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Conserved domains on  [gi|767999262|ref|XP_011524481|]
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GREB1-like protein isoform X11 [Homo sapiens]

Protein Classification

GREB1 domain-containing protein( domain architecture ID 12174538)

GREB1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GREB1 pfam15782
GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1-1154 0e+00

GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


:

Pssm-ID: 464866  Cd Length: 1102  Bit Score: 1918.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262     1 MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQH-PFSSADVKPKVEDLDKDlvnrytQNGSldfsn 79
Cdd:pfam15782    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNSVVPRPVFSQLYLEAEQQlSSLEGGSRNENDDEEED------EDGS----- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262    80 nltvnemeddeddeemsDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILV 159
Cdd:pfam15782   70 -----------------ESNSPPIPYQMKPPPEGCCTTDGFCQAGKDLRLVSLASEQIDVPAGFLLVGAKSPSLPEHLLV 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   160 CAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWK--E 237
Cdd:pfam15782  133 CAVDKRFLPDDNGRNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRNSQGVLVKGPLICWKgsE 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   238 CRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTDSPILSpansainlsgaqdltrnnnvvkplalslqvvgkt 317
Cdd:pfam15782  213 CRSRQSSASTCSSTPTSSPESPGLSANGSSEPYPTPASQLDSGHEP---------------------------------- 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   318 faADAANGNSSHGGKGSASSSTPAHtGNYSLSPRPSYasgdQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLS 397
Cdd:pfam15782  259 --QTAAVSHQVSNGNQSPPSSTLAK-LNPSAPPRPSV----LGTHSNSGPPKKRHKGWSPESSVPDSTLKVPVPSSRPST 331

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   398 RTEPLLSAPVPQTPLTGILQPRPIPA-----GETVIVPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKI 472
Cdd:pfam15782  332 SVSSVLTNGSPQSCLTQVLPPGPASAplvppGESVIVPDNLLNTCRLRPVILKGHGNLPYLTGNVNDVVVSPLLVSCYKS 411

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   473 PQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLGPDQVPLREEFEQIMLKAMQEFTLRE--RALQIGAQCVP------ 544
Cdd:pfam15782  412 SQTLPRAYEQYGLSPIQPLSVEMQILLTVYYLVQLGPDQVPLIEDLEQIFMRSWRESHLSEirQYQQMHAQCLPqtpssq 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   545 --VSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGISETLRTLSEMRHYQRlpDYVVVICASKIRGNEFCVVVLGQHQSR 622
Cdd:pfam15782  492 qpVTPAQLPWLAQLAASSCNEGVVVVECQYSLAEGLSETFRRLMEGKLENT--NYVVIICASRGRGTESCVVVTGKHQAR 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   623 ALAESMLTTSEFLKEISYELITGKVSFLASHFKTTSLGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQ 702
Cdd:pfam15782  570 ALAESMLSPSEGLKEISYELITGKVSELASHFKTLCPDGDLDKLLDKFQQERQGEVSSPLSGSQEEAVSSQEAAAMVPTT 649

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   703 NLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQSLDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENG 782
Cdd:pfam15782  650 CTEYSVEWHEIRPIQLAVARKLLSHVCAIADSSTQNLDLGSFSKVDFLILVPPSEVTYQQTVLHLWQSGVLVDLGLEQAS 729

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   783 TAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNL 862
Cdd:pfam15782  730 TSKQKAEQYVVKLDSEAQAKFESFLQEVKQNPYTLFVLVHDHAHWDLTSAISSSYSHSESGLGLVDRLLNCREVKDAPNI 809

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   863 LVLQVSSFPYTLQTQQSRISSSNEVHWIQL-DTGEDVGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERY 941
Cdd:pfam15782  810 LILHVTSFPYALQTQQTRISPYNEIHWPSAfSNGVDLYHERTRYFGLSEYLESTQSGHSLPLLRYDSSFESMVSALLERF 889

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   942 PRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTPETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEV 1021
Cdd:pfam15782  890 PKLHSAVIRTYVLIQHYSAALMAVSGSSQLKDHTSVETLEIVQDLINAPQQCPSGHGHMVLLRIPSLQLAMVAYERLCRV 969

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1022 RDKLGLQYRFEIILGNPATELSVATHFVARLKSWRGNEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRL 1101
Cdd:pfam15782  970 RDKLGLEYRFEIILGNPNSELTIGKHFVDQLKAWRKIEDADWVPRTYLELEGLPCILILSGKDPLGESLPRSLKYCDLRL 1049

                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767999262  1102 IDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDLSGKEQERAAVSENDSDE 1154
Cdd:pfam15782 1050 INSSYLTRTALEQELGLAAYYVSKEVPREPGVGSDLSESDAEKLSSTDNEDEE 1102
GREB1_C super family cl48431
GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1272-1900 0e+00

GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


The actual alignment was detected with superfamily member pfam20267:

Pssm-ID: 466417  Cd Length: 688  Bit Score: 1198.04  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1272 PPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQldPASGT 1351
Cdd:pfam20267    1 PPIVILPKAAYDIITSSDSSGLPRSSSLLPHASVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRQHHMDYSNR--TEGRS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1352 RNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTD-HNESSEVSQSEGEPWPDIESFSKMPFDVS 1430
Cdd:pfam20267   79 DNFHPRRLLLSGPPQVGKTGAYLQFLRILSRMLIRLLEVDVYDEEEININrQSESVQHYHQPNDPWPDLEIFKKMPFDYT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1431 VHDPKYSLMSLVYTEkLAGVKQEVIKESKVEE--PRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAF 1508
Cdd:pfam20267  159 IHDPKYEDASPVYSP-LYKPKSEGKPNPRRQEdvYLRRRTTRIRLSKYAAYNTYHHCEQCHQYMGFNPRYQMYESTLHAF 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1509 TFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKqNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHL 1588
Cdd:pfam20267  238 TFSSSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVSDK-NPDCIKSPIFTPTTGRHEHGLFNLYHAMDGASHL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1589 HLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLW 1668
Cdd:pfam20267  317 HILVVKEYEMAVYKKYWPNHIMLVLPSIFNGAGVGAAHFLIKELSYHNLELERNRQEELGVKRQDVWPFIVIADDSCVMW 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1669 NIHSVQEPSsqpmevGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNV 1748
Cdd:pfam20267  397 NAVDVDAES------GPSERNVSLKQVLQHMEATPKITHYALLGIRKWSSKLLSKKLKEPFSRCHLHDFILLNVDLTQNV 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1749 QYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIM--------------------------- 1801
Cdd:pfam20267  471 QYDQNRFTCEDVDFNLRLHSAGLLICRFNNFSVMKKQIAVGGYRDFHIKPKVSdnptsvspsqyicapdskhtflaapaq 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1802 --------------------------------------VAICYISSRPHSSNVNCEGVFFSGLLLYLCDSFVGAD-LKKF 1842
Cdd:pfam20267  551 lllekylqhtshklfplslknynhpvlsvdcylnlgpeISVCYVSSRPHSVNINTTGLLFSGLLLYLCDSFVTAGfLKKF 630

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767999262  1843 KFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDKPLYFLTGRHV 1900
Cdd:pfam20267  631 HFLKGATLCVICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANAKEDRPLFFLTGRHI 688
 
Name Accession Description Interval E-value
GREB1 pfam15782
GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1-1154 0e+00

GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 464866  Cd Length: 1102  Bit Score: 1918.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262     1 MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQH-PFSSADVKPKVEDLDKDlvnrytQNGSldfsn 79
Cdd:pfam15782    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNSVVPRPVFSQLYLEAEQQlSSLEGGSRNENDDEEED------EDGS----- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262    80 nltvnemeddeddeemsDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILV 159
Cdd:pfam15782   70 -----------------ESNSPPIPYQMKPPPEGCCTTDGFCQAGKDLRLVSLASEQIDVPAGFLLVGAKSPSLPEHLLV 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   160 CAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWK--E 237
Cdd:pfam15782  133 CAVDKRFLPDDNGRNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRNSQGVLVKGPLICWKgsE 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   238 CRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTDSPILSpansainlsgaqdltrnnnvvkplalslqvvgkt 317
Cdd:pfam15782  213 CRSRQSSASTCSSTPTSSPESPGLSANGSSEPYPTPASQLDSGHEP---------------------------------- 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   318 faADAANGNSSHGGKGSASSSTPAHtGNYSLSPRPSYasgdQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLS 397
Cdd:pfam15782  259 --QTAAVSHQVSNGNQSPPSSTLAK-LNPSAPPRPSV----LGTHSNSGPPKKRHKGWSPESSVPDSTLKVPVPSSRPST 331

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   398 RTEPLLSAPVPQTPLTGILQPRPIPA-----GETVIVPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKI 472
Cdd:pfam15782  332 SVSSVLTNGSPQSCLTQVLPPGPASAplvppGESVIVPDNLLNTCRLRPVILKGHGNLPYLTGNVNDVVVSPLLVSCYKS 411

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   473 PQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLGPDQVPLREEFEQIMLKAMQEFTLRE--RALQIGAQCVP------ 544
Cdd:pfam15782  412 SQTLPRAYEQYGLSPIQPLSVEMQILLTVYYLVQLGPDQVPLIEDLEQIFMRSWRESHLSEirQYQQMHAQCLPqtpssq 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   545 --VSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGISETLRTLSEMRHYQRlpDYVVVICASKIRGNEFCVVVLGQHQSR 622
Cdd:pfam15782  492 qpVTPAQLPWLAQLAASSCNEGVVVVECQYSLAEGLSETFRRLMEGKLENT--NYVVIICASRGRGTESCVVVTGKHQAR 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   623 ALAESMLTTSEFLKEISYELITGKVSFLASHFKTTSLGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQ 702
Cdd:pfam15782  570 ALAESMLSPSEGLKEISYELITGKVSELASHFKTLCPDGDLDKLLDKFQQERQGEVSSPLSGSQEEAVSSQEAAAMVPTT 649

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   703 NLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQSLDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENG 782
Cdd:pfam15782  650 CTEYSVEWHEIRPIQLAVARKLLSHVCAIADSSTQNLDLGSFSKVDFLILVPPSEVTYQQTVLHLWQSGVLVDLGLEQAS 729

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   783 TAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNL 862
Cdd:pfam15782  730 TSKQKAEQYVVKLDSEAQAKFESFLQEVKQNPYTLFVLVHDHAHWDLTSAISSSYSHSESGLGLVDRLLNCREVKDAPNI 809

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   863 LVLQVSSFPYTLQTQQSRISSSNEVHWIQL-DTGEDVGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERY 941
Cdd:pfam15782  810 LILHVTSFPYALQTQQTRISPYNEIHWPSAfSNGVDLYHERTRYFGLSEYLESTQSGHSLPLLRYDSSFESMVSALLERF 889

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   942 PRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTPETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEV 1021
Cdd:pfam15782  890 PKLHSAVIRTYVLIQHYSAALMAVSGSSQLKDHTSVETLEIVQDLINAPQQCPSGHGHMVLLRIPSLQLAMVAYERLCRV 969

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1022 RDKLGLQYRFEIILGNPATELSVATHFVARLKSWRGNEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRL 1101
Cdd:pfam15782  970 RDKLGLEYRFEIILGNPNSELTIGKHFVDQLKAWRKIEDADWVPRTYLELEGLPCILILSGKDPLGESLPRSLKYCDLRL 1049

                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767999262  1102 IDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDLSGKEQERAAVSENDSDE 1154
Cdd:pfam15782 1050 INSSYLTRTALEQELGLAAYYVSKEVPREPGVGSDLSESDAEKLSSTDNEDEE 1102
GREB1_C pfam20267
GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1272-1900 0e+00

GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 466417  Cd Length: 688  Bit Score: 1198.04  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1272 PPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQldPASGT 1351
Cdd:pfam20267    1 PPIVILPKAAYDIITSSDSSGLPRSSSLLPHASVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRQHHMDYSNR--TEGRS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1352 RNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTD-HNESSEVSQSEGEPWPDIESFSKMPFDVS 1430
Cdd:pfam20267   79 DNFHPRRLLLSGPPQVGKTGAYLQFLRILSRMLIRLLEVDVYDEEEININrQSESVQHYHQPNDPWPDLEIFKKMPFDYT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1431 VHDPKYSLMSLVYTEkLAGVKQEVIKESKVEE--PRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAF 1508
Cdd:pfam20267  159 IHDPKYEDASPVYSP-LYKPKSEGKPNPRRQEdvYLRRRTTRIRLSKYAAYNTYHHCEQCHQYMGFNPRYQMYESTLHAF 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1509 TFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKqNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHL 1588
Cdd:pfam20267  238 TFSSSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVSDK-NPDCIKSPIFTPTTGRHEHGLFNLYHAMDGASHL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1589 HLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLW 1668
Cdd:pfam20267  317 HILVVKEYEMAVYKKYWPNHIMLVLPSIFNGAGVGAAHFLIKELSYHNLELERNRQEELGVKRQDVWPFIVIADDSCVMW 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1669 NIHSVQEPSsqpmevGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNV 1748
Cdd:pfam20267  397 NAVDVDAES------GPSERNVSLKQVLQHMEATPKITHYALLGIRKWSSKLLSKKLKEPFSRCHLHDFILLNVDLTQNV 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1749 QYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIM--------------------------- 1801
Cdd:pfam20267  471 QYDQNRFTCEDVDFNLRLHSAGLLICRFNNFSVMKKQIAVGGYRDFHIKPKVSdnptsvspsqyicapdskhtflaapaq 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1802 --------------------------------------VAICYISSRPHSSNVNCEGVFFSGLLLYLCDSFVGAD-LKKF 1842
Cdd:pfam20267  551 lllekylqhtshklfplslknynhpvlsvdcylnlgpeISVCYVSSRPHSVNINTTGLLFSGLLLYLCDSFVTAGfLKKF 630

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767999262  1843 KFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDKPLYFLTGRHV 1900
Cdd:pfam20267  631 HFLKGATLCVICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANAKEDRPLFFLTGRHI 688
 
Name Accession Description Interval E-value
GREB1 pfam15782
GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1-1154 0e+00

GREB1 N-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 464866  Cd Length: 1102  Bit Score: 1918.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262     1 MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQH-PFSSADVKPKVEDLDKDlvnrytQNGSldfsn 79
Cdd:pfam15782    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNSVVPRPVFSQLYLEAEQQlSSLEGGSRNENDDEEED------EDGS----- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262    80 nltvnemeddeddeemsDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILV 159
Cdd:pfam15782   70 -----------------ESNSPPIPYQMKPPPEGCCTTDGFCQAGKDLRLVSLASEQIDVPAGFLLVGAKSPSLPEHLLV 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   160 CAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWK--E 237
Cdd:pfam15782  133 CAVDKRFLPDDNGRNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRNSQGVLVKGPLICWKgsE 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   238 CRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTDSPILSpansainlsgaqdltrnnnvvkplalslqvvgkt 317
Cdd:pfam15782  213 CRSRQSSASTCSSTPTSSPESPGLSANGSSEPYPTPASQLDSGHEP---------------------------------- 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   318 faADAANGNSSHGGKGSASSSTPAHtGNYSLSPRPSYasgdQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLS 397
Cdd:pfam15782  259 --QTAAVSHQVSNGNQSPPSSTLAK-LNPSAPPRPSV----LGTHSNSGPPKKRHKGWSPESSVPDSTLKVPVPSSRPST 331

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   398 RTEPLLSAPVPQTPLTGILQPRPIPA-----GETVIVPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKI 472
Cdd:pfam15782  332 SVSSVLTNGSPQSCLTQVLPPGPASAplvppGESVIVPDNLLNTCRLRPVILKGHGNLPYLTGNVNDVVVSPLLVSCYKS 411

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   473 PQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLGPDQVPLREEFEQIMLKAMQEFTLRE--RALQIGAQCVP------ 544
Cdd:pfam15782  412 SQTLPRAYEQYGLSPIQPLSVEMQILLTVYYLVQLGPDQVPLIEDLEQIFMRSWRESHLSEirQYQQMHAQCLPqtpssq 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   545 --VSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGISETLRTLSEMRHYQRlpDYVVVICASKIRGNEFCVVVLGQHQSR 622
Cdd:pfam15782  492 qpVTPAQLPWLAQLAASSCNEGVVVVECQYSLAEGLSETFRRLMEGKLENT--NYVVIICASRGRGTESCVVVTGKHQAR 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   623 ALAESMLTTSEFLKEISYELITGKVSFLASHFKTTSLGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQ 702
Cdd:pfam15782  570 ALAESMLSPSEGLKEISYELITGKVSELASHFKTLCPDGDLDKLLDKFQQERQGEVSSPLSGSQEEAVSSQEAAAMVPTT 649

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   703 NLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQSLDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENG 782
Cdd:pfam15782  650 CTEYSVEWHEIRPIQLAVARKLLSHVCAIADSSTQNLDLGSFSKVDFLILVPPSEVTYQQTVLHLWQSGVLVDLGLEQAS 729

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   783 TAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNL 862
Cdd:pfam15782  730 TSKQKAEQYVVKLDSEAQAKFESFLQEVKQNPYTLFVLVHDHAHWDLTSAISSSYSHSESGLGLVDRLLNCREVKDAPNI 809

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   863 LVLQVSSFPYTLQTQQSRISSSNEVHWIQL-DTGEDVGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERY 941
Cdd:pfam15782  810 LILHVTSFPYALQTQQTRISPYNEIHWPSAfSNGVDLYHERTRYFGLSEYLESTQSGHSLPLLRYDSSFESMVSALLERF 889

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262   942 PRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTPETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEV 1021
Cdd:pfam15782  890 PKLHSAVIRTYVLIQHYSAALMAVSGSSQLKDHTSVETLEIVQDLINAPQQCPSGHGHMVLLRIPSLQLAMVAYERLCRV 969

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1022 RDKLGLQYRFEIILGNPATELSVATHFVARLKSWRGNEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRL 1101
Cdd:pfam15782  970 RDKLGLEYRFEIILGNPNSELTIGKHFVDQLKAWRKIEDADWVPRTYLELEGLPCILILSGKDPLGESLPRSLKYCDLRL 1049

                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767999262  1102 IDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDLSGKEQERAAVSENDSDE 1154
Cdd:pfam15782 1050 INSSYLTRTALEQELGLAAYYVSKEVPREPGVGSDLSESDAEKLSSTDNEDEE 1102
GREB1_C pfam20267
GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first ...
 1272-1900 0e+00

GREB1 C-terminal region; GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.


Pssm-ID: 466417  Cd Length: 688  Bit Score: 1198.04  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1272 PPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQldPASGT 1351
Cdd:pfam20267    1 PPIVILPKAAYDIITSSDSSGLPRSSSLLPHASVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRQHHMDYSNR--TEGRS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1352 RNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTD-HNESSEVSQSEGEPWPDIESFSKMPFDVS 1430
Cdd:pfam20267   79 DNFHPRRLLLSGPPQVGKTGAYLQFLRILSRMLIRLLEVDVYDEEEININrQSESVQHYHQPNDPWPDLEIFKKMPFDYT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1431 VHDPKYSLMSLVYTEkLAGVKQEVIKESKVEE--PRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAF 1508
Cdd:pfam20267  159 IHDPKYEDASPVYSP-LYKPKSEGKPNPRRQEdvYLRRRTTRIRLSKYAAYNTYHHCEQCHQYMGFNPRYQMYESTLHAF 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1509 TFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKqNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHL 1588
Cdd:pfam20267  238 TFSSSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVSDK-NPDCIKSPIFTPTTGRHEHGLFNLYHAMDGASHL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1589 HLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLW 1668
Cdd:pfam20267  317 HILVVKEYEMAVYKKYWPNHIMLVLPSIFNGAGVGAAHFLIKELSYHNLELERNRQEELGVKRQDVWPFIVIADDSCVMW 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1669 NIHSVQEPSsqpmevGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNV 1748
Cdd:pfam20267  397 NAVDVDAES------GPSERNVSLKQVLQHMEATPKITHYALLGIRKWSSKLLSKKLKEPFSRCHLHDFILLNVDLTQNV 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1749 QYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIM--------------------------- 1801
Cdd:pfam20267  471 QYDQNRFTCEDVDFNLRLHSAGLLICRFNNFSVMKKQIAVGGYRDFHIKPKVSdnptsvspsqyicapdskhtflaapaq 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999262  1802 --------------------------------------VAICYISSRPHSSNVNCEGVFFSGLLLYLCDSFVGAD-LKKF 1842
Cdd:pfam20267  551 lllekylqhtshklfplslknynhpvlsvdcylnlgpeISVCYVSSRPHSVNINTTGLLFSGLLLYLCDSFVTAGfLKKF 630

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767999262  1843 KFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDKPLYFLTGRHV 1900
Cdd:pfam20267  631 HFLKGATLCVICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANAKEDRPLFFLTGRHI 688
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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