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Conserved domains on  [gi|767989273|ref|XP_011521115|]
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ER membrane protein complex subunit 8 isoform X2 [Homo sapiens]

Protein Classification

ER membrane protein complex subunit 8/9 family protein( domain architecture ID 11144097)

ER membrane protein complex (EMC) subunit 8/9 family protein is a component of the EMC that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized multi-pass membrane proteins like rhodopsins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UPF0172 pfam03665
Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 ...
 4-103 4.53e-48

Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.


:

Pssm-ID: 461011  Cd Length: 189  Bit Score: 153.16  E-value: 4.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989273    4 VKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKehlplggpgahhTLFVDCIPLFHGTLALAPMLEVALTLIDSWCK 83
Cdd:pfam03665   1 VEISTRAYAKILLHAAKYPHCAVNGVLLGKKSKDGS------------VEITDAIPLFHHWLTLSPMLEVALTQIDAYAK 68

                          90       100
                  ....*....|....*....|
gi 767989273   84 DHSYVIAGYYQANERVKDAS 103
Cdd:pfam03665  69 SKGLVIVGYYQANERLDDTS 88
 
Name Accession Description Interval E-value
UPF0172 pfam03665
Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 ...
 4-103 4.53e-48

Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.


Pssm-ID: 461011  Cd Length: 189  Bit Score: 153.16  E-value: 4.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989273    4 VKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKehlplggpgahhTLFVDCIPLFHGTLALAPMLEVALTLIDSWCK 83
Cdd:pfam03665   1 VEISTRAYAKILLHAAKYPHCAVNGVLLGKKSKDGS------------VEITDAIPLFHHWLTLSPMLEVALTQIDAYAK 68

                          90       100
                  ....*....|....*....|
gi 767989273   84 DHSYVIAGYYQANERVKDAS 103
Cdd:pfam03665  69 SKGLVIVGYYQANERLDDTS 88
MPN_UPF0172 cd08060
Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); ...
 6-103 1.15e-47

Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); This family includes Noc4p (neighbor of COX4; neighbor of Cytochrome c Oxidase 4; nucleolar complex associated 4 homolog) which belongs to the family of unknown function, UPF0172, with MPN/JAMM-like domains. Proteins in this family are homologs of the NOC4 gene which is conserved in eukaryotic members including human, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice. NOC4 highly expressed in the pancreas and moderately in liver, heart, lung, kidney, brain, skeletal muscle, and placenta. This nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.


Pssm-ID: 163691  Cd Length: 182  Bit Score: 152.06  E-value: 1.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989273   6 LTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPrkehlplggpgaHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDH 85
Cdd:cd08060    1 LSTLAYVKMLLHAAKYPHCAVNGLLLGKKSSG------------GSVEITDAVPLFHSCLALAPMLEVALALVDAYCKSS 68

                         90
                 ....*....|....*...
gi 767989273  86 SYVIAGYYQANERVKDAS 103
Cdd:cd08060   69 GLVIVGYYQANERLDDSS 86
 
Name Accession Description Interval E-value
UPF0172 pfam03665
Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 ...
 4-103 4.53e-48

Uncharacterized protein family (UPF0172); In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.


Pssm-ID: 461011  Cd Length: 189  Bit Score: 153.16  E-value: 4.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989273    4 VKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKehlplggpgahhTLFVDCIPLFHGTLALAPMLEVALTLIDSWCK 83
Cdd:pfam03665   1 VEISTRAYAKILLHAAKYPHCAVNGVLLGKKSKDGS------------VEITDAIPLFHHWLTLSPMLEVALTQIDAYAK 68

                          90       100
                  ....*....|....*....|
gi 767989273   84 DHSYVIAGYYQANERVKDAS 103
Cdd:pfam03665  69 SKGLVIVGYYQANERLDDTS 88
MPN_UPF0172 cd08060
Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); ...
 6-103 1.15e-47

Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p); This family includes Noc4p (neighbor of COX4; neighbor of Cytochrome c Oxidase 4; nucleolar complex associated 4 homolog) which belongs to the family of unknown function, UPF0172, with MPN/JAMM-like domains. Proteins in this family are homologs of the NOC4 gene which is conserved in eukaryotic members including human, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice. NOC4 highly expressed in the pancreas and moderately in liver, heart, lung, kidney, brain, skeletal muscle, and placenta. This nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.


Pssm-ID: 163691  Cd Length: 182  Bit Score: 152.06  E-value: 1.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989273   6 LTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPrkehlplggpgaHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDH 85
Cdd:cd08060    1 LSTLAYVKMLLHAAKYPHCAVNGLLLGKKSSG------------GSVEITDAVPLFHSCLALAPMLEVALALVDAYCKSS 68

                         90
                 ....*....|....*...
gi 767989273  86 SYVIAGYYQANERVKDAS 103
Cdd:cd08060   69 GLVIVGYYQANERLDDSS 86
MPN cd07767
Mpr1p, Pad1p N-terminal (MPN) domains; MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+) ...
 12-98 1.24e-17

Mpr1p, Pad1p N-terminal (MPN) domains; MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+) domains are found in the N-terminal termini of proteins with a variety of functions; they are components of the proteasome regulatory subunits, the signalosome (CSN), eukaryotic translation initiation factor 3 (eIF3) complexes, and regulators of transcription factors. These domains are isopeptidases that release ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. Catalytically active MPN domains contain a metalloprotease signature known as the JAB1/MPN/Mov34 metalloenzyme (JAMM) motif. For example, Rpn11 (also known as POH1 or PSMD14), a subunit of the 19S proteasome lid is involved in the ATP-dependent degradation of ubiquitinated proteins, contains the conserved JAMM motif involved in zinc ion coordination. Poh1 is a regulator of c-Jun, an important regulator of cell proliferation, differentiation, survival and death. JAB1 is a component of the COP9 signalosome (CSN), a regulatory particle of the ubiquitin (Ub)/26S proteasome system occurring in all eukaryotic cells; it cleaves the ubiquitin-like protein NEDD8 from the cullin subunit of the SCF (Skp1, Cullins, F-box proteins) family of E3 ubiquitin ligases. AMSH (associated molecule with the SH3 domain of STAM, also known as STAMBP), a member of JAMM/MPN+ deubiquitinases (DUBs), specifically cleaves Lys 63-linked polyubiquitin (poly-Ub) chains, thus facilitating the recycling and subsequent trafficking of receptors to the cell surface. Similarly, BRCC36, part of the nuclear complex that includes BRCA1 protein and is targeted to DNA damage foci after irradiation, specifically disassembles K63-linked polyUb. BRCC36 is aberrantly expressed in sporadic breast tumors, indicative of a potential role in the pathogenesis of the disease. Some variants of the JAB1/MPN domains lack key residues in their JAMM motif and are unable to coordinate a metal ion. Comparisons of key catalytic and metal binding residues explain why the MPN-containing proteins Mov34/PSMD7, Rpn8, CSN6, Prp8p, and the translation initiation factor 3 subunits f (p47) and h (p40) do not show catalytic isopeptidase activity. It has been proposed that the MPN domain in these proteins has a primarily structural function.


Pssm-ID: 163686 [Multi-domain]  Cd Length: 116  Bit Score: 73.31  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989273  12 CKMVLHGAKYPH-CAVNGLLVAEKQkprkehlplggpgaHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIA 90
Cdd:cd07767    1 LKMFLDAAKSINgKEVIGLLYGSKT--------------KKVLDVDEVIAVPFDEGDKDDNVWFLMYLDFKKLNAGLRIV 66


                 ....*...
gi 767989273  91 GYYQANER 98
Cdd:cd07767   67 GWYHTHPK 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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