NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767951709|ref|XP_011515799|]
View 

DNA repair-scaffolding protein isoform X5 [Homo sapiens]

Protein Classification

DUF4502 and DUF4503 domain-containing protein( domain architecture ID 10633128)

DUF4502 and DUF4503 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
521-870 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


:

Pssm-ID: 464397  Cd Length: 385  Bit Score: 670.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  521 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 600
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  601 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 680
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  681 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 760
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  761 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 840
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330       340       350
                  ....*....|....*....|....*....|
gi 767951709  841 SRPQCRVKVKLLQRSISSLLRFAAGEDGLY 870
Cdd:pfam14951 321 SRPQCTVKVKLLQKSISSLLNSAALEDGSY 350
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
11-369 0e+00

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


:

Pssm-ID: 464396  Cd Length: 384  Bit Score: 657.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709   11 KRKRSWNTECPSFPGERPLQVRRAGLRTAGAAASLSEAWLRCGEGFQNTSGNPSLTAEEKTITEKHLELCPRPKQETTTS 90
Cdd:pfam14950   1 KRKRNWDIEYPSFPGESPLQLRRAGLRTVGAAASLSEAWLRCGEGFQDTSGTPSLTAEKKTITEKHLELSPRPKKETTTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709   91 KSTSGLTDITWSSSGSDLSDEDKTLSQLQR------------------------DELQFIDWEIDSDRAEASDCDEFEDD 146
Cdd:pfam14950  81 KSTSGLVDITWSSSGSDLSDEDKTLPKPQRdnghsraarlcnrnilcpedgaseDELQVIDWEIDSDREDASECSEFEDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  147 EGAVEISDCASCASNQSLTSDEKLSELPKPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDP 226
Cdd:pfam14950 161 ESVVEISDCASCASSQSLTSEERLSELPKPSSTEILEYSSDSEKEDDPEHVLFIDSESPHKYHMDFGSDARQVMEKSKSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  227 RTKSTETILHTPQKPTAKFPRTPENSAKK-KLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILE 305
Cdd:pfam14950 241 RVKSTETILQTPQKQTAKFPKTPEDSAKKkKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767951709  306 LHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 369
Cdd:pfam14950 321 LHEECSMQVAMCEQLAGPGATSPSQGPAPRPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
521-870 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 670.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  521 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 600
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  601 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 680
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  681 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 760
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  761 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 840
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330       340       350
                  ....*....|....*....|....*....|
gi 767951709  841 SRPQCRVKVKLLQRSISSLLRFAAGEDGLY 870
Cdd:pfam14951 321 SRPQCTVKVKLLQKSISSLLNSAALEDGSY 350
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
11-369 0e+00

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 657.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709   11 KRKRSWNTECPSFPGERPLQVRRAGLRTAGAAASLSEAWLRCGEGFQNTSGNPSLTAEEKTITEKHLELCPRPKQETTTS 90
Cdd:pfam14950   1 KRKRNWDIEYPSFPGESPLQLRRAGLRTVGAAASLSEAWLRCGEGFQDTSGTPSLTAEKKTITEKHLELSPRPKKETTTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709   91 KSTSGLTDITWSSSGSDLSDEDKTLSQLQR------------------------DELQFIDWEIDSDRAEASDCDEFEDD 146
Cdd:pfam14950  81 KSTSGLVDITWSSSGSDLSDEDKTLPKPQRdnghsraarlcnrnilcpedgaseDELQVIDWEIDSDREDASECSEFEDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  147 EGAVEISDCASCASNQSLTSDEKLSELPKPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDP 226
Cdd:pfam14950 161 ESVVEISDCASCASSQSLTSEERLSELPKPSSTEILEYSSDSEKEDDPEHVLFIDSESPHKYHMDFGSDARQVMEKSKSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  227 RTKSTETILHTPQKPTAKFPRTPENSAKK-KLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILE 305
Cdd:pfam14950 241 RVKSTETILQTPQKQTAKFPKTPEDSAKKkKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767951709  306 LHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 369
Cdd:pfam14950 321 LHEECSMQVAMCEQLAGPGATSPSQGPAPRPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
521-870 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 670.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  521 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 600
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  601 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 680
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  681 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 760
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  761 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 840
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330       340       350
                  ....*....|....*....|....*....|
gi 767951709  841 SRPQCRVKVKLLQRSISSLLRFAAGEDGLY 870
Cdd:pfam14951 321 SRPQCTVKVKLLQKSISSLLNSAALEDGSY 350
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
11-369 0e+00

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 657.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709   11 KRKRSWNTECPSFPGERPLQVRRAGLRTAGAAASLSEAWLRCGEGFQNTSGNPSLTAEEKTITEKHLELCPRPKQETTTS 90
Cdd:pfam14950   1 KRKRNWDIEYPSFPGESPLQLRRAGLRTVGAAASLSEAWLRCGEGFQDTSGTPSLTAEKKTITEKHLELSPRPKKETTTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709   91 KSTSGLTDITWSSSGSDLSDEDKTLSQLQR------------------------DELQFIDWEIDSDRAEASDCDEFEDD 146
Cdd:pfam14950  81 KSTSGLVDITWSSSGSDLSDEDKTLPKPQRdnghsraarlcnrnilcpedgaseDELQVIDWEIDSDREDASECSEFEDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  147 EGAVEISDCASCASNQSLTSDEKLSELPKPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDP 226
Cdd:pfam14950 161 ESVVEISDCASCASSQSLTSEERLSELPKPSSTEILEYSSDSEKEDDPEHVLFIDSESPHKYHMDFGSDARQVMEKSKSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951709  227 RTKSTETILHTPQKPTAKFPRTPENSAKK-KLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILE 305
Cdd:pfam14950 241 RVKSTETILQTPQKQTAKFPKTPEDSAKKkKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767951709  306 LHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 369
Cdd:pfam14950 321 LHEECSMQVAMCEQLAGPGATSPSQGPAPRPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH