NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|768015772|ref|XP_011526824|]
View 

recombining binding protein suppressor of hairless-like protein isoform X1 [Homo sapiens]

Protein Classification

LAG1-DNAbind and BTD domain-containing protein( domain architecture ID 10558083)

LAG1-DNAbind and BTD domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LAG1-DNAbind pfam09271
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ...
 69-206 5.11e-62

LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.


:

Pssm-ID: 462735  Cd Length: 148  Bit Score: 197.53  E-value: 5.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015772   69 VRILHAKVAQKSYGNEKRFFCPPPCVYLSGPGWRVK--------------PGQDQAHQAGETGPTVCGYMG-LDSASGSA 133
Cdd:pfam09271   1 VIILHAKVAQKSYGTEKRFLCPPPCVYLLGPGWKTKstalspdnpltaprVTISISGEDSAEESQCIAWIGmIGSTSDQE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768015772  134 TETQKLNFEQQpdsrefGCAKTLYISDAD-KRKHFRLVLRLVLRGGRELGTFHSRLIKVISKPSQKKQSLKNTD 206
Cdd:pfam09271  81 TQQLDLVVWGR------CAAKTLYISDSDeKRKHFELLVKLFAPNGQEIGSFESKPIKVISKPSKKRQSLKNAD 148
BTD pfam09270
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ...
 234-343 3.02e-52

Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR).


:

Pssm-ID: 462734  Cd Length: 123  Bit Score: 171.36  E-value: 3.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015772  234 EDGAFVASARQWAAFTLHL-ADGHSAQGDFPPREGYVRYGSLVQLVCTVTGITLPPMIIRKVAKQCALLDVDEPISQLHK 312
Cdd:pfam09270   1 EGGAFHASSTQWGAFTIHLlDDNQGEQENFTVRDGFICYGSVVKLVCSVTGVALPPLIIRKVDKQQVILDADEPVSQLHK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 768015772  313 CAFQFPGSPPGgggtYLCLATEKVVQFQHQP 343
Cdd:pfam09270  81 CAFQMKDTERM----YLCLSQEKIIQFQATP 107
 
Name Accession Description Interval E-value
LAG1-DNAbind pfam09271
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ...
 69-206 5.11e-62

LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.


Pssm-ID: 462735  Cd Length: 148  Bit Score: 197.53  E-value: 5.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015772   69 VRILHAKVAQKSYGNEKRFFCPPPCVYLSGPGWRVK--------------PGQDQAHQAGETGPTVCGYMG-LDSASGSA 133
Cdd:pfam09271   1 VIILHAKVAQKSYGTEKRFLCPPPCVYLLGPGWKTKstalspdnpltaprVTISISGEDSAEESQCIAWIGmIGSTSDQE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768015772  134 TETQKLNFEQQpdsrefGCAKTLYISDAD-KRKHFRLVLRLVLRGGRELGTFHSRLIKVISKPSQKKQSLKNTD 206
Cdd:pfam09271  81 TQQLDLVVWGR------CAAKTLYISDSDeKRKHFELLVKLFAPNGQEIGSFESKPIKVISKPSKKRQSLKNAD 148
BTD pfam09270
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ...
 234-343 3.02e-52

Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR).


Pssm-ID: 462734  Cd Length: 123  Bit Score: 171.36  E-value: 3.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015772  234 EDGAFVASARQWAAFTLHL-ADGHSAQGDFPPREGYVRYGSLVQLVCTVTGITLPPMIIRKVAKQCALLDVDEPISQLHK 312
Cdd:pfam09270   1 EGGAFHASSTQWGAFTIHLlDDNQGEQENFTVRDGFICYGSVVKLVCSVTGVALPPLIIRKVDKQQVILDADEPVSQLHK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 768015772  313 CAFQFPGSPPGgggtYLCLATEKVVQFQHQP 343
Cdd:pfam09270  81 CAFQMKDTERM----YLCLSQEKIIQFQATP 107
 
Name Accession Description Interval E-value
LAG1-DNAbind pfam09271
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ...
 69-206 5.11e-62

LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.


Pssm-ID: 462735  Cd Length: 148  Bit Score: 197.53  E-value: 5.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015772   69 VRILHAKVAQKSYGNEKRFFCPPPCVYLSGPGWRVK--------------PGQDQAHQAGETGPTVCGYMG-LDSASGSA 133
Cdd:pfam09271   1 VIILHAKVAQKSYGTEKRFLCPPPCVYLLGPGWKTKstalspdnpltaprVTISISGEDSAEESQCIAWIGmIGSTSDQE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768015772  134 TETQKLNFEQQpdsrefGCAKTLYISDAD-KRKHFRLVLRLVLRGGRELGTFHSRLIKVISKPSQKKQSLKNTD 206
Cdd:pfam09271  81 TQQLDLVVWGR------CAAKTLYISDSDeKRKHFELLVKLFAPNGQEIGSFESKPIKVISKPSKKRQSLKNAD 148
BTD pfam09270
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ...
 234-343 3.02e-52

Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR).


Pssm-ID: 462734  Cd Length: 123  Bit Score: 171.36  E-value: 3.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015772  234 EDGAFVASARQWAAFTLHL-ADGHSAQGDFPPREGYVRYGSLVQLVCTVTGITLPPMIIRKVAKQCALLDVDEPISQLHK 312
Cdd:pfam09270   1 EGGAFHASSTQWGAFTIHLlDDNQGEQENFTVRDGFICYGSVVKLVCSVTGVALPPLIIRKVDKQQVILDADEPVSQLHK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 768015772  313 CAFQFPGSPPGgggtYLCLATEKVVQFQHQP 343
Cdd:pfam09270  81 CAFQMKDTERM----YLCLSQEKIIQFQATP 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH