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Conserved domains on  [gi|768012196|ref|XP_011525824|]
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zinc finger protein 264 isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-54 2.99e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768012196   13 SVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLG 54
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-529 7.78e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 225 RPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCN--ECGKAFTHRSNFVLHNRRHTGEKSFVCTecgQVFRHRPGFLRHY 302
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 303 VVHSG--ENPYECLECGKVFKHRSYlmwHQQTHTGEKPYE--------CSECGKVFLESAALIH-HYVIHTGEKPFECLE 371
Cdd:COG5048  109 SLSSSssNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 372 CGKAFNHRSYLKRHQ----RIHTGEKPFVCSECGK------AFTHCSTFILHKR--------AHTGEKPFECKECG---- 429
Cdd:COG5048  186 LLISSNVSTSIPSSSenspLSSSYSIPSSSSDQNLenssssLPLTTNSQLSPKSllsqspssLSSSDSSSSASESPrssl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 430 --KAFSNRKDLIRHFSIHTG-EKPYECVECGKAFTRMSGLTRHKR--IHSGE--KPYECVE--CGKSFCWSTNLIRHAII 500
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350
                 ....*....|....*....|....*....|.
gi 768012196 501 HTGEKPYKC--SECGKAFSRSSSLTQHQRMH 529
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-54 2.99e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768012196   13 SVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLG 54
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
14-56 3.53e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.96  E-value: 3.53e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 768012196    14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGDK 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.30e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.30e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768012196  14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-529 7.78e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 225 RPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCN--ECGKAFTHRSNFVLHNRRHTGEKSFVCTecgQVFRHRPGFLRHY 302
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 303 VVHSG--ENPYECLECGKVFKHRSYlmwHQQTHTGEKPYE--------CSECGKVFLESAALIH-HYVIHTGEKPFECLE 371
Cdd:COG5048  109 SLSSSssNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 372 CGKAFNHRSYLKRHQ----RIHTGEKPFVCSECGK------AFTHCSTFILHKR--------AHTGEKPFECKECG---- 429
Cdd:COG5048  186 LLISSNVSTSIPSSSenspLSSSYSIPSSSSDQNLenssssLPLTTNSQLSPKSllsqspssLSSSDSSSSASESPrssl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 430 --KAFSNRKDLIRHFSIHTG-EKPYECVECGKAFTRMSGLTRHKR--IHSGE--KPYECVE--CGKSFCWSTNLIRHAII 500
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350
                 ....*....|....*....|....*....|.
gi 768012196 501 HTGEKPYKC--SECGKAFSRSSSLTQHQRMH 529
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 9.30e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 9.30e-06
                          10        20
                  ....*....|....*....|....*.
gi 768012196  381 YLKRHQRIHTGEKPFVCSECGKAFTH 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-54 2.99e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768012196   13 SVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLG 54
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
14-56 3.53e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.96  E-value: 3.53e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 768012196    14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGDK 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.30e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.30e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768012196  14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-529 7.78e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 225 RPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCN--ECGKAFTHRSNFVLHNRRHTGEKSFVCTecgQVFRHRPGFLRHY 302
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 303 VVHSG--ENPYECLECGKVFKHRSYlmwHQQTHTGEKPYE--------CSECGKVFLESAALIH-HYVIHTGEKPFECLE 371
Cdd:COG5048  109 SLSSSssNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 372 CGKAFNHRSYLKRHQ----RIHTGEKPFVCSECGK------AFTHCSTFILHKR--------AHTGEKPFECKECG---- 429
Cdd:COG5048  186 LLISSNVSTSIPSSSenspLSSSYSIPSSSSDQNLenssssLPLTTNSQLSPKSllsqspssLSSSDSSSSASESPrssl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 430 --KAFSNRKDLIRHFSIHTG-EKPYECVECGKAFTRMSGLTRHKR--IHSGE--KPYECVE--CGKSFCWSTNLIRHAII 500
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350
                 ....*....|....*....|....*....|.
gi 768012196 501 HTGEKPYKC--SECGKAFSRSSSLTQHQRMH 529
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-536 8.99e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 8.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 152 SHNSCESGKDPMIQEEENN--FKCSECGKVFNKKHLLAGHEKIHSGVKPYECT--ECGKTFIKSTHLLQHHMIHTGERPY 227
Cdd:COG5048   13 NSVLSSTPKSTLKSLSNAPrpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 228 ECmeCGKAFNRKSYLTQHQRIHSGE---KPYKCNECGKAFTHR--------SNFVLHNRRHTGEKSFVCT---------- 286
Cdd:COG5048   93 LN--SKSLPLSNSKASSSSLSSSSSnsnDNNLLSSHSLPPSSRdpqlpdllSISNLRNNPLPGNNSSSVNtpqsnslhpp 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 287 -----ECGQVFRHRPGFLRHYVVHSGENPYECLECgkvfkHRSYLMWHQQTH----TGEKPYECSECGKVFLESaaLIHH 357
Cdd:COG5048  171 lpansLSKDPSSNLSLLISSNVSTSIPSSSENSPL-----SSSYSIPSSSSDqnleNSSSSLPLTTNSQLSPKS--LLSQ 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 358 YVIHTGeKPFECLECGKAFNHRSYLKRHQRIH----------TGEKPFVCSECGKAFTHCSTFILHKRA--HTGE--KPF 423
Cdd:COG5048  244 SPSSLS-SSDSSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPF 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 424 ECKE--CGKAFSNRKDLIRHFSIHTGEKPYECV--ECGKAFTRMS-----GLTRHKRIHSGEKPYECVE-CGKSFCWST- 492
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnSCIRNFKRDs 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 768012196 493 NLIRHAIIHTGEKPY--KCSECGKAFSRSSSLTQHQRMHTGKNPIS 536
Cdd:COG5048  403 NLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-402 1.14e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 197 KPYECTECGKTFIKSTHLLQH--HMIHTGE--RPYECME--CGKAFNRKSYLTQHQRIHSGEKPYKC--NECGKAFTHRS 268
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 269 NfvlhnrrhtgeksfvctecgqvfRHRPGFLRHYVVHSGENPYECL--ECGKVFKHRSYLMWHQQTHTGEKPYECSecgk 346
Cdd:COG5048  368 N-----------------------NEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCK---- 420

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768012196 347 vflesaalihhyvihtgekpfeCLECGKAFNHRSYLKRHQRIHTGEKPFVCSECGK 402
Cdd:COG5048  421 ----------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-548 1.70e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 253 KPYKCNECGKAFTHRSNFVLHNRRHTGEKSFVCTECGQVF-RHRPGFLRHYVVHSGENPYECLEcgkvfkHRSYLMWHQQ 331
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsFSRPLELSRHLRTHHNNPSDLNS------KSLPLSNSKA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 332 THTgEKPYECSECGKVFLESAALIHHYVIHTgEKPFECLEC--GKAFNHRSYLKRHQRIHTGEKPFVCS--ECGKAFTHC 407
Cdd:COG5048  106 SSS-SLSSSSSNSNDNNLLSSHSLPPSSRDP-QLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 408 STFILHKRAHTGEKPFECKECGKAFSNRKDLIRHFSIHTGEKPYECVECGKAF--------------------------- 460
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspsslsssdssssasesprs 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 461 ---TRMSGLTRHKRIHSGE-----KPYECVECGKSFCWSTNLIRH--AIIHTGE--KPYKCSE--CGKAFSRSSSLTQHQ 526
Cdd:COG5048  264 slpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340
                 ....*....|....*....|..
gi 768012196 527 RMHTGKNPISVTDVGRPFTSGQ 548
Cdd:COG5048  344 LLHTSISPAKEKLLNSSSKFSP 365
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 9.30e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 9.30e-06
                          10        20
                  ....*....|....*....|....*.
gi 768012196  381 YLKRHQRIHTGEKPFVCSECGKAFTH 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 5.32e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.32e-05
                          10        20
                  ....*....|....*....|....*.
gi 768012196  241 YLTQHQRIHSGEKPYKCNECGKAFTH 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-518 8.95e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.95e-05
                          10        20
                  ....*....|....*....|....*.
gi 768012196  493 NLIRHAIIHTGEKPYKCSECGKAFSR 518
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-471 1.83e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 244 QHQRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTGEKSFVCTECGQVFRHRPGFLRHYVVHSGE-------NPYECLEC 316
Cdd:COG5048  216 SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQC 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 317 GKVFKHRSYLMWHQQT--HTGE--KPYECSE--CGKVFLESAALIHHYVIHTGEKPFEC--LECGKAFNHRSYLKRHQRI 388
Cdd:COG5048  296 NISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSL 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 389 H-----TGEKPFVC--SECGKAFTHCSTFILHKRAHTGEKP--FECKECGKAFSNRKDLIRHFSIHTgEKPYECVECGKA 459
Cdd:COG5048  376 QqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKS 454

                        250
                 ....*....|..
gi 768012196 460 FTRMSGLTRHKR 471
Cdd:COG5048  455 FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-348 2.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.96e-04
                          10        20
                  ....*....|....*....|....
gi 768012196  325 YLMWHQQTHTGEKPYECSECGKVF 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 507-529 3.10e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|...
gi 768012196  507 YKCSECGKAFSRSSSLTQHQRMH 529
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
213-238 6.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.12e-04
                          10        20
                  ....*....|....*....|....*.
gi 768012196  213 HLLQHHMIHTGERPYECMECGKAFNR 238
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
466-488 1.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|...
gi 768012196  466 LTRHKRIHSGEKPYECVECGKSF 488
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 447-530 1.37e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 447 GEKPYEC--VECGKAFTRMSGLTRHkRIHSgekpyecvECGKSFCWSTNLIRHAIIHTGEKPYKCSECGKAFSRSSSLTQ 524
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 768012196 525 HqRMHT 530
Cdd:COG5189  417 H-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 367-389 1.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|...
gi 768012196  367 FECLECGKAFNHRSYLKRHQRIH 389
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 227-249 2.77e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.77e-03
                          10        20
                  ....*....|....*....|...
gi 768012196  227 YECMECGKAFNRKSYLTQHQRIH 249
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 311-333 4.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.13e-03
                          10        20
                  ....*....|....*....|...
gi 768012196  311 YECLECGKVFKHRSYLMWHQQTH 333
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-434 4.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.32e-03
                          10        20
                  ....*....|....*....|..
gi 768012196  413 HKRAHTGEKPFECKECGKAFSN 434
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 4.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 768012196  437 DLIRHFSIHTGEKPYECVECGKAFTR 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-301 6.87e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 6.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768012196 166 EEENNFKCSE--CGKVFNKKHLLAGHEKIHSGVKPYEC--TECGKTFIKSTH-----LLQHHMIHTGERPYECM--ECGK 234
Cdd:COG5048  317 ESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIR 396

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768012196 235 AFNRKSYLTQH--QRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTgEKSFVCTECGQVFRHRPGFLRH 301
Cdd:COG5048  397 NFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 255-277 8.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.89e-03
                          10        20
                  ....*....|....*....|...
gi 768012196  255 YKCNECGKAFTHRSNFVLHNRRH 277
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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