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Conserved domains on  [gi|768004134|ref|XP_011526616|]
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podocan-like protein 1 isoform X8 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-358 3.75e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 3.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  75 RSVYLHNNQLSNAglpPDAFRGSEAIATLSLSNNQLSYLPPSLP--PSLERLHLQNNLISKVPRgALSRQTQLRELYLQH 152
Cdd:COG4886  116 ESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 153 NQLTDSGldaTTFSKLHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLgsSG 230
Cdd:COG4886  192 NQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL--TD 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 231 LPagALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 310
Cdd:COG4886  265 LP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 768004134 311 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQL 358
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
261-463 4.73e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 4.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 261 RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRlasarvhhrAFRRLRALRSLDLAGNQLTRLPMGLP--TGLRTLQ 338
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 339 LQRNQLRMLePEPLAGLDQLRELSLAHNRLRvgDIgPGTWHELQALQMLDLSHNELSFVPPDL--PEALEELHLEGNRIG 416
Cdd:COG4886  143 LSNNQLTDL-PEPLGNLTNLKSLDLSNNQLT--DL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004134 417 HVgPEAFLSTPRLRALFLRANRLhmTSIaaEAFLGLPNLRVVDTAGN 463
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL--TDL--PELGNLTNLEELDLSNN 260
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-358 3.75e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 3.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  75 RSVYLHNNQLSNAglpPDAFRGSEAIATLSLSNNQLSYLPPSLP--PSLERLHLQNNLISKVPRgALSRQTQLRELYLQH 152
Cdd:COG4886  116 ESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 153 NQLTDSGldaTTFSKLHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLgsSG 230
Cdd:COG4886  192 NQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL--TD 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 231 LPagALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 310
Cdd:COG4886  265 LP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 768004134 311 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQL 358
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-439 4.34e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 96.84  E-value: 4.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  75 RSVYLHNNQLSnAGLPPDAFRGSEAIATLSLSNNQLS-YLPPSLPPSLERLHLQNNLIS-KVPR--GALSRqtqLRELYL 150
Cdd:PLN00113  96 QTINLSNNQLS-GPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPNdiGSFSS---LKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 151 QHNQLTdsGLDATTFSKLHSLEYLDLSHNQLT-TVPA--GLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLg 227
Cdd:PLN00113 172 GGNVLV--GKIPNSLTNLTSLEFLTLASNQLVgQIPRelGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL- 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 228 sSGLPAGALRPLRGLHTLHLYGNGL-DRVPPA-----------------------LPRRLRALVLPH---NHVAALGARD 280
Cdd:PLN00113 249 -TGPIPSSLGNLKNLQYLFLYQNKLsGPIPPSifslqklisldlsdnslsgeipeLVIQLQNLEILHlfsNNFTGKIPVA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 281 LVATPGLTELNLAYNRLASARVHHRAFRRLRALrsLDLAGNQLT-RLPMGLPTG-------------------------- 333
Cdd:PLN00113 328 LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTV--LDLSTNNLTgEIPEGLCSSgnlfklilfsnslegeipkslgacrs 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 334 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIGPGTWhELQALQMLDLSHNELSFVPPDL--PEALEELHLE 411
Cdd:PLN00113 406 LRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ-GRINSRKW-DMPSLQMLSLARNKFFGGLPDSfgSKRLENLDLS 483

                        410       420
                 ....*....|....*....|....*...
gi 768004134 412 GNRIGHVGPEAFLSTPRLRALFLRANRL 439
Cdd:PLN00113 484 RNQFSGAVPRKLGSLSELMQLKLSENKL 511
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
261-463 4.73e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 4.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 261 RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRlasarvhhrAFRRLRALRSLDLAGNQLTRLPMGLP--TGLRTLQ 338
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 339 LQRNQLRMLePEPLAGLDQLRELSLAHNRLRvgDIgPGTWHELQALQMLDLSHNELSFVPPDL--PEALEELHLEGNRIG 416
Cdd:COG4886  143 LSNNQLTDL-PEPLGNLTNLKSLDLSNNQLT--DL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004134 417 HVgPEAFLSTPRLRALFLRANRLhmTSIaaEAFLGLPNLRVVDTAGN 463
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL--TDL--PELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-291 5.41e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 5.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 103 LSLSNNQLSYLP-PSLPPSLERLHLQNNLISKVPrgALSRQTQLRELYLQHNQLTD-SGLDAttfskLHSLEYLDLSHNQ 180
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 181 LTTVpAGL--PRTLAILHLGRNRIRQ-----VEAARLHG-ARGLRYLLLQHNQLGSSglpaGALRPLRGLHTLHLYGNGL 252
Cdd:cd21340   80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAAlSNSLRVLNISGNNIDSL----EPLAPLRNLEQLDASNNQI 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004134 253 DRVPPALP-----RRLRALVLPHNHVAAL-GARD--LVATPGLTELN 291
Cdd:cd21340  155 SDLEELLDllsswPSLRELDLTGNPVCKKpKYRDkiILASKSLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
119-181 2.70e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 2.70e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004134  119 PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTdsGLDATTFSKLHSLEYLDLSHNQL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
332-394 1.50e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004134  332 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVgdIGPGTWHELQALQMLDLSHNEL 394
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 316-464 5.47e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 5.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 316 LDLAGNQLTRLPmGLP--TGLRTLQLQRNQLRMLEPepLAGLDQLRELSLAHNRLRV--GdigpgtWHELQALQMLDLSH 391
Cdd:cd21340   29 LYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveG------LENLTNLEELHIEN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 392 NELsfvPPDLP------------EALEELHLEGNRIGHVGPEAFLStpRLRALFLRANRLHMTSIAAEAFLGLPNLRVVD 459
Cdd:cd21340  100 QRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSLEPLAPLR--NLEQLDASNNQISDLEELLDLLSSWPSLRELD 174


                 ....*
gi 768004134 460 TAGNP 464
Cdd:cd21340  175 LTGNP 179
PLN03150 PLN03150
hypothetical protein; Provisional
 337-456 3.14e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 337 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQMLDLSHNELS-FVPPDLPE--ALEELHLEGN 413
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIR-GNI-PPSLGSITSLEVLDLSYNSFNgSIPESLGQltSLRILNLNGN 500

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768004134 414 RIGHVGPEAflstprLRALFLRANRLHMTSIAaeAFLGLPNLR 456
Cdd:PLN03150 501 SLSGRVPAA------LGGRLLHRASFNFTDNA--GLCGIPGLR 535
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-358 3.75e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 3.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  75 RSVYLHNNQLSNAglpPDAFRGSEAIATLSLSNNQLSYLPPSLP--PSLERLHLQNNLISKVPRgALSRQTQLRELYLQH 152
Cdd:COG4886  116 ESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 153 NQLTDSGldaTTFSKLHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLgsSG 230
Cdd:COG4886  192 NQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL--TD 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 231 LPagALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRL 310
Cdd:COG4886  265 LP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 768004134 311 RALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQL 358
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-439 4.34e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 96.84  E-value: 4.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  75 RSVYLHNNQLSnAGLPPDAFRGSEAIATLSLSNNQLS-YLPPSLPPSLERLHLQNNLIS-KVPR--GALSRqtqLRELYL 150
Cdd:PLN00113  96 QTINLSNNQLS-GPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPNdiGSFSS---LKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 151 QHNQLTdsGLDATTFSKLHSLEYLDLSHNQLT-TVPA--GLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLg 227
Cdd:PLN00113 172 GGNVLV--GKIPNSLTNLTSLEFLTLASNQLVgQIPRelGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL- 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 228 sSGLPAGALRPLRGLHTLHLYGNGL-DRVPPA-----------------------LPRRLRALVLPH---NHVAALGARD 280
Cdd:PLN00113 249 -TGPIPSSLGNLKNLQYLFLYQNKLsGPIPPSifslqklisldlsdnslsgeipeLVIQLQNLEILHlfsNNFTGKIPVA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 281 LVATPGLTELNLAYNRLASARVHHRAFRRLRALrsLDLAGNQLT-RLPMGLPTG-------------------------- 333
Cdd:PLN00113 328 LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTV--LDLSTNNLTgEIPEGLCSSgnlfklilfsnslegeipkslgacrs 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 334 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIGPGTWhELQALQMLDLSHNELSFVPPDL--PEALEELHLE 411
Cdd:PLN00113 406 LRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ-GRINSRKW-DMPSLQMLSLARNKFFGGLPDSfgSKRLENLDLS 483

                        410       420
                 ....*....|....*....|....*...
gi 768004134 412 GNRIGHVGPEAFLSTPRLRALFLRANRL 439
Cdd:PLN00113 484 RNQFSGAVPRKLGSLSELMQLKLSENKL 511
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
98-387 2.71e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 94.38  E-value: 2.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  98 EAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRgalSRQTQLRELYLQHNQLTDsgLDATTFSKLHSleyLDLS 177
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPA---TLPDTIQEMELSINRITE--LPERLPSALQS---LDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 178 HNQLTTVPAGLPRTLAILHLGRNRIRQVEAarlHGARGLRYLLLQHNQLgsSGLPAgALRPlrGLHTLHLYGNGLDRVPP 257
Cdd:PRK15370 271 HNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL--TALPE-TLPP--GLKTLEAGENALTSLPA 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 258 ALPRRLRALVLPHNHVAALGArdlVATPGLTElnlaynrlasarvhhrafrrlralrsLDLAGNQLTRLPMGLPTGLRTL 337
Cdd:PRK15370 343 SLPPELQVLDVSKNQITVLPE---TLPPTITT--------------------------LDVSRNALTNLPENLPAALQIM 393

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768004134 338 QLQRNQLRMLePEPLAGL----DQLRELSLAHNrlrvgdigPGTWHELQALQML 387
Cdd:PRK15370 394 QASRNNLVRL-PESLPHFrgegPQPTRIIVEYN--------PFSERTIQNMQRL 438
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-395 2.48e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 2.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 102 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQltdsgldatTFSKLHSLEYLDLSHNQL 181
Cdd:COG4886   55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 182 TTVPAGLPR--TLAILHLGRNRIRQVEAArLHGARGLRYLLLQHNQLgsSGLPAgALRPLRGLHTLHLYGNGLDRVPPAL 259
Cdd:COG4886  126 TDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDLPE-ELGNLTNLKELDLSNNQITDLPEPL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 260 --PRRLRALVLPHNHVAALGArDLVATPGLTELNLAYNRLASArvhhRAFRRLRALRSLDLAGNQLTRLPMGLP-TGLRT 336
Cdd:COG4886  202 gnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDLPPLANlTNLKT 276

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768004134 337 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQMLDLSHNELS 395
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
103-431 1.26e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 88.99  E-value: 1.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 103 LSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRgalSRQTQLRELYLQHNQLTdsgldattfsklhsleyldlshnqlt 182
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLT-------------------------- 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 183 TVPAGLPRTLAILHLGRNRIRQVeAARLHGArgLRYLLLQHNQLgsSGLPAGAlrPlRGLHTLHLYGNGLDRVPPALPRr 262
Cdd:PRK15370 234 SIPATLPDTIQEMELSINRITEL-PERLPSA--LQSLDLFHNKI--SCLPENL--P-EELRYLSVYDNSIRTLPAHLPS- 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 263 lralvlphnhvaalgardlvatpGLTELNlaynrlasarvhhrafrrlralrsldLAGNQLTRLPMGLPTGLRTLQLQRN 342
Cdd:PRK15370 305 -----------------------GITHLN--------------------------VQSNSLTALPETLPPGLKTLEAGEN 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 343 QLRMLePEPLAglDQLRELSLAHNRLRV-GDIGPGTwhelqaLQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVgPE 421
Cdd:PRK15370 336 ALTSL-PASLP--PELQVLDVSKNQITVlPETLPPT------ITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL-PE 405

                        330
                 ....*....|
gi 768004134 422 aflSTPRLRA 431
Cdd:PRK15370 406 ---SLPHFRG 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
261-463 4.73e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 4.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 261 RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRlasarvhhrAFRRLRALRSLDLAGNQLTRLPMGLP--TGLRTLQ 338
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 339 LQRNQLRMLePEPLAGLDQLRELSLAHNRLRvgDIgPGTWHELQALQMLDLSHNELSFVPPDL--PEALEELHLEGNRIG 416
Cdd:COG4886  143 LSNNQLTDL-PEPLGNLTNLKSLDLSNNQLT--DL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004134 417 HVgPEAFLSTPRLRALFLRANRLhmTSIaaEAFLGLPNLRVVDTAGN 463
Cdd:COG4886  219 DL-PEPLANLTNLETLDLSNNQL--TDL--PELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-440 4.32e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 4.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  97 SEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDL 176
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 177 SHNQlttvPAGLPRTLAILHLGRNRIRQVEAArLHGARGLRYLLLQHNQLGSsgLPAgALRPLRGLHTLHLYGNGLDRVP 256
Cdd:COG4886  104 SGNE----ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPE-PLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 257 PALprrlralvlphnhvaalgardlvatPGLTELNlaynrlasarvhhrafrrlralrSLDLAGNQLTRLPMGL--PTGL 334
Cdd:COG4886  176 EEL-------------------------GNLTNLK-----------------------ELDLSNNQITDLPEPLgnLTNL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 335 RTLQLQRNQLRMLePEPLAGLDQLRELSLAHNRLR-VGDIGpgtwhELQALQMLDLSHNELSFVPPDLP-EALEELHLEG 412
Cdd:COG4886  208 EELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTdLPELG-----NLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSN 281

                        330       340
                 ....*....|....*....|....*...
gi 768004134 413 NRIGHVGPEAFLSTPRLRALFLRANRLH 440
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSLLLLLLLLN 309
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-413 1.73e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.43  E-value: 1.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  77 VYLHNNQLSNAgLPPDAFrGSEAIATLSLSNNQLSYLPPSLP---PSLERLHL-QNNLISKVPRgALSRQTQLRELYLQH 152
Cdd:PLN00113 265 LFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGEIPELViqlQNLEILHLfSNNFTGKIPV-ALTSLPRLQVLQLWS 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 153 NQLtdSGLDATTFSKLHSLEYLDLSHNQLT-TVPAGLPRT--LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLgSS 229
Cdd:PLN00113 342 NKF--SGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF-SG 418

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 230 GLPAGALRpLRGLHTLHLYGNGL----DRVPPALPRrLRALVLPHNHVAAlGARDLVATPGLTELNLAYNRLASArvhhr 305
Cdd:PLN00113 419 ELPSEFTK-LPLVYFLDISNNNLqgriNSRKWDMPS-LQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGA----- 490

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 306 afrrlralrsldlagnqLTRLPMGLPTgLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQ 385
Cdd:PLN00113 491 -----------------VPRKLGSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS-GQI-PASFSEMPVLS 550

                        330       340       350
                 ....*....|....*....|....*....|.
gi 768004134 386 MLDLSHNELSF-VPPDLP--EALEELHLEGN 413
Cdd:PLN00113 551 QLDLSQNQLSGeIPKNLGnvESLVQVNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
174-484 7.31e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 7.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 174 LDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVeAARLHGarglrylllqhnqlgssglpagalrplrGLHTLHLYGNGLD 253
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG----------------------------NIKTLYANSNQLT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 254 RVPPALPRRLRALVLPHNHVaalgardlvatpglTELNlayNRLASArvhhrafrrlraLRSLDLAGNQLTRLPMGLPTG 333
Cdd:PRK15370 234 SIPATLPDTIQEMELSINRI--------------TELP---ERLPSA------------LQSLDLFHNKISCLPENLPEE 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 334 LRTLQLQRNQLRMLePEPLAglDQLRELSLAHNRLRV--GDIGPGtwhelqaLQMLDLSHNELSFVPPDLPEALEELHLE 411
Cdd:PRK15370 285 LRYLSVYDNSIRTL-PAHLP--SGITHLNVQSNSLTAlpETLPPG-------LKTLEAGENALTSLPASLPPELQVLDVS 354

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768004134 412 GNRIGhVGPEAFlsTPRLRALFLRANrlhmtsiaaeAFLGLPN-----LRVVDTAGNPeqvLIRLPPTTPRGpRAGGP 484
Cdd:PRK15370 355 KNQIT-VLPETL--PPTITTLDVSRN----------ALTNLPEnlpaaLQIMQASRNN---LVRLPESLPHF-RGEGP 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-291 5.41e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 5.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 103 LSLSNNQLSYLP-PSLPPSLERLHLQNNLISKVPrgALSRQTQLRELYLQHNQLTD-SGLDAttfskLHSLEYLDLSHNQ 180
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 181 LTTVpAGL--PRTLAILHLGRNRIRQ-----VEAARLHG-ARGLRYLLLQHNQLGSSglpaGALRPLRGLHTLHLYGNGL 252
Cdd:cd21340   80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAAlSNSLRVLNISGNNIDSL----EPLAPLRNLEQLDASNNQI 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 768004134 253 DRVPPALP-----RRLRALVLPHNHVAAL-GARD--LVATPGLTELN 291
Cdd:cd21340  155 SDLEELLDllsswPSLRELDLTGNPVCKKpKYRDkiILASKSLEVLD 201
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
81-368 1.45e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 70.19  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  81 NNQLSNAGLPPDafrgseaIATLSLSNNQLSYLPpSLPPSLERLHLQNNLISKVPrgalSRQTQLRELYLQHNQLTDSGL 160
Cdd:PRK15387 232 NNLTSLPALPPE-------LRTLEVSGNQLTSLP-VLPPGLLELSIFSNPLTHLP----ALPSGLCKLWIFGNQLTSLPV 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 161 DATtfsklhSLEYLDLSHNQLTTVPAgLPRTLAILHLGRNRIRQVEAArlhgARGLRYLLLQHNQLGS-SGLPAGalrpl 239
Cdd:PRK15387 300 LPP------GLQELSVSDNQLASLPA-LPSELCKLWAYNNQLTSLPTL----PSGLQELSVSDNQLASlPTLPSE----- 363

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 240 rgLHTLHLYGNGLDRVPpALPRrlralvlphnhvaalgardlvatpGLTELNLAYNRLASARVhhrafrRLRALRSLDLA 319
Cdd:PRK15387 364 --LYKLWAYNNRLTSLP-ALPS------------------------GLKELIVSGNRLTSLPV------LPSELKELMVS 410

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 768004134 320 GNQLTRLPMgLPTGLRTLQLQRNQLRMLePEPLAGLDQLRELSLAHNRL 368
Cdd:PRK15387 411 GNRLTSLPM-LPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPL 457
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 102-250 2.26e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 2.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 102 TLSLSNNQLSYLPP-SLPPSLERLHLQNNLISKVPRgaLSRQTQLRELYLQHNQLTD-SGLDattfsKLHSLEYLDLSHN 179
Cdd:cd21340   28 VLYLYDNKITKIENlEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVvEGLE-----NLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 180 QLttvPAGL-----PRTLA-------ILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHL 247
Cdd:cd21340  101 RL---PPGEkltfdPRSLAalsnslrVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDL 175


                 ...
gi 768004134 248 YGN 250
Cdd:cd21340  176 TGN 178
LRR_8 pfam13855
Leucine rich repeat;
119-181 2.70e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 2.70e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004134  119 PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTdsGLDATTFSKLHSLEYLDLSHNQL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
77-189 5.03e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.02  E-value: 5.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  77 VYLHNNQLS--NAGLPPDafrgseaIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRgalSRQTQLRELYLQHNQ 154
Cdd:PRK15370 309 LNVQSNSLTalPETLPPG-------LKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNA 378

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768004134 155 LTD--SGLDAttfsklhSLEYLDLSHNQLTTVPAGLP 189
Cdd:PRK15370 379 LTNlpENLPA-------ALQIMQASRNNLVRLPESLP 408
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-297 5.05e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.83  E-value: 5.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  84 LSNAGLPPDAFRGSEAIATLSLSNNQLSylpPSLPPSLERLHlqnnliskvprgalsRQTQLRELYLQHNQLTDSGLD-- 161
Cdd:cd00116   67 PRGLQSLLQGLTKGCGLQELDLSDNALG---PDGCGVLESLL---------------RSSSLQELKLNNNGLGDRGLRll 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 162 -ATTFSKLHSLEYLDLSHNQLTTVPA-----GLP--RTLAILHLGRNRIRQVEAARLhgARG------LRYLLLQHNQLG 227
Cdd:cd00116  129 aKGLKDLPPALEKLVLGRNRLEGASCealakALRanRDLKELNLANNGIGDAGIRAL--AEGlkancnLEVLDLNNNGLT 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 228 SSG--LPAGALRPLRGLHTLHLYGNGLDRVP--------PALPRRLRALVLPHNHVAALGARDLV----ATPGLTELNLA 293
Cdd:cd00116  207 DEGasALAETLASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLR 286


                 ....
gi 768004134 294 YNRL 297
Cdd:cd00116  287 GNKF 290
LRR_8 pfam13855
Leucine rich repeat;
332-394 1.50e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004134  332 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVgdIGPGTWHELQALQMLDLSHNEL 394
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 120-297 1.82e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.80  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 120 SLERLHLQNNLIS----KVPRGALSRQTQLRELYLQHNQLTDSGLD--ATTFSKLHSLEYLDLSHNQLTTvpAGL----- 188
Cdd:COG5238  181 SVETVYLGCNQIGdegiEELAEALTQNTTVTTLWLKRNPIGDEGAEilAEALKGNKSLTTLDLSNNQIGD--EGVialae 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 189 ----PRTLAILHLGRNRIrQVEAAR-----LHGARGLRYLLLQHNQLGSSGLPAGA--LRPLRGLHTLHLYGNGLD---- 253
Cdd:COG5238  259 alknNTTVETLYLSGNQI-GAEGAIalakaLQGNTTLTSLDLSVNRIGDEGAIALAegLQGNKTLHTLNLAYNGIGaqga 337

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768004134 254 -RVPPALP--RRLRALVLPHNHVAALGARDL----VATPGLTELNLAYNRL 297
Cdd:COG5238  338 iALAKALQenTTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNI 388
LRR_8 pfam13855
Leucine rich repeat;
143-202 1.77e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768004134  143 TQLRELYLQHNQLTDsgLDATTFSKLHSLEYLDLSHNQLTTVP----AGLPRtLAILHLGRNRI 202
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLPS-LRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
174-456 5.29e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.55  E-value: 5.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 174 LDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAArlhgARGLRYLLLQHNQLGSsgLPAgaLRPlrGLHTLHLYGNGLD 253
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL----PPELRTLEVSGNQLTS--LPV--LPP--GLLELSIFSNPLT 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 254 RVPpALPRRLRALVLPHNHVAALGardlVATPGLTELNLAYNRLASarvhhrAFRRLRALRSLDLAGNQLTRLPMgLPTG 333
Cdd:PRK15387 276 HLP-ALPSGLCKLWIFGNQLTSLP----VLPPGLQELSVSDNQLAS------LPALPSELCKLWAYNNQLTSLPT-LPSG 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 334 LRTLQLQRNQLRMLEPEPlaglDQLRELSLAHNRLRVgdigpgtwhelqalqmldlshnelsfvPPDLPEALEELHLEGN 413
Cdd:PRK15387 344 LQELSVSDNQLASLPTLP----SELYKLWAYNNRLTS---------------------------LPALPSGLKELIVSGN 392

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 768004134 414 RIGHVGpeafLSTPRLRALFLRANRLHMTSIAAEAFLGLPNLR 456
Cdd:PRK15387 393 RLTSLP----VLPSELKELMVSGNRLTSLPMLPSGLLSLSVYR 431
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 316-464 5.47e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 5.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 316 LDLAGNQLTRLPmGLP--TGLRTLQLQRNQLRMLEPepLAGLDQLRELSLAHNRLRV--GdigpgtWHELQALQMLDLSH 391
Cdd:cd21340   29 LYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveG------LENLTNLEELHIEN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 392 NELsfvPPDLP------------EALEELHLEGNRIGHVGPEAFLStpRLRALFLRANRLHMTSIAAEAFLGLPNLRVVD 459
Cdd:cd21340  100 QRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSLEPLAPLR--NLEQLDASNNQISDLEELLDLLSSWPSLRELD 174


                 ....*
gi 768004134 460 TAGNP 464
Cdd:cd21340  175 LTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
405-464 3.32e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  405 LEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLhmTSIAAEAFLGLPNLRVVDTAGNP 464
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 74-439 1.46e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.56  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  74 TRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYlpPSLPPSLERLHLQNNLISKVPrgalSRQTQ-LRELYLQH 152
Cdd:COG5238   90 LVVDWEGAEEVSPVALAETATAVATPPPDLRRIMAKTLE--DSLILYLALPRRINLIQVLKD----PLGGNaVHLLGLAA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 153 NQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPA-------GLPRTLAILHLGRNRI--RQVE--AARLHGARGLRYLLL 221
Cdd:COG5238  164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIeelaealTQNTTVTTLWLKRNPIgdEGAEilAEALKGNKSLTTLDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 222 QHNQLGSSGLP--AGALRPLRGLHTLHLYGNGLDrvppalprrlralvlpHNHVAALgARDLVATPGLTELNLAYNRLAS 299
Cdd:COG5238  244 SNNQIGDEGVIalAEALKNNTTVETLYLSGNQIG----------------AEGAIAL-AKALQGNTTLTSLDLSVNRIGD 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 300 ArvhhrafrrlralrsldlagnqltrlpmglptGLRTLQlqrnqlrmlepEPLAGLDQLRELSLAHNRlrvgdIGPGTWH 379
Cdd:COG5238  307 E--------------------------------GAIALA-----------EGLQGNKTLHTLNLAYNG-----IGAQGAI 338

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768004134 380 EL-QALQM------LDLSHNELSFVPPD-LPEALE------ELHLEGNRIGHVGPEAF---LSTPRLRALFLRANRL 439
Cdd:COG5238  339 ALaKALQEnttlhsLDLSDNQIGDEGAIaLAKYLEgnttlrELNLGKNNIGKQGAEALidaLQTNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
384-439 3.81e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 768004134  384 LQMLDLSHNELSFVPPDL---PEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRL 439
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
102-155 4.33e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 4.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 768004134  102 TLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 155
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
75-259 5.79e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.01  E-value: 5.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  75 RSVYLHNNQLSNAG-LPPdafrgseAIATLSLSNNQLSYLP-------------------PSLPPSLERLHLQNNLISKV 134
Cdd:PRK15387 245 RTLEVSGNQLTSLPvLPP-------GLLELSIFSNPLTHLPalpsglcklwifgnqltslPVLPPGLQELSVSDNQLASL 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 135 PrgalSRQTQLRELYLQHNQLtdsgldaTTFSKLHS-LEYLDLSHNQLTTVPAgLPRTLAILHLGRNRIRQVEAArlhgA 213
Cdd:PRK15387 318 P----ALPSELCKLWAYNNQL-------TSLPTLPSgLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPAL----P 381

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 214 RGLRYLLLQHNQLGSSGLPAGALRPL--------------RGLHTLHLYGNGLDRVPPAL 259
Cdd:PRK15387 382 SGLKELIVSGNRLTSLPVLPSELKELmvsgnrltslpmlpSGLLSLSVYRNQLTRLPESL 441
LRR_8 pfam13855
Leucine rich repeat;
75-131 2.64e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134   75 RSVYLHNNQLSNagLPPDAFRGSEAIATLSLSNNQLSYLPP---SLPPSLERLHLQNNLI 131
Cdd:pfam13855   4 RSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 143-183 2.71e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 2.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768004134  143 TQLRELYLQHNQLTDSGLdattFSKLHSLEYLDLSHNQLTT 183
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNKIT 37
PLN03150 PLN03150
hypothetical protein; Provisional
 337-456 3.14e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 337 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQMLDLSHNELS-FVPPDLPE--ALEELHLEGN 413
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIR-GNI-PPSLGSITSLEVLDLSYNSFNgSIPESLGQltSLRILNLNGN 500

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768004134 414 RIGHVGPEAflstprLRALFLRANRLHMTSIAaeAFLGLPNLR 456
Cdd:PLN03150 501 SLSGRVPAA------LGGRLLHRASFNFTDNA--GLCGIPGLR 535
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 73-230 3.36e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  73 TTRSVYLHNNQLSNAGLPPDAFR--------GSEAIATLSLSNNQLSY-----LPPSLP--PSLERLHLQNNLISkvPRG 137
Cdd:cd00116  104 LLRSSSLQELKLNNNGLGDRGLRllakglkdLPPALEKLVLGRNRLEGasceaLAKALRanRDLKELNLANNGIG--DAG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 138 ------ALSRQTQLRELYLQHNQLTDSG--LDATTFSKLHSLEYLDLSHNQLTTVPAglpRTLAilhlgrnrirqveAAR 209
Cdd:cd00116  182 iralaeGLKANCNLEVLDLNNNGLTDEGasALAETLASLKSLEVLNLGDNNLTDAGA---AALA-------------SAL 245

                        170       180
                 ....*....|....*....|.
gi 768004134 210 LHGARGLRYLLLQHNQLGSSG 230
Cdd:cd00116  246 LSPNISLLTLSLSCNDITDDG 266
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 147-463 3.45e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 147 ELYLQHNQLTDSGLdATTFSKLHSLEYLDLSHNQLTTVpaglprtlailhlgrnRIRQVeAARLHGARGLRYLLLQHNQL 226
Cdd:cd00116    2 QLSLKGELLKTERA-TELLPKLLCLQVLRLEGNTLGEE----------------AAKAL-ASALRPQPSLKELCLSLNET 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 227 GSS----GLPAGALRPLRGLHTLHLYGNGLDrvpPALPRRLRALVLphnhvaalgardlvaTPGLTELNLAYNRLAsarv 302
Cdd:cd00116   64 GRIprglQSLLQGLTKGCGLQELDLSDNALG---PDGCGVLESLLR---------------SSSLQELKLNNNGLG---- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 303 hhrafrrlralrslDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQ----LRELSLAHNRLRvgdiGPGTW 378
Cdd:cd00116  122 --------------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRanrdLKELNLANNGIG----DAGIR 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 379 H------ELQALQMLDLSHN--------ELSFVPPDLPeALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSI 444
Cdd:cd00116  184 AlaeglkANCNLEVLDLNNNgltdegasALAETLASLK-SLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDI 262

                        330       340
                 ....*....|....*....|....*.
gi 768004134 445 AAEAFLGL-------PNLRVVDTAGN 463
Cdd:cd00116  263 TDDGAKDLaevlaekESLLELDLRGN 288
LRR_8 pfam13855
Leucine rich repeat;
190-252 3.60e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004134  190 RTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLgsSGLPAGALRPLRGLHTLHLYGNGL 252
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 322-464 4.26e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 322 QLTRLPMGLPT--GLRTLQLQRNQLRMLEPEPLAGLDQ---LRELSLAHNRL--RVGDIGPGTWHELQ-ALQMLDLSHNE 393
Cdd:cd00116   69 GLQSLLQGLTKgcGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdRGLRLLAKGLKDLPpALEKLVLGRNR 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 394 LSFVP-PDLPEA------LEELHLEGNRIGHVG----PEAFLSTPRLRALFLRANRLHMT--SIAAEAFLGLPNLRVVDT 460
Cdd:cd00116  149 LEGAScEALAKAlranrdLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNNNGLTDEgaSALAETLASLKSLEVLNL 228


                 ....
gi 768004134 461 AGNP 464
Cdd:cd00116  229 GDNN 232
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-185 2.31e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134  78 YLHNNQLSNAglppDAFRGSEAIATLSLSNNQLSYLPP--SLPpSLERLHLQNNLISKV-------------------PR 136
Cdd:cd21340   30 YLYDNKITKI----ENLEFLTNLTHLYLQNNQIEKIENleNLV-NLKKLYLGGNRISVVeglenltnleelhienqrlPP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004134 137 G-----------ALSRQ--------------------TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVP 185
Cdd:cd21340  105 GekltfdprslaALSNSlrvlnisgnnidsleplaplRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 119-158 7.13e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 7.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 768004134  119 PSLERLHLQNNLISKVPrgALSRQTQLRELYLQHNQLTDS 158
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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