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Conserved domains on  [gi|767966325|ref|XP_011518587|]
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excitatory amino acid transporter 2 isoform X4 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10448728)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
42-492 1.62e-121

Sodium:dicarboxylate symporter family;


:

Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 363.38  E-value: 1.62e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325   42 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 120
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  121 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 200
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  201 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 280
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  281 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 360
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  361 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 440
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767966325  441 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 492
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
42-492 1.62e-121

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 363.38  E-value: 1.62e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325   42 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 120
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  121 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 200
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  201 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 280
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  281 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 360
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  361 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 440
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767966325  441 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 492
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
39-489 4.60e-120

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 360.58  E-value: 4.60e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  39 KNLLLTLTVFGVILGAVCGGLLrlaspiHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAM 117
Cdd:COG1301    2 KLSLTLQILIALVLGILLGLLL------PELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 118 VYYMSTTIIAAVLGVILVLAIHPGNPkLKKQLGPGKKNDEVSSLDaFLDLIRNLFPENLVQAcfqqiqtvtkkvlvappp 197
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAG-LNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------ 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 198 deeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLV 277
Cdd:COG1301  136 ----------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIV 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 278 IMIMWYSPLGIACLIcGKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGT 357
Cdd:COG1301  181 GWVMKLAPIGVFALI-AATVAKYGLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFST 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 358 ASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAAS 437
Cdd:COG1301  259 SSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAG 338

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767966325 438 IPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 489
Cdd:COG1301  339 VPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVV 390
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 39-483 4.09e-40

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 151.45  E-value: 4.09e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  39 KNLLLTLT---VFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLG 113
Cdd:PRK11283   2 KNIKFSLAwqiLIALVLGILLGAYLHYHSDSRDWLVSNLLSPaGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 114 TRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGP------GKKNDEVSSLD-AFLDLIRNLFPENLVQAcfqqiqt 186
Cdd:PRK11283  82 AKTIIYFEVITTVAIILGITLANVFQPGAGIDMSQLATvdiskyQSTTEEVQSHShGLMGTILSLIPTNIFAS------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 187 vtkkvlvapppdeeanatsavvsllnetvtevpeetkmvIKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKL-MVDF 265
Cdd:PRK11283 155 ---------------------------------------MAKG-------EMLPIIFFSVLFGLGLSSLPATHREpLVTV 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 266 FNILNEIVMKLVIMIMWYSPLGIACLICgkiiaikdlevvarqlgmymVTVIIGLIIHggiFLPLIYFVVTRKNPFSFFA 345
Cdd:PRK11283 189 FRSVSETMFKVTHMVMRYAPVGVFALIA--------------------VTVANFGFAS---LWPLAKLVLLVYFAILFFA 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 346 GI----------FQAW----------ITALGTASSAGTLPvtfRCLE--ENLGIDKRVTRFVLPVGATINMDGTALYEAV 403
Cdd:PRK11283 246 LVvlgivarlcgLSIWilirilkdelILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSI 322

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 404 AAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDS 483
Cdd:PRK11283 323 AAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNA 402
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
42-492 1.62e-121

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 363.38  E-value: 1.62e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325   42 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 120
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  121 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 200
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  201 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 280
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  281 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 360
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  361 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 440
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767966325  441 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 492
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
39-489 4.60e-120

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 360.58  E-value: 4.60e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  39 KNLLLTLTVFGVILGAVCGGLLrlaspiHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAM 117
Cdd:COG1301    2 KLSLTLQILIALVLGILLGLLL------PELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 118 VYYMSTTIIAAVLGVILVLAIHPGNPkLKKQLGPGKKNDEVSSLDaFLDLIRNLFPENLVQAcfqqiqtvtkkvlvappp 197
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAG-LNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------ 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 198 deeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLV 277
Cdd:COG1301  136 ----------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIV 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 278 IMIMWYSPLGIACLIcGKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGT 357
Cdd:COG1301  181 GWVMKLAPIGVFALI-AATVAKYGLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFST 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 358 ASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAAS 437
Cdd:COG1301  259 SSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAG 338

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767966325 438 IPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 489
Cdd:COG1301  339 VPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVV 390
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 39-483 4.09e-40

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 151.45  E-value: 4.09e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  39 KNLLLTLT---VFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLG 113
Cdd:PRK11283   2 KNIKFSLAwqiLIALVLGILLGAYLHYHSDSRDWLVSNLLSPaGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 114 TRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGP------GKKNDEVSSLD-AFLDLIRNLFPENLVQAcfqqiqt 186
Cdd:PRK11283  82 AKTIIYFEVITTVAIILGITLANVFQPGAGIDMSQLATvdiskyQSTTEEVQSHShGLMGTILSLIPTNIFAS------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 187 vtkkvlvapppdeeanatsavvsllnetvtevpeetkmvIKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKL-MVDF 265
Cdd:PRK11283 155 ---------------------------------------MAKG-------EMLPIIFFSVLFGLGLSSLPATHREpLVTV 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 266 FNILNEIVMKLVIMIMWYSPLGIACLICgkiiaikdlevvarqlgmymVTVIIGLIIHggiFLPLIYFVVTRKNPFSFFA 345
Cdd:PRK11283 189 FRSVSETMFKVTHMVMRYAPVGVFALIA--------------------VTVANFGFAS---LWPLAKLVLLVYFAILFFA 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 346 GI----------FQAW----------ITALGTASSAGTLPvtfRCLE--ENLGIDKRVTRFVLPVGATINMDGTALYEAV 403
Cdd:PRK11283 246 LVvlgivarlcgLSIWilirilkdelILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSI 322

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 404 AAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDS 483
Cdd:PRK11283 323 AAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNA 402
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 48-499 7.25e-39

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 147.74  E-value: 7.25e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  48 FGVILGAVCGGLLRLaspIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYYMSTTII 126
Cdd:PRK01663  11 FQVLVAIIIGILLGH---FYPELGAQMKPLGDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 127 AAVLGVILVLAIHPGNpklkkqlgpgKKNDEVSSLDA--------------FLDLIRNLFPENLVQAcfqqiqtvtkkvl 192
Cdd:PRK01663  88 ALIIGLIVVNVVQPGA----------GMNIDPATLDAkavaqyaaqaheqgTVDFLMDIIPTTVVGA------------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 193 vapppdeeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEI 272
Cdd:PRK01663 145 ---------------------------------------FASG-DILQVLLFAVLFGFALARLGEKGKPVFDFIESLSHV 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 273 VMKLVIMIMWYSPLG----IACLIcGKIiAIKDLevvaRQLGMYMVTViigliihggiFLPLIYFV------VTRKNPFS 342
Cdd:PRK01663 185 LFGIVNMIMKLAPIGafgaMAFTI-GKY-GVGSL----VQLGQLIGCF----------YITCILFVfvvlgaIARLTGFS 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 343 FFAgiFQAWITA-----LGTASSAGTLPVTFRCLEeNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLD 417
Cdd:PRK01663 249 IFK--FIRYIKEellivLGTSSSESALPRMMEKME-KLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLS 325

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 418 GGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVG-LPTEDISLLVAVDWLLDRMRTSVNVVGDSFgAGIVYHLSKSE 496
Cdd:PRK01663 326 IGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNGV-ATVVVAKWEKE 404


                 ...
gi 767966325 497 LDT 499
Cdd:PRK01663 405 LDR 407
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 47-482 5.21e-35

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 136.72  E-value: 5.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  47 VFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYYMSTTI 125
Cdd:PRK13027  13 VIALVLGVALGAFF-------PHFAESLKPLGDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 126 IAAVLGVILVLAIHPG---NPKLKkQLGPGKKNDEVS---SLDAFLDLIRNLFPENLVQAcfqqiqtvtkkvlvapppde 199
Cdd:PRK13027  86 IALVIGLVLAYLTGPGvgmNIDLR-SLDAASLAGYAKnaqSLKGTAGFLLKLIPTTAVDA-------------------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 200 eanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIM 279
Cdd:PRK13027 145 --------------------------------FAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSHVLFRIMGF 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 280 IMWYSPLGIACLIC---GKIiAIKDLevvaRQLGMYMVTVIIGLIIhggiFLPLIYFVVTRKNPFSFFAGIF---QAWIT 353
Cdd:PRK13027 192 IIKLAPLGVLGAIAfttGKY-GVGSL----KQLGMLVAVFYLTCFV----FVVVVLGAVMRLAGFSVFKLIRylrEELLI 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 354 ALGTASSAGTLPVTFRCLEeNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASV 433
Cdd:PRK13027 263 VLGTASSDAVLPQVMRKLE-HMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVSLVTSK 341

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 767966325 434 GAASIPSAGLVTMLLILTAVG-LPTEDISLLVAVDWLLDRMRTSVNVVGD 482
Cdd:PRK13027 342 GAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGN 391
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 39-489 2.71e-23

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 102.98  E-value: 2.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  39 KNLLLTLTVF-GVILGAVCGGLLRLA----SPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRL 112
Cdd:COG1823   26 KHVSFSKRVFtGLGLGILFGLILQLIygagSPVIKQSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLkNASSLGKI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 113 GTRAMVYYMSTTIIAAVLGVILVLAIHpgnpklkkqlgpgkkndevssLDAfldlirnlfpENLVQAcfqqiqtvtkkvl 192
Cdd:COG1823  106 SGLIIGILLGTTAIAALVGILVALLFG---------------------LTA----------EGLTQG------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 193 vappPDEEANATSavvslLNETVTEVPEETkmVIKKGLE------FKD--GMNVLGLIG--FFIAF-GIA----MGKMGD 257
Cdd:COG1823  142 ----AAETARGEA-----LEERLGEVEDLS--LPQQILSfiptnpFADltGARPTSTIAvvIFAAFlGIAalglRRKKPE 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 258 QAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICgKIIAIKDLEVVArQLGMYmvtVIIGLIIHGGIFL-PLIYFVVT 336
Cdd:COG1823  211 QAETFLKGIDALQAIVMRLVRLVLRLTPYGVLALMT-KVVATSDFADIL-NLGKF---VVASYVALIIMFIvHLLLLALA 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 337 RKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTA-LYEAVAAIFIAQMNGV- 414
Cdd:COG1823  286 GLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGCAgIYPAMLAVMIAPTVGIn 365

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767966325 415 VLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNvVGDSFGAGIV 489
Cdd:COG1823  366 PLDPSFILTLIAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAGLLISIEPLIDMGRTALN-VSGSMTAGTV 439
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 237-483 3.62e-13

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 70.46  E-value: 3.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 237 NVLGLIGFFIAFGIAMGKMGDQAKlmvDFFNILNEIVMKLVIMIMWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTV 316
Cdd:PRK14695  60 NYIGILSWAVIFGIAMREASKNSK---ELLKTIADVTSKIVEWIINLAPFGILGLVF-KTISDKGVGSLA-NYGILLVLL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 317 IIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQ-AWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMD 395
Cdd:PRK14695 135 VTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRvSGVTAFFTRSSATNIPVNMK-LCHDLGLNPDTYSVSIPLGSTINMA 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 396 GTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRT 475
Cdd:PRK14695 214 GVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIGVIQD 293


                 ....*...
gi 767966325 476 SVNVVGDS 483
Cdd:PRK14695 294 SCETALNS 301
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 237-455 2.72e-11

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 65.66  E-value: 2.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 237 NVLGLIGFFIAFGIAMGKMGDQAKlmvDFFNILNEIVMKLVIMIMWYSPLGIACLICGkIIAIKDLEVVARQLGMYMVTV 316
Cdd:PRK13628 146 NYIGILAWAIGLGLALRHASDTTK---NVVNDLSEAVSQIVKWVIRFAPIGIFGLVAS-TLAETGFSALAGYAQLLAVLV 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 317 IIGLIIHGGiFLPLIYFVVTRKNPFSF-FAGIFQAWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMD 395
Cdd:PRK13628 222 GCMLFVALV-VNPLIVFWKIRRNPYPLvFTCLRESGVTAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMA 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 396 GTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLvtmLLILTAVGL 455
Cdd:PRK13628 300 GAAITITVLTLAAVHTLGIPVDLPTALLLSVVAAISACGASGVAGGSL---LLIPLACSL 356
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
50-455 1.92e-09

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 59.80  E-value: 1.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325  50 VILGAVCGGLLRLASPihpDVVMLIAFPGDILMRMLK----MLILPLIISSLitglsgldakASGRLGTRA-----MVYY 120
Cdd:COG3633   19 ILIGLVLGILLALLSP---EAAKSVGLLGTLFVGALKavapILVFVLVMSAI----------ANHKQGQKTnmkpiIVLY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 121 MSTTIIAAVLGVILvlaihpgnpklkkqlgpgkkndevssldAFLdlirnlFPENLVqacfqqiqtvtkkvLVAPppDEE 200
Cdd:COG3633   86 LLGTFLAALVAVVA----------------------------SFL------FPTTLT--------------LVAA--AAD 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 201 ANATSAVVSLLNETVTevpeetKMV------IKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMvdfFNILNEIVM 274
Cdd:COG3633  116 LTPPGGIGEVLKTLLL------NVVdnpvnaLANA-------NYIGILAWAIGLGLALRHASDTTKTV---LSDLSDAVS 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 275 KLVIMIMWYSPLGIACLICGKI------IAIKDLEVVARQLGMyMVTVIIGLIihggiflPLIYFVVTRKNPFSF-FAGI 347
Cdd:COG3633  180 KIVRWVIRFAPLGIFGLVASTVattgfsALLGYAHLLAVLVGC-MLFVALVVN-------PLIVFLKIRRNPYPLvFTCL 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966325 348 FQAWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMDGtalyeavAAIFIAQMN-------GVVLDGGQ 420
Cdd:COG3633  252 RESGITAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMAG-------AAITITVLTlaavhtlGIEVDLPT 323

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 767966325 421 IVTVSLTATLASVGAASIPSAGLvtmLLILTAVGL 455
Cdd:COG3633  324 ALLLSVVAAVSACGASGVAGGSL---LLIPLACSL 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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