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chromatin assembly factor 1 subunit A isoform X2 [Homo sapiens]
CAF1-p150_N and CAF1-p150_C2 domain-containing protein( domain architecture ID 12173874)
protein containing domains CAF1-p150_N, CAF-1_p150, CAF1A, and CAF1-p150_C2
List of domain hits
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Name | Accession | Description | Interval | E-value | |||||
CAF1-p150_C2 | pfam15539 | CAF1 complex subunit p150, region binding to CAF1-p60 at C-term; CAF1-p150_C2 is part of the ... |
646-935 | 0e+00 | |||||
CAF1 complex subunit p150, region binding to CAF1-p60 at C-term; CAF1-p150_C2 is part of the binding region of the CAF1 complex p150 subunit to the p60 subunit. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. : Pssm-ID: 434777 Cd Length: 288 Bit Score: 561.53 E-value: 0e+00
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CAF1-p150_N | pfam15557 | CAF1 complex subunit p150, region binding to PCNA; CAF1-p150_N is part of the N-terminus of ... |
1-226 | 1.97e-150 | |||||
CAF1 complex subunit p150, region binding to PCNA; CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. : Pssm-ID: 464767 Cd Length: 230 Bit Score: 443.56 E-value: 1.97e-150
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CAF-1_p150 | pfam11600 | Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ... |
382-460 | 2.11e-27 | |||||
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis. : Pssm-ID: 402959 [Multi-domain] Cd Length: 164 Bit Score: 109.39 E-value: 2.11e-27
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CAF1A | pfam12253 | Chromatin assembly factor 1 subunit A; The CAF-1 or chromatin assembly factor-1 consists of ... |
539-582 | 5.11e-19 | |||||
Chromatin assembly factor 1 subunit A; The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A. The A domain is uniquely required for the progression of S phase in mouse cells, independent of its ability to promote histone deposition but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints. : Pssm-ID: 463507 Cd Length: 75 Bit Score: 82.16 E-value: 5.11e-19
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Name | Accession | Description | Interval | E-value | |||||
CAF1-p150_C2 | pfam15539 | CAF1 complex subunit p150, region binding to CAF1-p60 at C-term; CAF1-p150_C2 is part of the ... |
646-935 | 0e+00 | |||||
CAF1 complex subunit p150, region binding to CAF1-p60 at C-term; CAF1-p150_C2 is part of the binding region of the CAF1 complex p150 subunit to the p60 subunit. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. Pssm-ID: 434777 Cd Length: 288 Bit Score: 561.53 E-value: 0e+00
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CAF1-p150_N | pfam15557 | CAF1 complex subunit p150, region binding to PCNA; CAF1-p150_N is part of the N-terminus of ... |
1-226 | 1.97e-150 | |||||
CAF1 complex subunit p150, region binding to PCNA; CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. Pssm-ID: 464767 Cd Length: 230 Bit Score: 443.56 E-value: 1.97e-150
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CAF-1_p150 | pfam11600 | Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ... |
382-460 | 2.11e-27 | |||||
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis. Pssm-ID: 402959 [Multi-domain] Cd Length: 164 Bit Score: 109.39 E-value: 2.11e-27
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CAF1A | pfam12253 | Chromatin assembly factor 1 subunit A; The CAF-1 or chromatin assembly factor-1 consists of ... |
539-582 | 5.11e-19 | |||||
Chromatin assembly factor 1 subunit A; The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A. The A domain is uniquely required for the progression of S phase in mouse cells, independent of its ability to promote histone deposition but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints. Pssm-ID: 463507 Cd Length: 75 Bit Score: 82.16 E-value: 5.11e-19
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Name | Accession | Description | Interval | E-value | |||||
CAF1-p150_C2 | pfam15539 | CAF1 complex subunit p150, region binding to CAF1-p60 at C-term; CAF1-p150_C2 is part of the ... |
646-935 | 0e+00 | |||||
CAF1 complex subunit p150, region binding to CAF1-p60 at C-term; CAF1-p150_C2 is part of the binding region of the CAF1 complex p150 subunit to the p60 subunit. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. Pssm-ID: 434777 Cd Length: 288 Bit Score: 561.53 E-value: 0e+00
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CAF1-p150_N | pfam15557 | CAF1 complex subunit p150, region binding to PCNA; CAF1-p150_N is part of the N-terminus of ... |
1-226 | 1.97e-150 | |||||
CAF1 complex subunit p150, region binding to PCNA; CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. Pssm-ID: 464767 Cd Length: 230 Bit Score: 443.56 E-value: 1.97e-150
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CAF-1_p150 | pfam11600 | Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ... |
382-460 | 2.11e-27 | |||||
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis. Pssm-ID: 402959 [Multi-domain] Cd Length: 164 Bit Score: 109.39 E-value: 2.11e-27
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CAF1A | pfam12253 | Chromatin assembly factor 1 subunit A; The CAF-1 or chromatin assembly factor-1 consists of ... |
539-582 | 5.11e-19 | |||||
Chromatin assembly factor 1 subunit A; The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A. The A domain is uniquely required for the progression of S phase in mouse cells, independent of its ability to promote histone deposition but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints. Pssm-ID: 463507 Cd Length: 75 Bit Score: 82.16 E-value: 5.11e-19
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Blast search parameters | ||||
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