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767953316 210 GYVLGGLDWTQTFlgswfrtQNQVLFFFAAIIFTVSVAL 248
Cdd:cd06174  345 GPLLAGFLLAATF-------GLTGAFLVLAVLLLLAAIL 376
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 92-138 6.60e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.82  E-value: 6.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767953316  92 FLSPILGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFL 138
Cdd:cd17369  271 LIASVVAAITIPLFGWLSDR----VGRRPVYLAGALLAALFAFPFFW 313
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 68-266 6.98e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 6.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316  68 METALVTPIL------LQIGLPEQYYSLTWFLSPilGLIFTPLIGSASDRctlsWGRRRPFILALCVGVLFGVALFLNGS 141
Cdd:cd17474   13 LGVSIVDPILpaiaeaLGASPAQVGLLITAFTLP--AAVLMPVAGVLADR----FGRKKVLLPGLLLFGIGGLLCGLSDS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953316 142 AIGLALGdvpnR--QPIGIvltvlgvvvldfsadATEGPIRAYLL-DVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldw 218
Cdd:cd17474   87 FALLLAG----RalQGIGA---------------AGLGPLALTLIgDLFEGGERAKAMGLYEAALGLGIAVGPLLGG--- 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767953316 219 tqtFLG--SWFrtqnqVLFFFAAIIFTVSVALHLFsIDEEQYSPQQERSA 266
Cdd:cd17474  145 ---LLAaiSWR-----YPFFLLAALIPVAFLAILF-LLPEPKEKAKSSSA 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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