NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767983117|ref|XP_011519458|]
View 

C-myc promoter-binding protein isoform X8 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 13925073)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 308-492 2.38e-81

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 264.82  E-value: 2.38e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117   308 HTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLP 387
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117   388 LSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFI 467
Cdd:pfam02141   81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                          170       180
                   ....*....|....*....|....*.
gi 767983117   468 VGIDSRYFDLYDPPP-DVSCVDVDTN 492
Cdd:pfam02141  161 IGVHSRYFDLLEDPLdDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 559-632 1.46e-22

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 92.35  E-value: 1.46e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767983117    559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATdaaslFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEEC 632
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVIT-----FDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 194-276 1.13e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 85.08  E-value: 1.13e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117    194 LCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECwpsNSKYPLPVFSTFVLTGASAEKVYGAAI 273
Cdd:smart00800   10 VVGLDSDTGPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFVT---QTSSKDPQFFSFVLTDIDGSRRYGFCL 86


                    ...
gi 767983117    274 QFY 276
Cdd:smart00800   87 RFY 89
PPR_2 super family cl38385
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 808-848 4.73e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


The actual alignment was detected with superfamily member pfam13041:

Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 41.97  E-value: 4.73e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767983117   808 PDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITY 848
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 308-492 2.38e-81

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 264.82  E-value: 2.38e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117   308 HTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLP 387
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117   388 LSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFI 467
Cdd:pfam02141   81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                          170       180
                   ....*....|....*....|....*.
gi 767983117   468 VGIDSRYFDLYDPPP-DVSCVDVDTN 492
Cdd:pfam02141  161 IGVHSRYFDLLEDPLdDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 309-492 1.08e-66

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 222.84  E-value: 1.08e-66
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117    309 TNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHvLPIEKHISHFMHkvPFPSPQRPRILVQLSPHDNLILSQPVSSPLPL 388
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSN-LPLELLISLLLY--PVPPPGGSLVLVSLGPGDLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117    389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIV 468
Cdd:smart00799   78 IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 767983117    469 GIDSRYFDLYDPPP--DVSCVDVDTN 492
Cdd:smart00799  158 GVHSSYFEEVKELPdeDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 559-632 1.46e-22

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 92.35  E-value: 1.46e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767983117    559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATdaaslFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEEC 632
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVIT-----FDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 194-276 1.13e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 85.08  E-value: 1.13e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117    194 LCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECwpsNSKYPLPVFSTFVLTGASAEKVYGAAI 273
Cdd:smart00800   10 VVGLDSDTGPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFVT---QTSSKDPQFFSFVLTDIDGSRRYGFCL 86


                    ...
gi 767983117    274 QFY 276
Cdd:smart00800   87 RFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 212-273 2.26e-15

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 71.49  E-value: 2.26e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767983117   212 LICRYPQEDYESFSLPESVPLFCLPMGAtieCWPSNSKyplPVFSTFVLTGASAEKVYGAAI 273
Cdd:pfam03456    3 VLDRYPEDDWSDPPLPDGIPMFCFPEGL---ETLSSRE---PTFFSFVLTDEDGSRLYGACL 58
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 599-648 2.43e-15

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 71.07  E-value: 2.43e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767983117   599 FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSdkDASLAFFDDC 648
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 808-848 4.73e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 41.97  E-value: 4.73e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767983117   808 PDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITY 848
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 308-492 2.38e-81

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 264.82  E-value: 2.38e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117   308 HTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLP 387
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117   388 LSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFI 467
Cdd:pfam02141   81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                          170       180
                   ....*....|....*....|....*.
gi 767983117   468 VGIDSRYFDLYDPPP-DVSCVDVDTN 492
Cdd:pfam02141  161 IGVHSRYFDLLEDPLdDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 309-492 1.08e-66

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 222.84  E-value: 1.08e-66
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117    309 TNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHvLPIEKHISHFMHkvPFPSPQRPRILVQLSPHDNLILSQPVSSPLPL 388
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSN-LPLELLISLLLY--PVPPPGGSLVLVSLGPGDLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117    389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIV 468
Cdd:smart00799   78 IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 767983117    469 GIDSRYFDLYDPPP--DVSCVDVDTN 492
Cdd:smart00799  158 GVHSSYFEEVKELPdeDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 559-632 1.46e-22

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 92.35  E-value: 1.46e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767983117    559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATdaaslFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEEC 632
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVIT-----FDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 194-276 1.13e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 85.08  E-value: 1.13e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983117    194 LCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECwpsNSKYPLPVFSTFVLTGASAEKVYGAAI 273
Cdd:smart00800   10 VVGLDSDTGPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFVT---QTSSKDPQFFSFVLTDIDGSRRYGFCL 86


                    ...
gi 767983117    274 QFY 276
Cdd:smart00800   87 RFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 212-273 2.26e-15

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 71.49  E-value: 2.26e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767983117   212 LICRYPQEDYESFSLPESVPLFCLPMGAtieCWPSNSKyplPVFSTFVLTGASAEKVYGAAI 273
Cdd:pfam03456    3 VLDRYPEDDWSDPPLPDGIPMFCFPEGL---ETLSSRE---PTFFSFVLTDEDGSRLYGACL 58
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 599-648 2.43e-15

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 71.07  E-value: 2.43e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767983117   599 FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSdkDASLAFFDDC 648
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 808-848 4.73e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 41.97  E-value: 4.73e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767983117   808 PDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITY 848
Cdd:pfam13041    1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH