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Conserved domains on  [gi|767972284|ref|XP_011519109|]
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pregnancy zone protein isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
 744-830 4.15e-38

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


:

Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 136.95  E-value: 4.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  744 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 823
Cdd:pfam00207   1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80


                  ....*..
gi 767972284  824 LPKCIRG 830
Cdd:pfam00207  81 LDKCLKV 87
A2M_BRD pfam07703
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ...
 455-603 3.55e-31

Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.


:

Pssm-ID: 462235 [Multi-domain]  Cd Length: 139  Bit Score: 118.99  E-value: 3.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  455 IHLEPVAGTLPCGHTETITAHYTLNRQAMGElselSFHYLIMAKGVIVRSGthtlpvesgDMKGSFALSFPVESDVAPIA 534
Cdd:pfam07703   1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVG---------RGGVTTSFSLPVTAEMAPSA 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972284  535 RMFIFAI---LPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLM 603
Cdd:pfam07703  68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
 346-441 1.01e-29

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


:

Pssm-ID: 465507  Cd Length: 95  Bit Score: 113.11  E-value: 1.01e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  346 LKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSiSVNKLFVRVFTVHPN 425
Cdd:pfam17789   1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79

                          90
                  ....*....|....*.
gi 767972284  426 LCFHYSWVAEDHQGAQ 441
Cdd:pfam17789  80 LCPEHQALAEMYAEAY 95
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
 222-309 2.68e-28

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


:

Pssm-ID: 465509  Cd Length: 83  Bit Score: 108.51  E-value: 2.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  222 EFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSrvlncDKQEVCEEFSQQLNSNGCITQQVH 301
Cdd:pfam17791   1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDD-----SKRKCFESFSKELDKDGCGSASLS 75


                  ....*...
gi 767972284  302 TKMLQITN 309
Cdd:pfam17791  76 TEEFQLTF 83
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 128-220 4.13e-25

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


:

Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 100.08  E-value: 4.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQ 207
Cdd:pfam01835   2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81

                          90
                  ....*....|....
gi 767972284  208 TESGGRI-QHPFTV 220
Cdd:pfam01835  82 DGAGGSLgSGSFRV 95
 
Name Accession Description Interval E-value
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
 744-830 4.15e-38

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 136.95  E-value: 4.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  744 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 823
Cdd:pfam00207   1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80


                  ....*..
gi 767972284  824 LPKCIRG 830
Cdd:pfam00207  81 LDKCLKV 87
A2M_BRD pfam07703
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ...
 455-603 3.55e-31

Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.


Pssm-ID: 462235 [Multi-domain]  Cd Length: 139  Bit Score: 118.99  E-value: 3.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  455 IHLEPVAGTLPCGHTETITAHYTLNRQAMGElselSFHYLIMAKGVIVRSGthtlpvesgDMKGSFALSFPVESDVAPIA 534
Cdd:pfam07703   1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVG---------RGGVTTSFSLPVTAEMAPSA 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972284  535 RMFIFAI---LPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLM 603
Cdd:pfam07703  68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
 346-441 1.01e-29

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


Pssm-ID: 465507  Cd Length: 95  Bit Score: 113.11  E-value: 1.01e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  346 LKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSiSVNKLFVRVFTVHPN 425
Cdd:pfam17789   1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79

                          90
                  ....*....|....*.
gi 767972284  426 LCFHYSWVAEDHQGAQ 441
Cdd:pfam17789  80 LCPEHQALAEMYAEAY 95
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
 222-309 2.68e-28

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


Pssm-ID: 465509  Cd Length: 83  Bit Score: 108.51  E-value: 2.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  222 EFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSrvlncDKQEVCEEFSQQLNSNGCITQQVH 301
Cdd:pfam17791   1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDD-----SKRKCFESFSKELDKDGCGSASLS 75


                  ....*...
gi 767972284  302 TKMLQITN 309
Cdd:pfam17791  76 TEEFQLTF 83
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 128-220 4.13e-25

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 100.08  E-value: 4.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQ 207
Cdd:pfam01835   2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81

                          90
                  ....*....|....
gi 767972284  208 TESGGRI-QHPFTV 220
Cdd:pfam01835  82 DGAGGSLgSGSFRV 95
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 128-326 7.59e-17

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 85.90  E-value: 7.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELiPLIY-LENPRRNRIAQwQSLKL-EAGINQLSFPLSSEPIQGSYRVV 205
Cdd:COG2373   371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLeLTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  206 VQTESGGRI-QHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGL-ATVSLCRKLS----------- 272
Cdd:COG2373   449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkVEGEVTLRPArtafpgypgyr 528

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972284  273 --RVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQitNTGFEMKLRVEARIREEG 326
Cdd:COG2373   529 fgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAP--DAPGPLRATVEASVFESG 582
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 122-196 4.63e-03

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 40.83  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  122 LNTQSLVFVQTDKPMYKPGQTVRFRVVSvdenfrprneliP-----LIYLEnprRNRIAQWQSLKLEAGINQLSFPLSSE 196
Cdd:COG2373   720 AERPDRLELSLDKESYKPGETAKLLIQS------------PfagraLVTVE---RDGVLETQWVDVKGGGTTVEIPVTED 784
 
Name Accession Description Interval E-value
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
 744-830 4.15e-38

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 136.95  E-value: 4.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  744 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 823
Cdd:pfam00207   1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80


                  ....*..
gi 767972284  824 LPKCIRG 830
Cdd:pfam00207  81 LDKCLKV 87
A2M_BRD pfam07703
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ...
 455-603 3.55e-31

Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.


Pssm-ID: 462235 [Multi-domain]  Cd Length: 139  Bit Score: 118.99  E-value: 3.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  455 IHLEPVAGTLPCGHTETITAHYTLNRQAMGElselSFHYLIMAKGVIVRSGthtlpvesgDMKGSFALSFPVESDVAPIA 534
Cdd:pfam07703   1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVG---------RGGVTTSFSLPVTAEMAPSA 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972284  535 RMFIFAI---LPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLM 603
Cdd:pfam07703  68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
 346-441 1.01e-29

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


Pssm-ID: 465507  Cd Length: 95  Bit Score: 113.11  E-value: 1.01e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  346 LKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSiSVNKLFVRVFTVHPN 425
Cdd:pfam17789   1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79

                          90
                  ....*....|....*.
gi 767972284  426 LCFHYSWVAEDHQGAQ 441
Cdd:pfam17789  80 LCPEHQALAEMYAEAY 95
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
 222-309 2.68e-28

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


Pssm-ID: 465509  Cd Length: 83  Bit Score: 108.51  E-value: 2.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  222 EFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSrvlncDKQEVCEEFSQQLNSNGCITQQVH 301
Cdd:pfam17791   1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDD-----SKRKCFESFSKELDKDGCGSASLS 75


                  ....*...
gi 767972284  302 TKMLQITN 309
Cdd:pfam17791  76 TEEFQLTF 83
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 128-220 4.13e-25

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 100.08  E-value: 4.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQ 207
Cdd:pfam01835   2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81

                          90
                  ....*....|....
gi 767972284  208 TESGGRI-QHPFTV 220
Cdd:pfam01835  82 DGAGGSLgSGSFRV 95
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 128-326 7.59e-17

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 85.90  E-value: 7.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  128 VFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELiPLIY-LENPRRNRIAQwQSLKL-EAGINQLSFPLSSEPIQGSYRVV 205
Cdd:COG2373   371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLeLTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  206 VQTESGGRI-QHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGL-ATVSLCRKLS----------- 272
Cdd:COG2373   449 LYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkVEGEVTLRPArtafpgypgyr 528

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972284  273 --RVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQitNTGFEMKLRVEARIREEG 326
Cdd:COG2373   529 fgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAP--DAPGPLRATVEASVFESG 582
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 122-196 4.63e-03

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 40.83  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972284  122 LNTQSLVFVQTDKPMYKPGQTVRFRVVSvdenfrprneliP-----LIYLEnprRNRIAQWQSLKLEAGINQLSFPLSSE 196
Cdd:COG2373   720 AERPDRLELSLDKESYKPGETAKLLIQS------------PfagraLVTVE---RDGVLETQWVDVKGGGTTVEIPVTED 784
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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