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Conserved domains on  [gi|768018299|ref|XP_011527347|]
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alpha-tocopherol transfer protein-like isoform X3 [Homo sapiens]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10661176)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins

Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
128-240 9.46e-19

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 81.23  E-value: 9.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQVNGIVILADYKGVSLSKAShfGPFIAKK 207
Cdd:cd00170    9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLLKK 86
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299 208 VIGILQ-------------------------------------FFLHGSDLNSLHTNLPRSILPKEYGGT 240
Cdd:cd00170   87 LLKILQdhyperlkkiyivnapwifsalwkivkpflsektrkkIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
56-102 3.78e-12

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 59.87  E-value: 3.78e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 768018299    56 RDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 102
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
128-240 9.46e-19

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 81.23  E-value: 9.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQVNGIVILADYKGVSLSKAShfGPFIAKK 207
Cdd:cd00170    9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLLKK 86
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299 208 VIGILQ-------------------------------------FFLHGSDLNSLHTNLPRSILPKEYGGT 240
Cdd:cd00170   87 LLKILQdhyperlkkiyivnapwifsalwkivkpflsektrkkIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
128-239 5.11e-13

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 65.36  E-value: 5.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299  128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQS-EETQVNGIVILADYKGVSLSKASHFGPFIAK 206
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLmPEGQVEGLTVIIDLKGLSLSNMDWWSISLLK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768018299  207 KVIGILQ--------------------------------------FFLHGSDLNSLHTNLPRSILPKEYGG 239
Cdd:pfam00650  81 KIIKILQdnyperlgkilivnapwifntiwklikpfldpktrekiVFLKNSNEEELEKYIPPEQLPKEYGG 151
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
56-102 3.78e-12

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 59.87  E-value: 3.78e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 768018299    56 RDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 102
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
77-101 6.05e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 45.73  E-value: 6.05e-07
                          10        20
                  ....*....|....*....|....*
gi 768018299   77 DDAFLLRFLRARKFDYDRALQLLVN 101
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
128-240 9.46e-19

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 81.23  E-value: 9.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299 128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQVNGIVILADYKGVSLSKAShfGPFIAKK 207
Cdd:cd00170    9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLLKK 86
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299 208 VIGILQ-------------------------------------FFLHGSDLNSLHTNLPRSILPKEYGGT 240
Cdd:cd00170   87 LLKILQdhyperlkkiyivnapwifsalwkivkpflsektrkkIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
128-239 5.11e-13

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 65.36  E-value: 5.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018299  128 GFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQS-EETQVNGIVILADYKGVSLSKASHFGPFIAK 206
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLmPEGQVEGLTVIIDLKGLSLSNMDWWSISLLK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768018299  207 KVIGILQ--------------------------------------FFLHGSDLNSLHTNLPRSILPKEYGG 239
Cdd:pfam00650  81 KIIKILQdnyperlgkilivnapwifntiwklikpfldpktrekiVFLKNSNEEELEKYIPPEQLPKEYGG 151
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
56-102 3.78e-12

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 59.87  E-value: 3.78e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 768018299    56 RDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 102
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
77-101 6.05e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 45.73  E-value: 6.05e-07
                          10        20
                  ....*....|....*....|....*
gi 768018299   77 DDAFLLRFLRARKFDYDRALQLLVN 101
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKMLED 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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