NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767958017|ref|XP_011517207|]
View 

solute carrier family 28 member 3 isoform X1 [Homo sapiens]

Protein Classification

NupC/NupG family nucleoside CNT transporter( domain architecture ID 11489677)

NupC/NupG family nucleoside CNT transporter such as nucleoside permease NupC, which transports nucleosides with a high affinity except guanosine and deoxyguanosine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
229-640 1.92e-153

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


:

Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 450.99  E-value: 1.92e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  229 LVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYK 308
Cdd:TIGR00804   1 LISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  309 D--HFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKS 386
Cdd:TIGR00804  81 QdlFVFAFQVLPIIIFFSALISILYYLGIMQWVIRKIGWFLQKAMGTTKLESFSAAANIFLGQTEAPLVIRPYLGDMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  387 ELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSgNLLEAATQ 466
Cdd:TIGR00804 161 ELFTVMTSGMATIAGSVLGAYISMGVPATYLIAASVMAAPCALAFAKLIYPEVEESKEKSEEDVKLEEGDQ-NFFEAASN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  467 GASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFN 546
Cdd:TIGR00804 240 GALAGVKVVANVAAMLIAFVALLALINGILSWVGGWVGYGGLSFQLIFGYVFRPLAFLMGVPWSDAPLVAQLMGTKLAVN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  547 EFVAYEHLSKWIHLRKeggpkfvngvqqYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAG 626
Cdd:TIGR00804 320 EFVAYLDLSQYLQTRL------------WLSPKTEAIITFALCGFANFSSIGIILGGLGSLVPKRKSVISRLVLRALCAG 387
                         410
                  ....*....|....
gi 767958017  627 TVACFMTACIAGIL 640
Cdd:TIGR00804 388 TLVSLMSATIAGLY 401
 
Name Accession Description Interval E-value
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
229-640 1.92e-153

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 450.99  E-value: 1.92e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  229 LVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYK 308
Cdd:TIGR00804   1 LISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  309 D--HFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKS 386
Cdd:TIGR00804  81 QdlFVFAFQVLPIIIFFSALISILYYLGIMQWVIRKIGWFLQKAMGTTKLESFSAAANIFLGQTEAPLVIRPYLGDMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  387 ELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSgNLLEAATQ 466
Cdd:TIGR00804 161 ELFTVMTSGMATIAGSVLGAYISMGVPATYLIAASVMAAPCALAFAKLIYPEVEESKEKSEEDVKLEEGDQ-NFFEAASN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  467 GASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFN 546
Cdd:TIGR00804 240 GALAGVKVVANVAAMLIAFVALLALINGILSWVGGWVGYGGLSFQLIFGYVFRPLAFLMGVPWSDAPLVAQLMGTKLAVN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  547 EFVAYEHLSKWIHLRKeggpkfvngvqqYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAG 626
Cdd:TIGR00804 320 EFVAYLDLSQYLQTRL------------WLSPKTEAIITFALCGFANFSSIGIILGGLGSLVPKRKSVISRLVLRALCAG 387
                         410
                  ....*....|....
gi 767958017  627 TVACFMTACIAGIL 640
Cdd:TIGR00804 388 TLVSLMSATIAGLY 401
NupC COG1972
Nucleoside permease NupC [Nucleotide transport and metabolism];
227-642 8.62e-147

Nucleoside permease NupC [Nucleotide transport and metabolism];


Pssm-ID: 441575 [Multi-domain]  Cd Length: 406  Bit Score: 434.13  E-value: 8.62e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 227 QQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFG-- 304
Cdd:COG1972    2 NILIGLLGIAVLLGIAWLFSENRKAINWRTVGIGLALQLLLAFLVLKVPAGRAAFEALSDGVNKLLSYANEGTAFVFGgl 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 305 ---EKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLP 381
Cdd:COG1972   82 agpGLPGGFVFAFQVLPPIIFFSALISILYYLGILQFIVRGIGWVLSKILGTSGAESLSAAANIFLGQTEAPLVIKPYLA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 382 YITKSELHAIMTAGFSTIAGSVLGAYISF-GVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSgNL 460
Cdd:COG1972  162 KMTRSELFTVMTGGMATVAGSVLAAYASMlGVPAKYLLAASVMAAPAALLIAKILVPETEEPETDGVVEVEEEKEPA-NF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 461 LEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDypQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIG 540
Cdd:COG1972  241 IDAIAEGALDGLKLALNVGAMLIAFVALIALVNGILGGLGGLFG--GLSLQRILGYLFAPLAWLIGVPWSEALQAGSLMG 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 541 YKTFFNEFVAYEHLSKWIHlrkeggpkfvngvqQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAV 620
Cdd:COG1972  319 TKLVLNEFVAYLDLAKLLA--------------GALSPRTVAIVTYALCGFANFSSIGIQIGGIGALAPERRSDIARLGL 384
                        410       420
                 ....*....|....*....|..
gi 767958017 621 RALIAGTVACFMTACIAGILSS 642
Cdd:COG1972  385 KALLAGTLASLLSATIAGLFLG 406
Nucleos_tra2_C pfam07662
Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport ...
416-638 3.88e-101

Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.


Pssm-ID: 462223  Cd Length: 205  Bit Score: 308.94  E-value: 3.88e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  416 HLLTASVMSAPASLAAAKLFWPETEKPKITLKnamkmESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSA 495
Cdd:pfam07662   1 HLLTASVMSAPAALAISKLLYPETEEPPVKTG-----DEEEPANVLDAASNGALDGLKLALNIGAMLIAFVALVALINGL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  496 LSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHlrkeggpkfvngvQQY 575
Cdd:pfam07662  76 LGWIGGLFGFPGLSLQLILGYVFAPLAWLMGVPWDDALQVGSLMGTKLVLNEFVAYLDLGKLIA-------------AGA 142
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767958017  576 ISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAG 638
Cdd:pfam07662 143 LSPRSVAIATYALCGFANFSSIGIQIGGLGALAPERRGDIAKLGLRALLAGTLASLMSAAIAG 205
 
Name Accession Description Interval E-value
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
229-640 1.92e-153

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 450.99  E-value: 1.92e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  229 LVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYK 308
Cdd:TIGR00804   1 LISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  309 D--HFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKS 386
Cdd:TIGR00804  81 QdlFVFAFQVLPIIIFFSALISILYYLGIMQWVIRKIGWFLQKAMGTTKLESFSAAANIFLGQTEAPLVIRPYLGDMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  387 ELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSgNLLEAATQ 466
Cdd:TIGR00804 161 ELFTVMTSGMATIAGSVLGAYISMGVPATYLIAASVMAAPCALAFAKLIYPEVEESKEKSEEDVKLEEGDQ-NFFEAASN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  467 GASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFN 546
Cdd:TIGR00804 240 GALAGVKVVANVAAMLIAFVALLALINGILSWVGGWVGYGGLSFQLIFGYVFRPLAFLMGVPWSDAPLVAQLMGTKLAVN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  547 EFVAYEHLSKWIHLRKeggpkfvngvqqYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAG 626
Cdd:TIGR00804 320 EFVAYLDLSQYLQTRL------------WLSPKTEAIITFALCGFANFSSIGIILGGLGSLVPKRKSVISRLVLRALCAG 387
                         410
                  ....*....|....
gi 767958017  627 TVACFMTACIAGIL 640
Cdd:TIGR00804 388 TLVSLMSATIAGLY 401
NupC COG1972
Nucleoside permease NupC [Nucleotide transport and metabolism];
227-642 8.62e-147

Nucleoside permease NupC [Nucleotide transport and metabolism];


Pssm-ID: 441575 [Multi-domain]  Cd Length: 406  Bit Score: 434.13  E-value: 8.62e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 227 QQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFG-- 304
Cdd:COG1972    2 NILIGLLGIAVLLGIAWLFSENRKAINWRTVGIGLALQLLLAFLVLKVPAGRAAFEALSDGVNKLLSYANEGTAFVFGgl 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 305 ---EKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLP 381
Cdd:COG1972   82 agpGLPGGFVFAFQVLPPIIFFSALISILYYLGILQFIVRGIGWVLSKILGTSGAESLSAAANIFLGQTEAPLVIKPYLA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 382 YITKSELHAIMTAGFSTIAGSVLGAYISF-GVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSgNL 460
Cdd:COG1972  162 KMTRSELFTVMTGGMATVAGSVLAAYASMlGVPAKYLLAASVMAAPAALLIAKILVPETEEPETDGVVEVEEEKEPA-NF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 461 LEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDypQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIG 540
Cdd:COG1972  241 IDAIAEGALDGLKLALNVGAMLIAFVALIALVNGILGGLGGLFG--GLSLQRILGYLFAPLAWLIGVPWSEALQAGSLMG 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017 541 YKTFFNEFVAYEHLSKWIHlrkeggpkfvngvqQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAV 620
Cdd:COG1972  319 TKLVLNEFVAYLDLAKLLA--------------GALSPRTVAIVTYALCGFANFSSIGIQIGGIGALAPERRSDIARLGL 384
                        410       420
                 ....*....|....*....|..
gi 767958017 621 RALIAGTVACFMTACIAGILSS 642
Cdd:COG1972  385 KALLAGTLASLLSATIAGLFLG 406
Nucleos_tra2_C pfam07662
Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport ...
416-638 3.88e-101

Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.


Pssm-ID: 462223  Cd Length: 205  Bit Score: 308.94  E-value: 3.88e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  416 HLLTASVMSAPASLAAAKLFWPETEKPKITLKnamkmESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSA 495
Cdd:pfam07662   1 HLLTASVMSAPAALAISKLLYPETEEPPVKTG-----DEEEPANVLDAASNGALDGLKLALNIGAMLIAFVALVALINGL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  496 LSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHlrkeggpkfvngvQQY 575
Cdd:pfam07662  76 LGWIGGLFGFPGLSLQLILGYVFAPLAWLMGVPWDDALQVGSLMGTKLVLNEFVAYLDLGKLIA-------------AGA 142
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767958017  576 ISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAG 638
Cdd:pfam07662 143 LSPRSVAIATYALCGFANFSSIGIQIGGLGALAPERRGDIAKLGLRALLAGTLASLMSAAIAG 205
Gate pfam07670
Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for ...
313-411 8.41e-16

Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins. In the FeoB proteins, which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.


Pssm-ID: 429586 [Multi-domain]  Cd Length: 101  Bit Score: 73.44  E-value: 8.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958017  313 AFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTtgSSPIESVVASGNIFVGQTE----SPLLVRPYLPYITKSEL 388
Cdd:pfam07670   1 LLKVLPIILFFSVLISILEYSGLLDRIGKLLGPLMRPL--GLFPLPGKAAIALLLGFGAkevgVPLLATPYGIDTPRERL 78
                          90       100
                  ....*....|....*....|...
gi 767958017  389 HAIMTAGFSTIAGSVLGAYISFG 411
Cdd:pfam07670  79 AALLFTSFSTPCGATLPVYAGEL 101
Nucleos_tra2_N pfam01773
Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport ...
234-305 2.96e-14

Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the N terminus of this family


Pssm-ID: 460319 [Multi-domain]  Cd Length: 73  Bit Score: 68.17  E-value: 2.96e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767958017  234 GLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGE 305
Cdd:pfam01773   1 GLLVLLGIAWLFSKNRKAINWRTVIGGLALQFLLALFVLRTPAGRDAFKWISDGVTALLGYADAGTAFVFGG 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH