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Conserved domains on  [gi|767956397|ref|XP_011516580|]
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adenylate kinase 8 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 196-388 7.34e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.44  E-value: 7.34e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 352
Cdd:cd01428   80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767956397 353 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 388
Cdd:cd01428  156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
PLN02842 super family cl31938
nucleotide kinase
 29-176 4.81e-27

nucleotide kinase


The actual alignment was detected with superfamily member PLN02842:

Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.65  E-value: 4.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  29 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 108
Cdd:PLN02842  46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767956397 109 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 176
Cdd:PLN02842 126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 196-388 7.34e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.44  E-value: 7.34e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 352
Cdd:cd01428   80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767956397 353 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 388
Cdd:cd01428  156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 196-396 4.25e-40

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 4.25e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:COG0563    2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 347
Cdd:COG0563   81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767956397 348 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 396
Cdd:COG0563  161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 201-394 9.16e-40

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 148.47  E-value: 9.16e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 201 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 280
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 281 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 360
Cdd:PLN02842  84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767956397 361 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 394
Cdd:PLN02842 164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
199-373 1.93e-38

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 136.67  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  199 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 278
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  279 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 351
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 767956397  352 EEQVKLKMDLFYRNSADLEQLY 373
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
PLN02842 PLN02842
nucleotide kinase
 29-176 4.81e-27

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.65  E-value: 4.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  29 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 108
Cdd:PLN02842  46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767956397 109 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 176
Cdd:PLN02842 126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 28-175 7.41e-24

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 97.69  E-value: 7.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  28 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL---GITPRHVIVLSAPDTVLIERNLGK 104
Cdd:cd01428   47 KAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKGFILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGR 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767956397 105 RIDPQTGEIYHTTFDWPPESEIQNRlmvPEDisELETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDV 175
Cdd:cd01428  126 RICPVSGRVYHLGKDDVTGEPLSQR---SDD--NEETIKKRLEvYKEQTAPLIDYYKKkgKLVEIDGSGDIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 39-184 2.17e-23

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 96.92  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397   39 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRI-QTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTT 117
Cdd:TIGR01351  58 VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALdALLEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLK 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767956397  118 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVFYQALTYVQ 184
Cdd:TIGR01351 138 FNPPKVPGCDDctgeLLVQREDDTE-EVVKKRLEvYKEQTEPLIDYYKKrgILVQIDGNGPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 39-176 6.36e-21

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 90.19  E-value: 6.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  39 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 114
Cdd:COG0563   59 VPDEIVIGLVKERLAQPDC-ANGFILDGFPRTVAQAEALDELlaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767956397 115 HTTFDWPPESEI----QNRLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 176
Cdd:COG0563  138 HVKFNPPKVEGVcdkcGGELVQRADDNE-ETVRKRLEvYHEQTAPLIDYYRKkgKLVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
37-161 7.53e-18

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 7.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397   37 KTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL---RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEI 113
Cdd:pfam00406  53 ELVPDEVVVGLVKERLEQNDC-KNGFLLDGFPRTVPQAEaleELLERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRS 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767956397  114 YHTTFDwPPESEIQN-----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK 161
Cdd:pfam00406 132 YHLEFN-PPKVPGKDdvtgePLVQRSDDNE-ETVKKRLEtYHKQTKPLIDYYKK 183
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 195-389 3.52e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 3.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  195 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 274
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  275 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 354
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 767956397  355 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 389
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 196-388 7.34e-56

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 182.44  E-value: 7.34e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMykppPTMEIQARLLQNPKDAE 352
Cdd:cd01428   80 FILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHLG----KDDVTGEPLSQRSDDNE 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767956397 353 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTV 388
Cdd:cd01428  156 ETIKKRLEVYKEQTAPLIDYYkkkGKLVEIDGSGDIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 196-396 4.25e-40

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 141.80  E-value: 4.25e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:COG0563    2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-ANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 347
Cdd:COG0563   81 FILDGFPRTVAQAEaldeLLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVcdkcGGELVQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767956397 348 PKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 396
Cdd:COG0563  161 ADDNEETVRKRLEVYHEQTAPLIDYYrkkGKLVEIDGEGSIEEVTADILAIL 212
PLN02842 PLN02842
nucleotide kinase
 201-394 9.16e-40

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 148.47  E-value: 9.16e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 201 GPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHG 280
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 281 VPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMD 360
Cdd:PLN02842  84 YPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEKVKARLQ 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767956397 361 LFYRNSADLEQLYGSAI-TLNGDQDPYTVFEYIES 394
Cdd:PLN02842 164 IYKKNAEAILSTYSDIMvKIDGNRPKEVVFEEISS 198
ADK pfam00406
Adenylate kinase;
199-373 1.93e-38

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 136.67  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  199 LLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGWVL 278
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC-KNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  279 HGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTM----EIQARLLQNPKDA 351
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPgkddVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|..
gi 767956397  352 EEQVKLKMDLFYRNSADLEQLY 373
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYY 181
adk PRK00279
adenylate kinase; Reviewed
 196-394 8.03e-32

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 119.87  E-value: 8.03e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDC-KNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAHLLNR----LGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQN 347
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEmlkeLGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKcdvcGEELIQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767956397 348 PKDAEEQVKLKMDLFYRNSADLEQLYGSA---ITLNGDQDPYTVFEYIES 394
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKgklKKIDGTGSIDEVFADILK 210
PRK14530 PRK14530
adenylate kinase; Provisional
 195-396 3.27e-29

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 112.96  E-value: 3.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 195 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLK----EAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQD 270
Cdd:PRK14530   4 PRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankqMDISDMDTEYDTPGEYMDAGELVPDAVVNEIVEEALSDAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 271 ciqkGWVLHGVPRDLDQAHLLNRLGyNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQ 346
Cdd:PRK14530  84 ----GFVLDGYPRNLEQAEYLESIT-DLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVcdecGGELIQ 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767956397 347 NPKDAEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 396
Cdd:PRK14530 159 RDDDTEETVRERLDVFEENTEPVIEHYrdqGVLVEVDGEQTPDEVWADIQDAI 211
PLN02842 PLN02842
nucleotide kinase
 29-176 4.81e-27

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 112.65  E-value: 4.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  29 ARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDP 108
Cdd:PLN02842  46 AKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDP 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767956397 109 QTGEIYHTTFdWPPES-EIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVF 176
Cdd:PLN02842 126 VTGKIYHIKN-FPPESeEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSDIMVKIDGNRPKEVVF 193
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 28-175 7.41e-24

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 97.69  E-value: 7.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  28 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL---GITPRHVIVLSAPDTVLIERNLGK 104
Cdd:cd01428   47 KAKEYIDSGKLVPDEIVIKLLKERLKKPDC-KKGFILDGFPRTVDQAEALDELldeGIKPDKVIELDVPDEVLIERILGR 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767956397 105 RIDPQTGEIYHTTFDWPPESEIQNRlmvPEDisELETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDV 175
Cdd:cd01428  126 RICPVSGRVYHLGKDDVTGEPLSQR---SDD--NEETIKKRLEvYKEQTAPLIDYYKKkgKLVEIDGSGDIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 39-184 2.17e-23

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 96.92  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397   39 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRI-QTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTT 117
Cdd:TIGR01351  58 VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALdALLEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLK 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767956397  118 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVFYQALTYVQ 184
Cdd:TIGR01351 138 FNPPKVPGCDDctgeLLVQREDDTE-EVVKKRLEvYKEQTEPLIDYYKKrgILVQIDGNGPIDEVWKRILEALK 210
adk PRK02496
adenylate kinase; Provisional
 196-396 1.78e-22

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 93.66  E-value: 1.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:PRK02496   3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDA-ANG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLR-RIDpvtgeryhlmykppptmeiqarllqnpkD 350
Cdd:PRK02496  82 WILDGFPRKVTQAAFLDELlqeiGQSGERVVNLDVPDDVVVERLLARgRKD----------------------------D 133

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767956397 351 AEEQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 396
Cdd:PRK02496 134 TEEVIRRRLEVYREQTAPLIDYYrdrQKLLTIDGNQSVEAVTTELKAAL 182
PLN02674 PLN02674
adenylate kinase
 169-366 2.29e-22

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 94.95  E-value: 2.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 169 DQPCVDVFYQALTYVQSNHRTNApftpRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFE 248
Cdd:PLN02674  10 DVPSVDLMTELLRRMKCSSKPDK----RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 249 KEMAVPDSLLMKVLSQRLDQQDCiQKGWVLHGVPRDLDQAH----LLNRLGYNPNRVffLNVPF-DSIM-ERLTLRRIDP 322
Cdd:PLN02674  86 KGELVSDDLVVGIIDEAMKKPSC-QKGFILDGFPRTVVQAQkldeMLAKQGAKIDKV--LNFAIdDAILeERITGRWIHP 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767956397 323 VTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNS 366
Cdd:PLN02674 163 SSGRTYHTKFAPPKVPGVDdvtgEPLIQRKDDTAAVLKSRLEAFHKQT 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 39-176 6.36e-21

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 90.19  E-value: 6.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  39 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 114
Cdd:COG0563   59 VPDEIVIGLVKERLAQPDC-ANGFILDGFPRTVAQAEALDELlaelGIKLDAVIELDVDDEELVERLSGRRVCPNCGATY 137

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767956397 115 HTTFDWPPESEI----QNRLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 176
Cdd:COG0563  138 HVKFNPPKVEGVcdkcGGELVQRADDNE-ETVRKRLEvYHEQTAPLIDYYRKkgKLVEIDGEGSIEEVT 205
adk PRK00279
adenylate kinase; Reviewed
 39-176 4.27e-18

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 82.12  E-value: 4.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  39 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL----RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 114
Cdd:PRK00279  59 VPDEIVIGLVKERLAQPDC-KNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTY 137

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767956397 115 HTTFDWPPESEIQNR----LMVPEDISElETAQKLLE-YHRNIVRVIPSYPK--ILKVISADQPCVDVF 176
Cdd:PRK00279 138 HVKFNPPKVEGKCDVcgeeLIQRADDNE-ETVRKRLEvYHKQTAPLIDYYKKkgKLKKIDGTGSIDEVF 205
ADK pfam00406
Adenylate kinase;
37-161 7.53e-18

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 7.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397   37 KTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQAL---RIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEI 113
Cdd:pfam00406  53 ELVPDEVVVGLVKERLEQNDC-KNGFLLDGFPRTVPQAEaleELLERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRS 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767956397  114 YHTTFDwPPESEIQN-----RLMVPEDISElETAQKLLE-YHRNIVRVIPSYPK 161
Cdd:pfam00406 132 YHLEFN-PPKVPGKDdvtgePLVQRSDDNE-ETVKKRLEtYHKQTKPLIDYYKK 183
PRK14528 PRK14528
adenylate kinase; Provisional
 196-320 4.30e-17

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 78.90  E-value: 4.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADC-KNG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767956397 276 WVLHGVPRDLDQA----HLLNRLGYNPNRVFFLNVPFDSIMERLTLRRI 320
Cdd:PRK14528  82 FLLDGFPRTVEQAdaldALLKNEGKSIDKAINLEVPDGELLKRLLGRAE 130
PRK13808 PRK13808
adenylate kinase; Provisional
 196-294 2.69e-15

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 76.46  E-value: 2.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQkG 275
Cdd:PRK13808   2 RLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-G 80

                         90
                 ....*....|....*....
gi 767956397 276 WVLHGVPRDLDQAHLLNRL 294
Cdd:PRK13808  81 FILDGFPRTVPQAEALDAL 99
PRK14526 PRK14526
adenylate kinase; Provisional
 196-403 5.20e-15

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 73.35  E-value: 5.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKG 275
Cdd:PRK14526   2 KLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 276 WVLHGVPRDLDQAHLLNRLGYNPNRVFFLnVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEI----QARLLQNPKDA 351
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGIcdvcKGDLYQRKDDK 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767956397 352 EEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEyIESGIINPLPKK 403
Cdd:PRK14526 160 EESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDE-VKKKLIEIISKK 210
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 196-373 6.64e-15

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 73.68  E-value: 6.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQ-QDCIQK 274
Cdd:PTZ00088   8 KIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvTDDCFK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 275 GWVLHGVPRDLDQAhllNRLGYNPNRVFFLNV--PFDSIMERLTLRRIDPVTGERYHLM------YKPPPTMEIQ----- 341
Cdd:PTZ00088  88 GFILDGFPRNLKQC---KELGKITNIDLFVNIylPRNILIKKLLGRRICNTCNRNFNIAhirsdpYDMPPILPPAdcegc 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767956397 342 ---ARLLQNPKDAEEQVKLKMDLFYRNSADLEQLY 373
Cdd:PTZ00088 165 kgnPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFF 199
PRK14527 PRK14527
adenylate kinase; Provisional
 197-396 7.10e-15

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 72.52  E-value: 7.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 197 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKgw 276
Cdd:PRK14527   9 VIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV-- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 277 VLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptmeiqARLLQNPKDAE 352
Cdd:PRK14527  87 IFDGFPRTLAQAEALDRLleelGARLLAVVLLEVPDEELIRRIVER-----------------------ARQEGRSDDNE 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767956397 353 EQVKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVFEYIESGI 396
Cdd:PRK14527 144 ETVRRRQQVYREQTQPLVDYYearGHLKRVDGLGTPDEVYARILKAL 190
PRK14530 PRK14530
adenylate kinase; Provisional
 39-159 1.37e-12

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 66.35  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  39 VPSALLVQLIQERLAEEDcikqGWILDGIPETREQALRIQtlGITPRHVIV-LSAPDTVLIERNLGKRIDPQTGEIYHTT 117
Cdd:PRK14530  66 VPDAVVNEIVEEALSDAD----GFVLDGYPRNLEQAEYLE--SITDLDVVLyLDVSEEELVDRLTGRRVCPDCGANYHVE 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767956397 118 FDWPPESEIQN----RLMVPEDISElETAQKLLE-YHRNIVRVIPSY 159
Cdd:PRK14530 140 FNQPEEEGVCDecggELIQRDDDTE-ETVRERLDvFEENTEPVIEHY 185
adk PRK02496
adenylate kinase; Provisional
 39-150 1.51e-12

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 65.54  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  39 VPSALLVQLIQERLAEEDCiKQGWILDGIPETREQA----LRIQTLGITPRHVIVLSAPDTVLIERNLGK-RIDPQtgei 113
Cdd:PRK02496  60 VPDQLVLDLVQERLQQPDA-ANGWILDGFPRKVTQAafldELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDT---- 134

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767956397 114 yhttfdwppESEIQNRLMVPEDiselETAqKLLEYHR 150
Cdd:PRK02496 135 ---------EEVIRRRLEVYRE----QTA-PLIDYYR 157
AAA_17 pfam13207
AAA domain;
200-319 6.88e-12

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 62.64  E-value: 6.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  200 LGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTtfGELIQPFFEKEMAVPDSLLMKVLSQRLDqQDCIQKGWVLH 279
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIA-EEAGEGGVIVD 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767956397  280 GVPRDLDQAHLLNRL------GYNPNRVFFLNVPFDSIMERLTLRR 319
Cdd:pfam13207  78 GHPRIKTPAGYLPGLpvevlrELKPDAIILLEADPEEILERRLKDR 123
PRK14529 PRK14529
adenylate kinase; Provisional
 196-291 3.18e-11

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 62.81  E-value: 3.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDciQKG 275
Cdd:PRK14529   2 NILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG--KNG 79

                         90
                 ....*....|....*.
gi 767956397 276 WVLHGVPRDLDQAHLL 291
Cdd:PRK14529  80 WLLDGFPRNKVQAEKL 95
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 195-389 3.52e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 3.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  195 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQK 274
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  275 GWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRidpvtgeryhlmykppptmEIQARLlqnpKDAEEQ 354
Cdd:TIGR01360  84 GFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRA-------------------ETSGRV----DDNEKT 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 767956397  355 VKLKMDLFYRNSADLEQLY---GSAITLNGDQDPYTVF 389
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYetkGKLRKINAEGTVDDVF 178
PRK14531 PRK14531
adenylate kinase; Provisional
 196-318 4.11e-11

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 61.37  E-value: 4.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 196 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLdqQDCIQKG 275
Cdd:PRK14531   4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALNSGG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767956397 276 WVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLR 318
Cdd:PRK14531  82 WLLDGFPRTVAQAEalepLLEELKQPIEAVVLLELDDAVLIERLLAR 128
PRK14532 PRK14532
adenylate kinase; Provisional
 197-373 7.82e-11

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 60.99  E-value: 7.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 197 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCiQKGW 276
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEA-AGGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397 277 VLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVPFDSIMERLTLRridpvtgeryhlmykppptMEIQARllqnPKDAE 352
Cdd:PRK14532  82 IFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKR-------------------FEEQGR----PDDNP 138

                        170       180
                 ....*....|....*....|.
gi 767956397 353 EQVKLKMDLFYRNSADLEQLY 373
Cdd:PRK14532 139 EVFVTRLDAYNAQTAPLLPYY 159
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 197-318 1.67e-09

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 57.00  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  197 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADR-TTFGELIQPFFEKEMAVPDSLLMKVLSQRLdQQDCIQKG 275
Cdd:TIGR01359   2 VFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAI-QEDGSSKK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767956397  276 WVLHGVPRDLDQAHLLNRL---GYNPNRVFFLNVPFDSIMERLTLR 318
Cdd:TIGR01359  81 FLIDGFPRNEENLEAWEKLmdnKVNFKFVLFFDCPEETMIKRLLKR 126
PRK14528 PRK14528
adenylate kinase; Provisional
 28-130 4.24e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 55.79  E-value: 4.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  28 EARRLYLQRKTVPSALLVQLIQERLAEEDCiKQGWILDGIPETREQALR----IQTLGITPRHVIVLSAPDTVLIERNLG 103
Cdd:PRK14528  49 EAKRYMDAGDLVPDSVVIGIIKDRIREADC-KNGFLLDGFPRTVEQADAldalLKNEGKSIDKAINLEVPDGELLKRLLG 127

                         90       100
                 ....*....|....*....|....*..
gi 767956397 104 KRIDPQTGEiyhttfdwPPESEIQNRL 130
Cdd:PRK14528 128 RAEIEGRAD--------DNEATIKNRL 146
PLN02674 PLN02674
adenylate kinase
 39-175 1.55e-08

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 54.89  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  39 VPSALLVQLIQERLAEEDCIKqGWILDGIPETREQALRIQTL----GITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIY 114
Cdd:PLN02674  90 VSDDLVVGIIDEAMKKPSCQK-GFILDGFPRTVVQAQKLDEMlakqGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTY 168

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767956397 115 HTTFDwPP----------ESEIQNRlmvpEDISELeTAQKLLEYHRNIVRVIPSYPK--ILKVISADQPCVDV 175
Cdd:PLN02674 169 HTKFA-PPkvpgvddvtgEPLIQRK----DDTAAV-LKSRLEAFHKQTEPVIDYYAKkgVVANLHAEKPPKEV 235
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 2-122 1.95e-05

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 45.56  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397   2 WLCKHLNSSlltleNLILNEFSYTAT---EARRLYLQRKTVPSALLVQLIQERLAE-EDCIKQGWILDGIPETREQALRI 77
Cdd:PTZ00088  30 ENLKHINMG-----NILREEIKAKTTigkEIQKVVTSGNLVPDNLVIAIVKDEIAKvTDDCFKGFILDGFPRNLKQCKEL 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767956397  78 QTLgITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYH------TTFDWPP 122
Cdd:PTZ00088 105 GKI-TNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNiahirsDPYDMPP 154
PRK14527 PRK14527
adenylate kinase; Provisional
 39-104 4.45e-05

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 44.01  E-value: 4.45e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956397  39 VPSALLVQLIQERLAEEDCIKQgwILDGIPETREQA----LRIQTLGITPRHVIVLSAPDTVLIERNLGK 104
Cdd:PRK14527  65 VPDELILALIRDELAGMEPVRV--IFDGFPRTLAQAealdRLLEELGARLLAVVLLEVPDEELIRRIVER 132
AAA_17 pfam13207
AAA domain;
39-105 1.00e-04

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 41.84  E-value: 1.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767956397   39 VPSALLVQLIQERLAEEdCIKQGWILDGIPETREQALRIQTL------GITPRHVIVLSAPDTVLIERNLGKR 105
Cdd:pfam13207  52 EPQKELQKLAAERIAEE-AGEGGVIVDGHPRIKTPAGYLPGLpvevlrELKPDAIILLEADPEEILERRLKDR 123
PRK14529 PRK14529
adenylate kinase; Provisional
 39-106 1.43e-03

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 39.70  E-value: 1.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767956397  39 VPSALLVQLIQERLAEEDciKQGWILDGIPETREQALR----IQTLGITPRHVIVLSAPDTVLIERNLGKRI 106
Cdd:PRK14529  59 VPDDITIPMILETLKQDG--KNGWLLDGFPRNKVQAEKlweaLQKEGMKLDYVIEILLPREVAKNRIMGRRL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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