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Conserved domains on  [gi|767965527|ref|XP_011518252|]
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exostosin-2 isoform X1 [Homo sapiens]

Protein Classification

exostosin( domain architecture ID 10503393)

exostosin is a family 47 glycosyltransferase that is required for the biosynthesis of heparan-sulfate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
502-743 5.46e-124

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


:

Pssm-ID: 430488  Cd Length: 241  Bit Score: 370.47  E-value: 5.46e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  502 FTAIVLT-YDRVESLFRVITEVSKVPSLSKLLVVWNNqNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAV 580
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNN-PKPPPELSRWPGTGVPVTVIRQKRNSLNNRFLPYPEIETDAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  581 LAIDDDIiMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPG 660
Cdd:pfam09258  80 LSLDDDI-LLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  661 DIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEH 740
Cdd:pfam09258 159 SLRTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQI 238

                  ...
gi 767965527  741 RAD 743
Cdd:pfam09258 239 RLD 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
146-426 1.37e-58

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


:

Pssm-ID: 397245  Cd Length: 290  Bit Score: 200.73  E-value: 1.37e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  146 PKNKIKVYIYALKKYVDD---FGVSVSNTISREYNELLMAISDS--DYYTDDINRA-CLFVPSIDVLNQNTLRIKETAQA 219
Cdd:pfam03016   1 SCKGLKVYVYDLPPRFNEdllQPCRSLTGWYSAEQFLLESILHSriECRTSDPDEAdCFFVPFYASLDASRHLLNSALTD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  220 M---------AQLSRWDR--GTNHLLFNMLPGGPPdYNTALDVPRDRALLA--GGGFSTWTYRQGYDVSIPVYSPLSAEV 286
Cdd:pfam03016  81 LfrelldwlkSQYPYWNRsgGRDHFIVSGHPAWSF-RRTAPDVDWGRAMLLnlTVLFSEDQFRPGKDVALPYPTPFHPDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  287 -DLPEKGPGPRQYFLLSSQVGLHPEYREDLEALqvkhgesvlVLDKCTNLSEGVLSVRKRCHKhQVFDYPQVLQEATFCV 365
Cdd:pfam03016 160 gQWQDISPSNRRKTLLFFAGNRRRGYSGKIRPL---------LLEECKGNPDADICGGLQCTP-GRDKYMELLRSSRFCL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767965527  366 VLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSI 426
Cdd:pfam03016 230 QPPGDTPTSPRLFDALLAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
502-743 5.46e-124

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 370.47  E-value: 5.46e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  502 FTAIVLT-YDRVESLFRVITEVSKVPSLSKLLVVWNNqNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAV 580
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNN-PKPPPELSRWPGTGVPVTVIRQKRNSLNNRFLPYPEIETDAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  581 LAIDDDIiMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPG 660
Cdd:pfam09258  80 LSLDDDI-LLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  661 DIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEH 740
Cdd:pfam09258 159 SLRTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQI 238

                  ...
gi 767965527  741 RAD 743
Cdd:pfam09258 239 RLD 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
146-426 1.37e-58

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 200.73  E-value: 1.37e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  146 PKNKIKVYIYALKKYVDD---FGVSVSNTISREYNELLMAISDS--DYYTDDINRA-CLFVPSIDVLNQNTLRIKETAQA 219
Cdd:pfam03016   1 SCKGLKVYVYDLPPRFNEdllQPCRSLTGWYSAEQFLLESILHSriECRTSDPDEAdCFFVPFYASLDASRHLLNSALTD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  220 M---------AQLSRWDR--GTNHLLFNMLPGGPPdYNTALDVPRDRALLA--GGGFSTWTYRQGYDVSIPVYSPLSAEV 286
Cdd:pfam03016  81 LfrelldwlkSQYPYWNRsgGRDHFIVSGHPAWSF-RRTAPDVDWGRAMLLnlTVLFSEDQFRPGKDVALPYPTPFHPDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  287 -DLPEKGPGPRQYFLLSSQVGLHPEYREDLEALqvkhgesvlVLDKCTNLSEGVLSVRKRCHKhQVFDYPQVLQEATFCV 365
Cdd:pfam03016 160 gQWQDISPSNRRKTLLFFAGNRRRGYSGKIRPL---------LLEECKGNPDADICGGLQCTP-GRDKYMELLRSSRFCL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767965527  366 VLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSI 426
Cdd:pfam03016 230 QPPGDTPTSPRLFDALLAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
502-743 5.46e-124

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 370.47  E-value: 5.46e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  502 FTAIVLT-YDRVESLFRVITEVSKVPSLSKLLVVWNNqNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAV 580
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNN-PKPPPELSRWPGTGVPVTVIRQKRNSLNNRFLPYPEIETDAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  581 LAIDDDIiMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPG 660
Cdd:pfam09258  80 LSLDDDI-LLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  661 DIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEH 740
Cdd:pfam09258 159 SLRTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQI 238

                  ...
gi 767965527  741 RAD 743
Cdd:pfam09258 239 RLD 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
146-426 1.37e-58

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 200.73  E-value: 1.37e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  146 PKNKIKVYIYALKKYVDD---FGVSVSNTISREYNELLMAISDS--DYYTDDINRA-CLFVPSIDVLNQNTLRIKETAQA 219
Cdd:pfam03016   1 SCKGLKVYVYDLPPRFNEdllQPCRSLTGWYSAEQFLLESILHSriECRTSDPDEAdCFFVPFYASLDASRHLLNSALTD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  220 M---------AQLSRWDR--GTNHLLFNMLPGGPPdYNTALDVPRDRALLA--GGGFSTWTYRQGYDVSIPVYSPLSAEV 286
Cdd:pfam03016  81 LfrelldwlkSQYPYWNRsgGRDHFIVSGHPAWSF-RRTAPDVDWGRAMLLnlTVLFSEDQFRPGKDVALPYPTPFHPDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965527  287 -DLPEKGPGPRQYFLLSSQVGLHPEYREDLEALqvkhgesvlVLDKCTNLSEGVLSVRKRCHKhQVFDYPQVLQEATFCV 365
Cdd:pfam03016 160 gQWQDISPSNRRKTLLFFAGNRRRGYSGKIRPL---------LLEECKGNPDADICGGLQCTP-GRDKYMELLRSSRFCL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767965527  366 VLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSI 426
Cdd:pfam03016 230 QPPGDTPTSPRLFDALLAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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