|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
888-1149 |
1.53e-58 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 204.51 E-value: 1.53e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 888 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 965
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 966 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 1040
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 1041 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1118
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225
|
250 260 270
....*....|....*....|....*....|.
gi 767987211 1119 LNLSQNNITDLGAYKLAEALPSLAASLLRLR 1149
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLS 256
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
513-682 |
3.24e-51 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 177.88 E-value: 3.24e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 513 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 591
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 592 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 669
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|...
gi 767987211 670 MEQAQAYVMRYFE 682
Cdd:pfam05729 152 ESDRKQYVRKYFS 164
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
428-1199 |
4.41e-10 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 64.06 E-value: 4.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 428 NKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHR 507
Cdd:COG5635 88 ESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 508 RPRET--------RVIAVLGKAGQGKS----YWAgavSRAWACGRLPQYDFVFSVPCHCLNRPGDaygLQDLLFSLGPQP 575
Cdd:COG5635 168 ESLKRlelleakkKRLLILGEPGSGKTtllrYLA---LELAERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKR 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 576 LVAADEVFSHILKRpDRVLLILDGFEELeaqdgflhstcgPAPAEPCSLRGLLAGLFQKklLRGCTLLLTARPRGRLVQS 655
Cdd:COG5635 242 GGEPEDALERLLRN-GRLLLLLDGLDEV------------PDEADRDEVLNQLRRFLER--YPKARVIITSRPEGYDSSE 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 656 LSKADAlFELSGFSMEQAQAYVMRYFESsgMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLsealleLGEDAKLPST 735
Cdd:COG5635 307 LEGFEV-LELAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNPLLLTLLALL------LRERGELPDT 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 736 LTGLYVGLL---------GRAALDSPPGALAE----LAKLAWELgrrHQStlQEDQFPSADVRTWAMAKGLVQHPPRAAE 802
Cdd:COG5635 378 RAELYEQFVelllerwdeQRGLTIYRELSREElrelLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEALL 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 803 SELAFPSFLLQC---------------FLGALWLAlsgeikdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLI--FQPP 865
Cdd:COG5635 453 DELLLRTGLLVErgegrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLddVKQI 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 866 ARCLGALL-GPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDA 944
Cdd:COG5635 525 KELIDALLaRDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLL 604
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 945 HVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLScvtRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSL 1024
Cdd:COG5635 605 LLLLLLLLLLLLALALLLALLLLLLLLLLAELLLL---ALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAEL 681
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 1025 KDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVS 1104
Cdd:COG5635 682 LLALLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAV 761
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 1105 QLSATFPQLKSLETLNLSQN-NITDLGAYKLAEALPSLAASLLRLRDGGTRLFPEPRGGGFWKANHVRQLLPALSLTCRS 1183
Cdd:COG5635 762 LLASLLLALLLLSLLLLLVLlLALALLASLLLALLLLILLLVLLGSLLLLRLLDDLALLLLLALAAARLLLSSLALVALE 841
|
810
....*....|....*.
gi 767987211 1184 VFHCHLLVGLGIAPLA 1199
Cdd:COG5635 842 LARASLGASLVLLALL 857
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
812-917 |
1.56e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 42.66 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 812 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 880
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 767987211 881 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 917
Cdd:pfam17776 81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1113-1140 |
9.07e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.77 E-value: 9.07e-04
10 20
....*....|....*....|....*...
gi 767987211 1113 LKSLETLNLSQNNITDLGAYKLAEALPS 1140
Cdd:smart00368 1 NPSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
1084-1133 |
3.07e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.45 E-value: 3.07e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767987211 1084 SLQHLDLdalSENKIGDEGVsqlsatFPQLKSLETLNLSQNN-ITDLGAYK 1133
Cdd:pfam12799 2 NLEVLDL---SNNQITDIPP------LAKLPNLETLDLSGNNkITDLSDLA 43
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
888-1149 |
1.53e-58 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 204.51 E-value: 1.53e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 888 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 965
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 966 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 1040
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 1041 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1118
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225
|
250 260 270
....*....|....*....|....*....|.
gi 767987211 1119 LNLSQNNITDLGAYKLAEALPSLAASLLRLR 1149
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLS 256
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
513-682 |
3.24e-51 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 177.88 E-value: 3.24e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 513 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 591
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 592 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 669
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|...
gi 767987211 670 MEQAQAYVMRYFE 682
Cdd:pfam05729 152 ESDRKQYVRKYFS 164
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
428-1199 |
4.41e-10 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 64.06 E-value: 4.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 428 NKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHR 507
Cdd:COG5635 88 ESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 508 RPRET--------RVIAVLGKAGQGKS----YWAgavSRAWACGRLPQYDFVFSVPCHCLNRPGDaygLQDLLFSLGPQP 575
Cdd:COG5635 168 ESLKRlelleakkKRLLILGEPGSGKTtllrYLA---LELAERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKR 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 576 LVAADEVFSHILKRpDRVLLILDGFEELeaqdgflhstcgPAPAEPCSLRGLLAGLFQKklLRGCTLLLTARPRGRLVQS 655
Cdd:COG5635 242 GGEPEDALERLLRN-GRLLLLLDGLDEV------------PDEADRDEVLNQLRRFLER--YPKARVIITSRPEGYDSSE 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 656 LSKADAlFELSGFSMEQAQAYVMRYFESsgMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLsealleLGEDAKLPST 735
Cdd:COG5635 307 LEGFEV-LELAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNPLLLTLLALL------LRERGELPDT 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 736 LTGLYVGLL---------GRAALDSPPGALAE----LAKLAWELgrrHQStlQEDQFPSADVRTWAMAKGLVQHPPRAAE 802
Cdd:COG5635 378 RAELYEQFVelllerwdeQRGLTIYRELSREElrelLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEALL 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 803 SELAFPSFLLQC---------------FLGALWLAlsgeikdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLI--FQPP 865
Cdd:COG5635 453 DELLLRTGLLVErgegrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLddVKQI 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 866 ARCLGALL-GPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDA 944
Cdd:COG5635 525 KELIDALLaRDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLL 604
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 945 HVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLScvtRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSL 1024
Cdd:COG5635 605 LLLLLLLLLLLLALALLLALLLLLLLLLLAELLLL---ALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAEL 681
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 1025 KDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVS 1104
Cdd:COG5635 682 LLALLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAV 761
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 1105 QLSATFPQLKSLETLNLSQN-NITDLGAYKLAEALPSLAASLLRLRDGGTRLFPEPRGGGFWKANHVRQLLPALSLTCRS 1183
Cdd:COG5635 762 LLASLLLALLLLSLLLLLVLlLALALLASLLLALLLLILLLVLLGSLLLLRLLDDLALLLLLALAAARLLLSSLALVALE 841
|
810
....*....|....*.
gi 767987211 1184 VFHCHLLVGLGIAPLA 1199
Cdd:COG5635 842 LARASLGASLVLLALL 857
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1075-1138 |
2.62e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 51.33 E-value: 2.62e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767987211 1075 LVRILTAFSSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL 1138
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL 344
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1075-1174 |
5.05e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 50.56 E-value: 5.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 1075 LVRILTAFSSLQHLDLdalSENKIGDEGVSQLsATFPQL-KSLETLNLSQNNITDLGAYKLAEALpsLAASLLRLRDGGT 1153
Cdd:COG5238 340 LAKALQENTTLHSLDL---SDNQIGDEGAIAL-AKYLEGnTTLRELNLGKNNIGKQGAEALIDAL--QTNRLHTLILDGN 413
|
90 100
....*....|....*....|.
gi 767987211 1154 RLFPEPRGGGFWKANHVRQLL 1174
Cdd:COG5238 414 LIGAEAQQRLEQLLERIKSVY 434
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1083-1138 |
6.66e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 50.17 E-value: 6.66e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767987211 1083 SSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL 1138
Cdd:COG5238 264 TTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL 316
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1079-1131 |
3.28e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.62 E-value: 3.28e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767987211 1079 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDLGA 1131
Cdd:COG4886 132 LANLTNLKELDL---SNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTDLPE 176
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1079-1129 |
4.63e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.24 E-value: 4.63e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767987211 1079 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDL 1129
Cdd:COG4886 201 LGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL 243
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1086-1138 |
8.82e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 46.32 E-value: 8.82e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767987211 1086 QHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL 1138
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL 232
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
812-917 |
1.56e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 42.66 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987211 812 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 880
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 767987211 881 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 917
Cdd:pfam17776 81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
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|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1079-1131 |
2.18e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.31 E-value: 2.18e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767987211 1079 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDLGA 1131
Cdd:COG4886 109 LSNLTNLESLDL---SGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPE 153
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|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1079-1131 |
3.78e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.54 E-value: 3.78e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767987211 1079 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDLGA 1131
Cdd:COG4886 178 LGNLTNLKELDL---SNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPE 222
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1068-1138 |
4.13e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 4.13e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767987211 1068 GPQAFPKLVRILTAFSSLQhldldaLSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL 1138
Cdd:COG5238 196 GIEELAEALTQNTTVTTLW------LKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1079-1131 |
4.90e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.15 E-value: 4.90e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767987211 1079 LTAFSSLQHLDLdalSENKIgdegvSQLSATFPQLKSLETLNLSQNNITDLGA 1131
Cdd:COG4886 155 LGNLTNLKSLDL---SNNQL-----TDLPEELGNLTNLKELDLSNNQITDLPE 199
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|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1093-1138 |
6.35e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 43.63 E-value: 6.35e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767987211 1093 LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL 1138
Cdd:COG5238 327 LAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL 372
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1113-1140 |
9.07e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.77 E-value: 9.07e-04
10 20
....*....|....*....|....*...
gi 767987211 1113 LKSLETLNLSQNNITDLGAYKLAEALPS 1140
Cdd:smart00368 1 NPSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1077-1141 |
1.07e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.08 E-value: 1.07e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767987211 1077 RILTAFS-SLQHLDLdalSENKIGDegVSQLSAtfpqLKSLETLNLSQNNITDLGAykLAEALPSL 1141
Cdd:cd21340 113 RSLAALSnSLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDLEE--LLDLLSSW 167
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|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1079-1150 |
1.76e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 42.23 E-value: 1.76e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767987211 1079 LTAFSSLQHLDLdalSENKIGDegVSQLSatfpQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLRD 1150
Cdd:COG4886 224 LANLTNLETLDL---SNNQLTD--LPELG----NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
1084-1133 |
3.07e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.45 E-value: 3.07e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767987211 1084 SLQHLDLdalSENKIGDEGVsqlsatFPQLKSLETLNLSQNN-ITDLGAYK 1133
Cdd:pfam12799 2 NLEVLDL---SNNQITDIPP------LAKLPNLETLDLSGNNkITDLSDLA 43
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