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Conserved domains on  [gi|768007637|ref|XP_011524971|]
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zinc finger CCCH domain-containing protein 4 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 348-369 1.55e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


:

Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.55e-07
                           10        20
                   ....*....|....*....|..
gi 768007637   348 VICKYFVEGRCTWGDHCNFSHD 369
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
ZnF_C3H1 smart00356
zinc finger;
375-399 1.09e-05

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.09e-05
                            10        20
                    ....*....|....*....|....*
gi 768007637    375 KRELCKFYITGFCARAENCPYMHGD 399
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
1000-1239 2.59e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.69  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1000 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTdprlqkptdSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRV 1079
Cdd:PRK07003  352 LLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPG---------ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1080 LAAGGLGqgggggqssvlsgislydPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPfvrksaleQPETGKAG 1159
Cdd:PRK07003  423 AEAPPAA------------------PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDA--------QPPADSGS 476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1160 ADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPtlfgTVKQTPKTGSGSPFAGNSPAREGEQDAA 1239
Cdd:PRK07003  477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA----AAPPAPEARPPTPAAAAPAARAGGAAAA 552
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 851-1077 2.05e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  851 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVN---IPLDPLPGHPLRDPRSQLQQFSHIKKDVtlSKPSF 927
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  928 ARTVLWNPEDLIPLPIPKQDAVPPVPAALQSM-------PTLDPRLHRAATAGP-PNARQRPGASTDSSTQGANLPDFEL 999
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppppPTPEPAPHALVSATPlPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1000 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTAS-SRAAKPGPAEAPSPTASPSGDAS--PPATAPYD 1076
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAVLAPAAalPPAASPAG 2826


                  .
gi 768007637 1077 P 1077
Cdd:PHA03247 2827 P 2827
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 348-369 1.55e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.55e-07
                           10        20
                   ....*....|....*....|..
gi 768007637   348 VICKYFVEGRCTWGDHCNFSHD 369
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
ZnF_C3H1 smart00356
zinc finger;
375-399 1.09e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.09e-05
                            10        20
                    ....*....|....*....|....*
gi 768007637    375 KRELCKFYITGFCARAENCPYMHGD 399
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1000-1239 2.59e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.69  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1000 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTdprlqkptdSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRV 1079
Cdd:PRK07003  352 LLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPG---------ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1080 LAAGGLGqgggggqssvlsgislydPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPfvrksaleQPETGKAG 1159
Cdd:PRK07003  423 AEAPPAA------------------PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDA--------QPPADSGS 476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1160 ADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPtlfgTVKQTPKTGSGSPFAGNSPAREGEQDAA 1239
Cdd:PRK07003  477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA----AAPPAPEARPPTPAAAAPAARAGGAAAA 552
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 339-421 3.20e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 47.17  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  339 HQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKREL-CKFY-ITGFCARAENCPYMHGDfP------CKLY--HTT 408
Cdd:COG5084    96 HVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSSQGPpCRSFsLKGSCSSGPSCGYSHID-PdsfagnCDQYsgATY 174

                          90
                  ....*....|...
gi 768007637  409 GNCINGDDCMFSH 421
Cdd:COG5084   175 GFCPLGASCKFSH 187
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 379-397 1.74e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.74e-04
                           10
                   ....*....|....*....
gi 768007637   379 CKFYITGFCARAENCPYMH 397
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
PHA03247 PHA03247
large tegument protein UL36; Provisional
 851-1077 2.05e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  851 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVN---IPLDPLPGHPLRDPRSQLQQFSHIKKDVtlSKPSF 927
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  928 ARTVLWNPEDLIPLPIPKQDAVPPVPAALQSM-------PTLDPRLHRAATAGP-PNARQRPGASTDSSTQGANLPDFEL 999
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppppPTPEPAPHALVSATPlPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1000 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTAS-SRAAKPGPAEAPSPTASPSGDAS--PPATAPYD 1076
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAVLAPAAalPPAASPAG 2826


                  .
gi 768007637 1077 P 1077
Cdd:PHA03247 2827 P 2827
ZnF_C3H1 smart00356
zinc finger;
348-369 1.21e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 1.21e-03
                            10        20
                    ....*....|....*....|..
gi 768007637    348 VICKYFVEGRCTWGDHCNFSHD 369
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 945-1165 3.80e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 41.40  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637   945 KQDAVPPVPAalqsmPTLDPRLHRAATagppnarqrPGASTDSSTQGANLPDF---------ELLSRILKTVNAtGSSAA 1015
Cdd:TIGR01348   86 KKEAAPAPTA-----GAPAPAAQAQAA---------PAAGQSSGVQEVTVPDIgdiekvtviEVLVKVGDTVSA-DQSLI 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  1016 PGSSDK-------PSDPRVRKAPTDPRLQKPTDST-------ASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLA 1081
Cdd:TIGR01348  151 TLESDKasmevpaPASGVVKSVKVKVGDSVPTGDLiltlsvaGSTPATAPAPASAQPAAQSPAATQPEPAAAPAAAKAQA 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  1082 AGGLGQGGGGGqssvlsgiSLYDPRTPNAGGKATEPAADTgAQPKGAEGNGKSSASKAKEppFVrKSALEQPETGKAGAD 1161
Cdd:TIGR01348  231 PAPQQAGTQNP--------AKVDHAAPAVRRLAREFGVDL-SAVKGTGIKGRILREDVQR--FV-KEPSVRAQAAAASAA 298


                   ....
gi 768007637  1162 GGTP 1165
Cdd:TIGR01348  299 GGAP 302
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 348-369 1.55e-07

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 48.35  E-value: 1.55e-07
                           10        20
                   ....*....|....*....|..
gi 768007637   348 VICKYFVEGRCTWGDHCNFSHD 369
Cdd:pfam18044    1 RLCRYFQKGGCRYGDNCRFSHD 22
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 350-368 4.35e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 44.33  E-value: 4.35e-06
                           10
                   ....*....|....*....
gi 768007637   350 CKYFVEGRCTWGDHCNFSH 368
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
375-399 1.09e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.00  E-value: 1.09e-05
                            10        20
                    ....*....|....*....|....*
gi 768007637    375 KRELCKFYITGFCARAENCPYMHGD 399
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1000-1239 2.59e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.69  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1000 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTdprlqkptdSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRV 1079
Cdd:PRK07003  352 LLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPG---------ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1080 LAAGGLGqgggggqssvlsgislydPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPfvrksaleQPETGKAG 1159
Cdd:PRK07003  423 AEAPPAA------------------PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDA--------QPPADSGS 476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1160 ADGGTPTDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPtlfgTVKQTPKTGSGSPFAGNSPAREGEQDAA 1239
Cdd:PRK07003  477 ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA----AAPPAPEARPPTPAAAAPAARAGGAAAA 552
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 339-421 3.20e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 47.17  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  339 HQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKREL-CKFY-ITGFCARAENCPYMHGDfP------CKLY--HTT 408
Cdd:COG5084    96 HVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSSQGPpCRSFsLKGSCSSGPSCGYSHID-PdsfagnCDQYsgATY 174

                          90
                  ....*....|...
gi 768007637  409 GNCINGDDCMFSH 421
Cdd:COG5084   175 GFCPLGASCKFSH 187
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
948-1128 3.54e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.31  E-value: 3.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  948 AVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPdfellsrilktvnaTGSSAAPGSSDKPSDPRV 1027
Cdd:PRK07003  379 AVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAP--------------PAAPAPPATADRGDDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1028 RKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGgqssvlsgislyDPRT 1107
Cdd:PRK07003  445 GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVP------------DARA 512

                         170       180
                  ....*....|....*....|.
gi 768007637 1108 PNAGGKATEPAADTGAQPKGA 1128
Cdd:PRK07003  513 PAAASREDAPAAAAPPAPEAR 533
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 942-1143 5.99e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 5.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  942 PIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDfellsrilktVNATGSSAAPGSSDK 1021
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPG----------VAAPEHHPKHVAVPD 661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1022 PSDPRVRKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGIS 1101
Cdd:PRK07764  662 ASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 768007637 1102 LYDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPP 1143
Cdd:PRK07764  742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
942-1143 1.13e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  942 PIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSRILKTVNATGSSAAPGSSDK 1021
Cdd:PRK12323  375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1022 PSDP--RVRKAPTDPRLQKPTDSTASSRAAkPGPAEAPSPTASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSG 1099
Cdd:PRK12323  455 AAAPaaAARPAAAGPRPVAAAAAAAPARAA-PAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATAD 533

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 768007637 1100 ISlyDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPP 1143
Cdd:PRK12323  534 PD--DAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 851-1177 1.19e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  851 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVNIPLDPLPGHP--LRDPRSQLQQFSHIKKDVTLSKPSFA 928
Cdd:PHA03307   84 SRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSemLRPVGSPGPPPAASPPAAGASPAAVA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  929 RTVLWNPEDLIPLPIPKQDAVPPVPAAlqsmPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSRILKTVN 1008
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAPSSPP----AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1009 ATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASPSGDASPPAtapydPRVLAAGGLGQG 1088
Cdd:PHA03307  240 SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSS-----PGSGPAPSSPRA 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1089 GGGGQSSVLSGISLYDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSAS--KAKEPPFVRKSA-------LEQPETGKAG 1159
Cdd:PHA03307  315 SSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSspRKRPRPSRAPSSpaasagrPTRRRARAAV 394

                         330
                  ....*....|....*...
gi 768007637 1160 ADGGTPTDRYNSYNRPRP 1177
Cdd:PHA03307  395 AGRARRRDATGRFPAGRP 412
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 379-397 1.74e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.74e-04
                           10
                   ....*....|....*....
gi 768007637   379 CKFYITGFCARAENCPYMH 397
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
PHA03247 PHA03247
large tegument protein UL36; Provisional
 851-1077 2.05e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  851 PTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAVN---IPLDPLPGHPLRDPRSQLQQFSHIKKDVtlSKPSF 927
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  928 ARTVLWNPEDLIPLPIPKQDAVPPVPAALQSM-------PTLDPRLHRAATAGP-PNARQRPGASTDSSTQGANLPDFEL 999
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppppPTPEPAPHALVSATPlPPGPAAARQASPALPAAPAPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1000 LSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTAS-SRAAKPGPAEAPSPTASPSGDAS--PPATAPYD 1076
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAVLAPAAalPPAASPAG 2826


                  .
gi 768007637 1077 P 1077
Cdd:PHA03247 2827 P 2827
PHA03247 PHA03247
large tegument protein UL36; Provisional
 940-1232 2.33e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  940 PLPIPKQDAVPPVPAALQSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSRILKTVNATGSSAA---- 1015
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepd 2639

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1016 -PGSSDKPSDPRVRKAPTDPRLQKPTDSTASSRAAKP-GPAEAPSPTASP--------SGDASPPATAPYDPRVLAAGGL 1085
Cdd:PHA03247 2640 pHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAsSPPQRPRRRAARptvgsltsLADPPPPPPTPEPAPHALVSAT 2719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1086 GQGGGGGQSSVLSGISLYDPRTPNAGGKATEPAADTgAQPKGAEGNGKSSASKAKEPPFVRKSALEQPETGKAGADGGTP 1165
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768007637 1166 TDRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPTLFGTVKQTPKTGS----GSPFAGNSPAR 1232
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvapGGDVRRRPPSR 2869
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
374-399 3.43e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.10  E-value: 3.43e-04
                           10        20
                   ....*....|....*....|....*..
gi 768007637   374 KKRELCKFY-ITGFCARAENCPYMHGD 399
Cdd:pfam00642    1 YKTELCRFFlRTGYCKYGDRCKFAHGQ 27
PHA03247 PHA03247
large tegument protein UL36; Provisional
 846-1239 7.14e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  846 LARALPTSKPEGSLHSSPVGPSSSKgsgpppteEEEGERALREKAVNIPLDP-LPGHPLRDPRSQLQQFSHIKKDVTLSK 924
Cdd:PHA03247 2555 LPPAAPPAAPDRSVPPPRPAPRPSE--------PAVTSRARRPDAPPQSARPrAPVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  925 PSFAR----TVLWNPEDLIPLPIPKQDAVPPVPAAlqSMPTLDPRLHRAATAGPPNARQRPGASTDSSTQGANL-----P 995
Cdd:PHA03247 2627 PPPSPspaaNEPDPHPPPTVPPPERPRDDPAPGRV--SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadpppP 2704

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  996 DFELLSRILKTVNATGSSAAPGSSDK-----PSDPRVRKAPTDPrlqkPTDSTASSRAAKPGPAEAPSPTASPSGDASPP 1070
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQaspalPAAPAPPAVPAGP----ATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1071 ATAPYDPRVLAAGGLGQGGGGGQSSvlsgislyDPRTPNAGGKATEPAADTGAQPKGAEGNGKSSASKAKEPPFVRKSAL 1150
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPA--------DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637 1151 E-----------QPETGKAGADGGTPTdRYNSYNRPRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPTLFGTVKQTPKT 1219
Cdd:PHA03247 2853 GgsvapggdvrrRPPSRSPAAKPAAPA-RPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         410       420
                  ....*....|....*....|
gi 768007637 1220 GSGSPFAGNSPAREGEQDAA 1239
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAG 2951
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 981-1131 8.47e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 8.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  981 PGASTDsstQGANLPDFELLSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRlqkPTDSTASSRAAKPGPAEAPSPT 1060
Cdd:PRK07764  365 PSASDD---ERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAA---PAAAAAPAPAAAPQPAPAPAPA 438

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768007637 1061 ASPSGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKATEPAADTGAQPKGAEGN 1131
Cdd:PRK07764  439 PAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDA 509
ZnF_C3H1 smart00356
zinc finger;
348-369 1.21e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 1.21e-03
                            10        20
                    ....*....|....*....|..
gi 768007637    348 VICKYFVEGRCTWGDHCNFSHD 369
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 957-1074 1.49e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.79  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  957 QSMPTLDPRLHRAAtagppnARQRPGASTDSSTQGANLPDfellsrilktvnatgsSAAPGSSDKPSDPRVRKAPTDPRL 1036
Cdd:PHA03269   22 LNTNIPIPELHTSA------ATQKPDPAPAPHQAASRAPD----------------PAVAPTSAASRKPDLAQAPTPAAS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 768007637 1037 QKPTDSTASSRAA--KPGPAEAPSPTASPSGDAS-PPATAP 1074
Cdd:PHA03269   80 EKFDPAPAPHQAAsrAPDPAVAPQLAAAPKPDAAeAFTSAA 120
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 945-1165 3.80e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 41.40  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637   945 KQDAVPPVPAalqsmPTLDPRLHRAATagppnarqrPGASTDSSTQGANLPDF---------ELLSRILKTVNAtGSSAA 1015
Cdd:TIGR01348   86 KKEAAPAPTA-----GAPAPAAQAQAA---------PAAGQSSGVQEVTVPDIgdiekvtviEVLVKVGDTVSA-DQSLI 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  1016 PGSSDK-------PSDPRVRKAPTDPRLQKPTDST-------ASSRAAKPGPAEAPSPTASPSGDASPPATAPYDPRVLA 1081
Cdd:TIGR01348  151 TLESDKasmevpaPASGVVKSVKVKVGDSVPTGDLiltlsvaGSTPATAPAPASAQPAAQSPAATQPEPAAAPAAAKAQA 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  1082 AGGLGQGGGGGqssvlsgiSLYDPRTPNAGGKATEPAADTgAQPKGAEGNGKSSASKAKEppFVrKSALEQPETGKAGAD 1161
Cdd:TIGR01348  231 PAPQQAGTQNP--------AKVDHAAPAVRRLAREFGVDL-SAVKGTGIKGRILREDVQR--FV-KEPSVRAQAAAASAA 298


                   ....
gi 768007637  1162 GGTP 1165
Cdd:TIGR01348  299 GGAP 302
PHA03381 PHA03381
tegument protein VP22; Provisional
 972-1079 5.84e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 40.38  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768007637  972 AGPPNARqRPGASTDSSTQGAnlpdfellSRILKTVNATGSSAAPGSSDKPSDPRVRKAPTDPRLQKPTDSTASSRAAKP 1051
Cdd:PHA03381   85 ADPRPSR-RPHAQPEASGPGP--------ARGARGPAGSRGRGRRAESPSPRDPPNPKGASAPRGRKSACADSAALLDAP 155

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768007637 1052 GPAeAPSPTASPSG--------DASPPATAPYDPRV 1079
Cdd:PHA03381  156 APA-APKRQKTPAGlarklhfsTAPTSPTAPWTPRV 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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