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Conserved domains on  [gi|768008273|ref|XP_011525094|]
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transmembrane protein 145 isoform X2 [Homo sapiens]

Protein Classification

lung seven transmembrane receptor family protein( domain architecture ID 229834)

lung seven transmembrane receptor (LU7TM) family protein similar to Arabidopsis thaliana protein CANDIDATE G-PROTEIN COUPLED RECEPTORS 6 and 7 that play roles in plants and microbes interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lung_7-TM_R super family cl21735
Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic ...
 157-313 8.36e-41

Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.


The actual alignment was detected with superfamily member pfam10192:

Pssm-ID: 473945  Cd Length: 257  Bit Score: 144.70  E-value: 8.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008273  157 GLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFF 236
Cdd:pfam10192   1 GLKLEYEITLTNGGDFLTSHFSADEQGILELFFFFFLLYIILLIINIVFIQALKKRGLKHPVLKLLSVILLLELISLLLN 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768008273  237 CIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEA 313
Cdd:pfam10192  81 LIHLIVYSYNGIGIPLLQILGEILDILSQILFMLLLILLAKGWTITRYSLSSLNFVILLPIIILITVFQVILVIWYI 157
 
Name Accession Description Interval E-value
GpcrRhopsn4 pfam10192
Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven ...
 157-313 8.36e-41

Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.


Pssm-ID: 462989  Cd Length: 257  Bit Score: 144.70  E-value: 8.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008273  157 GLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFF 236
Cdd:pfam10192   1 GLKLEYEITLTNGGDFLTSHFSADEQGILELFFFFFLLYIILLIINIVFIQALKKRGLKHPVLKLLSVILLLELISLLLN 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768008273  237 CIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEA 313
Cdd:pfam10192  81 LIHLIVYSYNGIGIPLLQILGEILDILSQILFMLLLILLAKGWTITRYSLSSLNFVILLPIIILITVFQVILVIWYI 157
 
Name Accession Description Interval E-value
GpcrRhopsn4 pfam10192
Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven ...
 157-313 8.36e-41

Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.


Pssm-ID: 462989  Cd Length: 257  Bit Score: 144.70  E-value: 8.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008273  157 GLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFF 236
Cdd:pfam10192   1 GLKLEYEITLTNGGDFLTSHFSADEQGILELFFFFFLLYIILLIINIVFIQALKKRGLKHPVLKLLSVILLLELISLLLN 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768008273  237 CIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEA 313
Cdd:pfam10192  81 LIHLIVYSYNGIGIPLLQILGEILDILSQILFMLLLILLAKGWTITRYSLSSLNFVILLPIIILITVFQVILVIWYI 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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