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Conserved domains on  [gi|767996239|ref|XP_011523688|]
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coronin-6 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-490 1.34e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 280.24  E-value: 1.34e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL 238
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 239 LSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQREL 317
Cdd:PTZ00421 162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 318 GLWD-----------------------------------PGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGL 362
Cdd:PTZ00421 240 MLWDtrkmaspystvdldqssalfipffdedtnllyigsKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 363 DVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP---- 433
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmg 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 434 ---------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQ 487
Cdd:PTZ00421 398 asalspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQ 477


                 ...
gi 767996239 488 AQE 490
Cdd:PTZ00421 478 KKE 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-490 1.34e-88

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 280.24  E-value: 1.34e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL 238
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 239 LSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQREL 317
Cdd:PTZ00421 162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 318 GLWD-----------------------------------PGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGL 362
Cdd:PTZ00421 240 MLWDtrkmaspystvdldqssalfipffdedtnllyigsKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 363 DVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP---- 433
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmg 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 434 ---------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQ 487
Cdd:PTZ00421 398 asalspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQ 477


                 ...
gi 767996239 488 AQE 490
Cdd:PTZ00421 478 KKE 480
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 6.14e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 6.14e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996239   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-322 7.60e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 7.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHIFT 306
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                        170
                 ....*....|....*.
gi 767996239 307 TGftrmSQRELGLWDP 322
Cdd:cd00200  195 SS----SDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
149-324 1.68e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 1.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  159 TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTG 308
Cdd:COG2319  230 LWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR-TLTGHSG-GVNSVAFSPDGKLLASG 306

                        170
                 ....*....|....*.
gi 767996239 309 ftrMSQRELGLWDPGD 324
Cdd:COG2319  307 ---SDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-180 1.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.45e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767996239   149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-490 1.34e-88

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 280.24  E-value: 1.34e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL 238
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 239 LSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQREL 317
Cdd:PTZ00421 162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 318 GLWD-----------------------------------PGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGL 362
Cdd:PTZ00421 240 MLWDtrkmaspystvdldqssalfipffdedtnllyigsKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 363 DVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP---- 433
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmg 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 434 ---------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQ 487
Cdd:PTZ00421 398 asalspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQ 477


                 ...
gi 767996239 488 AQE 490
Cdd:PTZ00421 478 KKE 480
PTZ00420 PTZ00420
coronin; Provisional
 92-444 4.84e-54

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 190.93  E-value: 4.84e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239  92 ADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRvdkNYPLVT--GHTAPVLDIDWCPHNDNVIA 169
Cdd:PTZ00420  15 SNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSEILA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 170 SASDDTTIMVWQIP-DYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLddMHPDV 248
Cdd:PTZ00420  92 SGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI--NMPKK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 249 IHSVCWNSNGSLLATTCKDKTLRIIDPRKgQVVAERFAAHEGMRPMRAVFT-----RQGHIFTTGFTRMSQRELGLWD-- 321
Cdd:PTZ00420 170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDlk 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 322 ---------------------------------PGDSSIRYFEITDEPpfVHYLNTFSSKEPQRGMGFMPKRGLDVSKCE 368
Cdd:PTZ00420 249 nttsalvtmsidnasapliphydestgliyligKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996239 369 IARFYK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLRDgyvpPKHRELRVTKR 444
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 6.14e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 6.14e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996239   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-322 7.60e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 7.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHIFT 306
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                        170
                 ....*....|....*.
gi 767996239 307 TGftrmSQRELGLWDP 322
Cdd:cd00200  195 SS----SDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
149-324 1.68e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 1.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  159 TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTG 308
Cdd:COG2319  230 LWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR-TLTGHSG-GVNSVAFSPDGKLLASG 306

                        170
                 ....*....|....*.
gi 767996239 309 ftrMSQRELGLWDPGD 324
Cdd:COG2319  307 ---SDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
149-328 1.97e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 1.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTG 308
Cdd:COG2319  188 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR-TLTGHSG-SVRSVAFSPDGRLLASG 264

                        170       180
                 ....*....|....*....|
gi 767996239 309 ftrMSQRELGLWDPGDSSIR 328
Cdd:COG2319  265 ---SADGTVRLWDLATGELL 281
WD40 COG2319
WD40 repeat [General function prediction only];
148-324 2.39e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 2.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 148 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 227
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 228 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTT 307
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLAS 347

                        170
                 ....*....|....*..
gi 767996239 308 GFtrmSQRELGLWDPGD 324
Cdd:COG2319  348 GS---DDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-308 1.31e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 106 WDSSFCAVNPKFLAiiveAGGGGAFIVLPLaKTGRVDKNYplvTGHTAPVLDIDWCPHNDnVIASASDDTTIMVWQIPDY 185
Cdd:cd00200   55 RDVAASADGTYLAS----GSSDKTIRLWDL-ETGECVRTL---TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 186 tpmrnitEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTC 265
Cdd:cd00200  126 -------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767996239 266 KDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTTG 308
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGT-LRGHEN-GVNSVAFSPDGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
149-308 5.01e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 5.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  243 TGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT-------GELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVR 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTG 308
Cdd:COG2319  314 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR-TLTGHTG-AVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-290 1.10e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPHNDnVIASASDDTTIMVWQIpdytpmrNITEPIITLEGHSKRVGILSWHPTARNvLLSAGGDNVII 228
Cdd:cd00200  132 RGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDL-------RTGKCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIK 202

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996239 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEG 290
Cdd:cd00200  203 LWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT-LSGHTN 262
WD40 COG2319
WD40 repeat [General function prediction only];
147-276 6.47e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 6.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 147 LVTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDYTPMRnitepiiTLEGHSKRVGILSWHPTARnVLLSAGGDNV 226
Cdd:COG2319  283 TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGK-TLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767996239 227 IIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPR 276
Cdd:COG2319  354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
148-321 1.03e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 1.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 148 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 227
Cdd:COG2319   74 LLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 228 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTT 307
Cdd:COG2319  145 RLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR-TLTGHTG-AVRSVAFSPDGKLLAS 221

                        170
                 ....*....|....
gi 767996239 308 GFtrmSQRELGLWD 321
Cdd:COG2319  222 GS---ADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-272 1.69e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 136 AKTGRVDKNYplvTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTaR 215
Cdd:cd00200  164 LRTGKCVATL---TGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST-------GKCLGTLRGHENGVNSVAFSPD-G 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996239 216 NVLLSAGGDNVIIIWNVGTGEVLLSLDdMHPDVIHSVCWNSNGSLLATTCKDKTLRI 272
Cdd:cd00200  232 YLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 380-422 3.61e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 83.33  E-value: 3.61e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767996239  380 CEPIIMTVPRKS-DLFQDDLYPDTPGPEPALEADEWLSGQDAEP 422
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-321 5.14e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 5.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 194 PIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRII 273
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767996239 274 DPRKGQVVAErFAAHEGmrPMRAV-FTRQGHIFTTGftrMSQRELGLWD 321
Cdd:cd00200   79 DLETGECVRT-LTGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWD 121
WD40 COG2319
WD40 repeat [General function prediction only];
149-234 7.90e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 7.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  327 TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                 ....*.
gi 767996239 229 IWNVGT 234
Cdd:COG2319  398 LWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-180 1.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.45e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767996239   149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 234-274 2.79e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.79e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767996239   234 TGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIID 274
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-231 9.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 9.42e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767996239   193 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 231
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 160-257 9.68e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.19  E-value: 9.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239  160 WCPHNDnVIASASDDTTI--------MVWQIPdytpmrnitepiitLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWN 231
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 767996239  232 VGTGEVLLSLdDMHPDVIHSVCWNSN 257
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
149-180 1.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767996239  149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
193-231 9.99e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.99e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767996239  193 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 231
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
245-274 1.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.01e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767996239  245 HPDVIHSVCWNSNGSLLATTCKDKTLRIID 274
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 245-331 1.31e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 245 HPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV-FTRQGH-IFTTGFTRMSQrelgLWDP 322
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaASADGTyLASGSSDKTIR----LWDL 80

                         90
                 ....*....|
gi 767996239 323 -GDSSIRYFE 331
Cdd:cd00200   81 eTGECVRTLT 90
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-181 1.97e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 1.97e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767996239 149 TGHTAPVLDIDWCPHNdNVIASASDDTTIMVWQ 181
Cdd:cd00200  258 SGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
189-324 2.76e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996239 189 RNITEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDK 268
Cdd:COG2319   23 AALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLG-HTAAVLSVAFSPDGRLLASASADG 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996239 269 TLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTGFtrmSQRELGLWDPGD 324
Cdd:COG2319  101 TVRLWDLATGLLLR-TLTGHTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT 151
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 249-281 4.43e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 4.43e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767996239  249 IHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVV 281
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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