NCBI Conserved Domain Search

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1620-1733

2.75e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 139.85 E-value: 2.75e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1620 CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAqPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGT 1699
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEA-PPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 1700 DMPHPITSFSSALTLRFVSDSSISAGGFHTTVTA 1733
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

932-1041

1.06e-37

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 138.31 E-value: 1.06e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  932 CGEILTEST-GTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKS 1008
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSplLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 1009 IPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEA 1041
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1165-1275

2.13e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 134.46 E-value: 2.13e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1165 CGGNLT-TSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDE 1243
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 1244 KPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2689-2800

7.08e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 132.92 E-value: 7.08e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2689 CGG-IQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNS 2767
Cdd:cd00041     1 CGGtLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 2768 NPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNT 2800
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1391-1505

8.77e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 132.54 E-value: 8.77e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1391 CGGELSGAT-GSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQR 1469
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767960613 1470 SPENpmqVSSTGNELAIRFKTDLSINGRGFNASWQA 1505
Cdd:cd00041    81 LPPP---IISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2217-2333

9.83e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 129.84 E-value: 9.83e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2217 CGGNVYihdADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDrFDIEVTPNCTSNYLELRDGVDSDAPILSKF 2296
Cdd:cd00041     1 CGGTLT---ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEIYDGPSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767960613 2297 CGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI 2333
Cdd:cd00041    77 CGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

590-699

1.02e-34

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 129.45 E-value: 1.02e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  590 CGGILTGP-YGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTF 668
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767960613  669 SVPPLQTTGPFARIHFHSDSQISDQGFHITY 699
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1738-1847

2.59e-34

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 128.30 E-value: 2.59e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1738 CGGTFY-MAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNAT-GHLVGRYCGNS 1815
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTsSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 1816 FPLNYSSIvGHTLWVRFISDGSGSGTGFQATF 1847
Cdd:cd00041    81 LPPPIISS-GNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain;

1978-2088

3.77e-34

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 127.80 E-value: 3.77e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1978 CGGFLRtgDAPVFLFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGR 2056
Cdd:pfam00431    1 CGGVLT--DSSGSISSPNYPNPYPPNKDCVWLIRAPPgFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGS 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767960613  2057 EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
Cdd:pfam00431   79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1510-1617

4.20e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 125.22 E-value: 4.20e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1510 CGGIFQAP-SGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGRe 1584
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCsydyLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 1585 QLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFR 1617
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2452-2564

2.20e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 120.21 E-value: 2.20e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2452 CGGDLQGSI-GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSv 2530
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 2531 NVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTS 2564
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2336-2447

7.84e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 115.59 E-value: 7.84e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2336 CGGRVPGQ-SGVVESIGHPTlPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWD-NHTSGNILGRYCGN 2413
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDgPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 2414 TIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFES 2447
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2570-2686

1.44e-28

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 112.12 E-value: 1.44e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2570 CGGSLPNTPEGNFTSPGYDGvrNYSRNLNCEWTLSNPNqgNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRL 2648
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPN--NYPNNLNCVWTIEAPP--GYRIRLTFEDFDLESSPNCSYDYLEIYDGpSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767960613 2649 CGPSKPTlPLVIPYSQVWIHFVTNERVEHIGFHAKYSF 2686
Cdd:cd00041    77 CGSTLPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

817-927

1.84e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 109.04 E-value: 1.84e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  817 CGDELTG--EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTD 894
Cdd:cd00041     1 CGGTLTAstSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613  895 IPSFITSVYNFLYVTFVKSSSTENHGFMAKFSA 927
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1859-1962

1.96e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 108.65 E-value: 1.96e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1859 THGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQT-ESFSST 1937
Cdd:cd00041     9 TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLpPPIISS 88

                          90       100
                  ....*....|....*....|....*
gi 767960613 1938 GNSLTFHFYSDSSISGKGFLLEWFA 1962
Cdd:cd00041    89 GNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

474-585

2.73e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 108.27 E-value: 2.73e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  474 CGESLSG-INGSF-SYRSPDvGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGS 551
Cdd:cd00041     1 CGGTLTAsTSGTIsSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613  552 SLPHELLSSDNALYFHLYSEHLRNGRGFTVRWET 585
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1282-1388

4.89e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 107.88 E-value: 4.89e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1282 VIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP----RQMGRYCGVDLPP 1357
Cdd:cd00041     4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPstssPLLGRFCGSTLPP 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767960613 1358 PGSTTSSKLQVLLLTDGVGRReKGFQMQWFV 1388
Cdd:cd00041    84 PIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2092-2212

6.86e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 104.42 E-value: 6.86e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2092 CGGYLHADR-GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQpFQIPnGDSSCNQgDYLVLRNGPDICSPPLGppg 2170
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLE-SSPNCSY-DYLEIYDGPSTSSPLLG--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767960613 2171 gngHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEA 2212
Cdd:cd00041    75 ---RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

cubilin_NTD

cd22201

N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, ...

32-135

1.26e-25

N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, intestinal intrinsic factor receptor, intrinsic factor-cobalamin receptor, or intrinsic factor-vitamin B12 receptor) is an endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. It acts together with the 45-kDa transmembrane protein amnionless (AMN) to mediate endocytosis of the cobalamin (vitamin B12) binding intrinsic factor (CBLIF)-cobalamin complex. This model corresponds to the N-terminal domain of cubilin, which is responsible for the interaction with AMN. The cubilin interface with AMN is formed by the N-terminal strands of three cubilin chains.

Pssm-ID: 412063 Cd Length: 129 Bit Score: 104.34 E-value: 1.26e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   32 RQKRSINLQQPRMATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSA-----------I 100
Cdd:cd22201     4 RQKRDIYNDQPRIITEDGHLIFEAAYDKNISFRTSGNGRININDEDLLELLQQAKNNKSDIENLKQSElptfeqqlselV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767960613  101 GLPQNISSQIYQLNSKLVDLE-----------RKFQGLQQTVDKKV 135
Cdd:cd22201    84 GGPQGLLRRLALLENRTSGLSstlnnnirrlrRRLRRLERRVTRLE 129

CUB super family

cl00049

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1048-1157

1.12e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

The actual alignment was detected with superfamily member pfam00431:

Pssm-ID: 412131 [Multi-domain] Cd Length: 110 Bit Score: 95.05 E-value: 1.12e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1048 CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYtDFLEIRDGGYEKSPLLGIFYGSN 1127
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGY-DYVEIRDGPSASSPLLGRFCGSG 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613  1128 LPPTIISHSNKLWLKFKSDQIDTRSGFSAY 1157
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

708-815

1.30e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 89.39 E-value: 1.30e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  708 CGGNYTDP-EGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGET----LLGKVCGNG 782
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPStsspLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613  783 TISHIKSITNSVWIRFKIDASVEKASFRAVYQV 815
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

170-210

4.13e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.18 E-value: 4.13e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767960613  170 DVNECEIYSGtplsCQNGGTCVNTMGSYSCHCPPETYGPQC 210
Cdd:cd00054     1 DIDECASGNP----CQNGGTCVNTVGSYRCSCPPGYTGRNC 37

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2805-2866

6.24e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 55.88 E-value: 6.24e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767960613 2805 CGGIFH-SDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDgqCQNSFVK 2866
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN--CSYDYLE 61

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

432-468

7.72e-09

Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.41 E-value: 7.72e-09

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767960613  432 NINECLS-NPCLNGGTCVDGVDSFSCECTRLWTGALCQ 468
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

EGF_3

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...

353-387

5.08e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 51.06 E-value: 5.08e-08

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767960613   353 CSVSNGGCHPDASCSSTLGSLpLCTCLPGYTGNGY 387
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGV 34

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

137-167

5.80e-07

Pssm-ID: 238011 Cd Length: 38 Bit Score: 48.02 E-value: 5.80e-07

                          10        20        30
                  ....*....|....*....|....*....|.
gi 767960613  137 SSNPCQNGGTCLNLHDSFFCICPPQWKGPLC 167
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF_3

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...

309-347

1.14e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 47.21 E-value: 1.14e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767960613   309 CEINNGGCSV-AppvECVNTPGSSHCQaCPPGYQGDGRVC 347
Cdd:pfam12947    1 CSDNNGGCHPnA---TCTNTGGSFTCT-CNDGYTGDGVTC 36

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

399-430

1.34e-05

Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.16 E-value: 1.34e-05

                          10        20        30
                  ....*....|....*....|....*....|....
gi 767960613  399 CLS-HPCLN-GQCIDTVSGYFCKCDSGWTGVNCT 430
Cdd:cd00054     5 CASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38

EGF_CA

Calcium-binding EGF-like domain;

263-304

2.04e-04

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.69 E-value: 2.04e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767960613    263 DRDECSfQPGPCSTLVQCFNTQGSFYCgACPTGWQgNGYICE 304
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRC-ECPPGYT-DGRNCE 39

Name

Accession

Description

Interval

E-value

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1620-1733

2.75e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 139.85 E-value: 2.75e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1620 CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAqPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGT 1699
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEA-PPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 1700 DMPHPITSFSSALTLRFVSDSSISAGGFHTTVTA 1733
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

932-1041

1.06e-37

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 138.31 E-value: 1.06e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  932 CGEILTEST-GTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKS 1008
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSplLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 1009 IPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEA 1041
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain;

1620-1730

1.75e-36

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 134.73 E-value: 1.75e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1620 CGGHiLTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLnHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGT 1699
Cdd:pfam00431    1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGF-RVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGS 78

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  1700 DMPHPITSFSSALTLRFVSDSSISAGGFHTT 1730
Cdd:pfam00431   79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1165-1275

2.13e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 134.46 E-value: 2.13e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1165 CGGNLT-TSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDE 1243
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 1244 KPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2689-2800

7.08e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 132.92 E-value: 7.08e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2689 CGG-IQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNS 2767
Cdd:cd00041     1 CGGtLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 2768 NPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNT 2800
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1391-1505

8.77e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 132.54 E-value: 8.77e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1391 CGGELSGAT-GSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQR 1469
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767960613 1470 SPENpmqVSSTGNELAIRFKTDLSINGRGFNASWQA 1505
Cdd:cd00041    81 LPPP---IISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain;

1391-1502

1.72e-35

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 131.65 E-value: 1.72e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCtqrS 1470
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC---G 77

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767960613  1471 PENPMQVSSTGNELAIRFKTDLSINGRGFNAS 1502
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

CUB domain;

1165-1274

9.42e-35

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 129.72 E-value: 9.42e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEK 1244
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613  1245 PPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2217-2333

9.83e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 129.84 E-value: 9.83e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2217 CGGNVYihdADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDrFDIEVTPNCTSNYLELRDGVDSDAPILSKF 2296
Cdd:cd00041     1 CGGTLT---ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEIYDGPSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767960613 2297 CGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI 2333
Cdd:cd00041    77 CGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

590-699

1.02e-34

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 129.45 E-value: 1.02e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  590 CGGILTGP-YGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTF 668
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767960613  669 SVPPLQTTGPFARIHFHSDSQISDQGFHITY 699
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1738-1847

2.59e-34

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 128.30 E-value: 2.59e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1738 CGGTFY-MAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNAT-GHLVGRYCGNS 1815
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTsSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 1816 FPLNYSSIvGHTLWVRFISDGSGSGTGFQATF 1847
Cdd:cd00041    81 LPPPIISS-GNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain;

1978-2088

3.77e-34

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 127.80 E-value: 3.77e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1978 CGGFLRtgDAPVFLFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGR 2056
Cdd:pfam00431    1 CGGVLT--DSSGSISSPNYPNPYPPNKDCVWLIRAPPgFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGS 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767960613  2057 EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
Cdd:pfam00431   79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

932-1039

4.72e-34

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 127.80 E-value: 4.72e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   932 CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKSI 1009
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSplLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613  1010 PPSLTSSGNSLMLVFVTDSDLAYEGFLINY 1039
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1978-2088

3.78e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 125.22 E-value: 3.78e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1978 CGGFLrTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGR 2056
Cdd:cd00041     1 CGGTL-TASTSGTISSPNYPNNYPNNLNCVWTIEAPPgYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 2057 EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1510-1617

4.20e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 125.22 E-value: 4.20e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1510 CGGIFQAP-SGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGRe 1584
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCsydyLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 1585 QLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFR 1617
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1400-1503

1.27e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 123.27 E-value: 1.27e-32

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1400 GSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPmqVSS 1479
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPV--ISS 78

                            90       100
                    ....*....|....*....|....
gi 767960613   1480 TGNELAIRFKTDLSINGRGFNASW 1503
Cdd:smart00042   79 SSNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

590-699

2.57e-32

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 122.79 E-value: 2.57e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   590 CGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFS 669
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613   670 VPPLQTTGPFARIHFHSDSQISDQGFHITY 699
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

1510-1616

3.28e-32

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 122.40 E-value: 3.28e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY----DGLSSTMSRLARTCGrEQ 1585
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYveirDGPSASSPLLGRFCG-SG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  1586 LANPIVSSGNSLFLRFQSGPSRQNRGFRAQF 1616
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

2689-2797

1.34e-31

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 120.48 E-value: 1.34e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSN 2768
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100
                   ....*....|....*....|....*....
gi 767960613  2769 PRTIQSGSNQLVVTFNSDHSLQGGGFYAT 2797
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1747-1847

1.62e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 120.19 E-value: 1.62e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1747 GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGH-LVGRYCGNSFPLNYSSIVG 1825
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSpLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1826 HTLWVRFISDGSGSGTGFQATF 1847
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2452-2564

2.20e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 120.21 E-value: 2.20e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2452 CGGDLQGSI-GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSv 2530
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 2531 NVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTS 2564
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1631-1728

2.69e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 119.42 E-value: 2.69e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1631 TVSSPRFPANYPNNQNCSWIIQAqPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHP-ITSFS 1709
Cdd:smart00042    2 TITSPNYPQSYPNNLDCVWTIRA-PPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSS 80

                            90
                    ....*....|....*....
gi 767960613   1710 SALTLRFVSDSSISAGGFH 1728
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFS 99

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2698-2798

3.08e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 119.42 E-value: 3.08e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2698 GVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNS-NPRTIQSGS 2776
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   2777 NQLVVTFNSDHSLQGGGFYATW 2798
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

1738-1847

4.38e-31

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 119.32 E-value: 4.38e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1738 CGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSF 1816
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  1817 PLNYSSiVGHTLWVRFISDGSGSGTGFQATF 1847
Cdd:pfam00431   81 PEDIVS-SSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

2217-2331

6.09e-31

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 118.55 E-value: 6.09e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2217 CGGNVyihdADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDrFDIEVTPNCTSNYLELRDGVDSDAPILSKF 2296
Cdd:pfam00431    1 CGGVL----TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDECGYDYVEIRDGPSASSPLLGRF 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 767960613  2297 CGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331
Cdd:pfam00431   76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

941-1039

2.01e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 117.11 E-value: 2.01e-30

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    941 GTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGKSIPPS-LTSSG 1017
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDgpSASSPLLGRFCGSEAPPPvISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1018 NSLMLVFVTDSDLAYEGFLINY 1039
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1174-1274

3.42e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 116.34 E-value: 3.42e-30

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1174 GTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPP-LIRSSG 1252
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1253 DSMFIKLRTDEGQQGRGFKAEY 1274
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2336-2447

7.84e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 115.59 E-value: 7.84e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2336 CGGRVPGQ-SGVVESIGHPTlPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWD-NHTSGNILGRYCGN 2413
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDgPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 2414 TIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFES 2447
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2230-2331

3.29e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 113.64 E-value: 3.29e-29

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2230 GYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDrFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQ-WSS 2308
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPViSSS 79

                            90       100
                    ....*....|....*....|...
gi 767960613   2309 GEVMYLRFRSDNSPTHVGFKAKY 2331
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

2452-2562

3.92e-29

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 113.54 E-value: 3.92e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  2532 VSNeIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
Cdd:pfam00431   81 PED-IVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1519-1616

6.43e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 112.48 E-value: 6.43e-29

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1519 GEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSG 1594
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCeydyVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1595 NSLFLRFQSGPSRQNRGFRAQF 1616
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2570-2686

1.44e-28

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 112.12 E-value: 1.44e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2570 CGGSLPNTPEGNFTSPGYDGvrNYSRNLNCEWTLSNPNqgNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRL 2648
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPN--NYPNNLNCVWTIEAPP--GYRIRLTFEDFDLESSPNCSYDYLEIYDGpSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767960613 2649 CGPSKPTlPLVIPYSQVWIHFVTNERVEHIGFHAKYSF 2686
Cdd:cd00041    77 CGSTLPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1991-2088

1.98e-28

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 111.33 E-value: 1.98e-28

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1991 LFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGP-IRSTGEY 2068
Cdd:smart00042    3 ITSPNYPQSYPNNLDCVWTIRAPPgYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNS 82

                            90       100
                    ....*....|....*....|
gi 767960613   2069 MFIRFTSDSSVTRAGFNASF 2088
Cdd:smart00042   83 LTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

2336-2445

1.04e-27

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 109.31 E-value: 1.04e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2336 CGGRVPGQSGVVESIGHPTlPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGN-ILGRYCGNT 2414
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPN-PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSpLLGRFCGSG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  2415 IPDSIDTSSNTAVVRFVTDGSVTASGFRLRF 2445
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

817-927

1.84e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 109.04 E-value: 1.84e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  817 CGDELTG--EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTD 894
Cdd:cd00041     1 CGGTLTAstSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613  895 IPSFITSVYNFLYVTFVKSSSTENHGFMAKFSA 927
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1859-1962

1.96e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 108.65 E-value: 1.96e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1859 THGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQT-ESFSST 1937
Cdd:cd00041     9 TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLpPPIISS 88

                          90       100
                  ....*....|....*....|....*
gi 767960613 1938 GNSLTFHFYSDSSISGKGFLLEWFA 1962
Cdd:cd00041    89 GNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

474-585

2.73e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 108.27 E-value: 2.73e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  474 CGESLSG-INGSF-SYRSPDvGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGS 551
Cdd:cd00041     1 CGGTLTAsTSGTIsSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613  552 SLPHELLSSDNALYFHLYSEHLRNGRGFTVRWET 585
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1282-1388

4.89e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 107.88 E-value: 4.89e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1282 VIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP----RQMGRYCGVDLPP 1357
Cdd:cd00041     4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPstssPLLGRFCGSTLPP 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767960613 1358 PGSTTSSKLQVLLLTDGVGRReKGFQMQWFV 1388
Cdd:cd00041    84 PIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

599-699

4.99e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 107.09 E-value: 4.99e-27

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    599 GSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTT-G 677
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                            90       100
                    ....*....|....*....|..
gi 767960613    678 PFARIHFHSDSQISDQGFHITY 699
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2461-2562

9.29e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 106.32 E-value: 9.29e-27

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2461 GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSG 2540
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   2541 NTMKVIFFTDGSRPYGGFTASY 2562
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2092-2212

6.86e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 104.42 E-value: 6.86e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2092 CGGYLHADR-GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQpFQIPnGDSSCNQgDYLVLRNGPDICSPPLGppg 2170
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLE-SSPNCSY-DYLEIYDGPSTSSPLLG--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767960613 2171 gngHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEA 2212
Cdd:cd00041    75 ---RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

cubilin_NTD

cd22201

N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, ...

32-135

1.26e-25

Pssm-ID: 412063 Cd Length: 129 Bit Score: 104.34 E-value: 1.26e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   32 RQKRSINLQQPRMATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSA-----------I 100
Cdd:cd22201     4 RQKRDIYNDQPRIITEDGHLIFEAAYDKNISFRTSGNGRININDEDLLELLQQAKNNKSDIENLKQSElptfeqqlselV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767960613  101 GLPQNISSQIYQLNSKLVDLE-----------RKFQGLQQTVDKKV 135
Cdd:cd22201    84 GGPQGLLRRLALLENRTSGLSstlnnnirrlrRRLRRLERRVTRLE 129

CUB

CUB domain;

1288-1383

3.65e-25

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 102.37 E-value: 3.65e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1288 YGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPR----QMGRYCGVDLPPPGSTTS 1363
Cdd:pfam00431    9 SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSasspLLGRFCGSGIPEDIVSSS 88

                           90       100
                   ....*....|....*....|
gi 767960613  1364 SKLQVLLLTDGVGRReKGFQ 1383
Cdd:pfam00431   89 NQMTIKFVSDASVQK-RGFK 107

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2345-2445

5.60e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 101.31 E-value: 5.60e-25

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2345 GVVESIGHPTlPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNH-TSGNILGRYCGNTIPDS-IDTS 2422
Cdd:smart00042    1 GTITSPNYPQ-SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPvISSS 79

                            90       100
                    ....*....|....*....|...
gi 767960613   2423 SNTAVVRFVTDGSVTASGFRLRF 2445
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1861-1960

2.60e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 96.69 E-value: 2.60e-23

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQT--ESFSSTG 1938
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAppPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1939 NSLTFHFYSDSSISGKGFLLEW 1960
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1289-1386

3.95e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 96.31 E-value: 3.95e-23

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP----RQMGRYCGvDLPPPG--STT 1362
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPsassPLLGRFCG-SEAPPPviSSS 79

                            90       100
                    ....*....|....*....|....
gi 767960613   1363 SSKLQVLLLTDGVGRReKGFQMQW 1386
Cdd:smart00042   80 SNSLTLTFVSDSSVQK-RGFSARY 102

CUB

CUB domain;

1048-1157

1.12e-22

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 95.05 E-value: 1.12e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1048 CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYtDFLEIRDGGYEKSPLLGIFYGSN 1127
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGY-DYVEIRDGPSASSPLLGRFCGSG 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613  1128 LPPTIISHSNKLWLKFKSDQIDTRSGFSAY 1157
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

CUB domain;

1861-1956

1.31e-22

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 95.05 E-value: 1.31e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQT-ESFSSTGN 1939
Cdd:pfam00431   10 GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIpEDIVSSSN 89

                           90
                   ....*....|....*..
gi 767960613  1940 SLTFHFYSDSSISGKGF 1956
Cdd:pfam00431   90 QMTIKFVSDASVQKRGF 106

CUB

CUB domain;

2570-2684

1.55e-22

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 94.67 E-value: 1.55e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2570 CGGSLPNTPeGNFTSPGYDgvRNYSRNLNCEWTLSNPNqgNSSISIHFEDFYLESHQDCQFDVLEFRVGD-ADGPLMWRL 2648
Cdd:pfam00431    1 CGGVLTDSS-GSISSPNYP--NPYPPNKDCVWLIRAPP--GFRVKLTFQDFELEDHDECGYDYVEIRDGPsASSPLLGRF 75

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 767960613  2649 CGPSKPtLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
Cdd:pfam00431   76 CGSGIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1057-1158

1.99e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 94.40 E-value: 1.99e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1057 GTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYtDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHS 1136
Cdd:cd00041    11 GTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSY-DYLEIYDGPSTSSPLLGRFCGSTLPPPIISSG 89

                          90       100
                  ....*....|....*....|..
gi 767960613 1137 NKLWLKFKSDQIDTRSGFSAYW 1158
Cdd:cd00041    90 NSLTVRFRSDSSVTGRGFKATY 111

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2580-2684

5.84e-22

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 92.84 E-value: 5.84e-22

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2580 GNFTSPGYDGvrNYSRNLNCEWTLSNPNqgNSSISIHFEDFYLESHQDCQFDVLEFRVGD-ADGPLMWRLCGPSKPTLPL 2658
Cdd:smart00042    1 GTITSPNYPQ--SYPNNLDCVWTIRAPP--GYRIELQFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPVI 76

                            90       100
                    ....*....|....*....|....*.
gi 767960613   2659 VIPYSQVWIHFVTNERVEHIGFHAKY 2684
Cdd:smart00042   77 SSSSNSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

825-925

4.77e-21

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 90.14 E-value: 4.77e-21

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    825 GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIP-SFITSVY 903
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPpPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613    904 NFLYVTFVKSSSTENHGFMAKF 925
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

2092-2210

1.04e-20

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 89.66 E-value: 1.04e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2092 CGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFeQPFQIpNGDSSCnQGDYLVLRNGPDICSPPLGPpgg 2171
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFEL-EDHDEC-GYDYVEIRDGPSASSPLLGR--- 74

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 767960613  2172 nghFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
Cdd:pfam00431   75 ---FCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

708-815

1.30e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 89.39 E-value: 1.30e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  708 CGGNYTDP-EGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGET----LLGKVCGNG 782
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPStsspLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613  783 TISHIKSITNSVWIRFKIDASVEKASFRAVYQV 815
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2101-2210

1.32e-20

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 88.99 E-value: 1.32e-20

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEqPFQIpNGDSSCNQgDYLVLRNGPDicspplGPPGGNGHFCGSHA 2180
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDL-ESSDNCEY-DYVEIYDGPS------ASSPLLGRFCGSEA 71

                            90       100       110
                    ....*....|....*....|....*....|.
gi 767960613   2181 SSTLFTSD-NQMFVQFISDHSNEGQGFKIKY 2210
Cdd:smart00042   72 PPPVISSSsNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

817-925

4.29e-19

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 85.04 E-value: 4.29e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   817 CGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI-----GSSSILGspenkKY 890
Cdd:pfam00431    1 CGGVLTDSsGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpsASSPLLG-----RF 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 767960613   891 CGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKF 925
Cdd:pfam00431   76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

494-583

5.12e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 84.36 E-value: 5.12e-19

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    494 YVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSD-NALYFHLYSEH 572
Cdd:smart00042   12 YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSsNSLTLTFVSDS 91

                            90
                    ....*....|.
gi 767960613    573 LRNGRGFTVRW 583
Cdd:smart00042   92 SVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1057-1158

1.16e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 83.59 E-value: 1.16e-18

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1057 GTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYtDFLEIRDGGYEKSPLLGIFYGSNLPPTII-SH 1135
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEY-DYVEIYDGPSASSPLLGRFCGSEAPPPVIsSS 79

                            90       100
                    ....*....|....*....|...
gi 767960613   1136 SNKLWLKFKSDQIDTRSGFSAYW 1158
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

474-579

1.88e-18

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 83.11 E-value: 1.88e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   474 CGESLSGINGSF-SYRSPDvGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSS 552
Cdd:pfam00431    1 CGGVLTDSSGSIsSPNYPN-PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSG 79

                           90       100
                   ....*....|....*....|....*..
gi 767960613   553 LPHELLSSDNALYFHLYSEHLRNGRGF 579
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGF 106

CUB

CUB domain;

708-813

8.00e-18

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 81.19 E-value: 8.00e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGE----TLLGKVCGNGT 783
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPsassPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613   784 ISHIKSITNSVWIRFKIDASVEKASFRAVY 813
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

717-813

1.18e-14

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 72.04 E-value: 1.18e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    717 GELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGET----LLGKVCGNGTISH-IKSIT 791
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSasspLLGRFCGSEAPPPvISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613    792 NSVWIRFKIDASVEKASFRAVY 813
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

170-210

4.13e-09

Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.18 E-value: 4.13e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767960613  170 DVNECEIYSGtplsCQNGGTCVNTMGSYSCHCPPETYGPQC 210
Cdd:cd00054     1 DIDECASGNP----CQNGGTCVNTVGSYRCSCPPGYTGRNC 37

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2805-2866

6.24e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 55.88 E-value: 6.24e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767960613 2805 CGGIFH-SDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDgqCQNSFVK 2866
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN--CSYDYLE 61

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

432-468

7.72e-09

Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.41 E-value: 7.72e-09

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767960613  432 NINECLS-NPCLNGGTCVDGVDSFSCECTRLWTGALCQ 468
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

EGF_CA

Calcium-binding EGF-like domain;

170-210

1.01e-08

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 53.02 E-value: 1.01e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767960613    170 DVNECEIYSGtplsCQNGGTCVNTMGSYSCHCPPE-TYGPQC 210
Cdd:smart00179    1 DIDECASGNP----CQNGGTCVNTVGSYRCECPPGyTDGRNC 38

EGF_3

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...

353-387

5.08e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 51.06 E-value: 5.08e-08

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767960613   353 CSVSNGGCHPDASCSSTLGSLpLCTCLPGYTGNGY 387
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGV 34

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

137-167

5.80e-07

Pssm-ID: 238011 Cd Length: 38 Bit Score: 48.02 E-value: 5.80e-07

                          10        20        30
                  ....*....|....*....|....*....|.
gi 767960613  137 SSNPCQNGGTCLNLHDSFFCICPPQWKGPLC 167
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF_CA

Calcium-binding EGF-like domain;

432-468

8.71e-07

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 47.63 E-value: 8.71e-07

                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767960613    432 NINECLS-NPCLNGGTCVDGVDSFSCECTRLWT-GALCQ 468
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

EGF_3

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...

309-347

1.14e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 47.21 E-value: 1.14e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767960613   309 CEINNGGCSV-AppvECVNTPGSSHCQaCPPGYQGDGRVC 347
Cdd:pfam12947    1 CSDNNGGCHPnA---TCTNTGGSFTCT-CNDGYTGDGVTC 36

EGF_CA

pfam07645

Calcium-binding EGF domain;

170-203

3.91e-06

Calcium-binding EGF domain;

Pssm-ID: 429571 Cd Length: 32 Bit Score: 45.69 E-value: 3.91e-06

                           10        20        30
                   ....*....|....*....|....*....|....
gi 767960613   170 DVNECEIYsgtPLSCQNGGTCVNTMGSYSCHCPP 203
Cdd:pfam07645    1 DVDECATG---THNCPANTVCVNTIGSFECRCPD 31

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

399-430

1.34e-05

Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.16 E-value: 1.34e-05

                          10        20        30
                  ....*....|....*....|....*....|....
gi 767960613  399 CLS-HPCLN-GQCIDTVSGYFCKCDSGWTGVNCT 430
Cdd:cd00054     5 CASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38

CUB

CUB domain;

2805-2848

2.66e-05

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 45.75 E-value: 2.66e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767960613  2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFD 2848
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQ 44

EGF

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

136-165

2.97e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

Pssm-ID: 394967 Cd Length: 31 Bit Score: 43.14 E-value: 2.97e-05

                           10        20        30
                   ....*....|....*....|....*....|
gi 767960613   136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGP 165
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30

EGF_CA

Calcium-binding EGF-like domain;

137-160

4.45e-05

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 42.62 E-value: 4.45e-05

                            10        20
                    ....*....|....*....|....
gi 767960613    137 SSNPCQNGGTCLNLHDSFFCICPP 160
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPP 30

EGF

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

436-464

5.74e-05

Pssm-ID: 394967 Cd Length: 31 Bit Score: 42.37 E-value: 5.74e-05

                           10        20
                   ....*....|....*....|....*....
gi 767960613   436 CLSNPCLNGGTCVDGVDSFSCECTRLWTG 464
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29

EGF_CA

Calcium-binding EGF-like domain;

305-348

8.77e-05

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.85 E-value: 8.77e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767960613    305 DINECEINNgGCSvaPPVECVNTPGSSHCQaCPPGYQgDGRVCT 348
Cdd:smart00179    1 DIDECASGN-PCQ--NGGTCVNTVGSYRCE-CPPGYT-DGRNCE 39

EGF_CA

Calcium-binding EGF-like domain;

263-304

2.04e-04

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.69 E-value: 2.04e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767960613    263 DRDECSfQPGPCSTLVQCFNTQGSFYCgACPTGWQgNGYICE 304
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRC-ECPPGYT-DGRNCE 39

EGF

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

399-428

3.49e-04

Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.06 E-value: 3.49e-04

                           10        20        30
                   ....*....|....*....|....*....|.
gi 767960613   399 CLSHPCLN-GQCIDTVSGYFCKCDSGWTGVN 428
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2814-2866

4.68e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 41.99 E-value: 4.68e-04

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767960613   2814 GTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDnNFLIPSGDGqCQNSFVK 2866
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDLESSDN-CEYDYVE 51

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

305-343

5.93e-04

Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.54 E-value: 5.93e-04

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767960613  305 DINECEINNgGCSvaPPVECVNTPGSSHCQaCPPGYQGD 343
Cdd:cd00054     1 DIDECASGN-PCQ--NGGTCVNTVGSYRCS-CPPGYTGR 35

EGF

smart00181

Epidermal growth factor-like domain;

401-428

8.67e-04

Epidermal growth factor-like domain;

Pssm-ID: 214544 Cd Length: 35 Bit Score: 39.04 E-value: 8.67e-04

                            10        20
                    ....*....|....*....|....*...
gi 767960613    401 SHPCLNGQCIDTVSGYFCKCDSGWTGVN 428
Cdd:smart00181    5 GGPCSNGTCINTPGSYTCSCPPGYTGDK 32

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

263-298

1.77e-03

Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.77e-03

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767960613  263 DRDECSfQPGPCSTLVQCFNTQGSFYCgACPTGWQG 298
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRC-SCPPGYTG 34

Name

Accession

Description

Interval

E-value

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1620-1733

2.75e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 139.85 E-value: 2.75e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1620 CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAqPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGT 1699
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEA-PPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 1700 DMPHPITSFSSALTLRFVSDSSISAGGFHTTVTA 1733
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

932-1041

1.06e-37

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 138.31 E-value: 1.06e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  932 CGEILTEST-GTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKS 1008
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSplLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 1009 IPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEA 1041
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain;

1620-1730

1.75e-36

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 134.73 E-value: 1.75e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1620 CGGHiLTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLnHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGT 1699
Cdd:pfam00431    1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGF-RVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGS 78

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  1700 DMPHPITSFSSALTLRFVSDSSISAGGFHTT 1730
Cdd:pfam00431   79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1165-1275

2.13e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 134.46 E-value: 2.13e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1165 CGGNLT-TSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDE 1243
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 1244 KPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2689-2800

7.08e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 132.92 E-value: 7.08e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2689 CGG-IQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNS 2767
Cdd:cd00041     1 CGGtLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 2768 NPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNT 2800
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1391-1505

8.77e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 132.54 E-value: 8.77e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1391 CGGELSGAT-GSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQR 1469
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767960613 1470 SPENpmqVSSTGNELAIRFKTDLSINGRGFNASWQA 1505
Cdd:cd00041    81 LPPP---IISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain;

1391-1502

1.72e-35

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 131.65 E-value: 1.72e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCtqrS 1470
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC---G 77

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767960613  1471 PENPMQVSSTGNELAIRFKTDLSINGRGFNAS 1502
Cdd:pfam00431   78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

CUB domain;

1165-1274

9.42e-35

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 129.72 E-value: 9.42e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEK 1244
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613  1245 PPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2217-2333

9.83e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 129.84 E-value: 9.83e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2217 CGGNVYihdADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDrFDIEVTPNCTSNYLELRDGVDSDAPILSKF 2296
Cdd:cd00041     1 CGGTLT---ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPNCSYDYLEIYDGPSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767960613 2297 CGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI 2333
Cdd:cd00041    77 CGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

590-699

1.02e-34

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 129.45 E-value: 1.02e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  590 CGGILTGP-YGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTF 668
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767960613  669 SVPPLQTTGPFARIHFHSDSQISDQGFHITY 699
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1738-1847

2.59e-34

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 128.30 E-value: 2.59e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1738 CGGTFY-MAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNAT-GHLVGRYCGNS 1815
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTsSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 1816 FPLNYSSIvGHTLWVRFISDGSGSGTGFQATF 1847
Cdd:cd00041    81 LPPPIISS-GNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain;

1978-2088

3.77e-34

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 127.80 E-value: 3.77e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1978 CGGFLRtgDAPVFLFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGR 2056
Cdd:pfam00431    1 CGGVLT--DSSGSISSPNYPNPYPPNKDCVWLIRAPPgFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGS 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767960613  2057 EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
Cdd:pfam00431   79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

932-1039

4.72e-34

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 127.80 E-value: 4.72e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   932 CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKSI 1009
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSplLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613  1010 PPSLTSSGNSLMLVFVTDSDLAYEGFLINY 1039
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1978-2088

3.78e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 125.22 E-value: 3.78e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1978 CGGFLrTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGR 2056
Cdd:cd00041     1 CGGTL-TASTSGTISSPNYPNNYPNNLNCVWTIEAPPgYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767960613 2057 EIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATY 111

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1510-1617

4.20e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 125.22 E-value: 4.20e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1510 CGGIFQAP-SGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGRe 1584
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCsydyLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613 1585 QLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFR 1617
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1400-1503

1.27e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 123.27 E-value: 1.27e-32

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1400 GSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPmqVSS 1479
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPV--ISS 78

                            90       100
                    ....*....|....*....|....
gi 767960613   1480 TGNELAIRFKTDLSINGRGFNASW 1503
Cdd:smart00042   79 SSNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

590-699

2.57e-32

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 122.79 E-value: 2.57e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   590 CGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFS 669
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613   670 VPPLQTTGPFARIHFHSDSQISDQGFHITY 699
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

1510-1616

3.28e-32

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 122.40 E-value: 3.28e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY----DGLSSTMSRLARTCGrEQ 1585
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYveirDGPSASSPLLGRFCG-SG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  1586 LANPIVSSGNSLFLRFQSGPSRQNRGFRAQF 1616
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

2689-2797

1.34e-31

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 120.48 E-value: 1.34e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSN 2768
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100
                   ....*....|....*....|....*....
gi 767960613  2769 PRTIQSGSNQLVVTFNSDHSLQGGGFYAT 2797
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1747-1847

1.62e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 120.19 E-value: 1.62e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1747 GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGH-LVGRYCGNSFPLNYSSIVG 1825
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSpLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1826 HTLWVRFISDGSGSGTGFQATF 1847
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2452-2564

2.20e-31

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 120.21 E-value: 2.20e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2452 CGGDLQGSI-GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSv 2530
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS- 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 2531 NVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTS 2564
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1631-1728

2.69e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 119.42 E-value: 2.69e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1631 TVSSPRFPANYPNNQNCSWIIQAqPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHP-ITSFS 1709
Cdd:smart00042    2 TITSPNYPQSYPNNLDCVWTIRA-PPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSS 80

                            90
                    ....*....|....*....
gi 767960613   1710 SALTLRFVSDSSISAGGFH 1728
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFS 99

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2698-2798

3.08e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 119.42 E-value: 3.08e-31

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2698 GVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNS-NPRTIQSGS 2776
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   2777 NQLVVTFNSDHSLQGGGFYATW 2798
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

1738-1847

4.38e-31

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 119.32 E-value: 4.38e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1738 CGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSF 1816
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  1817 PLNYSSiVGHTLWVRFISDGSGSGTGFQATF 1847
Cdd:pfam00431   81 PEDIVS-SSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain;

2217-2331

6.09e-31

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 118.55 E-value: 6.09e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2217 CGGNVyihdADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDrFDIEVTPNCTSNYLELRDGVDSDAPILSKF 2296
Cdd:pfam00431    1 CGGVL----TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDECGYDYVEIRDGPSASSPLLGRF 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 767960613  2297 CGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331
Cdd:pfam00431   76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

941-1039

2.01e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 117.11 E-value: 2.01e-30

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    941 GTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGKSIPPS-LTSSG 1017
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDgpSASSPLLGRFCGSEAPPPvISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1018 NSLMLVFVTDSDLAYEGFLINY 1039
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1174-1274

3.42e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 116.34 E-value: 3.42e-30

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1174 GTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPP-LIRSSG 1252
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1253 DSMFIKLRTDEGQQGRGFKAEY 1274
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2336-2447

7.84e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 115.59 E-value: 7.84e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2336 CGGRVPGQ-SGVVESIGHPTlPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWD-NHTSGNILGRYCGN 2413
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDgPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613 2414 TIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFES 2447
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2230-2331

3.29e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 113.64 E-value: 3.29e-29

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2230 GYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDrFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQ-WSS 2308
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPViSSS 79

                            90       100
                    ....*....|....*....|...
gi 767960613   2309 GEVMYLRFRSDNSPTHVGFKAKY 2331
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

2452-2562

3.92e-29

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 113.54 E-value: 3.92e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  2532 VSNeIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
Cdd:pfam00431   81 PED-IVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1519-1616

6.43e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 112.48 E-value: 6.43e-29

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1519 GEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSG 1594
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCeydyVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1595 NSLFLRFQSGPSRQNRGFRAQF 1616
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2570-2686

1.44e-28

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 112.12 E-value: 1.44e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2570 CGGSLPNTPEGNFTSPGYDGvrNYSRNLNCEWTLSNPNqgNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRL 2648
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPN--NYPNNLNCVWTIEAPP--GYRIRLTFEDFDLESSPNCSYDYLEIYDGpSTSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767960613 2649 CGPSKPTlPLVIPYSQVWIHFVTNERVEHIGFHAKYSF 2686
Cdd:cd00041    77 CGSTLPP-PIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1991-2088

1.98e-28

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 111.33 E-value: 1.98e-28

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1991 LFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGP-IRSTGEY 2068
Cdd:smart00042    3 ITSPNYPQSYPNNLDCVWTIRAPPgYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNS 82

                            90       100
                    ....*....|....*....|
gi 767960613   2069 MFIRFTSDSSVTRAGFNASF 2088
Cdd:smart00042   83 LTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

2336-2445

1.04e-27

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 109.31 E-value: 1.04e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2336 CGGRVPGQSGVVESIGHPTlPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGN-ILGRYCGNT 2414
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPN-PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSpLLGRFCGSG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767960613  2415 IPDSIDTSSNTAVVRFVTDGSVTASGFRLRF 2445
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

817-927

1.84e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 109.04 E-value: 1.84e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  817 CGDELTG--EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTD 894
Cdd:cd00041     1 CGGTLTAstSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613  895 IPSFITSVYNFLYVTFVKSSSTENHGFMAKFSA 927
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1859-1962

1.96e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 108.65 E-value: 1.96e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1859 THGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQT-ESFSST 1937
Cdd:cd00041     9 TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLpPPIISS 88

                          90       100
                  ....*....|....*....|....*
gi 767960613 1938 GNSLTFHFYSDSSISGKGFLLEWFA 1962
Cdd:cd00041    89 GNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

474-585

2.73e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 108.27 E-value: 2.73e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  474 CGESLSG-INGSF-SYRSPDvGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGS 551
Cdd:cd00041     1 CGGTLTAsTSGTIsSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767960613  552 SLPHELLSSDNALYFHLYSEHLRNGRGFTVRWET 585
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1282-1388

4.89e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 107.88 E-value: 4.89e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1282 VIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP----RQMGRYCGVDLPP 1357
Cdd:cd00041     4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPstssPLLGRFCGSTLPP 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767960613 1358 PGSTTSSKLQVLLLTDGVGRReKGFQMQWFV 1388
Cdd:cd00041    84 PIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

599-699

4.99e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 107.09 E-value: 4.99e-27

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    599 GSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTT-G 677
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                            90       100
                    ....*....|....*....|..
gi 767960613    678 PFARIHFHSDSQISDQGFHITY 699
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2461-2562

9.29e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 106.32 E-value: 9.29e-27

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2461 GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSG 2540
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   2541 NTMKVIFFTDGSRPYGGFTASY 2562
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2092-2212

6.86e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 104.42 E-value: 6.86e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 2092 CGGYLHADR-GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQpFQIPnGDSSCNQgDYLVLRNGPDICSPPLGppg 2170
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLE-SSPNCSY-DYLEIYDGPSTSSPLLG--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767960613 2171 gngHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEA 2212
Cdd:cd00041    75 ---RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

cubilin_NTD

cd22201

N-terminal domain of cubilin and similar proteins; Cubilin (CUBN, also called 460 kDa receptor, ...

32-135

1.26e-25

Pssm-ID: 412063 Cd Length: 129 Bit Score: 104.34 E-value: 1.26e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   32 RQKRSINLQQPRMATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSA-----------I 100
Cdd:cd22201     4 RQKRDIYNDQPRIITEDGHLIFEAAYDKNISFRTSGNGRININDEDLLELLQQAKNNKSDIENLKQSElptfeqqlselV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767960613  101 GLPQNISSQIYQLNSKLVDLE-----------RKFQGLQQTVDKKV 135
Cdd:cd22201    84 GGPQGLLRRLALLENRTSGLSstlnnnirrlrRRLRRLERRVTRLE 129

CUB

CUB domain;

1288-1383

3.65e-25

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 102.37 E-value: 3.65e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1288 YGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPR----QMGRYCGVDLPPPGSTTS 1363
Cdd:pfam00431    9 SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSasspLLGRFCGSGIPEDIVSSS 88

                           90       100
                   ....*....|....*....|
gi 767960613  1364 SKLQVLLLTDGVGRReKGFQ 1383
Cdd:pfam00431   89 NQMTIKFVSDASVQK-RGFK 107

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2345-2445

5.60e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 101.31 E-value: 5.60e-25

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2345 GVVESIGHPTlPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNH-TSGNILGRYCGNTIPDS-IDTS 2422
Cdd:smart00042    1 GTITSPNYPQ-SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPvISSS 79

                            90       100
                    ....*....|....*....|...
gi 767960613   2423 SNTAVVRFVTDGSVTASGFRLRF 2445
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1861-1960

2.60e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 96.69 E-value: 2.60e-23

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQT--ESFSSTG 1938
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAppPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613   1939 NSLTFHFYSDSSISGKGFLLEW 1960
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1289-1386

3.95e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 96.31 E-value: 3.95e-23

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGP----RQMGRYCGvDLPPPG--STT 1362
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPsassPLLGRFCG-SEAPPPviSSS 79

                            90       100
                    ....*....|....*....|....
gi 767960613   1363 SSKLQVLLLTDGVGRReKGFQMQW 1386
Cdd:smart00042   80 SNSLTLTFVSDSSVQK-RGFSARY 102

CUB

CUB domain;

1048-1157

1.12e-22

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 95.05 E-value: 1.12e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1048 CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYtDFLEIRDGGYEKSPLLGIFYGSN 1127
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGY-DYVEIRDGPSASSPLLGRFCGSG 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613  1128 LPPTIISHSNKLWLKFKSDQIDTRSGFSAY 1157
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKAT 109

CUB

CUB domain;

1861-1956

1.31e-22

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 95.05 E-value: 1.31e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQT-ESFSSTGN 1939
Cdd:pfam00431   10 GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIpEDIVSSSN 89

                           90
                   ....*....|....*..
gi 767960613  1940 SLTFHFYSDSSISGKGF 1956
Cdd:pfam00431   90 QMTIKFVSDASVQKRGF 106

CUB

CUB domain;

2570-2684

1.55e-22

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 94.67 E-value: 1.55e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2570 CGGSLPNTPeGNFTSPGYDgvRNYSRNLNCEWTLSNPNqgNSSISIHFEDFYLESHQDCQFDVLEFRVGD-ADGPLMWRL 2648
Cdd:pfam00431    1 CGGVLTDSS-GSISSPNYP--NPYPPNKDCVWLIRAPP--GFRVKLTFQDFELEDHDECGYDYVEIRDGPsASSPLLGRF 75

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 767960613  2649 CGPSKPtLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
Cdd:pfam00431   76 CGSGIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

1057-1158

1.99e-22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 94.40 E-value: 1.99e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613 1057 GTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYtDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHS 1136
Cdd:cd00041    11 GTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSY-DYLEIYDGPSTSSPLLGRFCGSTLPPPIISSG 89

                          90       100
                  ....*....|....*....|..
gi 767960613 1137 NKLWLKFKSDQIDTRSGFSAYW 1158
Cdd:cd00041    90 NSLTVRFRSDSSVTGRGFKATY 111

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2580-2684

5.84e-22

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 92.84 E-value: 5.84e-22

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2580 GNFTSPGYDGvrNYSRNLNCEWTLSNPNqgNSSISIHFEDFYLESHQDCQFDVLEFRVGD-ADGPLMWRLCGPSKPTLPL 2658
Cdd:smart00042    1 GTITSPNYPQ--SYPNNLDCVWTIRAPP--GYRIELQFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPVI 76

                            90       100
                    ....*....|....*....|....*.
gi 767960613   2659 VIPYSQVWIHFVTNERVEHIGFHAKY 2684
Cdd:smart00042   77 SSSSNSLTLTFVSDSSVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

825-925

4.77e-21

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 90.14 E-value: 4.77e-21

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    825 GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIP-SFITSVY 903
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPpPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613    904 NFLYVTFVKSSSTENHGFMAKF 925
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

2092-2210

1.04e-20

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 89.66 E-value: 1.04e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  2092 CGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFeQPFQIpNGDSSCnQGDYLVLRNGPDICSPPLGPpgg 2171
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFEL-EDHDEC-GYDYVEIRDGPSASSPLLGR--- 74

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 767960613  2172 nghFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
Cdd:pfam00431   75 ---FCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

708-815

1.30e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 89.39 E-value: 1.30e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613  708 CGGNYTDP-EGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGET----LLGKVCGNG 782
Cdd:cd00041     1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPStsspLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767960613  783 TISHIKSITNSVWIRFKIDASVEKASFRAVYQV 815
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2101-2210

1.32e-20

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 88.99 E-value: 1.32e-20

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEqPFQIpNGDSSCNQgDYLVLRNGPDicspplGPPGGNGHFCGSHA 2180
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDL-ESSDNCEY-DYVEIYDGPS------ASSPLLGRFCGSEA 71

                            90       100       110
                    ....*....|....*....|....*....|.
gi 767960613   2181 SSTLFTSD-NQMFVQFISDHSNEGQGFKIKY 2210
Cdd:smart00042   72 PPPVISSSsNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

817-925

4.29e-19

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 85.04 E-value: 4.29e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   817 CGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI-----GSSSILGspenkKY 890
Cdd:pfam00431    1 CGGVLTDSsGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpsASSPLLG-----RF 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 767960613   891 CGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKF 925
Cdd:pfam00431   76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

494-583

5.12e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 84.36 E-value: 5.12e-19

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    494 YVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSD-NALYFHLYSEH 572
Cdd:smart00042   12 YPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSsNSLTLTFVSDS 91

                            90
                    ....*....|.
gi 767960613    573 LRNGRGFTVRW 583
Cdd:smart00042   92 SVQKRGFSARY 102

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

1057-1158

1.16e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 83.59 E-value: 1.16e-18

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   1057 GTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYtDFLEIRDGGYEKSPLLGIFYGSNLPPTII-SH 1135
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEY-DYVEIYDGPSASSPLLGRFCGSEAPPPVIsSS 79

                            90       100
                    ....*....|....*....|...
gi 767960613   1136 SNKLWLKFKSDQIDTRSGFSAYW 1158
Cdd:smart00042   80 SNSLTLTFVSDSSVQKRGFSARY 102

CUB

CUB domain;

474-579

1.88e-18

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 83.11 E-value: 1.88e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   474 CGESLSGINGSF-SYRSPDvGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSS 552
Cdd:pfam00431    1 CGGVLTDSSGSIsSPNYPN-PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSG 79

                           90       100
                   ....*....|....*....|....*..
gi 767960613   553 LPHELLSSDNALYFHLYSEHLRNGRGF 579
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGF 106

CUB

CUB domain;

708-813

8.00e-18

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 81.19 E-value: 8.00e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGE----TLLGKVCGNGT 783
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPsassPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 767960613   784 ISHIKSITNSVWIRFKIDASVEKASFRAVY 813
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

717-813

1.18e-14

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 72.04 E-value: 1.18e-14

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613    717 GELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGET----LLGKVCGNGTISH-IKSIT 791
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSasspLLGRFCGSEAPPPvISSSS 80

                            90       100
                    ....*....|....*....|..
gi 767960613    792 NSVWIRFKIDASVEKASFRAVY 813
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

170-210

4.13e-09

Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.18 E-value: 4.13e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767960613  170 DVNECEIYSGtplsCQNGGTCVNTMGSYSCHCPPETYGPQC 210
Cdd:cd00054     1 DIDECASGNP----CQNGGTCVNTVGSYRCSCPPGYTGRNC 37

CUB

CUB domain; extracellular domain; present in proteins mostly known to be involved in ...

2805-2866

6.24e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 55.88 E-value: 6.24e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767960613 2805 CGGIFH-SDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDgqCQNSFVK 2866
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN--CSYDYLE 61

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

432-468

7.72e-09

Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.41 E-value: 7.72e-09

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767960613  432 NINECLS-NPCLNGGTCVDGVDSFSCECTRLWTGALCQ 468
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

EGF_CA

Calcium-binding EGF-like domain;

170-210

1.01e-08

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 53.02 E-value: 1.01e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767960613    170 DVNECEIYSGtplsCQNGGTCVNTMGSYSCHCPPE-TYGPQC 210
Cdd:smart00179    1 DIDECASGNP----CQNGGTCVNTVGSYRCECPPGyTDGRNC 38

EGF_3

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...

353-387

5.08e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 51.06 E-value: 5.08e-08

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767960613   353 CSVSNGGCHPDASCSSTLGSLpLCTCLPGYTGNGY 387
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGV 34

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

137-167

5.80e-07

Pssm-ID: 238011 Cd Length: 38 Bit Score: 48.02 E-value: 5.80e-07

                          10        20        30
                  ....*....|....*....|....*....|.
gi 767960613  137 SSNPCQNGGTCLNLHDSFFCICPPQWKGPLC 167
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF_CA

Calcium-binding EGF-like domain;

432-468

8.71e-07

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 47.63 E-value: 8.71e-07

                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767960613    432 NINECLS-NPCLNGGTCVDGVDSFSCECTRLWT-GALCQ 468
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

EGF_3

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...

309-347

1.14e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 47.21 E-value: 1.14e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767960613   309 CEINNGGCSV-AppvECVNTPGSSHCQaCPPGYQGDGRVC 347
Cdd:pfam12947    1 CSDNNGGCHPnA---TCTNTGGSFTCT-CNDGYTGDGVTC 36

EGF_CA

pfam07645

Calcium-binding EGF domain;

170-203

3.91e-06

Calcium-binding EGF domain;

Pssm-ID: 429571 Cd Length: 32 Bit Score: 45.69 E-value: 3.91e-06

                           10        20        30
                   ....*....|....*....|....*....|....
gi 767960613   170 DVNECEIYsgtPLSCQNGGTCVNTMGSYSCHCPP 203
Cdd:pfam07645    1 DVDECATG---THNCPANTVCVNTIGSFECRCPD 31

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

399-430

1.34e-05

Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.16 E-value: 1.34e-05

                          10        20        30
                  ....*....|....*....|....*....|....
gi 767960613  399 CLS-HPCLN-GQCIDTVSGYFCKCDSGWTGVNCT 430
Cdd:cd00054     5 CASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38

CUB

CUB domain;

2805-2848

2.66e-05

CUB domain;

Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 45.75 E-value: 2.66e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767960613  2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFD 2848
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQ 44

EGF

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

136-165

2.97e-05

Pssm-ID: 394967 Cd Length: 31 Bit Score: 43.14 E-value: 2.97e-05

                           10        20        30
                   ....*....|....*....|....*....|
gi 767960613   136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGP 165
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30

EGF_CA

Calcium-binding EGF-like domain;

137-160

4.45e-05

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 42.62 E-value: 4.45e-05

                            10        20
                    ....*....|....*....|....
gi 767960613    137 SSNPCQNGGTCLNLHDSFFCICPP 160
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPP 30

EGF

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

436-464

5.74e-05

Pssm-ID: 394967 Cd Length: 31 Bit Score: 42.37 E-value: 5.74e-05

                           10        20
                   ....*....|....*....|....*....
gi 767960613   436 CLSNPCLNGGTCVDGVDSFSCECTRLWTG 464
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29

EGF

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...

137-165

7.80e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

Pssm-ID: 238010 Cd Length: 36 Bit Score: 42.08 E-value: 7.80e-05

                          10        20
                  ....*....|....*....|....*....
gi 767960613  137 SSNPCQNGGTCLNLHDSFFCICPPQWKGP 165
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32

EGF_CA

Calcium-binding EGF-like domain;

305-348

8.77e-05

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.85 E-value: 8.77e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767960613    305 DINECEINNgGCSvaPPVECVNTPGSSHCQaCPPGYQgDGRVCT 348
Cdd:smart00179    1 DIDECASGN-PCQ--NGGTCVNTVGSYRCE-CPPGYT-DGRNCE 39

EGF_CA

Calcium-binding EGF-like domain;

263-304

2.04e-04

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.69 E-value: 2.04e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767960613    263 DRDECSfQPGPCSTLVQCFNTQGSFYCgACPTGWQgNGYICE 304
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRC-ECPPGYT-DGRNCE 39

EGF

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

399-428

3.49e-04

Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.06 E-value: 3.49e-04

                           10        20        30
                   ....*....|....*....|....*....|.
gi 767960613   399 CLSHPCLN-GQCIDTVSGYFCKCDSGWTGVN 428
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31

EGF

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...

184-203

4.23e-04

Pssm-ID: 238010 Cd Length: 36 Bit Score: 39.77 E-value: 4.23e-04

                          10        20
                  ....*....|....*....|
gi 767960613  184 CQNGGTCVNTMGSYSCHCPP 203
Cdd:cd00053     8 CSNGGTCVNTPGSYRCVCPP 27

CUB

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...

2814-2866

4.68e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 41.99 E-value: 4.68e-04

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767960613   2814 GTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDnNFLIPSGDGqCQNSFVK 2866
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDLESSDN-CEYDYVE 51

DUF5885

pfam19232

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ...

207-467

4.84e-04

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.

Pssm-ID: 437064 Cd Length: 265 Bit Score: 44.61 E-value: 4.84e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   207 GPQCASKYDDCEG--GSVARCVHGICEDlmreqagepkyscvcdagwmfspNSPACTLDRdecsfQPGPCSTLVQCFNTQ 284
Cdd:pfam19232    2 PPNNPTNPDDCTPpcGGTQVCIDRQCKD-----------------------NTLACTTDA-----QCGTCMTCVAGACTP 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   285 GSFYCGACPTGwqgNGYICE-DINECEINNGGCSV--APPVECVNTPGSSHCQACPPGYQGDGRVC-------------- 347
Cdd:pfam19232   54 KASCCGGVTCG---AGQTCDaKTNTCVYVKGYCSAdhPCPSGSACDTAKNACIAQPPYGPDSGKGCvrgfgawiweldpa 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960613   348 --TLTDICSVSNGGCHPDASCSSTLGSLPLCTclpgytGNGYGPNGCVQLSNI------------CLSHPCLNGQCIDTV 413
Cdd:pfam19232  131 tnSGVWRCRCANGSLYNSAHECSPLADQTLCA------AENLDPNALVPASSVpafaaygwgnqpVLINKSTAGAAVPSP 204

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767960613   414 SGYFCKCDSGWTGVNCTENiNECLSNPCLNGGT--CVDGVDsFSC--------ECTRlWTGALC 467
Cdd:pfam19232  205 LAGVCPCKPGWAGGSCTED-RTCNGRGTWNETTgqCACNID-FSGhnscgddnNCTS-WTGPRC 265

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

305-343

5.93e-04

Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.54 E-value: 5.93e-04

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767960613  305 DINECEINNgGCSvaPPVECVNTPGSSHCQaCPPGYQGD 343
Cdd:cd00054     1 DIDECASGN-PCQ--NGGTCVNTVGSYRCS-CPPGYTGR 35

hEGF

pfam12661

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...

184-203

8.12e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.

Pssm-ID: 463660 Cd Length: 22 Bit Score: 38.85 E-value: 8.12e-04

                           10        20
                   ....*....|....*....|
gi 767960613   184 CQNGGTCVNTMGSYSCHCPP 203
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20

FXa_inhibition

pfam14670

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

309-347

8.29e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 39.15 E-value: 8.29e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767960613   309 CEINNGGCSvappVECVNTPGSSHCqACPPGY--QGDGRVC 347
Cdd:pfam14670    1 CSVNNGGCS----HLCLNTPGGYTC-SCPEGYelQDDGRTC 36

EGF

smart00181

Epidermal growth factor-like domain;

401-428

8.67e-04

Epidermal growth factor-like domain;

Pssm-ID: 214544 Cd Length: 35 Bit Score: 39.04 E-value: 8.67e-04

                            10        20
                    ....*....|....*....|....*...
gi 767960613    401 SHPCLNGQCIDTVSGYFCKCDSGWTGVN 428
Cdd:smart00181    5 GGPCSNGTCINTPGSYTCSCPPGYTGDK 32

EGF_CA

Calcium-binding EGF-like domain;

399-430

9.19e-04

Calcium-binding EGF-like domain;

Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 39.15 E-value: 9.19e-04

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 767960613    399 CLS-HPCLNG-QCIDTVSGYFCKCDSGWT-GVNCT 430
Cdd:smart00179    5 CASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39

EGF

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...

435-464

1.21e-03

Pssm-ID: 238010 Cd Length: 36 Bit Score: 38.61 E-value: 1.21e-03

                          10        20        30
                  ....*....|....*....|....*....|.
gi 767960613  435 EC-LSNPCLNGGTCVDGVDSFSCECTRLWTG 464
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTG 31

EGF_CA

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...

263-298

1.77e-03

Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.77e-03

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767960613  263 DRDECSfQPGPCSTLVQCFNTQGSFYCgACPTGWQG 298
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRC-SCPPGYTG 34

EGF

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...

184-209

2.44e-03

Pssm-ID: 394967 Cd Length: 31 Bit Score: 37.75 E-value: 2.44e-03

                           10        20
                   ....*....|....*....|....*.
gi 767960613   184 CQNGGTCVNTMGSYSCHCPPETYGPQ 209
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGKR 31

EGF