|
Name |
Accession |
Description |
Interval |
E-value |
| ATF7IP_BD |
pfam16788 |
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ... |
572-783 |
6.78e-76 |
|
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.
Pssm-ID: 465271 [Multi-domain] Cd Length: 214 Bit Score: 247.67 E-value: 6.78e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 572 NVQSKRRRYMEEeyeaeFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQ 651
Cdd:pfam16788 1 KENVKRMKTSEQ-----INENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIATELQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 652 AKIARLTKRFEAAKEDLKKrhehpPNPPVSPGKTVND--VNSNNNMSYRNAGTVRQMLESKRNVSESAPpsFQTPVNTVS 729
Cdd:pfam16788 76 AKIARLTKRFKAALEDLKK-----CLPPNSPSSNAASkvANSNTINLYRNAGSVRSMLESKRSVGESSP--FQPPEKASK 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972164 730 STNLVTPPAVVSSQPKLQTPVTSGSLT----ATSVLPAPNTATVV---ATTQVPSGNPQPT 783
Cdd:pfam16788 149 KINLTSPQNEVVSESNNQDDVMLISVEspnlTTPVTSNPTDTRKVtsgNSSNSPSAETEVM 209
|
|
| PTZ00341 |
PTZ00341 |
Ring-infected erythrocyte surface antigen; Provisional |
327-582 |
1.75e-06 |
|
Ring-infected erythrocyte surface antigen; Provisional
Pssm-ID: 173534 [Multi-domain] Cd Length: 1136 Bit Score: 52.10 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 327 KNGADEKLEQIQSKDSLDEKNKADNNIDAN-EETLEtddtticsdrppEN-EKKVEEDIitelalgEDAISSSMEIDQGE 404
Cdd:PTZ00341 929 KNQNENVPEHLKEHAEANIEEDAEENVEEDaEENVE------------ENvEENVEENV-------EENVEENVEENVEE 989
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 405 KNEDETSADLVETINENViEDNKSENILENTDSMETDEIIPILEKLAPSEDEltcfsktsllPIDETNPDLEEKMESSFg 484
Cdd:PTZ00341 990 NVEENVEENVEENIEENV-EENVEENIEENVEEYDEENVEEVEENVEEYDEE----------NVEEIEENAEENVEENI- 1057
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 485 spskQESSESLPKEaflvlsDEEDIsgEKDESEVISQNetcspaeVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKR 564
Cdd:PTZ00341 1058 ----EENIEEYDEE------NVEEI--EENIEENIEEN-------VEENVEENVEEIEENVEENVEENAEENAEENAEEN 1118
|
250
....*....|....*...
gi 767972164 565 SKSEDMDNVQSKRRRYME 582
Cdd:PTZ00341 1119 AEEYDDENPEEHNEEYDE 1136
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
118-295 |
5.67e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 50.55 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 118 EPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGD------PASGVLASGDSTSGdPTSSEPSSSDAASGDATSGDAPSGD 191
Cdd:PHA03307 78 EAPANESRSTPTWSLSTLAPASPAREGSPTPPGPsspdppPPTPPPASPPPSPA-PDLSEMLRPVGSPGPPPAASPPAAG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 192 VSPGDATSGDAT---ADDLSSGDPTSSDPI--PGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGD 266
Cdd:PHA03307 157 ASPAAVASDAASsrqAALPLSSPEETARAPssPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236
|
170 180
....*....|....*....|....*....
gi 767972164 267 LSSSELASDDLATGELASDELTSESTFDR 295
Cdd:PHA03307 237 SDSSSSESSGCGWGPENECPLPRPAPITL 265
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
713-930 |
2.33e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.31 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 713 VSESAPPSFQTPVNTVSSTNLVTPPAvvSSQPKLQTPVTSGSLTATSVLPA---PNTATVVA--------TTQVPSGNPQ 781
Cdd:PHA03247 2752 GGPARPARPPTTAGPPAPAPPAAPAA--GPPRRLTRPAVASLSESRESLPSpwdPADPPAAVlapaaalpPAASPAGPLP 2829
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 782 PTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSP--PTVSGLTKNPVSLPSLPNPTKPNNVPSVP 859
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAParPPVRRLARPAVSRSTESFALPPDQPERPP 2909
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972164 860 SPSIQRNPTASA---APLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAA 930
Cdd:PHA03247 2910 QPQAPPPPQPQPqppPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
130-441 |
2.57e-04 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 44.90 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 130 VSKLPAEPVSGDPAPGDLDA------GDPASGVLASGDSTSGDPTSSEP-SSSDAASGDATSGDAPSGDVSPGDATSGDA 202
Cdd:NF033609 544 VPEQPDEPGEIEPIPEDSDSdpgsdsGSDSSNSDSGSDSGSDSTSDSGSdSASDSDSASDSDSASDSDSASDSDSASDSD 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 203 TADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGEL 282
Cdd:NF033609 624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 283 ASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLET 362
Cdd:NF033609 704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 363 DDTTICSDRPPENEKKVEEDIITELALGEDAIS---SSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSME 439
Cdd:NF033609 784 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSD 863
|
..
gi 767972164 440 TD 441
Cdd:NF033609 864 SE 865
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
716-945 |
1.05e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.98 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 716 SAPPSFQTPVNTVSSTNLVTP------PAVVSSQPKLQTPVTSGSLTATSVL--PAPNTATVVATTQVPSGNPQ------ 781
Cdd:pfam05109 422 SKAPESTTTSPTLNTTGFAAPntttglPSSTHVPTNLTAPASTGPTVSTADVtsPTPAGTTSGASPVTPSPSPRdngtes 501
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 782 --PTISLQPLPVILHVPVAVSSQPQLLQSHPGTlvTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVP 859
Cdd:pfam05109 502 kaPDMTSPTSAVTTPTPNATSPTPAVTTPTPNA--TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSP 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 860 SPSIQR-NPTASAAPLGTTlAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRgpiqmKIPISAFSTSSAAEQNSNTTP 938
Cdd:pfam05109 580 TSAVTTpTPNATSPTVGET-SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTG-----QHNITSSSTSSMSLRPSSISE 653
|
....*..
gi 767972164 939 RIENQTN 945
Cdd:pfam05109 654 TLSPSTS 660
|
|
| KLF10_11_N |
cd21974 |
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ... |
733-917 |
8.03e-03 |
|
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.
Pssm-ID: 409243 [Multi-domain] Cd Length: 229 Bit Score: 39.15 E-value: 8.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 733 LVTPPAVVSSQPKL-QTPVTSGSLT-ATSVLPAPNTATVVATTQVPSGNPQPTISLQPLP-------VILHV--PVAVSS 801
Cdd:cd21974 43 APESPKDFHSLSSLcMTPPYSPPFFeASHSPSVASLHPPSAASSQPPPEPESSEPPAASPqraqatsVIRHTadPVPVSP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 802 QPQLLQSHPgtlvtnqpsgnvefISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPlgtTLAVQ 881
Cdd:cd21974 123 PPVLCQMLP--------------VSSSSGVIVAFLKAPQQPSPQPQKPALPQPQVVLVGGQVPQGPVMLVVP---QPAVP 185
|
170 180 190
....*....|....*....|....*....|....*.
gi 767972164 882 AVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQM 917
Cdd:cd21974 186 QPYVQPTVVTPGGTKLLPIAPAPGFIPSGQSSAPQP 221
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ATF7IP_BD |
pfam16788 |
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ... |
572-783 |
6.78e-76 |
|
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.
Pssm-ID: 465271 [Multi-domain] Cd Length: 214 Bit Score: 247.67 E-value: 6.78e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 572 NVQSKRRRYMEEeyeaeFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQ 651
Cdd:pfam16788 1 KENVKRMKTSEQ-----INENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIATELQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 652 AKIARLTKRFEAAKEDLKKrhehpPNPPVSPGKTVND--VNSNNNMSYRNAGTVRQMLESKRNVSESAPpsFQTPVNTVS 729
Cdd:pfam16788 76 AKIARLTKRFKAALEDLKK-----CLPPNSPSSNAASkvANSNTINLYRNAGSVRSMLESKRSVGESSP--FQPPEKASK 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972164 730 STNLVTPPAVVSSQPKLQTPVTSGSLT----ATSVLPAPNTATVV---ATTQVPSGNPQPT 783
Cdd:pfam16788 149 KINLTSPQNEVVSESNNQDDVMLISVEspnlTTPVTSNPTDTRKVtsgNSSNSPSAETEVM 209
|
|
| PTZ00341 |
PTZ00341 |
Ring-infected erythrocyte surface antigen; Provisional |
327-582 |
1.75e-06 |
|
Ring-infected erythrocyte surface antigen; Provisional
Pssm-ID: 173534 [Multi-domain] Cd Length: 1136 Bit Score: 52.10 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 327 KNGADEKLEQIQSKDSLDEKNKADNNIDAN-EETLEtddtticsdrppEN-EKKVEEDIitelalgEDAISSSMEIDQGE 404
Cdd:PTZ00341 929 KNQNENVPEHLKEHAEANIEEDAEENVEEDaEENVE------------ENvEENVEENV-------EENVEENVEENVEE 989
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 405 KNEDETSADLVETINENViEDNKSENILENTDSMETDEIIPILEKLAPSEDEltcfsktsllPIDETNPDLEEKMESSFg 484
Cdd:PTZ00341 990 NVEENVEENVEENIEENV-EENVEENIEENVEEYDEENVEEVEENVEEYDEE----------NVEEIEENAEENVEENI- 1057
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 485 spskQESSESLPKEaflvlsDEEDIsgEKDESEVISQNetcspaeVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKR 564
Cdd:PTZ00341 1058 ----EENIEEYDEE------NVEEI--EENIEENIEEN-------VEENVEENVEEIEENVEENVEENAEENAEENAEEN 1118
|
250
....*....|....*...
gi 767972164 565 SKSEDMDNVQSKRRRYME 582
Cdd:PTZ00341 1119 AEEYDDENPEEHNEEYDE 1136
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
118-295 |
5.67e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 50.55 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 118 EPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGD------PASGVLASGDSTSGdPTSSEPSSSDAASGDATSGDAPSGD 191
Cdd:PHA03307 78 EAPANESRSTPTWSLSTLAPASPAREGSPTPPGPsspdppPPTPPPASPPPSPA-PDLSEMLRPVGSPGPPPAASPPAAG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 192 VSPGDATSGDAT---ADDLSSGDPTSSDPI--PGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGD 266
Cdd:PHA03307 157 ASPAAVASDAASsrqAALPLSSPEETARAPssPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236
|
170 180
....*....|....*....|....*....
gi 767972164 267 LSSSELASDDLATGELASDELTSESTFDR 295
Cdd:PHA03307 237 SDSSSSESSGCGWGPENECPLPRPAPITL 265
|
|
| PRK13108 |
PRK13108 |
prolipoprotein diacylglyceryl transferase; Reviewed |
150-299 |
2.68e-05 |
|
prolipoprotein diacylglyceryl transferase; Reviewed
Pssm-ID: 237284 [Multi-domain] Cd Length: 460 Bit Score: 47.67 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 150 GDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDvsPGDATSGDATADDLSS-------------------- 209
Cdd:PRK13108 278 GREAPGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVG--PGEPNQPDDVAEAVKAevaevtdevaaesvvqvadr 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 210 -GDPTSSDPIPGEPVPVEPISGDCAADDIASSEitsVDLASGAPASTDPAsdDLASGDLSSSELASDDLATGELAS---D 285
Cdd:PRK13108 356 dGESTPAVEETSEADIEREQPGDLAGQAPAAHQ---VDAEAASAAPEEPA--ALASEAHDETEPEVPEKAAPIPDPakpD 430
|
170
....*....|....
gi 767972164 286 ELTSESTFDRTFEP 299
Cdd:PRK13108 431 ELAVAGPGDDPAEP 444
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
327-692 |
6.51e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.06 E-value: 6.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 327 KNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSD--RPPENEKKVEEDIITELALGEDAISSSMEIDQGE 404
Cdd:PTZ00121 1437 KKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEeaKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAK 1516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 405 KNEDETSADLVETINE--------NVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDEtNPDLE 476
Cdd:PTZ00121 1517 KAEEAKKADEAKKAEEakkadeakKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIE 1595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 477 EKMEssFGSPSKQESSESLPKEAFLVLSDEEdISGEKDESEVISQNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEK 556
Cdd:PTZ00121 1596 EVMK--LYEEEKKMKAEEAKKAEEAKIKAEE-LKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEE 1672
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 557 NEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDInQKLQKVIQWLLEEKLCALQC---AVFDKTLAElKTR 633
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK-KKAEELKKAEEENKIKAEEAkkeAEEDKKKAE-EAK 1750
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 767972164 634 VEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEhppNPPVSPGKTVNDVNSN 692
Cdd:PTZ00121 1751 KDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDE---KRRMEVDKKIKDIFDN 1806
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
713-930 |
2.33e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.31 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 713 VSESAPPSFQTPVNTVSSTNLVTPPAvvSSQPKLQTPVTSGSLTATSVLPA---PNTATVVA--------TTQVPSGNPQ 781
Cdd:PHA03247 2752 GGPARPARPPTTAGPPAPAPPAAPAA--GPPRRLTRPAVASLSESRESLPSpwdPADPPAAVlapaaalpPAASPAGPLP 2829
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 782 PTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSP--PTVSGLTKNPVSLPSLPNPTKPNNVPSVP 859
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAParPPVRRLARPAVSRSTESFALPPDQPERPP 2909
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972164 860 SPSIQRNPTASA---APLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAA 930
Cdd:PHA03247 2910 QPQAPPPPQPQPqppPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
130-441 |
2.57e-04 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 44.90 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 130 VSKLPAEPVSGDPAPGDLDA------GDPASGVLASGDSTSGDPTSSEP-SSSDAASGDATSGDAPSGDVSPGDATSGDA 202
Cdd:NF033609 544 VPEQPDEPGEIEPIPEDSDSdpgsdsGSDSSNSDSGSDSGSDSTSDSGSdSASDSDSASDSDSASDSDSASDSDSASDSD 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 203 TADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGEL 282
Cdd:NF033609 624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 283 ASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLET 362
Cdd:NF033609 704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 363 DDTTICSDRPPENEKKVEEDIITELALGEDAIS---SSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSME 439
Cdd:NF033609 784 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSD 863
|
..
gi 767972164 440 TD 441
Cdd:NF033609 864 SE 865
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
134-260 |
5.83e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.82 E-value: 5.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 134 PAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLS---SG 210
Cdd:PRK07764 649 APEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQaaqGA 728
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 767972164 211 DPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASD 260
Cdd:PRK07764 729 SAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
716-945 |
1.05e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 42.98 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 716 SAPPSFQTPVNTVSSTNLVTP------PAVVSSQPKLQTPVTSGSLTATSVL--PAPNTATVVATTQVPSGNPQ------ 781
Cdd:pfam05109 422 SKAPESTTTSPTLNTTGFAAPntttglPSSTHVPTNLTAPASTGPTVSTADVtsPTPAGTTSGASPVTPSPSPRdngtes 501
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 782 --PTISLQPLPVILHVPVAVSSQPQLLQSHPGTlvTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVP 859
Cdd:pfam05109 502 kaPDMTSPTSAVTTPTPNATSPTPAVTTPTPNA--TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSP 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 860 SPSIQR-NPTASAAPLGTTlAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRgpiqmKIPISAFSTSSAAEQNSNTTP 938
Cdd:pfam05109 580 TSAVTTpTPNATSPTVGET-SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTG-----QHNITSSSTSSMSLRPSSISE 653
|
....*..
gi 767972164 939 RIENQTN 945
Cdd:pfam05109 654 TLSPSTS 660
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
129-321 |
1.14e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.91 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 129 PVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPtSSEPSSSDAASGDATSGDAPSGDVSPgdATSGDATADDLS 208
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAA-GAALAPKAAAAAAATRAEAPPAAPAP--PATADRGDDAAD 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 209 SGDPTSSDpipgEPVPVEPisgDCAADDIASSEITSVDLASGAPASTDPASddlASGDLSSSELASDDLATGELASDELT 288
Cdd:PRK07003 445 GDAPVPAK----ANARASA---DSRCDERDAQPPADSGSASAPASDAPPDA---AFEPAPRAAAPSAATPAAVPDARAPA 514
|
170 180 190
....*....|....*....|....*....|...
gi 767972164 289 SESTFDRtfepkSVPVCEPVPEIDNIEPSSNKD 321
Cdd:PRK07003 515 AASREDA-----PAAAAPPAPEARPPTPAAAAP 542
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
716-944 |
1.29e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.00 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 716 SAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHV 795
Cdd:PHA03247 2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 796 PVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSP--PTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASA-- 871
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAParPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPqp 2923
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 872 -----------------APLGTTLAVQAVPTAHSI-------------VQATRTSLPTVGPSGLYSPSTNRGPIQMKIP- 920
Cdd:PHA03247 2924 ppppqpqppppppprpqPPLAPTTDPAGAGEPSGAvpqpwlgalvpgrVAVPRFRVPQPAPSREAPASSTPPLTGHSLSr 3003
|
250 260
....*....|....*....|....
gi 767972164 921 ISAFSTSSAAEQNSNTTPRIENQT 944
Cdd:PHA03247 3004 VSSWASSLALHEETDPPPVSLKQT 3027
|
|
| PHA02664 |
PHA02664 |
hypothetical protein; Provisional |
134-290 |
1.65e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 177447 Cd Length: 534 Bit Score: 42.30 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 134 PAEP----VSGDPApgdLDAGDPASGVLASGDSTSGdptssePSSSDAASGDATSgdapsgdvSPGDATSGDATADDLSS 209
Cdd:PHA02664 368 PAEPaalfVDGNEV---IAAGAAAAMIAAAERAANG------ARGSPMAAPEEGR--------AAAAAAAANAPADQDVE 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 210 GDPtSSDPIPGEPVPVEPISGDCAADDIASSEIT-----------SVDLASGAPASTDPASDDLASGDLSSSELASDDLA 278
Cdd:PHA02664 431 AEA-HDEFDQDPGAPAHADRADSDEDDMDEQESGderadgeddsdSSYSYSTTSSEDESDSADDSWGDESDSGIEHDDGG 509
|
170
....*....|..
gi 767972164 279 TGELASDELTSE 290
Cdd:PHA02664 510 VGQAIEEEEEEE 521
|
|
| PTZ00341 |
PTZ00341 |
Ring-infected erythrocyte surface antigen; Provisional |
329-586 |
1.82e-03 |
|
Ring-infected erythrocyte surface antigen; Provisional
Pssm-ID: 173534 [Multi-domain] Cd Length: 1136 Bit Score: 42.47 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 329 GADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIitelalgEDAISSSMEIDQGEKNED 408
Cdd:PTZ00341 897 GGGKKDKKAKKKDAKDLSGNIAHEINLINKELKNQNENVPEHLKEHAEANIEEDA-------EENVEEDAEENVEENVEE 969
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 409 ETSADLVETINENViEDNKSENILENTDSMETDEIIPILEklapsedeltcfsktsllpiDETNPDLEEKMESSFGSPSK 488
Cdd:PTZ00341 970 NVEENVEENVEENV-EENVEENVEENVEENVEENIEENVE--------------------ENVEENIEENVEEYDEENVE 1028
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 489 QESSESLPKEAFLVLSDEEDIsgEKDESEVISQN----ETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKR 564
Cdd:PTZ00341 1029 EVEENVEEYDEENVEEIEENA--EENVEENIEENieeyDEENVEEIEENIEENIEENVEENVEENVEEIEENVEENVEEN 1106
|
250 260
....*....|....*....|..
gi 767972164 565 SKSEDMDNVQSKRRRYMEEEYE 586
Cdd:PTZ00341 1107 AEENAEENAEENAEEYDDENPE 1128
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
723-929 |
2.52e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 41.48 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 723 TPVNTVSSTNLVTPPAVVSSQPKLQ--TPVTSGSLTATSVLPAPNTATVVATTqvpSGNPQPTISLQPLPVILHVPVAVS 800
Cdd:pfam17823 117 AAASSSPSSAAQSLPAAIAALPSEAfsAPRAAACRANASAAPRAAIAAASAPH---AASPAPRTAASSTTAASSTTAASS 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 801 SQPQLLQSHPGTLV-----------TNQPSGNVEFISVQSPPTVSGL------TKNPVSLPSL----------------- 846
Cdd:pfam17823 194 APTTAASSAPATLTpargistaataTGHPAAGTALAAVGNSSPAAGTvtaavgTVTPAALATLaaaagtvasaagtinmg 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 847 -PNPTKPNNVPSVPSPSIQRNPTASAAPlgttlavqavPTAHSIVQATrTSLPTVGPSGLYSPSTNRGPIQMKIPISAFS 925
Cdd:pfam17823 274 dPHARRLSPAKHMPSDTMARNPAAPMGA----------QAQGPIIQVS-TDQPVHNTAGEPTPSPSNTTLEPNTPKSVAS 342
|
....
gi 767972164 926 TSSA 929
Cdd:pfam17823 343 TNLA 346
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
127-276 |
2.77e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.70 E-value: 2.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 127 PEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSgdvSPGDATSGDATADD 206
Cdd:PHA03307 205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPT---RIWEASGWNGPSSR 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972164 207 LSSGDPTSSDPIP-GEPVPVEPISGDCAADDIASSEITSVDlaSGAPASTDPASDdlASGDLSSSELASDD 276
Cdd:PHA03307 282 PGPASSSSSPRERsPSPSPSSPGSGPAPSSPRASSSSSSSR--ESSSSSTSSSSE--SSRGAAVSPGPSPS 348
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
693-926 |
3.10e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.68 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 693 NNMSYRNAGTVRQMLESKRNVSES---APPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATV 769
Cdd:pfam03154 153 DNESDSDSSAQQQILQTQPPVLQAqsgAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQ 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 770 VATTQVPSGNPQPTISLQPLPV---------------ILHVPvaVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVS 834
Cdd:pfam03154 233 QTPTLHPQRLPSPHPPLQPMTQppppsqvspqplpqpSLHGQ--MPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVP 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 835 GLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGT-------TLAVQAVPTAHSIVQATRTSlptvGPSGLYS 907
Cdd:pfam03154 311 PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMphikpppTTPIPQLPNPQSHKHPPHLS----GPSPFQM 386
|
250
....*....|....*....
gi 767972164 908 PSTNRGPIQMKiPISAFST 926
Cdd:pfam03154 387 NSNLPPPPALK-PLSSLST 404
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
118-276 |
4.71e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.92 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 118 EPLSPHNITPEPVSklPAEPVSGDP---APGDLDAGDPASGVLASGDSTSG---DPTSSEPSSSDAASGDATSGDAPSGD 191
Cdd:PHA03307 18 GEFFPRPPATPGDA--ADDLLSGSQgqlVSDSAELAAVTVVAGAAACDRFEpptGPPPGPGTEAPANESRSTPTWSLSTL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 192 VSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSE 271
Cdd:PHA03307 96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP 175
|
....*
gi 767972164 272 LASDD 276
Cdd:PHA03307 176 LSSPE 180
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
325-608 |
6.55e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.51 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 325 LEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTicsdRPPENEKKVEEDIITELALGEDAISSSMEIDQGE 404
Cdd:PTZ00121 1680 AKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEEL----KKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE 1755
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 405 KN-------EDETSADLVETINENVIEDNKSENilENTDSMETDEIIPilEKLAPSEDELTCFSKTSLLPIDETNPDLEE 477
Cdd:PTZ00121 1756 KKkiahlkkEEEKKAEEIRKEKEAVIEEELDEE--DEKRRMEVDKKIK--DIFDNFANIIEGGKEGNLVINDSKEMEDSA 1831
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 478 KMESSFGSPSKQESSESLPKEAFlvlsDEEDISGEKDESEVISqnetcspaeveSNEKDNKPEEEEQVIHEDDERPSEKN 557
Cdd:PTZ00121 1832 IKEVADSKNMQLEEADAFEKHKF----NKNNENGEDGNKEADF-----------NKEKDLKEDDEEEIEEADEIEKIDKD 1896
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 767972164 558 EFSRRKRSKSEDMDNVQSKRRRYMEEEYEaefqvkitaKGDINQKLQKVIQ 608
Cdd:PTZ00121 1897 DIEREIPNNNMAGKNNDIIDDKLDKDEYI---------KRDAEETREEIIK 1938
|
|
| KLF10_11_N |
cd21974 |
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ... |
733-917 |
8.03e-03 |
|
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.
Pssm-ID: 409243 [Multi-domain] Cd Length: 229 Bit Score: 39.15 E-value: 8.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 733 LVTPPAVVSSQPKL-QTPVTSGSLT-ATSVLPAPNTATVVATTQVPSGNPQPTISLQPLP-------VILHV--PVAVSS 801
Cdd:cd21974 43 APESPKDFHSLSSLcMTPPYSPPFFeASHSPSVASLHPPSAASSQPPPEPESSEPPAASPqraqatsVIRHTadPVPVSP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 802 QPQLLQSHPgtlvtnqpsgnvefISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPlgtTLAVQ 881
Cdd:cd21974 123 PPVLCQMLP--------------VSSSSGVIVAFLKAPQQPSPQPQKPALPQPQVVLVGGQVPQGPVMLVVP---QPAVP 185
|
170 180 190
....*....|....*....|....*....|....*.
gi 767972164 882 AVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQM 917
Cdd:cd21974 186 QPYVQPTVVTPGGTKLLPIAPAPGFIPSGQSSAPQP 221
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
374-671 |
8.58e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 40.05 E-value: 8.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 374 ENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDS--METDEIIPILEKLA 451
Cdd:PRK03918 165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKevKELEELKEEIEELE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 452 PSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEA--------FLVLSDEEDISGEKDESEVISQ-- 521
Cdd:PRK03918 245 KELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAeeyiklseFYEEYLDELREIEKRLSRLEEEin 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 522 --NETCSPAEvESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDI 599
Cdd:PRK03918 325 giEERIKELE-EKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEI 403
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972164 600 NQKLQKVIQWL--LEEKLCALQCAVFDKTLAELKTRVEKIECNKRH-KTVLTELQAKIARLTKR---FEAAKEDLKKR 671
Cdd:PRK03918 404 EEEISKITARIgeLKKEIKELKKAIEELKKAKGKCPVCGRELTEEHrKELLEEYTAELKRIEKElkeIEEKERKLRKE 481
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
730-966 |
9.55e-03 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 39.52 E-value: 9.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 730 STNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPL-PVILHVPVAVSSQPQLLQS 808
Cdd:cd22540 181 SNTNSASLQVPGNVIKLQSGGNVALTLPVNNLVGTQDGATQLQLAAAPSKPSKKIRKKSAqAAQPAVTVAEQVETVLIET 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 809 HPGTLVtnQPSGNVEFisVQSPPTvsgltknpvslpslpnptkpnNVPSVPSPSIQrnptasAAPLGTTLAVQAVPTAHS 888
Cdd:cd22540 261 TADNII--QAGNNLLI--VQSPGT---------------------GQPAVLQQVQV------LQPKQEQQVVQIPQQALR 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 889 IVQATRTSLPTVGPSGLYSPSTNRG---PIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGN 965
Cdd:cd22540 310 VVQAASATLPTVPQKPLQNIQIQNSeptPTQVYIKTPSGEVQTVLLQEAPAATATPSSSTSTVQQQVTANNGTGTSKPNY 389
|
.
gi 767972164 966 A 966
Cdd:cd22540 390 N 390
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
718-900 |
9.74e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 39.75 E-value: 9.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 718 PPSFQTPVNTVSSTNLVTPP---AVVSSQPKLQTPVTSGSLTATSVLPAPNT----------------ATVVATTQVPSG 778
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTPPsqsQLQSQQPPREQPLPPAPLSMPHIKPPPTTpipqlpnpqshkhpphLSGPSPFQMNSN 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972164 779 NPQPTiSLQPL--------PVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTvSGLTKNPVSLPSLPNPT 850
Cdd:pfam03154 390 LPPPP-ALKPLsslsthhpPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPT-SGLHQVPSQSPFPQHPF 467
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 767972164 851 KPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTV 900
Cdd:pfam03154 468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPV 517
|
|
| |
