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Conserved domains on  [gi|767987524|ref|XP_011520915|]
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putative E3 ubiquitin-protein ligase UNKL isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_CCCH_5 super family cl39722
Unkempt Zinc finger domain 1 (Znf1); This is CCCH zinc finger 1 domain found in Unkempt ...
 25-60 3.31e-13

Unkempt Zinc finger domain 1 (Znf1); This is CCCH zinc finger 1 domain found in Unkempt N-terminal region. Unkempt is an evolutionary conserved RNA-binding protein that regulates translation of its target genes and is required for the establishment of the early bipolar neuronal morphology. It carries six CCCH zinc fingers (ZnFs) forming two compact clusters, ZnF1-3 and ZnF4-6, that recognize distinct trinucleotide RNA substrates. These clusters, recognize an unexpectedly short stretch of RNA sequence-only three consecutive ribonucleotides-with a varying degree of specificity. ZnF1-3 binds to the UUA motif of RNA substrates.


The actual alignment was detected with superfamily member pfam18384:

Pssm-ID: 375810  Cd Length: 40  Bit Score: 63.33  E-value: 3.31e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767987524   25 YRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQ 60
Cdd:pfam18384   1 YHYLKNFRVRQCPRFLQHHCPAHKPMTCFDWHFDNQ 36
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
306-332 1.22e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 36.02  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*..
gi 767987524  306 YKSTKCNDMRQTGYCPRGPFCAFAHVE 332
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
 
Name Accession Description Interval E-value
zf_CCCH_5 pfam18384
Unkempt Zinc finger domain 1 (Znf1); This is CCCH zinc finger 1 domain found in Unkempt ...
 25-60 3.31e-13

Unkempt Zinc finger domain 1 (Znf1); This is CCCH zinc finger 1 domain found in Unkempt N-terminal region. Unkempt is an evolutionary conserved RNA-binding protein that regulates translation of its target genes and is required for the establishment of the early bipolar neuronal morphology. It carries six CCCH zinc fingers (ZnFs) forming two compact clusters, ZnF1-3 and ZnF4-6, that recognize distinct trinucleotide RNA substrates. These clusters, recognize an unexpectedly short stretch of RNA sequence-only three consecutive ribonucleotides-with a varying degree of specificity. ZnF1-3 binds to the UUA motif of RNA substrates.


Pssm-ID: 375810  Cd Length: 40  Bit Score: 63.33  E-value: 3.31e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767987524   25 YRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQ 60
Cdd:pfam18384   1 YHYLKNFRVRQCPRFLQHHCPAHKPMTCFDWHFDNQ 36
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
306-332 1.22e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 36.02  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*..
gi 767987524  306 YKSTKCNDMRQTGYCPRGPFCAFAHVE 332
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
 
Name Accession Description Interval E-value
zf_CCCH_5 pfam18384
Unkempt Zinc finger domain 1 (Znf1); This is CCCH zinc finger 1 domain found in Unkempt ...
 25-60 3.31e-13

Unkempt Zinc finger domain 1 (Znf1); This is CCCH zinc finger 1 domain found in Unkempt N-terminal region. Unkempt is an evolutionary conserved RNA-binding protein that regulates translation of its target genes and is required for the establishment of the early bipolar neuronal morphology. It carries six CCCH zinc fingers (ZnFs) forming two compact clusters, ZnF1-3 and ZnF4-6, that recognize distinct trinucleotide RNA substrates. These clusters, recognize an unexpectedly short stretch of RNA sequence-only three consecutive ribonucleotides-with a varying degree of specificity. ZnF1-3 binds to the UUA motif of RNA substrates.


Pssm-ID: 375810  Cd Length: 40  Bit Score: 63.33  E-value: 3.31e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767987524   25 YRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQ 60
Cdd:pfam18384   1 YHYLKNFRVRQCPRFLQHHCPAHKPMTCFDWHFDNQ 36
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
306-332 1.22e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 36.02  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*..
gi 767987524  306 YKSTKCNDMRQTGYCPRGPFCAFAHVE 332
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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