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Conserved domains on  [gi|767954968|ref|XP_011516212|]
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transmembrane protein 8B isoform X10 [Homo sapiens]

Protein Classification

TMEM8 family protein( domain architecture ID 10572301)

TMEM8 family protein is a DUF3522 domain-containing protein; similar to Homo sapiens transmembrane protein 8B, post-GPI attachment to proteins factor 6 and protein myomaker

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3522 pfam12036
Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. ...
 271-383 3.27e-34

Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.


:

Pssm-ID: 463441  Cd Length: 183  Bit Score: 127.01  E-value: 3.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954968  271 MFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDqpgIVVFCIMDYDVLQFC-------DFLGSLMSVWVTVIAMARLQ 343
Cdd:pfam12036  15 AFLPAIYVALKRRYHFEAFVYTFTMFFSFMYHACD---SGVFCFMKYDVLQLCegdwhrlDNIGSILSFWVTFVYLADFD 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767954968  344 PVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGIL 383
Cdd:pfam12036  92 EVLKRFLHYFGLLLTAIAQEKDPWNLWNTLIPILIGLLIL 131
 
Name Accession Description Interval E-value
DUF3522 pfam12036
Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. ...
 271-383 3.27e-34

Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.


Pssm-ID: 463441  Cd Length: 183  Bit Score: 127.01  E-value: 3.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954968  271 MFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDqpgIVVFCIMDYDVLQFC-------DFLGSLMSVWVTVIAMARLQ 343
Cdd:pfam12036  15 AFLPAIYVALKRRYHFEAFVYTFTMFFSFMYHACD---SGVFCFMKYDVLQLCegdwhrlDNIGSILSFWVTFVYLADFD 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767954968  344 PVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGIL 383
Cdd:pfam12036  92 EVLKRFLHYFGLLLTAIAQEKDPWNLWNTLIPILIGLLIL 131
 
Name Accession Description Interval E-value
DUF3522 pfam12036
Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. ...
 271-383 3.27e-34

Protein of unknown function (DUF3522); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.


Pssm-ID: 463441  Cd Length: 183  Bit Score: 127.01  E-value: 3.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767954968  271 MFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDqpgIVVFCIMDYDVLQFC-------DFLGSLMSVWVTVIAMARLQ 343
Cdd:pfam12036  15 AFLPAIYVALKRRYHFEAFVYTFTMFFSFMYHACD---SGVFCFMKYDVLQLCegdwhrlDNIGSILSFWVTFVYLADFD 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767954968  344 PVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGIL 383
Cdd:pfam12036  92 EVLKRFLHYFGLLLTAIAQEKDPWNLWNTLIPILIGLLIL 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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