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Conserved domains on  [gi|768003200|ref|XP_011526446|]
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RNA exonuclease 1 homolog isoform X1 [Homo sapiens]

Protein Classification

EloA-BP1 and REX1_like domain-containing protein( domain architecture ID 13315180)

protein containing domains PTZ00449, EloA-BP1, and REX1_like

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EloA-BP1 pfam15870
ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically ...
 802-960 3.35e-86

ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically between 144 and 167 amino acids in length.


:

Pssm-ID: 464914  Cd Length: 163  Bit Score: 277.71  E-value: 3.35e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   802 KPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPG 881
Cdd:pfam15870    1 RPVIPTEFGSKVPTNIRQRYLNLFIDECLKICTSEQEAFERALEEEKAVYDRCSSKNIYLNVAVNTLKKLRKEVPSQSSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   882 LSKT----SGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAII 957
Cdd:pfam15870   81 VTKSsaisSNNKVVSHEAVLGGKLAAKTSFSINRNSKSIEEDLKGATLYRMLKEYLLTEEQLKENGYPRPHPDKPGRAVL 160


                   ...
gi 768003200   958 FTA 960
Cdd:pfam15870  161 FTA 163
REX1_like cd06145
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This ...
 1070-1203 1.46e-67

DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This subfamily is composed of RNA exonuclease 1 (REX1 or Rex1p), REX3 (or Rex3p), and similar eukaryotic proteins. In yeast, REX1 and REX3 are required for 5S rRNA and MRP (mitochondrial RNA processing) RNA maturation, respectively. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX1 is the major exonuclease responsible for pre-tRNA trail trimming and may also be involved in nuclear CCA turnover. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherichia coli RNase T.


:

Pssm-ID: 99848  Cd Length: 150  Bit Score: 223.90  E-value: 1.46e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1070 YALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1149
Cdd:cd06145     1 FALDCEMCYTTDGLELTRVTVVDENGKVVLDELVKPDGEIVDYNTRFSGITEEMLENVTTTLEDVQKKLLSLISPDTILV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 768003200 1150 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNGE 1203
Cdd:cd06145    81 GHSLENDLKALKLIHPRVIDTAILFPHPRGPPYKPSLKNLAKKYLGRDIQQGEG 134
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 400-688 1.23e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  400 KDKGRGRPVEKPRADKKGPQASSPrrkaERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTsgdsRPAAGRGPPRPLQL 479
Cdd:PTZ00449  583 KDPKHPKDPEEPKKPKRPRSAQRP----TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ----RPSSPERPEGPKII 654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  480 PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES---EDEAAGPGVPSVWPSALPSLSSDSDSDSDS 556
Cdd:PTZ00449  655 KSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFE 734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  557 SLGFPEAQGP-------PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEV-----------------DFDSDP 612
Cdd:PTZ00449  735 PIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEamkrpdspsehedkppgDHPSLP 814

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  613 ME----ECLRIfneSTSVKTEDRGRLARQPPKE--EKSEEKGLSGLTTL-----FPGQKRRI-------------SHLSK 668
Cdd:PTZ00449  815 KKrhrlDGLAL---STTDLESDAGRIAKDASGKivKLKRSKSFDDLTTVeeaeeMGAEARKIvvdddgteaddedTHPPE 891

                         330       340
                  ....*....|....*....|
gi 768003200  669 QGQEVEPPRRGPAVPPARPP 688
Cdd:PTZ00449  892 EKHKSEVRRRRPPKKPSKPK 911
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1207-1367 2.18e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1207 LPWGRPCAGAGCSPHLPRSGWAqlqrgrrrlhAPGdleGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPKQcNKSPVTR 1286
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSV----------APG---GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFAL 2900

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1287 PPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLASLETAAdgdqdrARPHPARSPSCPSCQALPPGWWPA 1366
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA------GAGEPSGAVPQPWLGALVPGRVAV 2974


                  .
gi 768003200 1367 P 1367
Cdd:PHA03247 2975 P 2975
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 115-481 1.64e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  115 TTREHRSAEAP----ALAPRGPNASPTVGPDEDAFPlafdysPGSHGLLSPdagyQPTPLAAPAEPGSKYSLASLDRGQG 190
Cdd:PHA03247 2583 TSRARRPDAPPqsarPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP----PPSPSPAANEPDPHPPPTVPPPERP 2652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  191 RGGGGggaleyvPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSArhLSRASSRDERAAKRPRGSRGSEPYTP 270
Cdd:PHA03247 2653 RDDPA-------PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS--LADPPPPPPTPEPAPHALVSATPLPP 2723

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  271 APKKLCDPFGSCDAR-FSDSEDEAATVPGNE-----PTTASTPKARADPEIKATGQPPSKEglEAEGGGLRETKETA-VQ 343
Cdd:PHA03247 2724 GPAAARQASPALPAApAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLT--RPAVASLSESRESLpSP 2801

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  344 CDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPS------CKDGAQGKDKtkdkgRGRPVEKPRADKKG 417
Cdd:PHA03247 2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPppslplGGSVAPGGDV-----RRRPPSRSPAAKPA 2876

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768003200  418 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPD 481
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
 
Name Accession Description Interval E-value
EloA-BP1 pfam15870
ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically ...
 802-960 3.35e-86

ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically between 144 and 167 amino acids in length.


Pssm-ID: 464914  Cd Length: 163  Bit Score: 277.71  E-value: 3.35e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   802 KPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPG 881
Cdd:pfam15870    1 RPVIPTEFGSKVPTNIRQRYLNLFIDECLKICTSEQEAFERALEEEKAVYDRCSSKNIYLNVAVNTLKKLRKEVPSQSSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   882 LSKT----SGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAII 957
Cdd:pfam15870   81 VTKSsaisSNNKVVSHEAVLGGKLAAKTSFSINRNSKSIEEDLKGATLYRMLKEYLLTEEQLKENGYPRPHPDKPGRAVL 160


                   ...
gi 768003200   958 FTA 960
Cdd:pfam15870  161 FTA 163
REX1_like cd06145
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This ...
 1070-1203 1.46e-67

DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This subfamily is composed of RNA exonuclease 1 (REX1 or Rex1p), REX3 (or Rex3p), and similar eukaryotic proteins. In yeast, REX1 and REX3 are required for 5S rRNA and MRP (mitochondrial RNA processing) RNA maturation, respectively. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX1 is the major exonuclease responsible for pre-tRNA trail trimming and may also be involved in nuclear CCA turnover. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherichia coli RNase T.


Pssm-ID: 99848  Cd Length: 150  Bit Score: 223.90  E-value: 1.46e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1070 YALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1149
Cdd:cd06145     1 FALDCEMCYTTDGLELTRVTVVDENGKVVLDELVKPDGEIVDYNTRFSGITEEMLENVTTTLEDVQKKLLSLISPDTILV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 768003200 1150 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNGE 1203
Cdd:cd06145    81 GHSLENDLKALKLIHPRVIDTAILFPHPRGPPYKPSLKNLAKKYLGRDIQQGEG 134
EXOIII smart00479
exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other ...
 1069-1199 3.58e-23

exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases;


Pssm-ID: 214685 [Multi-domain]  Cd Length: 169  Bit Score: 97.76  E-value: 3.58e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   1069 IYALDCEMSYTTYG----LELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSvTLRDVQAVLLSMFSA 1144
Cdd:smart00479    2 LVVIDCETTGLDPGkdeiIEIAAVDVDGGEIIEVFDTYVKPDRPITDYATEIHGITPEMLDDAP-TFEEVLEELLEFLRG 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768003200   1145 DTILIGHSLESDLLALKVIH----------STVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQ 1199
Cdd:smart00479   81 RILVAGNSAHFDLRFLKLEHprlgikqppkLPVIDTLKLARATNPGLPKYSLKKLAKRLLLEVIQ 145
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 400-688 1.23e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  400 KDKGRGRPVEKPRADKKGPQASSPrrkaERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTsgdsRPAAGRGPPRPLQL 479
Cdd:PTZ00449  583 KDPKHPKDPEEPKKPKRPRSAQRP----TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ----RPSSPERPEGPKII 654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  480 PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES---EDEAAGPGVPSVWPSALPSLSSDSDSDSDS 556
Cdd:PTZ00449  655 KSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFE 734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  557 SLGFPEAQGP-------PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEV-----------------DFDSDP 612
Cdd:PTZ00449  735 PIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEamkrpdspsehedkppgDHPSLP 814

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  613 ME----ECLRIfneSTSVKTEDRGRLARQPPKE--EKSEEKGLSGLTTL-----FPGQKRRI-------------SHLSK 668
Cdd:PTZ00449  815 KKrhrlDGLAL---STTDLESDAGRIAKDASGKivKLKRSKSFDDLTTVeeaeeMGAEARKIvvdddgteaddedTHPPE 891

                         330       340
                  ....*....|....*....|
gi 768003200  669 QGQEVEPPRRGPAVPPARPP 688
Cdd:PTZ00449  892 EKHKSEVRRRRPPKKPSKPK 911
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1207-1367 2.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1207 LPWGRPCAGAGCSPHLPRSGWAqlqrgrrrlhAPGdleGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPKQcNKSPVTR 1286
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSV----------APG---GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFAL 2900

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1287 PPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLASLETAAdgdqdrARPHPARSPSCPSCQALPPGWWPA 1366
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA------GAGEPSGAVPQPWLGALVPGRVAV 2974


                  .
gi 768003200 1367 P 1367
Cdd:PHA03247 2975 P 2975
PHA03247 PHA03247
large tegument protein UL36; Provisional
 115-481 1.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  115 TTREHRSAEAP----ALAPRGPNASPTVGPDEDAFPlafdysPGSHGLLSPdagyQPTPLAAPAEPGSKYSLASLDRGQG 190
Cdd:PHA03247 2583 TSRARRPDAPPqsarPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP----PPSPSPAANEPDPHPPPTVPPPERP 2652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  191 RGGGGggaleyvPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSArhLSRASSRDERAAKRPRGSRGSEPYTP 270
Cdd:PHA03247 2653 RDDPA-------PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS--LADPPPPPPTPEPAPHALVSATPLPP 2723

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  271 APKKLCDPFGSCDAR-FSDSEDEAATVPGNE-----PTTASTPKARADPEIKATGQPPSKEglEAEGGGLRETKETA-VQ 343
Cdd:PHA03247 2724 GPAAARQASPALPAApAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLT--RPAVASLSESRESLpSP 2801

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  344 CDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPS------CKDGAQGKDKtkdkgRGRPVEKPRADKKG 417
Cdd:PHA03247 2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPppslplGGSVAPGGDV-----RRRPPSRSPAAKPA 2876

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768003200  418 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPD 481
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
 
Name Accession Description Interval E-value
EloA-BP1 pfam15870
ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically ...
 802-960 3.35e-86

ElonginA binding-protein 1; This domain family is found in eukaryotes, and is typically between 144 and 167 amino acids in length.


Pssm-ID: 464914  Cd Length: 163  Bit Score: 277.71  E-value: 3.35e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   802 KPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPG 881
Cdd:pfam15870    1 RPVIPTEFGSKVPTNIRQRYLNLFIDECLKICTSEQEAFERALEEEKAVYDRCSSKNIYLNVAVNTLKKLRKEVPSQSSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   882 LSKT----SGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAII 957
Cdd:pfam15870   81 VTKSsaisSNNKVVSHEAVLGGKLAAKTSFSINRNSKSIEEDLKGATLYRMLKEYLLTEEQLKENGYPRPHPDKPGRAVL 160


                   ...
gi 768003200   958 FTA 960
Cdd:pfam15870  161 FTA 163
REX1_like cd06145
DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This ...
 1070-1203 1.46e-67

DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; This subfamily is composed of RNA exonuclease 1 (REX1 or Rex1p), REX3 (or Rex3p), and similar eukaryotic proteins. In yeast, REX1 and REX3 are required for 5S rRNA and MRP (mitochondrial RNA processing) RNA maturation, respectively. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX1 is the major exonuclease responsible for pre-tRNA trail trimming and may also be involved in nuclear CCA turnover. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherichia coli RNase T.


Pssm-ID: 99848  Cd Length: 150  Bit Score: 223.90  E-value: 1.46e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1070 YALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1149
Cdd:cd06145     1 FALDCEMCYTTDGLELTRVTVVDENGKVVLDELVKPDGEIVDYNTRFSGITEEMLENVTTTLEDVQKKLLSLISPDTILV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 768003200 1150 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNGE 1203
Cdd:cd06145    81 GHSLENDLKALKLIHPRVIDTAILFPHPRGPPYKPSLKNLAKKYLGRDIQQGEG 134
DEDDh_RNase cd06137
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonucleases PAN2, RNA exonuclease (REX) ...
 1070-1203 4.23e-33

DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonucleases PAN2, RNA exonuclease (REX)-1,-3, and -4, ISG20, and similar proteins; This group is composed of eukaryotic exoribonucleases that include PAN2, RNA exonuclease 1 (REX1 or Rex1p), REX3 (Rex3p), REX4 (or Rex4p), ISG20, and similar proteins. They are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. PAN2 is the catalytic subunit of poly(A) nuclease (PAN), a Pab1p-dependent 3'-5' exoribonuclease which plays an important role in the posttranscriptional maturation of pre-mRNAs. REX proteins are required for the processing and maturation of many RNA species, and ISG20 is an interferon-induced antiviral exonuclease with a strong preference for single-stranded RNA.


Pssm-ID: 99840  Cd Length: 161  Bit Score: 125.86  E-value: 4.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1070 YALDCEMSYTTYGL-ELTRVTV-VDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLAD---TSVTLR--DVQAVLLSMF 1142
Cdd:cd06137     1 VALDCEMVGLADGDsEVVRISAvDVLTGEVLIDSLVRPSVRVTDWRTRFSGVTPADLEEaakAGKTIFgwEAARAALWKF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768003200 1143 S-ADTILIGHSLESDLLALKVIHSTVVDTSVLFPHRLGLPY---KRSLRNLMADYLRQIIQDNGE 1203
Cdd:cd06137    81 IdPDTILVGHSLQNDLDALRMIHTRVVDTAILTREAVKGPLakrQWSLRTLCRDFLGLKIQGGGE 145
EXOIII smart00479
exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other ...
 1069-1199 3.58e-23

exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases;


Pssm-ID: 214685 [Multi-domain]  Cd Length: 169  Bit Score: 97.76  E-value: 3.58e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   1069 IYALDCEMSYTTYG----LELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSvTLRDVQAVLLSMFSA 1144
Cdd:smart00479    2 LVVIDCETTGLDPGkdeiIEIAAVDVDGGEIIEVFDTYVKPDRPITDYATEIHGITPEMLDDAP-TFEEVLEELLEFLRG 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768003200   1145 DTILIGHSLESDLLALKVIH----------STVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQ 1199
Cdd:smart00479   81 RILVAGNSAHFDLRFLKLEHprlgikqppkLPVIDTLKLARATNPGLPKYSLKKLAKRLLLEVIQ 145
REX4_like cd06144
DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product ...
 1099-1200 3.20e-18

DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins; This subfamily is composed of RNA exonuclease 4 (REX4 or Rex4p), XPMC2, Interferon (IFN) Stimulated Gene product of 20 kDa (ISG20), and similar proteins. REX4 is involved in pre-rRNA processing. It controls the ratio between the two forms of 5.8S rRNA in yeast. XPMC2 is a Xenopus gene which was identified through its ability to correct a mitotic defect in fission yeast. The human homolog of XPMC2 (hPMC2) may be involved in angiotensin II-induced adrenal cell cycle progression and cell proliferation. ISG20 is an IFN-induced antiviral exonuclease with a strong preference for single-stranded RNA and minor activity towards single-stranded DNA. These proteins are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherchia coli RNase T.


Pssm-ID: 99847  Cd Length: 152  Bit Score: 82.95  E-value: 3.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1099 YDTFVKPDNEIVDYNTRFSGVTEADLADtSVTLRDVQAVLLSMFsADTILIGHSLESDLLALKVIHST--VVDTSVLFP- 1175
Cdd:cd06144    33 YDTYVKPQEPVTDYRTAVSGIRPEHLKD-APDFEEVQKKVAELL-KGRILVGHALKNDLKVLKLDHPKklIRDTSKYKPl 110

                          90       100
                  ....*....|....*....|....*
gi 768003200 1176 HRLGLPYKRSLRNLMADYLRQIIQD 1200
Cdd:cd06144   111 RKTAKGKSPSLKKLAKQLLGLDIQE 135
ISG20 cd06149
DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar ...
 1071-1199 4.52e-12

DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins; Interferon (IFN) Stimulated Gene product of 20 kDa (ISG20) is an IFN-induced antiviral exonuclease with a strong preference for single-stranded RNA and minor activity towards single-stranded DNA. It was also independently identified by its response to estrogen and was called HEM45 (human estrogen regulated transcript). ISG20 is a DEDDh-type DnaQ-like 3'-5' exonuclease containing three conserved sequence motifs termed ExoI, ExoII and ExoIII with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ISG20 may be a major effector of innate immunity against pathogens including viruses, bacteria, and parasites. It is located in promyelocytic leukemia (PML) nuclear bodies, sites for oncogenic DNA viral transcription and replication. It may carry out its function by degrading viral RNAs as part of the IFN-regulated antiviral response.


Pssm-ID: 99852  Cd Length: 157  Bit Score: 65.54  E-value: 4.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1071 ALDCEMSYTTYGL---ELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADtSVTLRDVQAVLLSMFSAdTI 1147
Cdd:cd06149     2 AIDCEMVGTGPGGresELARCSIVNYHGDVLYDKYIRPEGPVTDYRTRWSGIRRQHLVN-ATPFAVAQKEILKILKG-KV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 768003200 1148 LIGHSLESDLLALKVIHS--TVVDTS--VLFPHRLGLPYKR--SLRNLMADYLRQIIQ 1199
Cdd:cd06149    80 VVGHAIHNDFKALKYFHPkhMTRDTStiPLLNRKAGFPENCrvSLKVLAKRLLHRDIQ 137
PAN2_exo cd06143
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2; PAN2 is the catalytic ...
 1100-1202 1.92e-10

DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2; PAN2 is the catalytic subunit of poly(A) nuclease (PAN), a Pab1p-dependent 3'-5' exoribonuclease which plays an important role in the posttranscriptional maturation of pre-mRNAs. PAN catalyzes the deadenylation of poly(A) tails, which are initially synthesized to default lengths of 70 to 90, to mRNA-specific lengths of 55 to 71. Pab1p and PAN also play a role in the export and decay of mRNA. PAN2 contains a DEDDh-type DnaQ-like 3'-5' exonuclease domain with three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis.


Pssm-ID: 99846  Cd Length: 174  Bit Score: 61.09  E-value: 1.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1100 DTFVKPDNEIVDYNTRFSGVTEADL-ADTS----VTLRDVQAVLLSMFSADTILIGHSLESDL--LALKVIHSTVVDTSV 1172
Cdd:cd06143    52 DDYISTTEPVVDYLTRFSGIKPGDLdPKTSsknlTTLKSAYLKLRLLVDLGCIFVGHGLAKDFrvINIQVPKEQVIDTVE 131

                          90       100       110
                  ....*....|....*....|....*....|
gi 768003200 1173 LFphRLGLPYKRSLRNLMADYLRQIIQDNG 1202
Cdd:cd06143   132 LF--HLPGQRKLSLRFLAWYLLGEKIQSET 159
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 400-688 1.23e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  400 KDKGRGRPVEKPRADKKGPQASSPrrkaERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTsgdsRPAAGRGPPRPLQL 479
Cdd:PTZ00449  583 KDPKHPKDPEEPKKPKRPRSAQRP----TRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ----RPSSPERPEGPKII 654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  480 PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES---EDEAAGPGVPSVWPSALPSLSSDSDSDSDS 556
Cdd:PTZ00449  655 KSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFE 734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  557 SLGFPEAQGP-------PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEV-----------------DFDSDP 612
Cdd:PTZ00449  735 PIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEamkrpdspsehedkppgDHPSLP 814

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  613 ME----ECLRIfneSTSVKTEDRGRLARQPPKE--EKSEEKGLSGLTTL-----FPGQKRRI-------------SHLSK 668
Cdd:PTZ00449  815 KKrhrlDGLAL---STTDLESDAGRIAKDASGKivKLKRSKSFDDLTTVeeaeeMGAEARKIvvdddgteaddedTHPPE 891

                         330       340
                  ....*....|....*....|
gi 768003200  669 QGQEVEPPRRGPAVPPARPP 688
Cdd:PTZ00449  892 EKHKSEVRRRRPPKKPSKPK 911
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1207-1367 2.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1207 LPWGRPCAGAGCSPHLPRSGWAqlqrgrrrlhAPGdleGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPKQcNKSPVTR 1286
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSV----------APG---GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFAL 2900

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1287 PPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLASLETAAdgdqdrARPHPARSPSCPSCQALPPGWWPA 1366
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA------GAGEPSGAVPQPWLGALVPGRVAV 2974


                  .
gi 768003200 1367 P 1367
Cdd:PHA03247 2975 P 2975
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1219-1369 2.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1219 SPHLPRSGWAQLQRGRRRLHAP--GDLEGSRRRQDQAMTPA-RLPPASPAVPLVLSPMPLPKQCNK---SPVTRPPGRG- 1291
Cdd:PHA03247 2669 RLGRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPAlpaAPAPPAVPAGp 2748

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1292 ----SPEQRDELAARERPAQPTPAHVlphPSAGPHP-LPPSPLASLETAADGDQDRARPHPARSPSCPSCQALPPGWWPA 1366
Cdd:PHA03247 2749 atpgGPARPARPPTTAGPPAPAPPAA---PAAGPPRrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825


                  ...
gi 768003200 1367 PLL 1369
Cdd:PHA03247 2826 GPL 2828
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1239-1367 8.18e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1239 APGDLEGSRRRQDQAMTPARLPPASPAVPLVLSPMPLPkqcnksPVTRPPGRGSPEQRDELAARERPAQPTPAHVLPHPS 1318
Cdd:PRK12323  380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR------AVAAAPARRSPAPEALAAARQASARGPGGAPAPAPA 453

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768003200 1319 AGPHPLP--PSPLASLETAADGDQDRARPHPARSPSCPSCQALPPgWWPAP 1367
Cdd:PRK12323  454 PAAAPAAaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP-WEELP 503
PHA03247 PHA03247
large tegument protein UL36; Provisional
 115-481 1.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  115 TTREHRSAEAP----ALAPRGPNASPTVGPDEDAFPlafdysPGSHGLLSPdagyQPTPLAAPAEPGSKYSLASLDRGQG 190
Cdd:PHA03247 2583 TSRARRPDAPPqsarPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP----PPSPSPAANEPDPHPPPTVPPPERP 2652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  191 RGGGGggaleyvPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSArhLSRASSRDERAAKRPRGSRGSEPYTP 270
Cdd:PHA03247 2653 RDDPA-------PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS--LADPPPPPPTPEPAPHALVSATPLPP 2723

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  271 APKKLCDPFGSCDAR-FSDSEDEAATVPGNE-----PTTASTPKARADPEIKATGQPPSKEglEAEGGGLRETKETA-VQ 343
Cdd:PHA03247 2724 GPAAARQASPALPAApAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLT--RPAVASLSESRESLpSP 2801

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  344 CDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPS------CKDGAQGKDKtkdkgRGRPVEKPRADKKG 417
Cdd:PHA03247 2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPppslplGGSVAPGGDV-----RRRPPSRSPAAKPA 2876

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768003200  418 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPD 481
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 39-477 2.05e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200   39 SGAPGDGGEAPPAAGLGYDPYNPELPKPPAQrengtlGLGEEPRPDVLELELVNQAIEAVRSEveleqrryrellettRE 118
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFEPPTGPPPG------PGTEAPANESRSTPTWSLSTLAPASP---------------AR 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  119 HRSAEAPALAPRG--PNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSkyslasldrgqGRGGGGG 196
Cdd:PHA03307  103 EGSPTPPGPSSPDppPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAS-----------DAASSRQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  197 GALeyvpkAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPlsnySARHLSRASSRDERAAKRPRGSRGsepytPAPKKLC 276
Cdd:PHA03307  172 AAL-----PLSSPEETARAPSSPPAEPPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAAD-----DAGASSS 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  277 DPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIkatgQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKP 356
Cdd:PHA03307  238 DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWN----GPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200  357 ASPAQVQSSQDG-GCPKEGKPKKKKTGAPPAPSCKDGAQGKDktkDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKK 435
Cdd:PHA03307  314 ASSSSSSSRESSsSSTSSSSESSRGAAVSPGPSPSRSPSPSR---PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRA 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 768003200  436 KPSSATPVATSGK-GRPDRPARRPSPTSGDSRPAAGRGPPRPL 477
Cdd:PHA03307  391 RAAVAGRARRRDAtGRFPAGRPRPSPLDAGAASGAFYARYPLL 433
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1252-1362 2.34e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1252 QAMTPARLPPASPAVPLVLSPMPlPKQcnKSPVTRPPGRGSPEQRDELAAR----ERPAQPTPAHVLPHPsagPHPLPPS 1327
Cdd:PRK14951  385 EAAAPAAAPVAQAAAAPAPAAAP-AAA--ASAPAAPPAAAPPAPVAAPAAAapaaAPAAAPAAVALAPAP---PAQAAPE 458

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768003200 1328 PLASLETAADG-DQDRARPHPARSPSCPSCQALPPG 1362
Cdd:PRK14951  459 TVAIPVRVAPEpAVASAAPAPAAAPAAARLTPTEEG 494
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1231-1367 2.96e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1231 QRGRRRLHAPGD---LEGSRRR---------QDQAMTPARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPGRGSPEQRDE 1298
Cdd:PHA03247 2665 RRARRLGRAAQAsspPQRPRRRaarptvgslTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768003200 1299 LAARERPAQPTPAHVLPHPSAGPHPLPPSplasletAADGDQDRARPHPARSPSCPSCQALPPGWWPAP 1367
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPAPAPPA-------APAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1211-1367 4.67e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1211 RPCAGAGCSPHLPRSGWAQLQRGRRRLHAPGDLEGSRRRQDQAMTPARLPPASPAVplvlSPMPLPKQCNKSPVTRPPGR 1290
Cdd:PRK12323  401 APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAA----APAAAARPAAAGPRPVAAAA 476

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1291 GSPEQRDELAARERPA--QPTPAHVLPHPSAGPHPLPPSP--------LASLETAADGDQDRARPHPARSPSCPSCQALP 1360
Cdd:PRK12323  477 AAAPARAAPAAAPAPAddDPPPWEELPPEFASPAPAQPDAapagwvaeSIPDPATADPDDAFETLAPAPAAAPAPRAAAA 556


                  ....*..
gi 768003200 1361 PGWWPAP 1367
Cdd:PRK12323  557 TEPVVAP 563
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1257-1381 5.56e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1257 ARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPGRGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPlasletaa 1336
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP-------- 2934

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 768003200 1337 dgdqDRARPHPARSPSC-PSCQALPPGWWPAPLLLTWVAGR-ACPRF 1381
Cdd:PHA03247 2935 ----PPPRPQPPLAPTTdPAGAGEPSGAVPQPWLGALVPGRvAVPRF 2977
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1251-1361 5.60e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1251 DQAMTPARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPGrgSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPLA 1330
Cdd:PHA03247 2774 APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL--APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851

                          90       100       110
                  ....*....|....*....|....*....|.
gi 768003200 1331 SLETAADGDQDRARPHPARSPSCPSCQALPP 1361
Cdd:PHA03247 2852 LGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1257-1367 9.52e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 9.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768003200 1257 ARLPPASPAVPLVLSPMPLPKQCNKSPVTRPPG-------RGSPEQRDELAARERPAQPTPAHVLPHPSAGPHPLPPSPL 1329
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapaagppRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 768003200 1330 ASLETAADGDQDRARPHPARSPSCPSCQALPPGWWPAP 1367
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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