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Conserved domains on  [gi|767994883|ref|XP_011523151|]
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leucine-rich repeat-containing protein 37A2 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 2.36e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.10  E-value: 2.36e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883   560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 3.48e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 3.48e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994883   892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1018 2.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886   116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883  946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKL 1018
Cdd:COG4886   191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEEL 255
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 206-704 1.69e-12

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 72.04  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767994883  634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 1.78e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 55.06  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767994883   689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
 
Name Accession Description Interval E-value
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 2.36e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.10  E-value: 2.36e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883   560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 3.48e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 3.48e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994883   892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1018 2.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886   116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883  946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKL 1018
Cdd:COG4886   191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEEL 255
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 206-704 1.69e-12

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 72.04  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767994883  634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 251-319 1.16e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 61.23  E-value: 1.16e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994883   251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 1.78e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 55.06  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767994883   689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 874-978 4.76e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 4.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340    77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767994883  938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340   143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
 
Name Accession Description Interval E-value
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 2.36e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.10  E-value: 2.36e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883   560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 3.48e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 3.48e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994883   892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1018 2.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886   116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883  946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKL 1018
Cdd:COG4886   191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEEL 255
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 206-704 1.69e-12

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 72.04  E-value: 1.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767994883  634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1006 5.66e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  868 TILNFQGNYISYIDGNVWKAYSwTEKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERhTFEPLPFLKFINLSCN 947
Cdd:COG4886   162 KSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN 238

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767994883  948 VITELSfgtfqAWHGMQFLHKLILNHNPLTTVedPYLFKLPALKYLDMGTTlvPLTTLK 1006
Cdd:COG4886   239 QLTDLP-----ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNN--QLTDLK 288
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 251-319 1.16e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 61.23  E-value: 1.16e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994883   251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 352-429 3.99e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 59.68  E-value: 3.99e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767994883   352 EHELSISEQQQPVQPSESPREVEssptqqetpGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVV---------AQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEA 69
LRR_8 pfam13855
Leucine rich repeat;
914-976 5.44e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.44e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883   914 SLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFqawHGMQFLHKLILNHNPL 976
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 1.78e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 55.06  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767994883   689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PHA03247 PHA03247
large tegument protein UL36; Provisional
 190-752 1.05e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  190 PYPGSLPPELRVKS-------DEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPqlleeePSSMQQEAP 262
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppprpaPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  263 alPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVevtiTSEPTNETESSQAQQETPIQFPEEVEPSATQQEA 342
Cdd:PHA03247 2628 --PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA----RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADP 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  343 PIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQP-----PEHHEVTVSPPGHHQTHHLASPSVSVKPPDV 417
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  418 QLTIAAEPSAevgtslvhQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQetsfqSPEPINNENPSPTQQE 497
Cdd:PHA03247 2782 RLTRPAVASL--------SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT-----SAQPTAPPPPPGPPPP 2848

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  498 AAAEHPQTAEEGESSlthQEAPAQTPEFPNVVVAQPPEhSHLTQATVQPLDLGFTITPESKTEvelsPTMKETPTQPPKK 577
Cdd:PHA03247 2849 SLPLGGSVAPGGDVR---RRPPSRSPAAKPAAPARPPV-RRLARPAVSRSTESFALPPDQPER----PPQPQAPPPPQPQ 2920

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  578 VVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSH 657
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  658 LTRATVQPLDLGFTITPksmtevepstalmttAPPPGHPEVTL-PPSDKGQAQHSHLTQATVQPLDLEltiTTKPTTEVK 736
Cdd:PHA03247 3001 LSRVSSWASSLALHEET---------------DPPPVSLKQTLwPPDDTEDSDADSLFDSDSERSDLE---ALDPLPPEP 3062

                         570
                  ....*....|....*.
gi 767994883  737 PSPTTEETSTQPPDLG 752
Cdd:PHA03247 3063 HDPFAHEPDPATPEAG 3078
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
900-1018 1.14e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  900 NLTEL---HKDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLSCNVITEL--SFGTFQAwhgmqfLHKLILNHN 974
Cdd:COG4886    97 NLTELdlsGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLpePLGNLTN------LKSLDLSNN 169

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767994883  975 PLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTVELEKL 1018
Cdd:COG4886   170 QLTDLPEE-LGNLTNLKELDLSNN--QITDLPEPLGNLTNLEEL 210
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 508-565 1.19e-07

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 49.67  E-value: 1.19e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883   508 EGESSLTHQEAPAQTPEFPNVVVAQPP---------------EHSHLTQATVQPLDLGFTITPESKTEVELSP 565
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPvhhevtvptpgqgqaQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
823-1018 6.87e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 6.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  823 KASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLT 902
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  903 ELhkDSFEGLLSLQYLDLSCNKiqsierhTFEPLPFLKFINLSCNVITELSFGTFQawhgMQFLHKLILNHNPLTTVEDP 982
Cdd:COG4886    88 GL--TDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN----LTNLKELDLSNNQLTDLPEP 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 767994883  983 yLFKLPALKYLDMGTTlvPLTTLKNILMMTVELEKL 1018
Cdd:COG4886   155 -LGNLTNLKSLDLSNN--QLTDLPEELGNLTNLKEL 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1010 1.44e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  868 TILNFQGNYISYIDGNVwKAYSWTEKLILRENNLTELhkDSFEGLLSLQYLDLSCNKIQSIErhTFEPLPFLKFINLSCN 947
Cdd:COG4886   208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994883  948 VITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILM 1010
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
rne PRK10811
ribonuclease E; Reviewed
 223-593 1.44e-06

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 52.35  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  223 ETQNPETLEDIQSSSLQQEAPAQLPQ-LLEEEPSSMQQEAPALPPEssmesltlpnHEVSVQPPGEDQAYYHLPNITVKP 301
Cdd:PRK10811  655 ESQQAEVTEKARTQDEQQQAPRRERQrRRNDEKRQAQQEAKALNVE----------EQSVQETEQEERVQQVQPRRKQRQ 724

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  302 ADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPV---PPMEHELSISEQQQ-----PVQPSESPREV 373
Cdd:PRK10811  725 LNQKVRIEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPVvaqTAPEQDEENNAENRdnngmPRRSRRSPRHL 804

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  374 ------------ESSPTQQETP----GQPPE--------HHEVTvsPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEV 429
Cdd:PRK10811  805 rvsgqrrrryrdERYPTQSPMPltvaCASPEmasgkvwiRYPVV--RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPV 882

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  430 GTSLVHQEATTrlsgsgnDVEPPAIQHGGPPLLPESSEEAGPLAVQqetsfqspEPInNENPSPTQQEAAAEHPQTAEEG 509
Cdd:PRK10811  883 VSAPVVEAVAE-------VVEEPVVVAEPQPEEVVVVETTHPEVIA--------APV-TEQPQVITESDVAVAQEVAEHA 946

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  510 ESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgfTITPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVT 589
Cdd:PRK10811  947 EPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPV-----VAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMT 1021


                  ....*
gi 767994883  590 N-PTP 593
Cdd:PRK10811 1022 RaPAP 1026
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 874-978 4.76e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 4.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340    77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767994883  938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340   143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 307-702 1.46e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.38  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   307 TITSEPTNETES-SQAQQETPIQFPEEVEpsaTQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVE--SSPTQQETP 383
Cdd:pfam03154  147 SIPSPQDNESDSdSSAQQQILQTQPPVLQ---AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatSQPPNQTQS 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   384 GQPPeHHEVTVSPPGHHQthHLASPsvsvKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVE--PPAIQHGGPP- 460
Cdd:pfam03154  224 TAAP-HTLIQQTPTLHPQ--RLPSP----HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQtgPSHMQHPVPPq 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   461 ---LLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPeFPNVVVAQPPEH- 536
Cdd:pfam03154  297 pfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTP-IPQLPNPQSHKHp 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   537 SHLTQATVQPLDLGFTITPESKTEVELSPTMKETPTQPPKKVVPQlrvyqgvtnptpGQDQAQHPVSPSVTVQLLDLGLT 616
Cdd:pfam03154  376 PHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ------------SQQLPPPPAQPPVLTQSQSLPPP 443

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   617 ITPEPTTEVGHSTPPKRTIvsPKHPEVTLPHPdqvqtqhshltraTVQPLDLGFTITPKSMTEVEP--STALMTTAPPPG 694
Cdd:pfam03154  444 AASHPPTSGLHQVPSQSPF--PQHPFVPGGPP-------------PITPPSGPPTSTSSAMPGIQPpsSASVSSSGPVPA 508


                   ....*...
gi 767994883   695 HPEVTLPP 702
Cdd:pfam03154  509 AVSCPLPP 516
rne PRK10811
ribonuclease E; Reviewed
 299-538 5.04e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 47.34  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  299 VKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsiseqqqPVQPSESPREvesspt 378
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE--------PQPEEVVVVE------ 913

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  379 qqetpgqppEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTrlsgsgndveppaiqhgg 458
Cdd:PRK10811  914 ---------TTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETA------------------ 966

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  459 PPLLPESSEEAGPLAVQQETsfqSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAqtPEFpnvvVAQPPEHSH 538
Cdd:PRK10811  967 EVVVAEPEVVAQPAAPVVAE---VAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTRAPA--PEY----VPEAPRHSD 1037
rne PRK10811
ribonuclease E; Reviewed
 215-418 1.10e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.19  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  215 PSQFHLEPETQNPETLEDIQSSSLQQEAPAQlpqllEEEPSSMQQEAPALPPEssmesltlPNHEVSVQPPGEDQAYYHL 294
Cdd:PRK10811  850 PQDVQVEEQREAEEVQVQPVVAEVPVAAAVE-----PVVSAPVVEAVAEVVEE--------PVVVAEPQPEEVVVVETTH 916

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  295 PNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPpmehelsisEQQQPVQPSESPREVE 374
Cdd:PRK10811  917 PEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVA---------EPEVVAQPAAPVVAEV 987

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 767994883  375 SSPTQQETPGQPPEHHEVTVSPPGHHqtHHLASPSVSVKPPDVQ 418
Cdd:PRK10811  988 AAEVETVTAVEPEVAPAQVPEATVEH--NHATAPMTRAPAPEYV 1029
PHA03247 PHA03247
large tegument protein UL36; Provisional
 346-777 2.17e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  346 PPVPPMEHELSISEQQQPVQPSesPREVESSPTQQET-PGQPPEHHEVTV------SPPGHHQTHHLASPSVSVKPPDVQ 418
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPA--PRPSEPAVTSRARrPDAPPQSARPRApvddrgDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  419 LTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPP--------AIQHGGPPLLPEssEEAGPLAVQQETSFQSPEPINNE- 489
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSPPQRPR--RRAARPTVGSLTSLADPPPPPPTp 2708

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  490 NPSPTQQEAAAEHPQTAeegesslthQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgftitpesktevelsPTMKE 569
Cdd:PHA03247 2709 EPAPHALVSATPLPPGP---------AAARQASPALPAAPAPPAVPAGPATPGGPAR------------------PARPP 2761

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  570 TPTQPPKKVVPQLRvyqgvtnPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVghSTPPKRTIVSPKHPEVTLPHPD 649
Cdd:PHA03247 2762 TTAGPPAPAPPAAP-------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA--VLAPAAALPPAASPAGPLPPPT 2832

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  650 QVQTQHSHLTRATVQP-LDLGFTITPKS-MTEVEPSTALMTTAPPPGHPevtlPPSDKGQAQHSHLTQATVQPLDlelTI 727
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPsLPLGGSVAPGGdVRRRPPSRSPAAKPAAPARP----PVRRLARPAVSRSTESFALPPD---QP 2905

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 767994883  728 TTKPTTEVKPSPTTEETSTQPPDLGlaiiPEPTTETRHSTALEKTTAPRP 777
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQ----PPPPPPPRPQPPLAPTTDPAG 2951
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 914-954 2.98e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.98e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767994883   914 SLQYLDLSCNKIQSIErhTFEPLPFLKFINLS-CNVITELSF 954
Cdd:pfam12799    2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSgNNKITDLSD 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 46-535 5.86e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   46 PLQLTSNPLGPPDSWSSHSSHFPREsPHAPTLPADPwdfdhLGPSASSEMPAPPQESTENLVPFLDTWDSAGEQPLEPEQ 125
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQ-SARPRAPVDD-----RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  126 FLASQQDLKDKLSPQERlpVSPKKlkkdPAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLP--PELRVKS 203
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGR--VSRPR----RARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPepAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  204 DEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQlPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQ 283
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  284 P------PGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVE----------------PSATQQE 341
Cdd:PHA03247 2797 SlpspwdPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrrppsrSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  342 APIEPPV----------PPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:PHA03247 2877 APARPPVrrlarpavsrSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  412 VKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSgndvEPPAIQHGGPplLPESSEEAGPLAVQQETSFQSPEPINNENP 491
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA----SSTPPLTGHS--LSRVSSWASSLALHEETDPPPVSLKQTLWP 3030

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 767994883  492 SPTQQEAAAEHPQTAEEGESSLthqEAPAQTPEFPNVVVAQPPE 535
Cdd:PHA03247 3031 PDDTEDSDADSLFDSDSERSDL---EALDPLPPEPHDPFAHEPD 3071
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 892-929 6.12e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 6.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767994883   892 EKLILRENNLTELhkDSFEGLLSLQYLDLS-CNKIQSIE 929
Cdd:pfam12799    4 EVLDLSNNQITDI--PPLAKLPNLETLDLSgNNKITDLS 40
rne PRK10811
ribonuclease E; Reviewed
 302-717 1.20e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 43.10  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  302 ADVEVTITSEPTNETESSQAQQETPI---QFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESS-- 376
Cdd:PRK10811  651 AETRESQQAEVTEKARTQDEQQQAPRrerQRRRNDEKRQAQQEAKALNVEEQSVQETEQEERVQQVQPRRKQRQLNQKvr 730

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  377 -PTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVqLTIAAEPSAEVGTSLVHQEATTR--------LSGSGN 447
Cdd:PRK10811  731 iEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPVV-AQTAPEQDEENNAENRDNNGMPRrsrrsprhLRVSGQ 809

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  448 ------DVEPPaiqhggppllpesSEEAGPLAVqqetSFQSPE----------PInnenPSPTQQEAAAEHPQTAEEGES 511
Cdd:PRK10811  810 rrrryrDERYP-------------TQSPMPLTV----ACASPEmasgkvwiryPV----VRPQDVQVEEQREAEEVQVQP 868

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  512 SLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgfTITPESKTEVELSPTMKETP-TQPPKKVVPQLRVYQGVTN 590
Cdd:PRK10811  869 VVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE-----PQPEEVVVVETTHPEVIAAPvTEQPQVITESDVAVAQEVA 943

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  591 PTPGQDQAQHPVSPSVTVQLldlglTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVqpldlgf 670
Cdd:PRK10811  944 EHAEPVVEPQDETADIEEAA-----ETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATV------- 1011

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994883  671 titpksmtEVEPSTALMTTAP-------PPGHPEVTLPPSD---KGQA-QHSHLTQAT 717
Cdd:PRK10811 1012 --------EHNHATAPMTRAPapeyvpeAPRHSDWQRPTFAfegKGAAgGHSATHHAS 1061
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 891-976 3.15e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  891 TEKLILRENNLTELH-KDSFEGL---LSLQYLDLSCNKIQSIER------HTFEPLPFLKFINLSCNVITELSFGTFQAW 960
Cdd:cd00116    25 LQVLRLEGNTLGEEAaKALASALrpqPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESL 104

                          90
                  ....*....|....*.
gi 767994883  961 HGMQFLHKLILNHNPL 976
Cdd:cd00116   105 LRSSSLQELKLNNNGL 120
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 190-468 3.46e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.56  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   190 PYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEP-----ET-QNPETLEDIQ-SSSLQQEAPAQLPQLLEEEPSSMQQEAP 262
Cdd:pfam09770  107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvrtgyEKyKEPEPIPDLQvDASLWGVAPKKAAAPAPAPQPAAQPASL 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   263 ALPPESSMeSLtlpnHEVsvqppgEDQAYYHLPNITVKPADVEVTITSEPTnetessQAQQETPIQFPEEVEPSATQQEA 342
Cdd:pfam09770  187 PAPSRKMM-SL----EEV------EAAMRAQAKKPAQQPAPAPAQPPAAPP------AQQAQQQQQFPPQIQQQQQPQQQ 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   343 PIEPPvPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPehhevtvsPPGHHQTHHLASPSVsvkPPDVQLTIA 422
Cdd:pfam09770  250 PQQPQ-QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPP--------PVPVQPTQILQNPNR---LSAARVGYP 317

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 767994883   423 AEPSAEVGTSLVHQEATTRLSGSGNdvePPAIQHggPPLLPESSEE 468
Cdd:pfam09770  318 QNPQPGVQPAPAHQAHRQQGSFGRQ---APIITH--PQQLAQLSEE 358
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 154-602 4.76e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.86  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  154 PAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPElrvksdEPPGPSEQVGPSQFHLEPETQNP-ETLED 232
Cdd:PRK14949  362 PVKRWQVDDPAEISLPEGQTPSALAAAVQAPHANEPQFVNAAPAE------KKTALTEQTTAQQQVQAANAEAVaEADAS 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  233 IQSSSLQQEAPAQLPQLLEEEPSSMQ---QEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHlPNITVKPADVEVTIT 309
Cdd:PRK14949  436 AEPADTVEQALDDESELLAALNAEQAvilSQAQSQGFEASSSLDADNSAVPEQIDSTAEQSVVN-PSVTDTQVDDTSASN 514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  310 SEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsISEQQQPVQPSESPREVESSPTQQETPGQPPEH 389
Cdd:PRK14949  515 NSAADNTVDDNYSAEDTLESNGLDEGDYAQDSAPLDAYQDDYVAF--SSESYNALSDDEQHSANVQSAQSAAEAQPSSQS 592

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  390 HEVTVSPPghhqthhlaSPSVSVKPPDV-QLTIAAEPS--AEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESS 466
Cdd:PRK14949  593 LSPISAVT---------TAAASLADDDIlDAVLAARDSllSDLDALSPKEGDGKKSSADRKPKTPPSRAPPASLSKPASS 663

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  467 EEAGPLAVQQETSFQS-PEPINNENPSPTQ-QEAAAEHPQT----------AEEGESSLTHQEAPAQTPEFPNVV----- 529
Cdd:PRK14949  664 PDASQTSASFDLDPDFeLATHQSVPEAALAsGSAPAPPPVPdpydrppweeAPEVASANDGPNNAAEGNLSESVEdasns 743

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767994883  530 ----VAQPPEHSHLTQATVQPldlgftitpesktevelsPTMKETPTQPPKKVVPQlrvyQGVTNPTPGQDQAQHPV 602
Cdd:PRK14949  744 elqaVEQQATHQPQVQAEAQS------------------PASTTALTQTSSEVQDT----ELNLVLLSSGSITGHPL 798
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 38-383 7.11e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 7.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883    38 QPLEWVKDPLQLTSNPLGPPdswsshsSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAG 117
Cdd:pfam03154  250 QPMTQPPPPSQVSPQPLPQP-------SLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   118 EQPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSlaeiigitrQLSTPQSQKQtlqneysstdtPYPGSLPP 197
Cdd:pfam03154  323 QRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIP---------QLPNPQSHKH-----------PPHLSGPS 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   198 ELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLleeepssmqQEAPALPPESSMESLTLPN 277
Cdd:pfam03154  383 PFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVL---------TQSQSLPPPAASHPPTSGL 453

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883   278 HEVSVQPPGEDQAYYHLPNITVKPAdvevtitSEPTNETESSQaqqeTPIQFPEEVEPSATQQ-EAPIEPPVPPME-HEL 355
Cdd:pfam03154  454 HQVPSQSPFPQHPFVPGGPPPITPP-------SGPPTSTSSAM----PGIQPPSSASVSSSGPvPAAVSCPLPPVQiKEE 522

                          330       340
                   ....*....|....*....|....*...
gi 767994883   356 SISEQQQPVQPSESPREVESSPTQQETP 383
Cdd:pfam03154  523 ALDEAEEPESPPPPPRSPSPEPTVVNTP 550
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
301-510 7.33e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 40.42  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  301 PADVEVTITSEPTNETE---SSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPvQPSESPrEVESSP 377
Cdd:PRK14960  363 PNEILVSEPVQQNGQAEvglNSQAQTAQEITPVSAVQPVEVISQPAMVEPEPEPEPEPEPEPEPEP-EPEPEP-EPEPEP 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  378 tqqetpgQPPEHHEVTVSPPGHHQTHHLASPSVSvkppdVQLTIAAEPSAEVGTS-LVHQEATTRLsgsgNDVEPPAIQH 456
Cdd:PRK14960  441 -------EPQPNQDLMVFDPNHHELIGLESAVVQ-----ETVSVLEEDFIPVPEQkLVQVQAETQV----KQIEPEPAST 504

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994883  457 GGPPLLPESSEEAGPLAVQQETSFQSPEPINNENP----SPTQQEAAAEHPQTAEEGE 510
Cdd:PRK14960  505 AEPIGLFEASSAEFSLAQDTSAYDLVSEPVIEQQSlvqaEIVETVAVVKEPNATDNSQ 562
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
306-383 8.28e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 39.62  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994883  306 VTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIE-PPVPPMEhelsiSEQQQP--VQPSESPREVESSPTQQET 382
Cdd:PRK13042   21 ITTTTQAANATTPSSTKVEAPQSTPPSTKVEAPQSKPNATtPPSTKVE-----APQQTPnaTTPSSTKVETPQSPTTKQV 95


                  .
gi 767994883  383 P 383
Cdd:PRK13042   96 P 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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