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Conserved domains on  [gi|767954680|ref|XP_011516098|]
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coiled-coil domain-containing protein 171 isoform X17 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
6-639 8.79e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.70  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     6 NREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQE-----EQWEAERRELQFIVQEQDTAVQNMHKK 80
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDElaeelAELEEKLEELKEELESLEAELEELEAE 366
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    81 VEKLETEHMDCSDLLRRQTSELeFSTQRE--------ERLRKEFEATTLRVRKLEENIEAERAAHLESKFnsEIIQLRIR 152
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKV-AQLELQiaslnneiERLEARLERLEDRRERLQQEIEELLKKLEEAEL--KELQAELE 443
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   153 DLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE-----KEYFSKNKKLNEDIEEQKKVIID 227
Cdd:TIGR02168  444 ELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLErlqenLEGFSEGVKALLKNQSGLSGILG 523
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   228 -------------------LSKRLQY----NEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGI 284
Cdd:TIGR02168  524 vlselisvdegyeaaieaaLGGRLQAvvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGV 603
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   285 HKDKDK-PPSFSVVLE-RLRRTL--TDYQNKLEDASNELNSMNDV----------------KEKACNELDSTKQKIDSHT 344
Cdd:TIGR02168  604 AKDLVKfDPKLRKALSyLLGGVLvvDDLDNALELAKKLRPGYRIVtldgdlvrpggvitggSAKTNSSILERRREIEELE 683
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   345 KNIK-------ELQDKLADVNKELSHLHTKCADREAL---ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDA 414
Cdd:TIGR02168  684 EKIEeleekiaELEKALAELRKELEELEEELEQLRKEleeLSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEI 763
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   415 EEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFswSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQE 494
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQL--KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   495 DTftkvaeqikaqescwHRQKKELELQyselflevqkraqkfQEIAEKNMEKLN-HIEKSHEQLVlensHFKKLLSQTQR 573
Cdd:TIGR02168  842 DL---------------EEQIEELSED---------------IESLAAEIEELEeLIEELESELE----ALLNERASLEE 887
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   574 EQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL----FKLEIRTLAQALSTVEEKKQEEAK 639
Cdd:TIGR02168  888 ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELrlegLEVRIDNLQERLSEEYSLTLEEAE 957
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
821-992 7.99e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.32  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  821 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGlqmQLNEFKQSKLITHEKFESACEELNNALLRE 900
Cdd:COG1196   242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA---EEYELLAELARLEQDIARLEERRRELEERL 318
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  901 EQAQM----LLNEQA---QQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRL 973
Cdd:COG1196   319 EELEEelaeLEEELEeleEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
                         170
                  ....*....|....*....
gi 767954680  974 EENIHDAESALRMAAKDKE 992
Cdd:COG1196   399 AAQLEELEEAEEALLERLE 417
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
6-639 8.79e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.70  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     6 NREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQE-----EQWEAERRELQFIVQEQDTAVQNMHKK 80
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDElaeelAELEEKLEELKEELESLEAELEELEAE 366
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    81 VEKLETEHMDCSDLLRRQTSELeFSTQRE--------ERLRKEFEATTLRVRKLEENIEAERAAHLESKFnsEIIQLRIR 152
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKV-AQLELQiaslnneiERLEARLERLEDRRERLQQEIEELLKKLEEAEL--KELQAELE 443
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   153 DLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE-----KEYFSKNKKLNEDIEEQKKVIID 227
Cdd:TIGR02168  444 ELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLErlqenLEGFSEGVKALLKNQSGLSGILG 523
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   228 -------------------LSKRLQY----NEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGI 284
Cdd:TIGR02168  524 vlselisvdegyeaaieaaLGGRLQAvvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGV 603
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   285 HKDKDK-PPSFSVVLE-RLRRTL--TDYQNKLEDASNELNSMNDV----------------KEKACNELDSTKQKIDSHT 344
Cdd:TIGR02168  604 AKDLVKfDPKLRKALSyLLGGVLvvDDLDNALELAKKLRPGYRIVtldgdlvrpggvitggSAKTNSSILERRREIEELE 683
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   345 KNIK-------ELQDKLADVNKELSHLHTKCADREAL---ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDA 414
Cdd:TIGR02168  684 EKIEeleekiaELEKALAELRKELEELEEELEQLRKEleeLSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEI 763
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   415 EEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFswSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQE 494
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQL--KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   495 DTftkvaeqikaqescwHRQKKELELQyselflevqkraqkfQEIAEKNMEKLN-HIEKSHEQLVlensHFKKLLSQTQR 573
Cdd:TIGR02168  842 DL---------------EEQIEELSED---------------IESLAAEIEELEeLIEELESELE----ALLNERASLEE 887
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   574 EQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL----FKLEIRTLAQALSTVEEKKQEEAK 639
Cdd:TIGR02168  888 ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELrlegLEVRIDNLQERLSEEYSLTLEEAE 957
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
7-273 1.04e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.03  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    7 REYDLLMKEKSRLEKTL-----QEALEKHQREKNEMESHirETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKV 81
Cdd:COG1196   213 ERYRELKEELKELEAELlllklRELEAELEELEAELEEL--EAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   82 EKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVE 161
Cdd:COG1196   291 YELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  162 KASQAEAVADLEIIKNEFKEVESA---YEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKS 238
Cdd:COG1196   371 EAELAEAEEELEELAEELLEALRAaaeLAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 767954680  239 CSELQEELVMAKKHQAFLVETCENNVKELESILDS 273
Cdd:COG1196   451 EAELEEEEEALLELLAELLEEAALLEAALAELLEE 485
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
7-245 2.02e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 55.51  E-value: 2.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     7 REYDLLMKEKSRLEKTLQEALEKHQREKNEMEshiRETALEEFRLQEEqweaeRRELQFIVQEQDTAVQNMHKKVEKLET 86
Cdd:pfam17380  314 RRRKLEEAEKARQAEMDRQAAIYAEQERMAME---RERELERIRQEER-----KRELERIRQEEIAMEISRMRELERLQM 385
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    87 EHMDCSDLLRRQ-TSELEFSTQREERLRK--EFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKA 163
Cdd:pfam17380  386 ERQQKNERVRQElEAARKVKILEEERQRKiqQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERL 465
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   164 SQAEA---VADLEIIKNEFKEVESAYEREKHNAQESFA-KLNLLEKEyfSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSC 239
Cdd:pfam17380  466 RQQEEerkRKKLELEKEKRDRKRAEEQRRKILEKELEErKQAMIEEE--RKRKLLEKEMEERQKAIYEEERRREAEEERR 543

                   ....*.
gi 767954680   240 SELQEE 245
Cdd:pfam17380  544 KQQEME 549
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
74-641 9.41e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.14  E-value: 9.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   74 VQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRK---EFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLR 150
Cdd:PRK03918  195 IKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEElkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKE 274
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  151 IRDLEgalqvekasqaEAVADLEiiknEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEdIEEQKKVIIDLSK 230
Cdd:PRK03918  275 IEELE-----------EKVKELK----ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEING-IEERIKELEEKEE 338
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  231 RLQYNEKSCSELQEEL-VMAKKHQAFlvETCENNVKELESILDSFTVsgqwtsgihKDKDKPPSFSVVLERLRRTLTDYQ 309
Cdd:PRK03918  339 RLEELKKKLKELEKRLeELEERHELY--EEAKAKKEELERLKKRLTG---------LTPEKLEKELEELEKAKEEIEEEI 407
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  310 NKLEDASNELNSMNDVKEKACNELDSTKQKI--------DSHTKNI-KELQDKLADVNKELSHLhtkcADREALISTLKV 380
Cdd:PRK03918  408 SKITARIGELKKEIKELKKAIEELKKAKGKCpvcgreltEEHRKELlEEYTAELKRIEKELKEI----EEKERKLRKELR 483
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  381 ELQNVLHCWE---KEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAgcvLIKQPEGMLDKFswselcavlqEN 457
Cdd:PRK03918  484 ELEKVLKKESeliKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIK---LKGEIKSLKKEL----------EK 550
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  458 VDALIADLNRANEKIRHLEyicKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWhrqKKELELQYSELFLEV-QKRAQKF 536
Cdd:PRK03918  551 LEELKKKLAELEKKLDELE---EELAELLKELEELGFESVEELEERLKELEPFY---NEYLELKDAEKELEReEKELKKL 624
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  537 QEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQ-----REQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVN 611
Cdd:PRK03918  625 EEELDKAFEELAETEKRLEELRKELEELEKKYSEEEyeelrEEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELE 704
                         570       580       590
                  ....*....|....*....|....*....|
gi 767954680  612 TFELFKLEIRTLAQALSTVEEKKQEEAKMK 641
Cdd:PRK03918  705 EREKAKKELEKLEKALERVEELREKVKKYK 734
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
821-992 7.99e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.32  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  821 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGlqmQLNEFKQSKLITHEKFESACEELNNALLRE 900
Cdd:COG1196   242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA---EEYELLAELARLEQDIARLEERRRELEERL 318
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  901 EQAQM----LLNEQA---QQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRL 973
Cdd:COG1196   319 EELEEelaeLEEELEeleEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
                         170
                  ....*....|....*....
gi 767954680  974 EENIHDAESALRMAAKDKE 992
Cdd:COG1196   399 AAQLEELEEAEEALLERLE 417
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
845-1090 5.60e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 5.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   845 RLE--VTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKL-ITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL 921
Cdd:TIGR02168  190 RLEdiLNELERQLKSLERQAEKAERYKELKAELRELELaLLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKL 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   922 ELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDkecvanhmrav 1001
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE----------- 338
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  1002 entLHKVRDQISLswSAASRNDFTLQLPKLHLETFAMEGLKGGPEvvacqamiksfmDVYQLASTRIMTLEKEMTSHRSH 1081
Cdd:TIGR02168  339 ---LAELEEKLEE--LKEELESLEAELEELEAELEELESRLEELE------------EQLETLRSKVAQLELQIASLNNE 401

                   ....*....
gi 767954680  1082 IAALKSELH 1090
Cdd:TIGR02168  402 IERLEARLE 410
PRK11281 PRK11281
mechanosensitive channel MscK;
818-984 1.72e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  818 KSTASLQKQILGFTQRLhaaeverRSLRLEVTEFKRSVNEMKKE----LDKAQgLQMQLNEfkqskliTHEKFESACEEL 893
Cdd:PRK11281   80 EETEQLKQQLAQAPAKL-------RQAQAELEALKDDNDEETREtlstLSLRQ-LESRLAQ-------TLDQLQNAQNDL 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  894 N--NALL-----REEQAQMLLNEQAQQLQELNykLELHSSEEADKN-----QTLGEAVKSLSEAKMELRRKD-------Q 954
Cdd:PRK11281  145 AeyNSQLvslqtQPERAQAALYANSQRLQQIR--NLLKGGKVGGKAlrpsqRVLLQAEQALLNAQNDLQRKSlegntqlQ 222
                         170       180       190
                  ....*....|....*....|....*....|
gi 767954680  955 SLRQLNRHLTQLEQDkrRLEENIHDAESAL 984
Cdd:PRK11281  223 DLLQKQRDYLTARIQ--RLEHQLQLLQEAI 250
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
6-639 8.79e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.70  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     6 NREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQE-----EQWEAERRELQFIVQEQDTAVQNMHKK 80
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDElaeelAELEEKLEELKEELESLEAELEELEAE 366
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    81 VEKLETEHMDCSDLLRRQTSELeFSTQRE--------ERLRKEFEATTLRVRKLEENIEAERAAHLESKFnsEIIQLRIR 152
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKV-AQLELQiaslnneiERLEARLERLEDRRERLQQEIEELLKKLEEAEL--KELQAELE 443
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   153 DLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE-----KEYFSKNKKLNEDIEEQKKVIID 227
Cdd:TIGR02168  444 ELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLErlqenLEGFSEGVKALLKNQSGLSGILG 523
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   228 -------------------LSKRLQY----NEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGI 284
Cdd:TIGR02168  524 vlselisvdegyeaaieaaLGGRLQAvvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGV 603
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   285 HKDKDK-PPSFSVVLE-RLRRTL--TDYQNKLEDASNELNSMNDV----------------KEKACNELDSTKQKIDSHT 344
Cdd:TIGR02168  604 AKDLVKfDPKLRKALSyLLGGVLvvDDLDNALELAKKLRPGYRIVtldgdlvrpggvitggSAKTNSSILERRREIEELE 683
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   345 KNIK-------ELQDKLADVNKELSHLHTKCADREAL---ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDA 414
Cdd:TIGR02168  684 EKIEeleekiaELEKALAELRKELEELEEELEQLRKEleeLSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEI 763
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   415 EEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFswSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQE 494
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQL--KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   495 DTftkvaeqikaqescwHRQKKELELQyselflevqkraqkfQEIAEKNMEKLN-HIEKSHEQLVlensHFKKLLSQTQR 573
Cdd:TIGR02168  842 DL---------------EEQIEELSED---------------IESLAAEIEELEeLIEELESELE----ALLNERASLEE 887
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   574 EQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL----FKLEIRTLAQALSTVEEKKQEEAK 639
Cdd:TIGR02168  888 ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELrlegLEVRIDNLQERLSEEYSLTLEEAE 957
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
7-273 1.04e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.03  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    7 REYDLLMKEKSRLEKTL-----QEALEKHQREKNEMESHirETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKV 81
Cdd:COG1196   213 ERYRELKEELKELEAELlllklRELEAELEELEAELEEL--EAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   82 EKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVE 161
Cdd:COG1196   291 YELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  162 KASQAEAVADLEIIKNEFKEVESA---YEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKS 238
Cdd:COG1196   371 EAELAEAEEELEELAEELLEALRAaaeLAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 767954680  239 CSELQEELVMAKKHQAFLVETCENNVKELESILDS 273
Cdd:COG1196   451 EAELEEEEEALLELLAELLEEAALLEAALAELLEE 485
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
14-220 2.88e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 2.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    14 KEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDtavqnmhKKVEKLETEHMDCSD 93
Cdd:TIGR02169  740 EELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQ-------AELSKLEEEVSRIEA 812
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    94 LLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLES-----KFNSEI--IQLRIRDLEGALQVEKASQA 166
Cdd:TIGR02169  813 RLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLngkkeELEEELeeLEAALRDLESRLGDLKKERD 892
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767954680   167 EAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEE 220
Cdd:TIGR02169  893 ELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
305-1097 3.54e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 61.23  E-value: 3.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   305 LTDYQNKLEDASNELNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQN 384
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLAN 313
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   385 VLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKltflhtlyqhlvagcvlikqpegmldkfswselcAVLQENVDALIAD 464
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKL----------------------------------EELKEELESLEAE 359
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   465 LNRANEKIRHLEyickNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELElqyselflEVQKRAQKFQEIAEKNM 544
Cdd:TIGR02168  360 LEELEAELEELE----SRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLE--------RLEDRRERLQQEIEELL 427
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   545 EKLNHIEKSHEQLVLENShfKKLLSQTQREQMSLLAacalmagalyplysrscALSTQRDFLQEQVNTFELFKLEIRTLA 624
Cdd:TIGR02168  428 KKLEEAELKELQAELEEL--EEELEELQEELERLEE-----------------ALEELREELEEAEQALDAAERELAQLQ 488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   625 QALSTVEEKKQEEAKmkkktfkgliriFRKGVIAVLA-ANRLKILGQSCASLFTWMESFK--------EGIGMLVCTGEP 695
Cdd:TIGR02168  489 ARLDSLERLQENLEG------------FSEGVKALLKnQSGLSGILGVLSELISVDEGYEaaieaalgGRLQAVVVENLN 556
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   696 QDKhkfpkhqkeqlrclQALSWLTSSDLLAAiisSMAELQDVIGKADPNSR---ICGHLLIGAAKNSFAKLMDKISLVME 772
Cdd:TIGR02168  557 AAK--------------KAIAFLKQNELGRV---TFLPLDSIKGTEIQGNDreiLKNIEGFLGVAKDLVKFDPKLRKALS 619
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   773 ciPLHSSRSITyvekDSLVQ--RLAHGLHKVNTLALKYG--LRGHVPITKSTASLQKQILGFTQrlhaaevERRSLRLEV 848
Cdd:TIGR02168  620 --YLLGGVLVV----DDLDNalELAKKLRPGYRIVTLDGdlVRPGGVITGGSAKTNSSILERRR-------EIEELEEKI 686
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   849 TEFKRSVNEMKKELDKAQGLQMQL-NEFKQSKLITHE---KFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELH 924
Cdd:TIGR02168  687 EELEEKIAELEKALAELRKELEELeEELEQLRKELEElsrQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEEL 766
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   925 SSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENT 1004
Cdd:TIGR02168  767 EERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  1005 LHKVRDQISLswSAASRNDFTLQLPKLHLETFAMEGLKGGPEvvacqAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAA 1084
Cdd:TIGR02168  847 IEELSEDIES--LAAEIEELEELIEELESELEALLNERASLE-----EALALLRSELEELSEELRELESKRSELRRELEE 919
                          810
                   ....*....|...
gi 767954680  1085 LKSELHTACLREN 1097
Cdd:TIGR02168  920 LREKLAQLELRLE 932
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
17-361 4.20e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 61.23  E-value: 4.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    17 SRLEKtlQEALEKHQREKNEMESHIRET--ALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDL 94
Cdd:TIGR02168  671 SILER--RREIEELEEKIEELEEKIAELekALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEER 748
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    95 LRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEI 174
Cdd:TIGR02168  749 IAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLES 828
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   175 IKNEFKEVESAYER---EKHNAQESFAKLNL---------------LEKEYFSKNkKLNEDIEEQKKVIIDLSKRLQYNE 236
Cdd:TIGR02168  829 LERRIAATERRLEDleeQIEELSEDIESLAAeieeleelieeleseLEALLNERA-SLEEALALLRSELEELSEELRELE 907
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   237 KSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSvvLERLRRTLTDYQNKLEDAS 316
Cdd:TIGR02168  908 SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDD--EEEARRRLKRLENKIKELG 985
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767954680   317 N-ELNSMNDVKE----------------KACNELDSTKQKIDSHTKNikELQDKLADVNKEL 361
Cdd:TIGR02168  986 PvNLAAIEEYEElkerydfltaqkedltEAKETLEEAIEEIDREARE--RFKDTFDQVNENF 1045
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
8-250 4.35e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 4.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     8 EYDLLMKEKSRLEKTLQEALEKHQREKNEMEShiRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETE 87
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQE--LEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRER 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    88 HMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAE 167
Cdd:TIGR02168  311 LANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ 390
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   168 AVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKK-LNEDIEEQKKVIIDLSKRLQYNEKSCSELQEEL 246
Cdd:TIGR02168  391 LELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKeLQAELEELEEELEELQEELERLEEALEELREEL 470

                   ....
gi 767954680   247 VMAK 250
Cdd:TIGR02168  471 EEAE 474
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
7-245 2.02e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 55.51  E-value: 2.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     7 REYDLLMKEKSRLEKTLQEALEKHQREKNEMEshiRETALEEFRLQEEqweaeRRELQFIVQEQDTAVQNMHKKVEKLET 86
Cdd:pfam17380  314 RRRKLEEAEKARQAEMDRQAAIYAEQERMAME---RERELERIRQEER-----KRELERIRQEEIAMEISRMRELERLQM 385
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    87 EHMDCSDLLRRQ-TSELEFSTQREERLRK--EFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKA 163
Cdd:pfam17380  386 ERQQKNERVRQElEAARKVKILEEERQRKiqQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERL 465
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   164 SQAEA---VADLEIIKNEFKEVESAYEREKHNAQESFA-KLNLLEKEyfSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSC 239
Cdd:pfam17380  466 RQQEEerkRKKLELEKEKRDRKRAEEQRRKILEKELEErKQAMIEEE--RKRKLLEKEMEERQKAIYEEERRREAEEERR 543

                   ....*.
gi 767954680   240 SELQEE 245
Cdd:pfam17380  544 KQQEME 549
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
2-204 3.77e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 3.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    2 IQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHirETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKV 81
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEEL--EEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   82 EKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVE 161
Cdd:COG1196   375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767954680  162 KASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE 204
Cdd:COG1196   455 EEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLL 497
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
149-406 4.54e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 4.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   149 LRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNeDIEEQKKVIIDL 228
Cdd:TIGR02168  232 LRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEIS-RLEQQKQILRER 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   229 SKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKD-KDKPPSFSVVLERLRRTLTD 307
Cdd:TIGR02168  311 LANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEElESRLEELEEQLETLRSKVAQ 390
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   308 YQNKLEDASNELNSMNDVKEKACNELDSTKQKIDSHTK-----NIKELQDKLADVNKELSHLHTKCADREALISTLKVEL 382
Cdd:TIGR02168  391 LELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKkleeaELKELQAELEELEEELEELQEELERLEEALEELREEL 470
                          250       260
                   ....*....|....*....|....
gi 767954680   383 QNVLHCWEKEKAQAAQSESELQKL 406
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDSL 494
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
2-256 5.04e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    2 IQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMES-----HIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQN 76
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELELEEaqaeeYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   77 MHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEG 156
Cdd:COG1196   328 LEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEE 407
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  157 ALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNE 236
Cdd:COG1196   408 AEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELA 487
                         250       260
                  ....*....|....*....|
gi 767954680  237 KSCSELQEELVMAKKHQAFL 256
Cdd:COG1196   488 EAAARLLLLLEAEADYEGFL 507
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
74-641 9.41e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.14  E-value: 9.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   74 VQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRK---EFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLR 150
Cdd:PRK03918  195 IKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEElkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKE 274
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  151 IRDLEgalqvekasqaEAVADLEiiknEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEdIEEQKKVIIDLSK 230
Cdd:PRK03918  275 IEELE-----------EKVKELK----ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEING-IEERIKELEEKEE 338
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  231 RLQYNEKSCSELQEEL-VMAKKHQAFlvETCENNVKELESILDSFTVsgqwtsgihKDKDKPPSFSVVLERLRRTLTDYQ 309
Cdd:PRK03918  339 RLEELKKKLKELEKRLeELEERHELY--EEAKAKKEELERLKKRLTG---------LTPEKLEKELEELEKAKEEIEEEI 407
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  310 NKLEDASNELNSMNDVKEKACNELDSTKQKI--------DSHTKNI-KELQDKLADVNKELSHLhtkcADREALISTLKV 380
Cdd:PRK03918  408 SKITARIGELKKEIKELKKAIEELKKAKGKCpvcgreltEEHRKELlEEYTAELKRIEKELKEI----EEKERKLRKELR 483
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  381 ELQNVLHCWE---KEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAgcvLIKQPEGMLDKFswselcavlqEN 457
Cdd:PRK03918  484 ELEKVLKKESeliKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIK---LKGEIKSLKKEL----------EK 550
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  458 VDALIADLNRANEKIRHLEyicKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWhrqKKELELQYSELFLEV-QKRAQKF 536
Cdd:PRK03918  551 LEELKKKLAELEKKLDELE---EELAELLKELEELGFESVEELEERLKELEPFY---NEYLELKDAEKELEReEKELKKL 624
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  537 QEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQ-----REQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVN 611
Cdd:PRK03918  625 EEELDKAFEELAETEKRLEELRKELEELEKKYSEEEyeelrEEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELE 704
                         570       580       590
                  ....*....|....*....|....*....|
gi 767954680  612 TFELFKLEIRTLAQALSTVEEKKQEEAKMK 641
Cdd:PRK03918  705 EREKAKKELEKLEKALERVEELREKVKKYK 734
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
16-331 9.77e-07

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 52.98  E-value: 9.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    16 KSRLEKTLQEALEKHQreKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLl 95
Cdd:pfam07888   33 QNRLEECLQERAELLQ--AQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSAS- 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    96 rrqtseLEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEII 175
Cdd:pfam07888  110 ------SEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQT 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   176 KNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNE------DIEEQKKVIIDLSKRLQYNEKSCSELQEEL--- 246
Cdd:pfam07888  184 EEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTahrkeaENEALLEELRSLQERLNASERKVEGLGEELssm 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   247 ------VMAKKHQAFLvETCENNVKELESILDSFTVSGQWTS-------GIHKDKDKPPSFSVVLERLRRTLTDYQNKLE 313
Cdd:pfam07888  264 aaqrdrTQAELHQARL-QAAQLTLQLADASLALREGRARWAQeretlqqSAEADKDRIEKLSAELQRLEERLQEERMERE 342
                          330
                   ....*....|....*...
gi 767954680   314 DASNELNsmndvKEKACN 331
Cdd:pfam07888  343 KLEVELG-----REKDCN 355
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
2-200 1.65e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.76  E-value: 1.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     2 IQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMEShiRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKV 81
Cdd:TIGR02169  303 IASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEE--LEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEF 380
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    82 EKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVE 161
Cdd:TIGR02169  381 AETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQL 460
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 767954680   162 KASQAEAVADLEIIKNEFKEVesayEREKHNAQESFAKL 200
Cdd:TIGR02169  461 AADLSKYEQELYDLKEEYDRV----EKELSKLQRELAEA 495
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
17-416 2.11e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.38  E-value: 2.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    17 SRLEKTLQEaLEKHQREKNEMESHIRETALEEFRLQEEQWEAER-RELQFIVQEqdTAVQNMHKKVEKLETEHMDCSDLL 95
Cdd:TIGR02169  170 RKKEKALEE-LEEVEENIERLDLIIDEKRQQLERLRREREKAERyQALLKEKRE--YEGYELLKEKEALERQKEAIERQL 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    96 RRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAEraahleskfnSEIIQLRIRDLEGALQVEKASQAEAVAdleii 175
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDL----------GEEEQLRVKEKIGELEAEIASLERSIA----- 311
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   176 knefkevesAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQynekscsELQEELvmakkhqaf 255
Cdd:TIGR02169  312 ---------EKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYA-------ELKEEL--------- 366
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   256 lvetcENNVKELESIldsftvsgqwtsgihkdkdkppsfSVVLERLRRTLTDYQNKLEDASNELNSMNDVKEKACNELDS 335
Cdd:TIGR02169  367 -----EDLRAELEEV------------------------DKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQR 417
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   336 TKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELqnvlhcwEKEKAQAAQSESELQKLSQAFHKDAE 415
Cdd:TIGR02169  418 LSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADL-------SKYEQELYDLKEEYDRVEKELSKLQR 490

                   .
gi 767954680   416 E 416
Cdd:TIGR02169  491 E 491
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
17-642 2.62e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.90  E-value: 2.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    17 SRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAER--RELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDL 94
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKalEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    95 LRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEA---ERAAHLESKFNSEIIQLRIRDlegaLQVEKASQAEAVAD 171
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKlqeEELKLLAKEEEELKSELLKLE----RRKVDDEEKLKESE 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   172 LEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKK 251
Cdd:pfam02463  321 KEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELK 400
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   252 HQAflvetcENNVKELESILDSFTVSGQwtsgihKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNELNSMNDVKEKACN 331
Cdd:pfam02463  401 SEE------EKEAQLLLELARQLEDLLK------EEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELK 468
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   332 ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFH 411
Cdd:pfam02463  469 KSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTA 548
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   412 KDAE-EKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQ 490
Cdd:pfam02463  549 VIVEvSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGI 628
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   491 -QTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKlLS 569
Cdd:pfam02463  629 lKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE-QR 707
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767954680   570 QTQREQMSLLAACALMAGALYPLYSRScalSTQRDFLQEQVNTFELFKLEIRTlaQALSTVEEKKQEEAKMKK 642
Cdd:pfam02463  708 EKEELKKLKLEAEELLADRVQEAQDKI---NEELKLLKQKIDEEEEEEEKSRL--KKEEKEEEKSELSLKEKE 775
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
138-396 6.09e-06

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 50.31  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  138 LESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAyerekhnAQESFAKLNLLEKEYFSKNKKLNEd 217
Cdd:PRK05771   40 LSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEEL-------IKDVEEELEKIEKEIKELEEEISE- 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  218 IEEQKKVIIDLSKRLQYNEKSCSELQEELvmAKKH-QAFLVETCENNVKELESILDSFTVsgqwtSGIHKDKDKPPSFSV 296
Cdd:PRK05771  112 LENEIKELEQEIERLEPWGNFDLDLSLLL--GFKYvSVFVGTVPEDKLEELKLESDVENV-----EYISTDKGYVYVVVV 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  297 VLerlrrtltdyQNKLEDASNELNSmNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADreaLIS 376
Cdd:PRK05771  185 VL----------KELSDEVEEELKK-LGFERLELEEEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLE---ELL 250
                         250       260
                  ....*....|....*....|
gi 767954680  377 TLKVELQNvlhcwEKEKAQA 396
Cdd:PRK05771  251 ALYEYLEI-----ELERAEA 265
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
2-384 6.42e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 6.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     2 IQNCNREYDLLMKEKSRLEKTLQeALEKHQREKNEMESHIretalEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKV 81
Cdd:TIGR04523  182 KLNIQKNIDKIKNKLLKLELLLS-NLKKKIQKNKSLESQI-----SELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQL 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    82 EKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEatTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVE 161
Cdd:TIGR04523  256 NQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLN--QLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQN 333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   162 KASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEyfskNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSE 241
Cdd:TIGR04523  334 NKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKE----NQSYKQEIKNLESQINDLESKIQNQEKLNQQ 409
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   242 LQEELVMAKKhqaflvetcENNVKELESILDSFTVSGQwTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNELNS 321
Cdd:TIGR04523  410 KDEQIKKLQQ---------EKELLEKEIERLKETIIKN-NSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINK 479
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767954680   322 MNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQN 384
Cdd:TIGR04523  480 IKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISD 542
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
821-992 7.99e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.32  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  821 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGlqmQLNEFKQSKLITHEKFESACEELNNALLRE 900
Cdd:COG1196   242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA---EEYELLAELARLEQDIARLEERRRELEERL 318
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  901 EQAQM----LLNEQA---QQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRL 973
Cdd:COG1196   319 EELEEelaeLEEELEeleEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
                         170
                  ....*....|....*....
gi 767954680  974 EENIHDAESALRMAAKDKE 992
Cdd:COG1196   399 AAQLEELEEAEEALLERLE 417
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2-473 1.39e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    2 IQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESH--IRETALEEfrlQEEQWEAERRELQFIVQEQDTAVQNMH- 78
Cdd:COG4913   297 LEELRAELARLEAELERLEARLDALREELDELEAQIRGNggDRLEQLER---EIERLERELEERERRRARLEALLAALGl 373
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   79 -----------------KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEAttLRVRKLeeNIEAeraahlesk 141
Cdd:COG4913   374 plpasaeefaalraeaaALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIAS--LERRKS--NIPA--------- 440
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  142 fnsEIIQLRiRDLEGALQVeKASQAEAVADLEIIKNEFKEVESAYEREKHNaqesfAKLNLL-EKEYFSK-------NK- 212
Cdd:COG4913   441 ---RLLALR-DALAEALGL-DEAELPFVGELIEVRPEEERWRGAIERVLGG-----FALTLLvPPEHYAAalrwvnrLHl 510
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  213 -------KLNEDIEEQKKVIID---LSKRLQYNEKSCSE-LQEELvmakkHQAFLVETCEnNVKELESILDSFTVSGQ-- 279
Cdd:COG4913   511 rgrlvyeRVRTGLPDPERPRLDpdsLAGKLDFKPHPFRAwLEAEL-----GRRFDYVCVD-SPEELRRHPRAITRAGQvk 584
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  280 --WTSGIHKDKDKPPSFSVV--------------LERLRRTLTDYQNKLEDASNELNSMNDVKE--KACNELDSTKQKID 341
Cdd:COG4913   585 gnGTRHEKDDRRRIRSRYVLgfdnraklaaleaeLAELEEELAEAEERLEALEAELDALQERREalQRLAEYSWDEIDVA 664
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  342 SHTKNIKELQDKLADV---NKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKL 418
Cdd:COG4913   665 SAEREIAELEAELERLdasSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR 744
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767954680  419 TFLHTLYQHLVAGCVLIKQPEGMLDKfswselcavLQENVDALIADLNRANEKIR 473
Cdd:COG4913   745 LELRALLEERFAAALGDAVERELREN---------LEERIDALRARLNRAEEELE 790
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
300-984 2.64e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 2.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   300 RLRRTLTDYQnKLEDASNELnsmndvkEKACNELDSTKQKidshTKNIKELQDKLADVNKELSHLHTKCADREalISTLK 379
Cdd:TIGR02168  180 KLERTRENLD-RLEDILNEL-------ERQLKSLERQAEK----AERYKELKAELRELELALLVLRLEELREE--LEELQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   380 VELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVagcvLIKQPEGMLdkfswselcAVLQENVD 459
Cdd:TIGR02168  246 EELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALAN----EISRLEQQK---------QILRERLA 312
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   460 ALIADLNRANEKIRHLEyickNKSDTMRE---LQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKF 536
Cdd:TIGR02168  313 NLERQLEELEAQLEELE----SKLDELAEelaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV 388
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   537 QEI---AEKNMEKLNHIEKSHEQLvleNSHFKKLLSQTQREQMSLLAAcalmagALYPLYSRSCALSTQRDFLQEQVNTF 613
Cdd:TIGR02168  389 AQLelqIASLNNEIERLEARLERL---EDRRERLQQEIEELLKKLEEA------ELKELQAELEELEEELEELQEELERL 459
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   614 ELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFR------KGVIAVLA-ANRLKILGQSCASLFTWMESFK--- 683
Cdd:TIGR02168  460 EEALEELREELEEAEQALDAAERELAQLQARLDSLERLQEnlegfsEGVKALLKnQSGLSGILGVLSELISVDEGYEaai 539
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   684 -----EGIGMLVCTGEPQDKhkfpkhqkeqlrclQALSWLTSSDLLAAiisSMAELQDVIGKADPNSR---ICGHLLIGA 755
Cdd:TIGR02168  540 eaalgGRLQAVVVENLNAAK--------------KAIAFLKQNELGRV---TFLPLDSIKGTEIQGNDreiLKNIEGFLG 602
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   756 AKNSFAKLMDKISLVMEciPLHSSRSITyvekDSLVQ--RLAHGLHKVNTLALKYG---------LRGHVPITKSTASLQ 824
Cdd:TIGR02168  603 VAKDLVKFDPKLRKALS--YLLGGVLVV----DDLDNalELAKKLRPGYRIVTLDGdlvrpggviTGGSAKTNSSILERR 676
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   825 KQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQ----GLQMQLNEFKQSKLITHEKFESACEELNNALLRE 900
Cdd:TIGR02168  677 REIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRkeleELSRQISALRKDLARLEAEVEQLEERIAQLSKEL 756
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   901 EQAQMLLNEQAQQLQELNYKLELHSSEEADKNQ----------TLGEAVKSLSEAKMELRRKDQSLRQ-----------L 959
Cdd:TIGR02168  757 TELEAEIEELEERLEEAEEELAEAEAEIEELEAqieqlkeelkALREALDELRAELTLLNEEAANLRErleslerriaaT 836
                          730       740
                   ....*....|....*....|....*
gi 767954680   960 NRHLTQLEQDKRRLEENIHDAESAL 984
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAAEI 861
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
845-1090 5.60e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 5.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   845 RLE--VTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKL-ITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL 921
Cdd:TIGR02168  190 RLEdiLNELERQLKSLERQAEKAERYKELKAELRELELaLLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKL 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   922 ELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDkecvanhmrav 1001
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE----------- 338
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  1002 entLHKVRDQISLswSAASRNDFTLQLPKLHLETFAMEGLKGGPEvvacqamiksfmDVYQLASTRIMTLEKEMTSHRSH 1081
Cdd:TIGR02168  339 ---LAELEEKLEE--LKEELESLEAELEELEAELEELESRLEELE------------EQLETLRSKVAQLELQIASLNNE 401

                   ....*....
gi 767954680  1082 IAALKSELH 1090
Cdd:TIGR02168  402 IERLEARLE 410
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-405 6.68e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.37  E-value: 6.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    2 IQNCNREYDLLMKEKSRLEKTLQEaLEKHQREKnemESHIRETALEEFRLQEEQWEAER-RELQFIVQEQDTAVQNMHKK 80
Cdd:PRK03918  240 IEELEKELESLEGSKRKLEEKIRE-LEERIEEL---KKEIEELEEKVKELKELKEKAEEyIKLSEFYEEYLDELREIEKR 315
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   81 VEKLETEhmdcSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEA-ERAAHLESKFNseiiqlRIRDLEGALQ 159
Cdd:PRK03918  316 LSRLEEE----INGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELyEEAKAKKEELE------RLKKRLTGLT 385
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  160 VEKasqaeavadleiIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNE----------------------D 217
Cdd:PRK03918  386 PEK------------LEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEElkkakgkcpvcgrelteehrkeL 453
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  218 IEEQKKVIIDLSKRLQYNEKSCSELQEELV-----MAKKHQAFLVETCENNVKELESILDSFTvsgqwtsgihkdkdkpp 292
Cdd:PRK03918  454 LEEYTAELKRIEKELKEIEEKERKLRKELRelekvLKKESELIKLKELAEQLKELEEKLKKYN----------------- 516
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  293 sfsvvLERLRRTLTDYQnKLEDASNELNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADR- 371
Cdd:PRK03918  517 -----LEELEKKAEEYE-KLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEEl 590
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 767954680  372 EALISTLK------VELQNVLHCWEKEKAQAAQSESELQK 405
Cdd:PRK03918  591 EERLKELEpfyneyLELKDAEKELEREEKELKKLEEELDK 630
PTZ00121 PTZ00121
MAEBL; Provisional
7-403 9.50e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 9.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    7 REYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETA--LEEFRLQEEQWEA-------ERRELQFIVQEQDTAVQNM 77
Cdd:PTZ00121 1483 KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAkkADEAKKAEEAKKAdeakkaeEKKKADELKKAEELKKAEE 1562
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   78 HKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTL----RVRKLEE-NIEAE--RAAHLESKFNSEIIQLR 150
Cdd:PTZ00121 1563 KKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKmkaeEAKKAEEaKIKAEelKKAEEEKKKVEQLKKKE 1642
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  151 IRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEK-EYFSKNKKLNEDIEEQKKVIIDLS 229
Cdd:PTZ00121 1643 AEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEaEEAKKAEELKKKEAEEKKKAEELK 1722
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  230 KRLQYNEKSCSELQ-EELVMAKKHQAFLVETCENN-----VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 303
Cdd:PTZ00121 1723 KAEEENKIKAEEAKkEAEEDKKKAEEAKKDEEEKKkiahlKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKD 1802
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  304 TLTDYQNKLEDASNELNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQ 383
Cdd:PTZ00121 1803 IFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEE 1882
                         410       420
                  ....*....|....*....|
gi 767954680  384 NVLHCWEKEKAQAAQSESEL 403
Cdd:PTZ00121 1883 EIEEADEIEKIDKDDIEREI 1902
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
24-245 1.16e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.91  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   24 QEALEKHQREKNEMESHIRETaleEFRLQEEQweAERRELQFIVQEQDTAVQNMHKKVEKLETEhmdcsdlLRRQTSELE 103
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAEL---EKELAALK--KEEKALLKQLAALERRIAALARRIRALEQE-------LAALEAELA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  104 FSTQREERLRKEFEATTLRVRKLEENIE-AERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAvADLEIIKNEFKEV 182
Cdd:COG4942    87 ELEKEIAELRAELEAQKEELAELLRALYrLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQA-EELRADLAELAAL 165
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767954680  183 ESAYEREKhnaqesfAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEE 245
Cdd:COG4942   166 RAELEAER-------AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQE 221
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
7-206 1.41e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     7 REYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRlqEEQWEAERRELQFIVQEQDTAVQNMHKKVEK--- 83
Cdd:pfam17380  368 EEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKILEEER--QRKIQQQKVEMEQIRAEQEEARQREVRRLEEera 445
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    84 LETEHMDCSDLLRRQTSELeFSTQREERLRKEFE----------ATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRD 153
Cdd:pfam17380  446 REMERVRLEEQERQQQVER-LRQQEEERKRKKLElekekrdrkrAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEE 524
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767954680   154 LEGALQVEkasQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKE 206
Cdd:pfam17380  525 RQKAIYEE---ERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMERE 574
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
857-1027 2.88e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  857 EMKKELD--KAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQT 934
Cdd:COG1196   217 ELKEELKelEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  935 LGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKV---RDQ 1011
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAeaeLAE 376
                         170
                  ....*....|....*.
gi 767954680 1012 ISLSWSAASRNDFTLQ 1027
Cdd:COG1196   377 AEEELEELAEELLEAL 392
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
12-246 3.31e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.91  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   12 LMKEKSRLEKTLQEALEkHQREKNEMESHIRET-----ALEEFRLQEEQWEAERRELQFIVQEQDTA-VQNMHKKVEKLE 85
Cdd:COG4913   216 YMLEEPDTFEAADALVE-HFDDLERAHEALEDAreqieLLEPIRELAERYAAARERLAELEYLRAALrLWFAQRRLELLE 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   86 TEhmdcsdlLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESkfnseiIQLRIRDLEGALQVEKASQ 165
Cdd:COG4913   295 AE-------LEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQ------LEREIERLERELEERERRR 361
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  166 AEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEyfsknkkLNEDIEEQKKVIIDLSKRLQynekscsELQEE 245
Cdd:COG4913   362 ARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEA-------LEEALAEAEAALRDLRRELR-------ELEAE 427

                  .
gi 767954680  246 L 246
Cdd:COG4913   428 I 428
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
291-509 3.55e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  291 PPSFSVVLERLRRTLTDYQNKLEDASNELNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCAD 370
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  371 REALISTLKVELQNVLhcwekEKAQAAQSESELQ-KLSQAFHKDAEEKLTFLHTLYQHLVAgcvLIKQPEGMLDKFswSE 449
Cdd:COG4942    95 LRAELEAQKEELAELL-----RALYRLGRQPPLAlLLSPEDFLDAVRRLQYLKYLAPARRE---QAEELRADLAEL--AA 164
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  450 LCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQES 509
Cdd:COG4942   165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEE 224
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
14-251 3.75e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.63  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    14 KEKSRLEKTLQEALEKHQREKNEMESHIretalEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSD 93
Cdd:TIGR04523  401 QNQEKLNQQKDEQIKKLQQEKELLEKEI-----ERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSR 475
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    94 LLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIeaeraahleSKFNSEIIQLRIRdlEGALQVEKASQAEAVADLE 173
Cdd:TIGR04523  476 SINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKV---------KDLTKKISSLKEK--IEKLESEKKEKESKISDLE 544
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   174 --IIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKK 251
Cdd:TIGR04523  545 deLNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKK 624
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
15-407 5.60e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 44.33  E-value: 5.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    15 EKSRLEK--TLQEALEKHQREKNEMESHI--RETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVeKLETEHMD 90
Cdd:pfam05483  207 ENARLEMhfKLKEDHEKIQHLEEEYKKEIndKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKT-KLQDENLK 285
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    91 CS----DLLRRQTSELEFSTQR----EERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIR----DLEGAL 158
Cdd:pfam05483  286 ELiekkDHLTKELEDIKMSLQRsmstQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEattcSLEELL 365
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   159 QVEKASQAEAVADLEIIKNEFKEVESAYE---REKHNAQESFAKLN--LLEKE-YFSKNKKLNEDIEEQKKVIIDLSKRL 232
Cdd:pfam05483  366 RTEQQRLEKNEDQLKIITMELQKKSSELEemtKFKNNKEVELEELKkiLAEDEkLLDEKKQFEKIAEELKGKEQELIFLL 445
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   233 QYNEKSCSELQEELVMAKKHQAFLVETCENNVKELES---------------ILDSFTVSGQWTSGIHKDKDKPPSFSVV 297
Cdd:pfam05483  446 QAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKeklknieltahcdklLLENKELTQEASDMTLELKKHQEDIINC 525
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   298 LERLRRTLTDYQNKLEDASNELNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADreaLIST 377
Cdd:pfam05483  526 KKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNN---LKKQ 602
                          410       420       430
                   ....*....|....*....|....*....|
gi 767954680   378 LKVELQNVLHCWEKEKAQAAQSESELQKLS 407
Cdd:pfam05483  603 IENKNKNIEELHQENKALKKKGSAENKQLN 632
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
301-577 5.65e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 44.34  E-value: 5.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   301 LRRTLTDYQNKLEDASNELNSMNDVK-------EKACNELDSTKQKIDShTKNIKElqDKLADVNKELSHLHTKCADREA 373
Cdd:pfam15921  108 LRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQNTVHELEA-AKCLKE--DMLEDSNTQIEQLRKMMLSHEG 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   374 LIStlkvELQNVLHCWEKEKAQAAQSESELQKLS-QAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCA 452
Cdd:pfam15921  185 VLQ----EIRSILVDFEEASGKKIYEHDSMSTMHfRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIEL 260
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   453 VLQENVDALIADLNRANEKIRHLeyicKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKR 532
Cdd:pfam15921  261 LLQQHQDRIEQLISEHEVEITGL----TEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREA 336
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 767954680   533 AQKFQEiaeknmeklnHIEKSHEQLVLENSHFKKllSQTQREQMS 577
Cdd:pfam15921  337 KRMYED----------KIEELEKQLVLANSELTE--ARTERDQFS 369
PTZ00121 PTZ00121
MAEBL; Provisional
7-572 5.72e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    7 REYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEfrlqeeqwEAERRELQFIVQEQDTAVQNMHKKVEKLET 86
Cdd:PTZ00121 1077 KDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAE--------EAKKKAEDARKAEEARKAEDARKAEEARKA 1148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   87 EHMDCSDLLRR--QTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEiiqlRIRDLEGALQVEKAS 164
Cdd:PTZ00121 1149 EDAKRVEIARKaeDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAE----EERKAEEARKAEDAK 1224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  165 QAEAVADLEIIKnefKEVESAYEREKHNAQESFAKLNLLEKEYFSKN---------------------KKLNEDIEEQKK 223
Cdd:PTZ00121 1225 KAEAVKKAEEAK---KDAEEAKKAEEERNNEEIRKFEEARMAHFARRqaaikaeearkadelkkaeekKKADEAKKAEEK 1301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  224 VIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESildSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 303
Cdd:PTZ00121 1302 KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEA---AKAEAEAAADEAEAAEEKAEAAEKKKEEAKK 1378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  304 TLTDYQNKLEDA--SNELNSMNDVKEKACNELdstkQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVE 381
Cdd:PTZ00121 1379 KADAAKKKAEEKkkADEAKKKAEEDKKKADEL----KKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAE 1454
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  382 lqnvlhcwEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHtlyqhlvagcvLIKQPEGMLDKFSWSELCAVLQENVDal 461
Cdd:PTZ00121 1455 --------EAKKAEEAKKKAEEAKKADEAKKKAEEAKKADE-----------AKKKAEEAKKKADEAKKAAEAKKKAD-- 1513
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  462 iaDLNRANEkirhleyicKNKSDTMRELQQTQEDTFTKVAEQIKAQESCwhRQKKELELQYSELFLEVQKRAQKFQEIAE 541
Cdd:PTZ00121 1514 --EAKKAEE---------AKKADEAKKAEEAKKADEAKKAEEKKKADEL--KKAEELKKAEEKKKAEEAKKAEEDKNMAL 1580
                         570       580       590
                  ....*....|....*....|....*....|.
gi 767954680  542 KNMEKLNHIEKSHEQLVLENSHFKKLLSQTQ 572
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKAEE 1611
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
833-992 7.64e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 7.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  833 RLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQ----GLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLN 908
Cdd:COG1196   226 EAELLLLKLRELEAELEELEAELEELEAELEELEaelaELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIA 305
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  909 EQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAA 988
Cdd:COG1196   306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385

                  ....
gi 767954680  989 KDKE 992
Cdd:COG1196   386 EELL 389
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2-389 9.36e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    2 IQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKV 81
Cdd:COG4717    97 LEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQ 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   82 EKLETEHMDCS----DLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGA 157
Cdd:COG4717   177 EELEELLEQLSlateEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAA 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  158 LQVEKASQAEAVADLEIIKNEF--------KEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLS 229
Cdd:COG4717   257 ALLALLGLGGSLLSLILTIAGVlflvlgllALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSP 336
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  230 KRLQYNEKSCSELQEELVMAKKHQAFLveTCENNVKELESILDSFTVSG--QWTSGIHKDKDKppsfsvvlERLRRTLTD 307
Cdd:COG4717   337 EELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALLAEAGVEDeeELRAALEQAEEY--------QELKEELEE 406
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  308 YQNKLEDASNELNSMNDV--KEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHT--KCADREALISTLKVELQ 383
Cdd:COG4717   407 LEEQLEELLGELEELLEAldEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEdgELAELLQELEELKAELR 486

                  ....*.
gi 767954680  384 NVLHCW 389
Cdd:COG4717   487 ELAEEW 492
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
827-992 1.01e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  827 ILGFT--QRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLnefkqsklithekfeSACEELNNALLREEQAQ 904
Cdd:COG4913   603 VLGFDnrAKLAALEAELAELEEELAEAEERLEALEAELDALQERREAL---------------QRLAEYSWDEIDVASAE 667
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  905 MLLNEQAQQLQELnyklelhsseEADkNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESAL 984
Cdd:COG4913   668 REIAELEAELERL----------DAS-SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRL 736

                  ....*...
gi 767954680  985 RMAAKDKE 992
Cdd:COG4913   737 EAAEDLAR 744
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
12-258 1.11e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   12 LMKEKSRLEKTLQE-----ALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTaVQNMHKKVEKLET 86
Cdd:PRK03918  478 LRKELRELEKVLKKeseliKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKS-LKKELEKLEELKK 556
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   87 EHMDCSDLLRRQTSEL-EFSTQREERLRKEFEATTLRVRKLEEnIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQ 165
Cdd:PRK03918  557 KLAELEKKLDELEEELaELLKELEELGFESVEELEERLKELEP-FYNEYLELKDAEKELEREEKELKKLEEELDKAFEEL 635
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  166 AEAVADLEIIKNEFKEVESAYEREKH-NAQESFAKlnlLEKEYFSKNKKLnEDIEEQKKVIIDLSKRLQYNEKSCSELQE 244
Cdd:PRK03918  636 AETEKRLEELRKELEELEKKYSEEEYeELREEYLE---LSRELAGLRAEL-EELEKRREEIKKTLEKLKEELEEREKAKK 711
                         250
                  ....*....|....
gi 767954680  245 ELVMAKKHQAFLVE 258
Cdd:PRK03918  712 ELEKLEKALERVEE 725
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
821-977 1.36e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  821 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEkfesaceelnnallrE 900
Cdd:COG1579    34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEALQKE---------------I 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767954680  901 EQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELrrkDQSLRQLNRHLTQLEQDKRRLEENI 977
Cdd:COG1579    99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAEL---DEELAELEAELEELEAEREELAAKI 172
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
10-232 1.63e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.90  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    10 DLLMKEKSRLEKTLQEALEKHQREKNEM------------ESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTA---- 73
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLvqangelekasrEETFARTALKNARLDLRRLFDEKQSEKDKKNKALAErkds 679
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    74 ----VQNMHKKVEKLETEHMDCSDLLRRQTSELefSTQREERLRKEFEATTLRVRKLEENIEAERAAHleSKFNSEIIQL 149
Cdd:pfam12128  680 anerLNSLEAQLKQLDKKHQAWLEEQKEQKREA--RTEKQAYWQVVEGALDAQLALLKAAIAARRSGA--KAELKALETW 755
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   150 RIRDLEGalqveKASQAEAVADLeiiKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLS 229
Cdd:pfam12128  756 YKRDLAS-----LGVDPDVIAKL---KREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQ 827

                   ...
gi 767954680   230 KRL 232
Cdd:pfam12128  828 QQL 830
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
114-405 1.66e-03

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 42.32  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   114 KEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLE------------GALQVEKASQAEAVADLEIIKNEFKE 181
Cdd:pfam05701   70 EELESTKRLIEELKLNLERAQTEEAQAKQDSELAKLRVEEMEqgiadeasvaakAQLEVAKARHAAAVAELKSVKEELES 149
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   182 VESAY-----ERE--KHNAQESFAKLNLLEKEYFSKNKKLNE-------------DIEEQK--------KVIIDLSKRLQ 233
Cdd:pfam05701  150 LRKEYaslvsERDiaIKRAEEAVSASKEIEKTVEELTIELIAtkeslesahaahlEAEEHRigaalareQDKLNWEKELK 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   234 YNEKSCSELQEELVMAKKHQAFLvETCENNVKELESILDSFTVS--GQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNK 311
Cdd:pfam05701  230 QAEEELQRLNQQLLSAKDLKSKL-ETASALLLDLKAELAAYMESklKEEADGEGNEKKTSTSIQAALASAKKELEEVKAN 308
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   312 LEDASNELNSMNDV---------KEKAcnELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVEL 382
Cdd:pfam05701  309 IEKAKDEVNCLRVAaaslrseleKEKA--ELASLRQREGMASIAVSSLEAELNRTKSEIALVQAKEKEAREKMVELPKQL 386
                          330       340
                   ....*....|....*....|...
gi 767954680   383 QNVLHCWEKEKAQAAQSESELQK 405
Cdd:pfam05701  387 QQAAQEAEEAKSLAQAAREELRK 409
PRK11281 PRK11281
mechanosensitive channel MscK;
818-984 1.72e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  818 KSTASLQKQILGFTQRLhaaeverRSLRLEVTEFKRSVNEMKKE----LDKAQgLQMQLNEfkqskliTHEKFESACEEL 893
Cdd:PRK11281   80 EETEQLKQQLAQAPAKL-------RQAQAELEALKDDNDEETREtlstLSLRQ-LESRLAQ-------TLDQLQNAQNDL 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  894 N--NALL-----REEQAQMLLNEQAQQLQELNykLELHSSEEADKN-----QTLGEAVKSLSEAKMELRRKD-------Q 954
Cdd:PRK11281  145 AeyNSQLvslqtQPERAQAALYANSQRLQQIR--NLLKGGKVGGKAlrpsqRVLLQAEQALLNAQNDLQRKSlegntqlQ 222
                         170       180       190
                  ....*....|....*....|....*....|
gi 767954680  955 SLRQLNRHLTQLEQDkrRLEENIHDAESAL 984
Cdd:PRK11281  223 DLLQKQRDYLTARIQ--RLEHQLQLLQEAI 250
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
816-989 1.74e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  816 ITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQG-LQMQLNEFKQSKLITHEKFESACEELN 894
Cdd:COG4942    53 LLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEeLAELLRALYRLGRQPPLALLLSPEDFL 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  895 ---------NALLREEQAQML-LNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKME----LRRKDQSLRQLN 960
Cdd:COG4942   133 davrrlqylKYLAPARREQAEeLRADLAELAALRAELEAERAELEALLAELEEERAALEALKAErqklLARLEKELAELA 212
                         170       180
                  ....*....|....*....|....*....
gi 767954680  961 RHLTQLEQDKRRLEENIHDAESALRMAAK 989
Cdd:COG4942   213 AELAELQQEAEELEALIARLEAEAAAAAE 241
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
837-1013 1.87e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   837 AEVERRSLRLEvtEFKRSVNEMKKELDKAQGLqmqLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQE 916
Cdd:TIGR02169  674 AELQRLRERLE--GLKRELSSLQSELRRIENR---LDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSS 748
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   917 LNYKLELHSSEEADKNQTLGEAVKSLSEAKMEL-----RRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDK 991
Cdd:TIGR02169  749 LEQEIENVKSELKELEARIEELEEDLHKLEEALndleaRLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEK 828
                          170       180
                   ....*....|....*....|..
gi 767954680   992 ECVANHMRAVENTLHKVRDQIS 1013
Cdd:TIGR02169  829 EYLEKEIQELQEQRIDLKEQIK 850
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
156-409 1.98e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  156 GALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYfsknKKLNEDIEEQKKVIIDLSKRLQYN 235
Cdd:COG3883     2 LALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEY----NELQAELEALQAEIDKLQAEIAEA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  236 EKSCSELQEELvmakKHQAFLVETCENNVKELESILDSftvsgqwtsgihkdkdkpPSFSVVLERL--RRTLTDYQNKLe 313
Cdd:COG3883    78 EAEIEERREEL----GERARALYRSGGSVSYLDVLLGS------------------ESFSDFLDRLsaLSKIADADADL- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  314 dasneLNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELshlhtkcADREALISTLKVELQNVLHCWEKEK 393
Cdd:COG3883   135 -----LEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQ-------AEQEALLAQLSAEEAAAEAQLAELE 202
                         250
                  ....*....|....*.
gi 767954680  394 AQAAQSESELQKLSQA 409
Cdd:COG3883   203 AELAAAEAAAAAAAAA 218
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
15-361 2.42e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.04  E-value: 2.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    15 EKSRLEKTLQEALEKHQREKNEMESHIRETALE-EFRLQEEQWEAERRELQFIVQ------------EQDTAVQNMHKKV 81
Cdd:pfam05557   76 ELNRLKKKYLEALNKKLNEKESQLADAREVISClKNELSELRRQIQRAELELQSTnseleelqerldLLKAKASEAEQLR 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    82 EKLETEHMDCSDlLRRQTSELEFSTQREER---LRKEFEATTLRVRKLEENIEA--ERAAHL-ESKFNSEIIQLRIRDLE 155
Cdd:pfam05557  156 QNLEKQQSSLAE-AEQRIKELEFEIQSQEQdseIVKNSKSELARIPELEKELERlrEHNKHLnENIENKLLLKEEVEDLK 234
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   156 GALQVEKASQAEAVA---DLEIIKNEFKEVESAYEREKHNAQESFA-----------KLNLLEKEYFSKN---------K 212
Cdd:pfam05557  235 RKLEREEKYREEAATlelEKEKLEQELQSWVKLAQDTGLNLRSPEDlsrrieqlqqrEIVLKEENSSLTSsarqlekarR 314
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   213 KLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSG---IHKDKD 289
Cdd:pfam05557  315 ELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSNYSPQLLERIEEAedmTQKMQA 394
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767954680   290 KPPSFSVVLERLRRTLTDYQNKLEDASNELNSMNdvKEKACNELDSTKQKIDSHTKNIKELQ---DKLADVNKEL 361
Cdd:pfam05557  395 HNEEMEAQLSVAEEELGGYKQQAQTLERELQALR--QQESLADPSYSKEEVDSLRRKLETLElerQRLREQKNEL 467
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
12-388 2.68e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.96  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    12 LMKEKSRLEKTLQEALEKHQREKNEMESHIRetaleefrLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDC 91
Cdd:TIGR00606  413 LCADLQSKERLKQEQADEIRDEKKGLGRTIE--------LKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAE 484
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    92 SDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQL-------RIRDLEGALQVEKAS 164
Cdd:TIGR00606  485 RELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKdkmdkdeQIRKIKSRHSDELTS 564
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   165 QAEAVADLEIIKNEFKEVEsayeREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRL------QYNEKS 238
Cdd:TIGR00606  565 LLGYFPNKKQLEDWLHSKS----KEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESD 640
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   239 CSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDyqnKLEDASNE 318
Cdd:TIGR00606  641 LERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPD---KLKSTESE 717
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   319 LNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHC 388
Cdd:TIGR00606  718 LKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVC 787
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
171-360 2.72e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   171 DLEIIKNEFKEVESAYEREkhnAQESFAKLNLLEKEYF------SKNKKLNedieeqkKVIIDLSKRLQYNEKSCSELQE 244
Cdd:TIGR01612 1545 DSEIIIKEIKDAHKKFILE---AEKSEQKIKEIKKEKFrieddaAKNDKSN-------KAAIDIQLSLENFENKFLKISD 1614
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   245 elvMAKKHQAFLVETcennvKELESILDSFTVSGQWTSgIHKDKDKPPSFSVVLERLRrtltDYQNKLEDASNELNSMNd 324
Cdd:TIGR01612 1615 ---IKKKINDCLKET-----ESIEKKISSFSIDSQDTE-LKENGDNLNSLQEFLESLK----DQKKNIEDKKKELDELD- 1680
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 767954680   325 vkekacNELDSTKQKIDSHTKN----IKELQDKLADVNKE 360
Cdd:TIGR01612 1681 ------SEIEKIEIDVDQHKKNyeigIIEKIKEIAIANKE 1714
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
13-408 2.81e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.02  E-value: 2.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    13 MKEKSRLE-KTLQEALEKHQREKNEMEShIRETALEEFRLQ---EEQWEAERRELQFIVQEQDTAVQNMHKK-------V 81
Cdd:pfam05483  273 LEEKTKLQdENLKELIEKKDHLTKELED-IKMSLQRSMSTQkalEEDLQIATKTICQLTEEKEAQMEELNKAkaahsfvV 351
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    82 EKLETEHMDCSDLLRRQTselefstQREERLRKEFEATTLRVRKleENIEAERAAHLESKFNSEIIQLRIRDLEGALQVE 161
Cdd:pfam05483  352 TEFEATTCSLEELLRTEQ-------QRLEKNEDQLKIITMELQK--KSSELEEMTKFKNNKEVELEELKKILAEDEKLLD 422
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   162 KASQAEAVAD-LEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLS----KRLQYNE 236
Cdd:pfam05483  423 EKKQFEKIAEeLKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTahcdKLLLENK 502
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   237 KSCSELQEELVMAKKHQaflvETCENNVKELESILDsftvsgQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDAS 316
Cdd:pfam05483  503 ELTQEASDMTLELKKHQ----EDIINCKKQEERMLK------QIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSE 572
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   317 NELNSMN----------DVKEKACNELdstKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVL 386
Cdd:pfam05483  573 ENARSIEyevlkkekqmKILENKCNNL---KKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAK 649
                          410       420
                   ....*....|....*....|..
gi 767954680   387 HCWEkEKAQAAQSESELQKLSQ 408
Cdd:pfam05483  650 QKFE-EIIDNYQKEIEDKKISE 670
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
68-251 2.98e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   68 QEQDTAVQNMHKKVEKLETEhmdcsdlLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAhLESKfnSEII 147
Cdd:COG3883    19 QAKQKELSELQAELEAAQAE-------LDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE-IEER--REEL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  148 QLRIRDL------EGALQV--------EKASQAEAV-----ADLEIIkNEFKEVESAYEREKHNAQESFAKLNLLEKEYF 208
Cdd:COG3883    89 GERARALyrsggsVSYLDVllgsesfsDFLDRLSALskiadADADLL-EELKADKAELEAKKAELEAKLAELEALKAELE 167
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767954680  209 SKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKK 251
Cdd:COG3883   168 AAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEA 210
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
821-1013 4.51e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  821 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGlQMQLNEFKQSKLITHEkfesacEELNNAL--L 898
Cdd:COG4942    30 EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ-ELAALEAELAELEKEI------AELRAELeaQ 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  899 REEQAQMLLneQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAkmelrRKDQsLRQLNRHLTQLEQDKRRLEENIH 978
Cdd:COG4942   103 KEELAELLR--ALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPA-----RREQ-AEELRADLAELAALRAELEAERA 174
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 767954680  979 DAESALRMAAKDKECVANHMRAVENTLHKVRDQIS 1013
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELA 209
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
6-362 5.05e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.20  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    6 NREYDLLMKEKSRLEKTLQ------EALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQF-IVQEQDTAVQNMH 78
Cdd:PRK03918  299 SEFYEEYLDELREIEKRLSrleeeiNGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYeEAKAKKEELERLK 378
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   79 KKVEKLETEHMDcsdllrrqtSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDL---- 154
Cdd:PRK03918  379 KRLTGLTPEKLE---------KELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELteeh 449
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  155 ------EGALQVEKASQ--AEAVADLEIIKNEFKEVESAYEREKH------------NAQESFAKLNLLEKEyfsknkKL 214
Cdd:PRK03918  450 rkelleEYTAELKRIEKelKEIEEKERKLRKELRELEKVLKKESEliklkelaeqlkELEEKLKKYNLEELE------KK 523
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  215 NEDIEEQKKVIIDLSKRLQYNEKSCSELQEelvmAKKHQAFLVETCENNVKELESILDSFTVSGQwtsgihkdkdkpPSF 294
Cdd:PRK03918  524 AEEYEKLKEKLIKLKGEIKSLKKELEKLEE----LKKKLAELEKKLDELEEELAELLKELEELGF------------ESV 587
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680  295 SVVLERLRRTLTDYQ--NKLEDASNELNSMNDVKEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELS 362
Cdd:PRK03918  588 EELEERLKELEPFYNeyLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYS 657
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
19-545 5.06e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.26  E-value: 5.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    19 LEKTLQEALEKHQREKnemeSHIRETALE-EFRLQEEQWEAE------RRElqfiVQEQDTAVQNMHKKVEKLETEHMDC 91
Cdd:pfam15921   90 LQRRLNESNELHEKQK----FYLRQSVIDlQTKLQEMQMERDamadirRRE----SQSQEDLRNQLQNTVHELEAAKCLK 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    92 SDLLRRQTSELEfstqreeRLRK---EFEATTLRVRKLEenIEAERAAHLESKFNSEIIQLRIRDLEGALqvekaSQAEA 168
Cdd:pfam15921  162 EDMLEDSNTQIE-------QLRKmmlSHEGVLQEIRSIL--VDFEEASGKKIYEHDSMSTMHFRSLGSAI-----SKILR 227
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   169 VADLEI--IKNEFKEVESAYEREKHNAQEsfaKLNLLEKEYFSKNKKLnedIEEQKKVIIDLSKRLQYNEKSCSELQEEL 246
Cdd:pfam15921  228 ELDTEIsyLKGRIFPVEDQLEALKSESQN---KIELLLQQHQDRIEQL---ISEHEVEITGLTEKASSARSQANSIQSQL 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   247 VMAKKHQAFLVETCENNVKELESildsftvsgqwtsgihkdkdkppSFSVVLERLRRTLTDYQNKLEDASNELNSMNDVK 326
Cdd:pfam15921  302 EIIQEQARNQNSMYMRQLSDLES-----------------------TVSQLRSELREAKRMYEDKIEELEKQLVLANSEL 358
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   327 EKACNELDSTKQKIDSHTKNIKELQDKLADVNKELS---------------------HLHTKCADR-------EALISTL 378
Cdd:pfam15921  359 TEARTERDQFSQESGNLDDQLQKLLADLHKREKELSlekeqnkrlwdrdtgnsitidHLRRELDDRnmevqrlEALLKAM 438
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   379 KVELQNVLhcwEKEKAQAAQSESELQKLSqAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLdkfswSELCAVLQEN- 457
Cdd:pfam15921  439 KSECQGQM---ERQMAAIQGKNESLEKVS-SLTAQLESTKEMLRKVVEELTAKKMTLESSERTV-----SDLTASLQEKe 509
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   458 --VDALIADL----NRANEKIRHLEYIcKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELEL--QYSELFLEV 529
Cdd:pfam15921  510 raIEATNAEItklrSRVDLKLQELQHL-KNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLvgQHGRTAGAM 588
                          570
                   ....*....|....*..
gi 767954680   530 Q-KRAQKFQEIAEKNME 545
Cdd:pfam15921  589 QvEKAQLEKEINDRRLE 605
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
8-410 6.04e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 40.87  E-value: 6.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680     8 EYDLLMKEKSRLEKTLQEAL-EKHQREKN---EMES----------------HIR----ETALEEFRLqEEQWEAERREL 63
Cdd:pfam15921  364 ERDQFSQESGNLDDQLQKLLaDLHKREKElslEKEQnkrlwdrdtgnsitidHLRreldDRNMEVQRL-EALLKAMKSEC 442
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680    64 QFIVQEQDTAVQNMHKKVEK---LETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA--AHL 138
Cdd:pfam15921  443 QGQMERQMAAIQGKNESLEKvssLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAeiTKL 522
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   139 ESKFNSEIIQLR--------IRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSK 210
Cdd:pfam15921  523 RSRVDLKLQELQhlknegdhLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDR 602
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   211 NKKLNE-DIEEQKKviidlSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKD-- 287
Cdd:pfam15921  603 RLELQEfKILKDKK-----DAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDye 677
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   288 ------KDKPPSFSVVLERLRRTLTDYQNKLEDASNELNSMNDVKEKAC-------NELDSTKQKIDSHTKNIKELQDKL 354
Cdd:pfam15921  678 vlkrnfRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMkvamgmqKQITAKRGQIDALQSKIQFLEEAM 757
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767954680   355 ADVNKELSHLHTKCADREALISTLKVELQN------VLHCWEKE-KAQAAQSESELQKLSQAF 410
Cdd:pfam15921  758 TNANKEKHFLKEEKNKLSQELSTVATEKNKmageleVLRSQERRlKEKVANMEVALDKASLQF 820
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
842-976 6.25e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.77  E-value: 6.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954680   842 RSLRLEVTEFKRSVNEMKKELDKAQ----GLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQEL 917
Cdd:TIGR04523  214 KSLESQISELKKQNNQLKDNIEKKQqeinEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQL 293
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767954680   918 NYKLE-LHSSEEADKNQTLGEAVKS----LSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEEN 976
Cdd:TIGR04523  294 KSEISdLNNQKEQDWNKELKSELKNqekkLEEIQNQISQNNKIISQLNEQISQLKKELTNSESE 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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