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Conserved domains on  [gi|767966096|ref|XP_011518491|]
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cadherin-related family member 5 isoform X3 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-343 7.33e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 7.33e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966096 274 IYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP--SPMTFLLLVKGQ-QADLARYSVTQVTVE 343
Cdd:cd11304   19 VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATdGGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-120 5.52e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.38  E-value: 5.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096  37 FEVEENTNVTEPLVDIHV-----PEGQEVT--LGALSTPFAFRIQGN--QLFLNVTPDYEEKSLLEAQLLCQSGGT--LV 105
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdpdsGENGEVTysIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTATDGGGppLS 83

                         90
                 ....*....|....*
gi 767966096 106 TQLRVFVSVLDVNDN 120
Cdd:cd11304   84 STATVTITVLDVNDN 98
PRK12438 super family cl46960
hypothetical protein; Provisional
 417-515 5.40e-03

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PRK12438:

Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 40.23  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096 417 LTTTTLAQAGAFYAEVEAHNTVTSGTATT----VIEIQVSEQEPPST-------AQTPEAGTSQPMPPGMGTSTshqpTT 485
Cdd:PRK12438 830 LLTLPIADGGILYVEPLYTERISTSPSSStfpqLSRVLVSVREPRTEggvrvgyAPTLAEALDQVFGPGTGRVA----TA 905

                         90       100       110
                 ....*....|....*....|....*....|
gi 767966096 486 PGGGTAQTPEPGTSQPMPLSKSTPSSGGGP 515
Cdd:PRK12438 906 PGGDAASAPPPGAGPPAPPQAVPPPRTTQP 935
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-343 7.33e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 7.33e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966096 274 IYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP--SPMTFLLLVKGQ-QADLARYSVTQVTVE 343
Cdd:cd11304   19 VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATdGGGPPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 276-314 3.15e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.42  E-value: 3.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767966096   276 AEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARS 314
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP 40
Cadherin pfam00028
Cadherin domain;
253-343 3.92e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 3.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096  253 YHGAVPTGhILPSPLVLRpgpIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQA 330
Cdd:pfam00028   1 YSASVPEN-APVGTEVLT---VTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdrESIGEYELTVEATDS 76

                          90
                  ....*....|....
gi 767966096  331 DL-ARYSVTQVTVE 343
Cdd:pfam00028  77 GGpPLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-120 5.52e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.38  E-value: 5.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096  37 FEVEENTNVTEPLVDIHV-----PEGQEVT--LGALSTPFAFRIQGN--QLFLNVTPDYEEKSLLEAQLLCQSGGT--LV 105
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdpdsGENGEVTysIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTATDGGGppLS 83

                         90
                 ....*....|....*
gi 767966096 106 TQLRVFVSVLDVNDN 120
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-122 3.60e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 3.60e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767966096    71 FRI--QGNQLFLNVTPDYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAP 122
Cdd:smart00112  26 FSIdpETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
PRK12438 PRK12438
hypothetical protein; Provisional
 417-515 5.40e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 40.23  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096 417 LTTTTLAQAGAFYAEVEAHNTVTSGTATT----VIEIQVSEQEPPST-------AQTPEAGTSQPMPPGMGTSTshqpTT 485
Cdd:PRK12438 830 LLTLPIADGGILYVEPLYTERISTSPSSStfpqLSRVLVSVREPRTEggvrvgyAPTLAEALDQVFGPGTGRVA----TA 905

                         90       100       110
                 ....*....|....*....|....*....|
gi 767966096 486 PGGGTAQTPEPGTSQPMPLSKSTPSSGGGP 515
Cdd:PRK12438 906 PGGDAASAPPPGAGPPAPPQAVPPPRTTQP 935
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-343 7.33e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 7.33e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966096 274 IYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP--SPMTFLLLVKGQ-QADLARYSVTQVTVE 343
Cdd:cd11304   19 VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATdGGGPPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 276-314 3.15e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.42  E-value: 3.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767966096   276 AEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARS 314
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP 40
Cadherin pfam00028
Cadherin domain;
253-343 3.92e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 3.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096  253 YHGAVPTGhILPSPLVLRpgpIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQA 330
Cdd:pfam00028   1 YSASVPEN-APVGTEVLT---VTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdrESIGEYELTVEATDS 76

                          90
                  ....*....|....
gi 767966096  331 DL-ARYSVTQVTVE 343
Cdd:pfam00028  77 GGpPLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-120 5.52e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.38  E-value: 5.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096  37 FEVEENTNVTEPLVDIHV-----PEGQEVT--LGALSTPFAFRIQGN--QLFLNVTPDYEEKSLLEAQLLCQSGGT--LV 105
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdpdsGENGEVTysIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTATDGGGppLS 83

                         90
                 ....*....|....*
gi 767966096 106 TQLRVFVSVLDVNDN 120
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-122 3.60e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 3.60e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767966096    71 FRI--QGNQLFLNVTPDYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAP 122
Cdd:smart00112  26 FSIdpETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
PRK12438 PRK12438
hypothetical protein; Provisional
 417-515 5.40e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 40.23  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966096 417 LTTTTLAQAGAFYAEVEAHNTVTSGTATT----VIEIQVSEQEPPST-------AQTPEAGTSQPMPPGMGTSTshqpTT 485
Cdd:PRK12438 830 LLTLPIADGGILYVEPLYTERISTSPSSStfpqLSRVLVSVREPRTEggvrvgyAPTLAEALDQVFGPGTGRVA----TA 905

                         90       100       110
                 ....*....|....*....|....*....|
gi 767966096 486 PGGGTAQTPEPGTSQPMPLSKSTPSSGGGP 515
Cdd:PRK12438 906 PGGDAASAPPPGAGPPAPPQAVPPPRTTQP 935
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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