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Conserved domains on  [gi|767987554|ref|XP_011520927|]
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calpain-15 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CysPc cd00044
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. ...
544-859 2.40e-119

Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.


:

Pssm-ID: 238004 [Multi-domain]  Cd Length: 315  Bit Score: 371.28  E-value: 2.40e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  544 NIVAFCRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRatWSVFHTLRPSDILQGLLGNCW 621
Cdd:cd00044     1 TLLQICLLSGVLFEDPDFPPNDSSLGFDdsLSNGQPKKVIEWKRPSEIFADDGNSNP--RLFVNGASPSDVCQGILGDCW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  622 FLSALAVLAERPDLVERVMVTRSL---CAEGAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALA 698
Cdd:cd00044    79 FLAALAALAERPELLKRVIPPDQSfeeNYAGIYHFRFWKNGEWVEVVIDDRLPTSNGGLLFMHSRDRNELWVALLEKAYA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  699 KLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTnpreePVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVddsAYES 778
Cdd:cd00044   159 KLHGSYEALVGGNTAEALEDLTGGPTERIDLKSADA-----SSGDNDLFALLLSFLQGGSLIGCSTGSRSEEE---ARTA 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  779 LGLRPRHAYSILDVRDVQ--GTRLLRLRNPWGRFSWNGSWSDEWPHW--PGHLRGELMPHGSSEGVFWMEYGDFVRYFDS 854
Cdd:cd00044   231 NGLVKGHAYSVLDVREVQeeGLRLLRLRNPWGVGEWWGGWSDDSSEWwvIDAERKKLLLSGKDDGEFWMSFEDFLRNFDG 310

                  ....*
gi 767987554  855 VDICK 859
Cdd:cd00044   311 LYVCN 315
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
73-97 2.70e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.22  E-value: 2.70e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554     73 GEWSCVRCTFLNPAGQRQCSICEAP 97
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
482-506 5.48e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 38.07  E-value: 5.48e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554    482 GQWACPACTLLNALRAKHCAACHTP 506
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
213-237 9.12e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.68  E-value: 9.12e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554    213 GGWACPRCTLHNTPVASSCSVCGGP 237
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
412-435 8.44e-03

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 35.02  E-value: 8.44e-03
                           10        20
                   ....*....|....*....|....
gi 767987554   412 WSCAKCTLRNPTVAPRCSACGCSK 435
Cdd:pfam00641    5 WDCSKCLVQNFATSTKCVACQAPK 28
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
141-363 9.23e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  141 PAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEKEEQEEEEGAAEP--RGGWACP 218
Cdd:PRK07764  591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDasDGGDGWP 670
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  219 RCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAPAGfHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVP 298
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG-QADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPP 749
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767987554  299 PFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAP----QGSGWAGASRLAELLSGKRL 363
Cdd:PRK07764  750 DPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDdedrRDAEEVAMELLEEELGAKKI 818
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
115-137 9.63e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.60  E-value: 9.63e-03
                            10        20
                    ....*....|....*....|...
gi 767987554    115 KWPCARCTFRNFLGKEACEVCGF 137
Cdd:smart00547    2 DWECPACTFLNFASRSKCFACGA 24
 
Name Accession Description Interval E-value
CysPc cd00044
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. ...
544-859 2.40e-119

Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.


Pssm-ID: 238004 [Multi-domain]  Cd Length: 315  Bit Score: 371.28  E-value: 2.40e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  544 NIVAFCRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRatWSVFHTLRPSDILQGLLGNCW 621
Cdd:cd00044     1 TLLQICLLSGVLFEDPDFPPNDSSLGFDdsLSNGQPKKVIEWKRPSEIFADDGNSNP--RLFVNGASPSDVCQGILGDCW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  622 FLSALAVLAERPDLVERVMVTRSL---CAEGAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALA 698
Cdd:cd00044    79 FLAALAALAERPELLKRVIPPDQSfeeNYAGIYHFRFWKNGEWVEVVIDDRLPTSNGGLLFMHSRDRNELWVALLEKAYA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  699 KLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTnpreePVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVddsAYES 778
Cdd:cd00044   159 KLHGSYEALVGGNTAEALEDLTGGPTERIDLKSADA-----SSGDNDLFALLLSFLQGGSLIGCSTGSRSEEE---ARTA 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  779 LGLRPRHAYSILDVRDVQ--GTRLLRLRNPWGRFSWNGSWSDEWPHW--PGHLRGELMPHGSSEGVFWMEYGDFVRYFDS 854
Cdd:cd00044   231 NGLVKGHAYSVLDVREVQeeGLRLLRLRNPWGVGEWWGGWSDDSSEWwvIDAERKKLLLSGKDDGEFWMSFEDFLRNFDG 310

                  ....*
gi 767987554  855 VDICK 859
Cdd:cd00044   311 LYVCN 315
Peptidase_C2 pfam00648
Calpain family cysteine protease;
556-859 4.00e-113

Calpain family cysteine protease;


Pssm-ID: 459889 [Multi-domain]  Cd Length: 295  Bit Score: 353.73  E-value: 4.00e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554   556 FVDDSFPPGPESVGFPAGDSVQQRVrQWLRPQEINCS-VFRDHRATwsvfhtlrPSDILQGLLGNCWFLSALAVLAERPD 634
Cdd:pfam00648    1 FEDPEFPADDSSLGYPPSPPPPRGV-EWKRPKEICSNpQFIVDGAS--------RFDICQGELGDCWLLAAIASLTLNPK 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554   635 LVERVMVTR---SLCAEGAYQVRLCKDGTWTTVLVDDMLPCdEAGCLLFSQ-AQRKQLWVALIEKALAKLHGSYFALQAG 710
Cdd:pfam00648   72 LLERVVPPDqsfEENYAGIFHFRFWRFGEWVDVVIDDRLPT-RNGKLLFVHsRDKNEFWSALLEKAYAKLHGSYEALKGG 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554   711 RAIEGLATLTGAPCESLALQLSSTNpreepvdtdlIWAKMLSSKEAGFLMGASCGGGNMKvDDSAYESLGLRPRHAYSIL 790
Cdd:pfam00648  151 STSEALEDFTGGVAESYDLKEPPPN----------LFEILLKALERGSLMGCSIDATSAA-EEEARTPNGLVKGHAYSVT 219
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767987554   791 DVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICK 859
Cdd:pfam00648  220 GVRKVnlkgGKVRLIRLRNPWGEVEWNGAWSDGSPEWqtvSPEEKEELGLTKKDDGEFWMSFEDFLKYFTDLEICN 295
CysPc smart00230
Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). ...
542-869 3.13e-112

Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit).


Pssm-ID: 128526  Cd Length: 318  Bit Score: 352.40  E-value: 3.13e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    542 WENIVAFCRENNVSFVDDSFPPGPESVGFpagDSVQQRVRQWLRPQEINCSvfrdhrATWSVFhTLRPSDILQGLLGNCW 621
Cdd:smart00230    1 YEALRQYCKESGTLFEDPLFPANNGSLFF---SQRQRKFVVWKRPHEIFEN------PPFIVG-GASRTDICQGVLGDCW 70
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    622 FLSALAVLAERPDLVERVMV-TRSLCAE--GAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALA 698
Cdd:smart00230   71 LLAALASLTLREKLLDRVIPhDQEFSENyaGIFHFRFWRFGKWVDVVIDDRLPTYNGELVFMHSNSRNEFWSALLEKAYA 150
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    699 KLHGSYFALQAGRAIEGLATLTGAPCESLALQlsstnprEEPVDTDLIWAKMLSSKEAGFLMGASCGGGNmKVDDSAYES 778
Cdd:smart00230  151 KLNGCYEALKGGSTTEALEDLTGGVAESIDLK-------EASKDPDNLFEDLFKAFERGSLMGCSIGAGT-AVEEEEQKD 222
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    779 LGLRPRHAYSILDVRDVQGTR--LLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYGDFVRYFD 853
Cdd:smart00230  223 CGLVKGHAYSVTDVREVQGRRqeLLRLRNPWGQVEWNGPWSDDSPEWrsvSASEKKNLGLTFDDDGEFWMSFEDFLRHFD 302
                           330
                    ....*....|....*.
gi 767987554    854 SVDICKVHSDWQEARV 869
Cdd:smart00230  303 KVEICNLNPDSLEERS 318
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
73-97 2.70e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.22  E-value: 2.70e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554     73 GEWSCVRCTFLNPAGQRQCSICEAP 97
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
482-506 5.48e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 38.07  E-value: 5.48e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554    482 GQWACPACTLLNALRAKHCAACHTP 506
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
480-506 6.29e-04

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.10  E-value: 6.29e-04
                           10        20
                   ....*....|....*....|....*..
gi 767987554   480 RPGQWACPACTLLNALRAKHCAACHTP 506
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAP 27
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
213-237 9.12e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.68  E-value: 9.12e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554    213 GGWACPRCTLHNTPVASSCSVCGGP 237
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
412-435 8.44e-03

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 35.02  E-value: 8.44e-03
                           10        20
                   ....*....|....*....|....
gi 767987554   412 WSCAKCTLRNPTVAPRCSACGCSK 435
Cdd:pfam00641    5 WDCSKCLVQNFATSTKCVACQAPK 28
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
141-363 9.23e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  141 PAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEKEEQEEEEGAAEP--RGGWACP 218
Cdd:PRK07764  591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDasDGGDGWP 670
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  219 RCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAPAGfHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVP 298
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG-QADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPP 749
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767987554  299 PFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAP----QGSGWAGASRLAELLSGKRL 363
Cdd:PRK07764  750 DPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDdedrRDAEEVAMELLEEELGAKKI 818
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
115-137 9.63e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.60  E-value: 9.63e-03
                            10        20
                    ....*....|....*....|...
gi 767987554    115 KWPCARCTFRNFLGKEACEVCGF 137
Cdd:smart00547    2 DWECPACTFLNFASRSKCFACGA 24
 
Name Accession Description Interval E-value
CysPc cd00044
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. ...
544-859 2.40e-119

Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.


Pssm-ID: 238004 [Multi-domain]  Cd Length: 315  Bit Score: 371.28  E-value: 2.40e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  544 NIVAFCRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRatWSVFHTLRPSDILQGLLGNCW 621
Cdd:cd00044     1 TLLQICLLSGVLFEDPDFPPNDSSLGFDdsLSNGQPKKVIEWKRPSEIFADDGNSNP--RLFVNGASPSDVCQGILGDCW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  622 FLSALAVLAERPDLVERVMVTRSL---CAEGAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALA 698
Cdd:cd00044    79 FLAALAALAERPELLKRVIPPDQSfeeNYAGIYHFRFWKNGEWVEVVIDDRLPTSNGGLLFMHSRDRNELWVALLEKAYA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  699 KLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTnpreePVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVddsAYES 778
Cdd:cd00044   159 KLHGSYEALVGGNTAEALEDLTGGPTERIDLKSADA-----SSGDNDLFALLLSFLQGGSLIGCSTGSRSEEE---ARTA 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  779 LGLRPRHAYSILDVRDVQ--GTRLLRLRNPWGRFSWNGSWSDEWPHW--PGHLRGELMPHGSSEGVFWMEYGDFVRYFDS 854
Cdd:cd00044   231 NGLVKGHAYSVLDVREVQeeGLRLLRLRNPWGVGEWWGGWSDDSSEWwvIDAERKKLLLSGKDDGEFWMSFEDFLRNFDG 310

                  ....*
gi 767987554  855 VDICK 859
Cdd:cd00044   311 LYVCN 315
Peptidase_C2 pfam00648
Calpain family cysteine protease;
556-859 4.00e-113

Calpain family cysteine protease;


Pssm-ID: 459889 [Multi-domain]  Cd Length: 295  Bit Score: 353.73  E-value: 4.00e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554   556 FVDDSFPPGPESVGFPAGDSVQQRVrQWLRPQEINCS-VFRDHRATwsvfhtlrPSDILQGLLGNCWFLSALAVLAERPD 634
Cdd:pfam00648    1 FEDPEFPADDSSLGYPPSPPPPRGV-EWKRPKEICSNpQFIVDGAS--------RFDICQGELGDCWLLAAIASLTLNPK 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554   635 LVERVMVTR---SLCAEGAYQVRLCKDGTWTTVLVDDMLPCdEAGCLLFSQ-AQRKQLWVALIEKALAKLHGSYFALQAG 710
Cdd:pfam00648   72 LLERVVPPDqsfEENYAGIFHFRFWRFGEWVDVVIDDRLPT-RNGKLLFVHsRDKNEFWSALLEKAYAKLHGSYEALKGG 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554   711 RAIEGLATLTGAPCESLALQLSSTNpreepvdtdlIWAKMLSSKEAGFLMGASCGGGNMKvDDSAYESLGLRPRHAYSIL 790
Cdd:pfam00648  151 STSEALEDFTGGVAESYDLKEPPPN----------LFEILLKALERGSLMGCSIDATSAA-EEEARTPNGLVKGHAYSVT 219
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767987554   791 DVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICK 859
Cdd:pfam00648  220 GVRKVnlkgGKVRLIRLRNPWGEVEWNGAWSDGSPEWqtvSPEEKEELGLTKKDDGEFWMSFEDFLKYFTDLEICN 295
CysPc smart00230
Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). ...
542-869 3.13e-112

Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit).


Pssm-ID: 128526  Cd Length: 318  Bit Score: 352.40  E-value: 3.13e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    542 WENIVAFCRENNVSFVDDSFPPGPESVGFpagDSVQQRVRQWLRPQEINCSvfrdhrATWSVFhTLRPSDILQGLLGNCW 621
Cdd:smart00230    1 YEALRQYCKESGTLFEDPLFPANNGSLFF---SQRQRKFVVWKRPHEIFEN------PPFIVG-GASRTDICQGVLGDCW 70
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    622 FLSALAVLAERPDLVERVMV-TRSLCAE--GAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALA 698
Cdd:smart00230   71 LLAALASLTLREKLLDRVIPhDQEFSENyaGIFHFRFWRFGKWVDVVIDDRLPTYNGELVFMHSNSRNEFWSALLEKAYA 150
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    699 KLHGSYFALQAGRAIEGLATLTGAPCESLALQlsstnprEEPVDTDLIWAKMLSSKEAGFLMGASCGGGNmKVDDSAYES 778
Cdd:smart00230  151 KLNGCYEALKGGSTTEALEDLTGGVAESIDLK-------EASKDPDNLFEDLFKAFERGSLMGCSIGAGT-AVEEEEQKD 222
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554    779 LGLRPRHAYSILDVRDVQGTR--LLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYGDFVRYFD 853
Cdd:smart00230  223 CGLVKGHAYSVTDVREVQGRRqeLLRLRNPWGQVEWNGPWSDDSPEWrsvSASEKKNLGLTFDDDGEFWMSFEDFLRHFD 302
                           330
                    ....*....|....*.
gi 767987554    854 SVDICKVHSDWQEARV 869
Cdd:smart00230  303 KVEICNLNPDSLEERS 318
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
73-97 2.70e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.22  E-value: 2.70e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554     73 GEWSCVRCTFLNPAGQRQCSICEAP 97
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
482-506 5.48e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 38.07  E-value: 5.48e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554    482 GQWACPACTLLNALRAKHCAACHTP 506
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
480-506 6.29e-04

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.10  E-value: 6.29e-04
                           10        20
                   ....*....|....*....|....*..
gi 767987554   480 RPGQWACPACTLLNALRAKHCAACHTP 506
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAP 27
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
213-237 9.12e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.68  E-value: 9.12e-04
                            10        20
                    ....*....|....*....|....*
gi 767987554    213 GGWACPRCTLHNTPVASSCSVCGGP 237
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
412-435 8.44e-03

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 35.02  E-value: 8.44e-03
                           10        20
                   ....*....|....*....|....
gi 767987554   412 WSCAKCTLRNPTVAPRCSACGCSK 435
Cdd:pfam00641    5 WDCSKCLVQNFATSTKCVACQAPK 28
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
141-363 9.23e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  141 PAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEKEEQEEEEGAAEP--RGGWACP 218
Cdd:PRK07764  591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDasDGGDGWP 670
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987554  219 RCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAPAGfHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVP 298
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG-QADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPP 749
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767987554  299 PFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAP----QGSGWAGASRLAELLSGKRL 363
Cdd:PRK07764  750 DPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDdedrRDAEEVAMELLEEELGAKKI 818
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
115-137 9.63e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.60  E-value: 9.63e-03
                            10        20
                    ....*....|....*....|...
gi 767987554    115 KWPCARCTFRNFLGKEACEVCGF 137
Cdd:smart00547    2 DWECPACTFLNFASRSKCFACGA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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