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Conserved domains on  [gi|767996247|ref|XP_011523691|]
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coronin-6 isoform X5 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-282 1.98e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 174.70  E-value: 1.98e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 235
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767996247 236 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVA 282
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS 204
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-282 1.98e-50

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 174.70  E-value: 1.98e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 235
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767996247 236 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVA 282
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS 204
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 3.36e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 3.36e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996247   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-283 6.39e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.72  E-value: 6.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996247 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172
WD40 COG2319
WD40 repeat [General function prediction only];
148-283 6.57e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 6.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 148 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 227
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996247 228 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-180 2.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.20e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767996247   149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-282 1.98e-50

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 174.70  E-value: 1.98e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 235
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767996247 236 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVA 282
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS 204
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 3.36e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 3.36e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996247   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
PTZ00420 PTZ00420
coronin; Provisional
 92-280 1.16e-28

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 115.82  E-value: 1.16e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247  92 ADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRvdkNYPLVT--GHTAPVLDIDWCPHNDNVIA 169
Cdd:PTZ00420  15 SNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSEILA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 170 SASDDTTIMVWQIP-DYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLddMHPDV 248
Cdd:PTZ00420  92 SGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI--NMPKK 169

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767996247 249 IHSVCWNSNGSLLATTCKDKTLRIIDPRKGQV 280
Cdd:PTZ00420 170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEI 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-283 6.39e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.72  E-value: 6.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996247 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-283 1.02e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 1.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPHNDnVIASASDDTTIMVWQIPDYtpmrnitEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:cd00200   90 TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIK 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996247 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:cd00200  161 LWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-283 6.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 6.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPHNDnVIASASDDTTIMVWQIpdytpmrNITEPIITLEGHSKRVGILSWHPTARNvLLSAGGDNVII 228
Cdd:cd00200  132 RGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDL-------RTGKCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIK 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996247 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:cd00200  203 LWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
148-283 6.57e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 6.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 148 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 227
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996247 228 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325
WD40 COG2319
WD40 repeat [General function prediction only];
149-283 9.71e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 9.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  159 TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVR 229

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996247 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:COG2319  230 LWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
WD40 COG2319
WD40 repeat [General function prediction only];
149-283 1.28e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 1.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996247 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:COG2319  188 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241
WD40 COG2319
WD40 repeat [General function prediction only];
149-283 5.55e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 5.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  243 TGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT-------GELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVR 313

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996247 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:COG2319  314 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
147-276 3.27e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 3.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 147 LVTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDYTPMRnitepiiTLEGHSKRVGILSWHPTARnVLLSAGGDNV 226
Cdd:COG2319  283 TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGK-TLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767996247 227 IIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPR 276
Cdd:COG2319  354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-272 2.04e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 2.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 136 AKTGRVDKNYplvTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTaR 215
Cdd:cd00200  164 LRTGKCVATL---TGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST-------GKCLGTLRGHENGVNSVAFSPD-G 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996247 216 NVLLSAGGDNVIIIWNVGTGEVLLSLDdMHPDVIHSVCWNSNGSLLATTCKDKTLRI 272
Cdd:cd00200  232 YLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-281 2.25e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 2.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 194 PIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRII 273
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78


                 ....*...
gi 767996247 274 DPRKGQVV 281
Cdd:cd00200   79 DLETGECV 86
WD40 COG2319
WD40 repeat [General function prediction only];
146-283 8.49e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 8.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 146 PLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPdytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDN 225
Cdd:COG2319   30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA--------GALLATLLGHTAAVLSVAFSPDGR-LLASASADG 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767996247 226 VIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAV 283
Cdd:COG2319  101 TVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157
WD40 COG2319
WD40 repeat [General function prediction only];
149-234 2.71e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  327 TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                 ....*.
gi 767996247 229 IWNVGT 234
Cdd:COG2319  398 LWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-180 2.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.20e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767996247   149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 234-274 4.13e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767996247   234 TGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIID 274
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-231 1.37e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.37e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767996247   193 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 231
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 160-257 2.20e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 42.27  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996247  160 WCPHNDnVIASASDDTTI--------MVWQIPdytpmrnitepiitLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWN 231
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 767996247  232 VGTGEVLLSLdDMHPDVIHSVCWNSN 257
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
149-180 2.74e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.74e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767996247  149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
245-274 1.46e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.46e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767996247  245 HPDVIHSVCWNSNGSLLATTCKDKTLRIID 274
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
193-231 1.59e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.59e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767996247  193 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 231
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 249-292 8.34e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 8.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767996247  249 IHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVV-AVSALSKPPAC 292
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVhHFSAGSDLITC 85
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-181 1.93e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 1.93e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767996247 149 TGHTAPVLDIDWCPHNdNVIASASDDTTIMVWQ 181
Cdd:cd00200  258 SGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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