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Conserved domains on  [gi|767998268|ref|XP_011524137|]
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cytochrome b5 isoform X1 [Homo sapiens]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 13-85 6.53e-28

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 96.15  E-value: 6.53e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767998268  13 TLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTD-AREMSKTFIIGELH 85
Cdd:pfam00173  1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDaAEKLLKKYRIGELA 74
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 13-85 6.53e-28

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 96.15  E-value: 6.53e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767998268  13 TLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTD-AREMSKTFIIGELH 85
Cdd:pfam00173  1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDaAEKLLKKYRIGELA 74
PLN02252 PLN02252
nitrate reductase [NADPH]
 7-84 2.17e-23

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 92.43  E-value: 2.17e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767998268   7 EAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVgHSTDAREMSKTFIIGEL 84
Cdd:PLN02252 515 TGSKQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGEL 591
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 6-84 2.24e-19

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 75.46  E-value: 2.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998268  6 DEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDV-GHSTDAREMSKTFIIGEL 84
Cdd:COG5274  12 AAPEKTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTKhPHSPKAERLLESYRIGRL 91
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 13-85 6.53e-28

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 96.15  E-value: 6.53e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767998268  13 TLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTD-AREMSKTFIIGELH 85
Cdd:pfam00173  1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDaAEKLLKKYRIGELA 74
PLN02252 PLN02252
nitrate reductase [NADPH]
 7-84 2.17e-23

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 92.43  E-value: 2.17e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767998268   7 EAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVgHSTDAREMSKTFIIGEL 84
Cdd:PLN02252 515 TGSKQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGEL 591
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 6-84 2.24e-19

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 75.46  E-value: 2.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998268  6 DEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDV-GHSTDAREMSKTFIIGEL 84
Cdd:COG5274  12 AAPEKTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTKhPHSPKAERLLESYRIGRL 91
PLN03199 PLN03199
delta6-acyl-lipid desaturase-like protein; Provisional
 2-87 3.09e-11

delta6-acyl-lipid desaturase-like protein; Provisional


Pssm-ID: 178740 [Multi-domain]  Cd Length: 485  Bit Score: 57.74  E-value: 3.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998268   2 AEQSDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFlEEHPGGeEVLREQAGGDATENFEDVgHSTDAREMSKTFII 81
Cdd:PLN03199  16 ALKLAEKPQKISWQEVKKHASPDDAWIIHQNKVYDVSNW-HDHPGG-AVIFTHAGDDMTDIFAAF-HAPGSQALMKKFYI 92


                 ....*.
gi 767998268  82 GELHPD 87
Cdd:PLN03199  93 GDLIPE 98
PLN03198 PLN03198
delta6-acyl-lipid desaturase; Provisional
 10-84 1.78e-09

delta6-acyl-lipid desaturase; Provisional


Pssm-ID: 178739 [Multi-domain]  Cd Length: 526  Bit Score: 52.77  E-value: 1.78e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767998268  10 KYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGeEVLREQAGGDATENFEDVgHSTDAREMSKTFIIGEL 84
Cdd:PLN03198 104 KSHLLSEVAAHNKPNDCWIVIKNKVYDVSDFAAEHPGG-SVISTYFGRDGTDAFSSF-HAASTWKILQDFYIGDV 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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