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GDP-fucose protein O-fucosyltransferase 2 isoform X13 [Homo sapiens]
O-fucosyltransferase family protein( domain architecture ID 94843)
O-fucosyltransferase family protein may be involved in glycan metabolism by O-fucosylation of protein substrates
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
O-FucT_like super family | cl16914 | GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ... |
45-196 | 9.99e-78 | |||
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. The actual alignment was detected with superfamily member cd11298: Pssm-ID: 450121 Cd Length: 374 Bit Score: 239.09 E-value: 9.99e-78
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Name | Accession | Description | Interval | E-value | |||
O-FucT-2 | cd11298 | GDP-fucose protein O-fucosyltransferase 2; O-FucT-2 adds O-fucose to thrombospondin type 1 ... |
45-196 | 9.99e-78 | |||
GDP-fucose protein O-fucosyltransferase 2; O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. Pssm-ID: 211384 Cd Length: 374 Bit Score: 239.09 E-value: 9.99e-78
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O-FucT | pfam10250 | GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ... |
45-109 | 6.20e-15 | |||
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. Pssm-ID: 463023 [Multi-domain] Cd Length: 247 Bit Score: 71.95 E-value: 6.20e-15
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Name | Accession | Description | Interval | E-value | |||
O-FucT-2 | cd11298 | GDP-fucose protein O-fucosyltransferase 2; O-FucT-2 adds O-fucose to thrombospondin type 1 ... |
45-196 | 9.99e-78 | |||
GDP-fucose protein O-fucosyltransferase 2; O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. Pssm-ID: 211384 Cd Length: 374 Bit Score: 239.09 E-value: 9.99e-78
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O-FucT | pfam10250 | GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ... |
45-109 | 6.20e-15 | |||
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. Pssm-ID: 463023 [Multi-domain] Cd Length: 247 Bit Score: 71.95 E-value: 6.20e-15
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O-FucT-1 | cd11302 | GDP-fucose protein O-fucosyltransferase 1; The protein O-fucosyltransferase 1 (Ofut1 or ... |
80-156 | 9.81e-04 | |||
GDP-fucose protein O-fucosyltransferase 1; The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). Pssm-ID: 211388 Cd Length: 347 Bit Score: 39.91 E-value: 9.81e-04
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