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Conserved domains on  [gi|768015805|ref|XP_011526832|]
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V-set and transmembrane domain-containing protein 2-like protein isoform X1 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 43-127 3.72e-10

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 54.19  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805   43 FTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWWYvrshrdwtDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGT 122
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTVTGTPDP----EVSWFK--------DGQPLRSSDRFKVTYEGGTYTLTISNVQPDDSGK 70


                  ....*
gi 768015805  123 YECRV 127
Cdd:pfam07679  71 YTCVA 75
 
Name Accession Description Interval E-value
I-set pfam07679
Immunoglobulin I-set domain;
43-127 3.72e-10

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 54.19  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805   43 FTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWWYvrshrdwtDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGT 122
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTVTGTPDP----EVSWFK--------DGQPLRSSDRFKVTYEGGTYTLTISNVQPDDSGK 70


                  ....*
gi 768015805  123 YECRV 127
Cdd:pfam07679  71 YTCVA 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 47-127 6.21e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 6.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805    47 PHDMTARTGEDVEMACSFRGSGSPSYsleiqWWYvrshrdWTDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGTYECR 126
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-----TWY------KQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCA 69


                   .
gi 768015805   127 V 127
Cdd:smart00410  70 A 70
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 41-147 4.40e-07

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 46.50  E-value: 4.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805  41 ALFTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWWYVRSHRDWTDKQAW--ASNQVVKVVGSNISH---KLRLSRV 115
Cdd:cd20940    1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQLWdgARLDRVHINATYHQHatsTISIDNL 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768015805 116 KPTDEGTYECRVidfSDGKARHH-----KVKaYLRVQ 147
Cdd:cd20940   77 TEEDTGTYECRA---SNDPDRNHltrapKVK-WIRSQ 109
 
Name Accession Description Interval E-value
I-set pfam07679
Immunoglobulin I-set domain;
43-127 3.72e-10

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 54.19  E-value: 3.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805   43 FTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWWYvrshrdwtDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGT 122
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTVTGTPDP----EVSWFK--------DGQPLRSSDRFKVTYEGGTYTLTISNVQPDDSGK 70


                  ....*
gi 768015805  123 YECRV 127
Cdd:pfam07679  71 YTCVA 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 47-127 6.21e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 6.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805    47 PHDMTARTGEDVEMACSFRGSGSPSYsleiqWWYvrshrdWTDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGTYECR 126
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-----TWY------KQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCA 69


                   .
gi 768015805   127 V 127
Cdd:smart00410  70 A 70
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 43-127 1.06e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 49.87  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805   43 FTETPHDMTARTGEDVEMACSFRGSGSPSYsleiqWWYVrshrdwtDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGT 122
Cdd:pfam13927   4 ITVSPSSVTVREGETVTLTCEATGSPPPTI-----TWYK-------NGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGT 71


                  ....*
gi 768015805  123 YECRV 127
Cdd:pfam13927  72 YTCVA 76
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 41-147 4.40e-07

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 46.50  E-value: 4.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805  41 ALFTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWWYVRSHRDWTDKQAW--ASNQVVKVVGSNISH---KLRLSRV 115
Cdd:cd20940    1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQLWdgARLDRVHINATYHQHatsTISIDNL 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768015805 116 KPTDEGTYECRVidfSDGKARHH-----KVKaYLRVQ 147
Cdd:cd20940   77 TEEDTGTYECRA---SNDPDRNHltrapKVK-WIRSQ 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-133 6.84e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.22  E-value: 6.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805   45 ETPHDMTARTGEDVEMACSFrgsgSPSYSLEIQW--WYvRSHRDWTDKQA---WASNQVVKVVG-----------SNISh 108
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTY----SSSMSEASTSvyWY-RQPPGKGPTFLiayYSNGSEEGVKKgrfsgrgdpsnGDGS- 74

                          90       100
                  ....*....|....*....|....*
gi 768015805  109 kLRLSRVKPTDEGTYECRVIDFSDG 133
Cdd:pfam07686  75 -LTIQNLTLSDSGTYTCAVIPSGEG 98
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 58-137 2.11e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.78  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805  58 VEMACSFRGSGSPsyslEIQWWYvrshrdwtDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGTYECRVIDFSDGKARH 137
Cdd:cd00096    1 VTLTCSASGNPPP----TITWYK--------NGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSASA 68
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 43-125 6.98e-04

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 37.23  E-value: 6.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805  43 FTETPHDMTARTGEDVEMACSFRGSGSPsyslEIQWwyVRSHRDWTdkQAWASNQVVKVVGsnishKLRLSRVKPTDEGT 122
Cdd:cd20976    4 FSSVPKDLEAVEGQDFVAQCSARGKPVP----RITW--IRNAQPLQ--YAADRSTCEAGVG-----ELHIQDVLPEDHGT 70


                 ...
gi 768015805 123 YEC 125
Cdd:cd20976   71 YTC 73
IgI_2_Robo cd05724
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 47-125 1.13e-03

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of the Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit-2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409389 [Multi-domain]  Cd Length: 87  Bit Score: 36.61  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805  47 PHDMTARTGEDVEMACSF-RGSGSPsyslEIQWWyvrshRDwtDKQAWASNQVVKVVGSNishKLRLSRVKPTDEGTYEC 125
Cdd:cd05724    4 PSDTQVAVGEMAVLECSPpRGHPEP----TVSWR-----KD--GQPLNLDNERVRIVDDG---NLLIAEARKSDEGTYKC 69
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 44-125 3.25e-03

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 35.61  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805  44 TETPHDMTARTGEDVEMACsfRGSGSPSYSLEiqwWYVRSHRDWTDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGTY 123
Cdd:cd07693    4 VEHPSDLIVSKGDPATLNC--KAEGRPTPTIQ---WLKNGQPLETDKDDPRSHRIVLPSGSLFFLRVVHGRKGRSDEGVY 78


                 ..
gi 768015805 124 EC 125
Cdd:cd07693   79 VC 80
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 51-133 5.31e-03

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 35.24  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015805  51 TARTGEDVEMACSFrgsgSPSYS---LEIQWwyVRSH-----------RDWTDKQAWASNQVVKVVGSNISH---KLRLS 113
Cdd:cd05713   11 LALVGEDAELPCHL----SPKMSaehMEVRW--FRSQfspvvhlyrdgQDQEEEQMPEYRGRTELLKDAIAEgsvALRIH 84

                         90       100
                 ....*....|....*....|
gi 768015805 114 RVKPTDEGTYECRvidFSDG 133
Cdd:cd05713   85 NVRPSDEGQYTCF---FRSG 101
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 55-127 5.63e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 34.48  E-value: 5.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768015805   55 GEDVEMACSFRGSGSPsysLEIQWWYvrshrdwTDKQAWASNQVVKVVGSNISHKLRLSRVKPTDEGTYECRV 127
Cdd:pfam00047  11 GDSATLTCSASTGSPG---PDVTWSK-------EGGTLIESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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