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structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 [Homo sapiens]
HATPase_SMCHD1-like and SMC_hinge domain-containing protein( domain architecture ID 13015024)
protein containing domains HATPase_SMCHD1-like, SMC_prok_B, and SMC_hinge
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||||
HATPase_SMCHD1-like | cd16937 | Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge ... |
128-246 | 8.47e-84 | ||||||
Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein; This family includes histidine kinase-like ATPase (HATPase) domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein, which is involved in gene silencing and in DNA damage. It has critical roles in X-chromosome inactivation and is also an important regulator of autosomal gene clusters. Upon DNA damage, SMCHD1 promotes non-homologous end joining and inhibits homologous recombination repair. SMCHD1 is implicated in the pathogenesis of facioscapulohumeral muscular dystrophy. : Pssm-ID: 340414 [Multi-domain] Cd Length: 119 Bit Score: 269.94 E-value: 8.47e-84
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SMC_hinge | smart00968 | SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC ... |
1720-1846 | 1.26e-17 | ||||||
SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction. : Pssm-ID: 214944 [Multi-domain] Cd Length: 120 Bit Score: 80.74 E-value: 1.26e-17
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SMC_prok_B super family | cl37069 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1621-1958 | 6.11e-10 | ||||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] The actual alignment was detected with superfamily member TIGR02168: Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 64.69 E-value: 6.11e-10
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Name | Accession | Description | Interval | E-value | ||||||
HATPase_SMCHD1-like | cd16937 | Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge ... |
128-246 | 8.47e-84 | ||||||
Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein; This family includes histidine kinase-like ATPase (HATPase) domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein, which is involved in gene silencing and in DNA damage. It has critical roles in X-chromosome inactivation and is also an important regulator of autosomal gene clusters. Upon DNA damage, SMCHD1 promotes non-homologous end joining and inhibits homologous recombination repair. SMCHD1 is implicated in the pathogenesis of facioscapulohumeral muscular dystrophy. Pssm-ID: 340414 [Multi-domain] Cd Length: 119 Bit Score: 269.94 E-value: 8.47e-84
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SMC_hinge | smart00968 | SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC ... |
1720-1846 | 1.26e-17 | ||||||
SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction. Pssm-ID: 214944 [Multi-domain] Cd Length: 120 Bit Score: 80.74 E-value: 1.26e-17
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SMC_hinge | pfam06470 | SMC proteins Flexible Hinge Domain; This family represents the hinge region of the SMC ... |
1721-1847 | 3.35e-14 | ||||||
SMC proteins Flexible Hinge Domain; This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction. Pssm-ID: 461926 [Multi-domain] Cd Length: 116 Bit Score: 70.75 E-value: 3.35e-14
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SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1621-1958 | 6.11e-10 | ||||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 64.69 E-value: 6.11e-10
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HATPase_c_3 | pfam13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ... |
143-255 | 1.03e-07 | ||||||
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 433332 [Multi-domain] Cd Length: 135 Bit Score: 52.72 E-value: 1.03e-07
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Name | Accession | Description | Interval | E-value | ||||||
HATPase_SMCHD1-like | cd16937 | Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge ... |
128-246 | 8.47e-84 | ||||||
Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein; This family includes histidine kinase-like ATPase (HATPase) domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein, which is involved in gene silencing and in DNA damage. It has critical roles in X-chromosome inactivation and is also an important regulator of autosomal gene clusters. Upon DNA damage, SMCHD1 promotes non-homologous end joining and inhibits homologous recombination repair. SMCHD1 is implicated in the pathogenesis of facioscapulohumeral muscular dystrophy. Pssm-ID: 340414 [Multi-domain] Cd Length: 119 Bit Score: 269.94 E-value: 8.47e-84
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SMC_hinge | smart00968 | SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC ... |
1720-1846 | 1.26e-17 | ||||||
SMC proteins Flexible Hinge Domain; This entry represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction. Pssm-ID: 214944 [Multi-domain] Cd Length: 120 Bit Score: 80.74 E-value: 1.26e-17
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SMC_hinge | pfam06470 | SMC proteins Flexible Hinge Domain; This family represents the hinge region of the SMC ... |
1721-1847 | 3.35e-14 | ||||||
SMC proteins Flexible Hinge Domain; This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction. Pssm-ID: 461926 [Multi-domain] Cd Length: 116 Bit Score: 70.75 E-value: 3.35e-14
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SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1621-1958 | 6.11e-10 | ||||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 64.69 E-value: 6.11e-10
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HATPase_c_3 | pfam13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ... |
143-255 | 1.03e-07 | ||||||
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 433332 [Multi-domain] Cd Length: 135 Bit Score: 52.72 E-value: 1.03e-07
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HATPase_MORC-like | cd16931 | Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ... |
142-194 | 3.85e-03 | ||||||
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker. Pssm-ID: 340408 [Multi-domain] Cd Length: 118 Bit Score: 39.31 E-value: 3.85e-03
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HATPase_MutL-MLH-PMS-like | cd16926 | Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ... |
147-216 | 6.02e-03 | ||||||
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease. Pssm-ID: 340403 [Multi-domain] Cd Length: 188 Bit Score: 40.11 E-value: 6.02e-03
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