|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
52-547 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 662.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 52 RAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEAdvrfssqnrksgsaaPHQLPDNETDCGWAPFDKNNYQQLLG 131
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPP---------------PNIVLNNTTWCGWAPFDGKNGTELLG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 132 ALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCL 211
Cdd:cd17344 66 ALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 212 GNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvthskg 291
Cdd:cd17344 146 GNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 292 yengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFAK 371
Cdd:cd17344 211 ------------------------------------------------------------------PGVIEFSLCLFFAK 224
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 372 LVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLE 451
Cdd:cd17344 225 LVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMT 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 452 ATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPSGWSNVFYMLMF 531
Cdd:cd17344 305 TNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIA 384
|
490
....*....|....*.
gi 768020997 532 ADACALLFLIRLIHKE 547
Cdd:cd17344 385 ADVCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
52-544 |
1.01e-96 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 300.00 E-value: 1.01e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 52 RAFIFILTFLLYASFHLSRKPISIVKgelhkyctawdeadVRFSSQNRKSGSAAPHQLPDNETDCGWAPFDKNNYQQLLG 131
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVK--------------PSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 132 ALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGL----GYFYNIHsfgFYVVTQVINGLVQTTGWPSV 207
Cdd:cd17342 67 VLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVltewLHFYNKY---LYCILWVLNGLLQSTGWPCV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 208 VTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvt 287
Cdd:cd17342 144 VAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP----------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 288 hskgyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCL 367
Cdd:cd17342 213 ----------------------------------------------------------------------PGVIPYSLAY 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 368 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFS-TVS 446
Cdd:cd17342 223 ACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYShSPS 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 447 KMGLEATIamLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPS-GWSNV 525
Cdd:cd17342 303 DKVLNAFV--MTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRlGWMWV 380
|
490
....*....|....*....
gi 768020997 526 FYMLMFADACALLFLIRLI 544
Cdd:cd17342 381 FYFFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
52-544 |
8.95e-76 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 244.49 E-value: 8.95e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 52 RAFIFILTFLLYASFHLSRKPISIVKGELHkyctawdeadvrfssqnrksgsaapHQLPDNETDCGWapfdknnyqqllg 131
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIV-------------------------EEIGLSKDDLGI------------- 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 132 aLDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCL 211
Cdd:cd17312 43 -IGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLL 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 212 GNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvthsk 290
Cdd:cd17312 117 GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYgWRAAFLVPGIVGLVVAIILFFFLRDSP-------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 291 gyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFA 370
Cdd:cd17312 183 -------------------------------------------------------------------PYVWVLSLAYAFV 195
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 371 KLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL--EKRASTCGLMLLLAAPTLYIFSTVSKm 448
Cdd:cd17312 196 YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPH- 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 449 GLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKslkgnahALSTVTAIIDGTGSVGAALGPLLAGLLSPS-GWSNVFY 527
Cdd:cd17312 275 NKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKE-------AAGTATGFVGLFGYLGASLAGLPLGYIIDHyGWSTVFY 347
|
490
....*....|....*..
gi 768020997 528 MLMFADACALLFLIRLI 544
Cdd:cd17312 348 FLISAALLSVLLLLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
136-546 |
4.12e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 112.66 E-value: 4.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 136 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 215
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 216 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstlvthskgyen 294
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLLA--------------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 295 gtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkipgviefsLCLLFAKLVS 374
Cdd:COG2271 187 ----------------------------------------------------------------------LAYFLVYFAL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 375 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYIFSTVSkmGLEAT 453
Cdd:COG2271 197 YGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLP--SPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 454 IAMLLLSGALVSGPYTLITTAVSADLGThkslkgnaHALSTVTAIIDGTGSVGAALGPLLA-GLLSPSGWSNVFYMLMFA 532
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAAL 346
|
410
....*....|....
gi 768020997 533 DACALLFLIRLIHK 546
Cdd:COG2271 347 ALLAALLALLLLRE 360
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
130-541 |
3.32e-26 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 110.79 E-value: 3.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 130 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYnIHSFGFYVVTQVINGLVQTTGWPSVVT 209
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA-TSSVGLMFILLFLNGWFQGMGWPPSGR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 210 CLGNWFGKGRRGLIMGVWN-SHTSVGNILGSLI---AGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVrcsstl 285
Cdd:cd17345 119 TMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESE------ 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 286 vthskgyenGTNRLRlqkqILKSEKNKPLDPEMQCLLLSDGKgsihpnhvvilpgdggsgtaaISFTGALKIPGVIEFSL 365
Cdd:cd17345 193 ---------GLPPIE----EYKGDYPEEADGEEEEQELSAWE---------------------IFVKYVLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 366 CLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGLMLLLAAPTLYIFS 443
Cdd:cd17345 239 ANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 444 TVSKMGLEATIAMLLlsGALVSGPYTLI-----------TTAVSADL-GTHKSLKGNAHALSTVTAIIDGtgsvgaalgp 511
Cdd:cd17345 319 LAPNVLVDLIALIAL--GFLIYGPVMLIglqalelvpkkAAGTAAGLtGLFGYLGGSVLATALIGIIVDH---------- 386
|
410 420 430
....*....|....*....|....*....|
gi 768020997 512 llagllspSGWSNVFYMLMFADACALLFLI 541
Cdd:cd17345 387 --------FGWNGGFIVLLASCILAIIFLA 408
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
130-492 |
1.80e-24 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 105.15 E-value: 1.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 130 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgyFYNihSFGFYVVTQVINGLVQTTGWPSVVT 209
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 210 CLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWV--STCWGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvt 287
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaeLYSWHWVFIVPGIIAIIVSLICFLLLRDSP----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 288 hskgyengtnrlrlqkqilKSEKNKPLDPEMqclllSDGKGSIHPNHvvilpgDGGSGTAAISFTGALKIPGVIEFSLCL 367
Cdd:TIGR00881 176 -------------------QSCGLPPAEEMP-----NEEPDGDAEKK------EEELTKKQIFLQYVLLNKVLWYISLGY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 368 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL--EKRASTCGLMLLLAAPTLYIFSTV 445
Cdd:TIGR00881 226 VFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLN 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 768020997 446 SKMGLEATIAMLLLSGALVSGPYTLITTAVSaDLGtHKSLKGNAHAL 492
Cdd:TIGR00881 306 PAANPLMDLICLFALGFLVYGPQMLIGVIAS-ELA-PKKAAGTAAGF 350
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
129-484 |
3.19e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.32 E-value: 3.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 129 LLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVV 208
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 209 TCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVS-TCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVrcsstlvt 287
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESKR-------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 288 hskgyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvviLPGDGGSGTAAISFTGALKIPGVIEFSLCL 367
Cdd:pfam07690 180 --------------------------------------------------PKPAEEARLSLIVAWKALLRDPVLWLLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 368 LFAKLVSYTFLFWLPLYITnVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSK 447
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT 288
|
330 340 350
....*....|....*....|....*....|....*..
gi 768020997 448 MGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKS 484
Cdd:pfam07690 289 LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
136-543 |
3.26e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 86.47 E-value: 3.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 136 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 215
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 216 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLiehpndvrcsstlvthskgyen 294
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFgWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 295 gtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFAKLVS 374
Cdd:cd17319 179 ---------------------------------------------------------------RQVWGLALGYFGINYAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 375 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLEATI 454
Cdd:cd17319 196 YGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 455 AMLLLSGALVSGPYTLITTaVSADLgthkslkGNAHALSTVTAIIDGTGSVGAALGPLL--AGLLSPSGWSNVFYMLMFA 532
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLigYLVDATGSYTAAFLFLAAV 347
|
410
....*....|.
gi 768020997 533 DACALLFLIRL 543
Cdd:cd17319 348 ALLAALLVLLL 358
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
98-497 |
1.07e-17 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 85.46 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 98 NRKSGSAAphqLPD--NETDcgwapFDKNNyqqlLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALF 175
Cdd:cd17343 18 NRKSFSFV---LPSlmNELG-----LDKSD----LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 176 GlgYFYNIHSFGFYvvtQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWV-STCWGLSF 254
Cdd:cd17343 86 S--GSSSVWVFSIL---WFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLAlSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 255 VVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnh 334
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKG------------------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 335 vvilpGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILA 414
Cdd:cd17343 198 -----KKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 415 GVISDRLEKRASTCG----------LMLLLAAPTLYIFS-TVSKMGLEATIAML-LLSGALVSGPYTLIttAVSADLGTH 482
Cdd:cd17343 273 GYLSDWAVAKHGSSSrgnprmplalVFMAGLTVSLHLFRvHITSDSSELFILLLgFLIGFSLYGPIAIF--GVIANESAP 350
|
410
....*....|....*
gi 768020997 483 KSLKGNAHALSTVTA 497
Cdd:cd17343 351 SHLCGTSHAIVALAA 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
136-541 |
2.08e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.02 E-value: 2.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 136 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 215
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 216 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVStCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVrcsstlvthskgyeng 295
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILAS-SLGFGWRAVFLIAAALALLAAILLLLVVPDP---------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 296 tnrlrlqkqilkseknkpldpemqclllsdgkgsihPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSY 375
Cdd:cd06174 177 ------------------------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 376 TFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLyiFSTVSKMGLEATIA 455
Cdd:cd06174 221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL--ALLLLAPSLLLLLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 456 MLLLSGALVSGPYTLITTAVSADLgthksLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPsGWSNVFYMLMFADAC 535
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFALIAELF-----PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF-GLTGAFLVLAVLLLL 372
|
....*.
gi 768020997 536 ALLFLI 541
Cdd:cd06174 373 AAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
136-482 |
5.61e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 82.33 E-value: 5.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 136 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 215
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 216 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRcsstlvthskgyen 294
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWVFLVNAVLALLALLLLLRLLPESRPAAR-------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 295 gtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsGTAAISFTGALKIPGVIEFSLCLLFAKLVS 374
Cdd:COG2814 194 --------------------------------------------------ARLRGSLRELLRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 375 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYIFSTvskmGLEAT 453
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFgRRRLLLIGLLLLALGLLLLALAG----SLWLL 299
|
330 340
....*....|....*....|....*....
gi 768020997 454 IAMLLLSGALVSGPYTLITTAVSADLGTH 482
Cdd:COG2814 300 LLALFLLGFGFGLLFPLLQALVAELAPPE 328
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
140-463 |
2.07e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.38 E-value: 2.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 140 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 219
Cdd:COG2223 52 VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 220 RGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTlvthskgyengtNR 298
Cdd:COG2223 127 RGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK------------AS 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 299 LRLQKQILKSeknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFAKLVSYTFL 378
Cdd:COG2223 195 LRDQLEALRD-------------------------------------------------PRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 379 FWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLeATIAMLL 458
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL-FLVLFLL 304
|
....*
gi 768020997 459 LSGAL 463
Cdd:COG2223 305 LGLAL 309
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
99-489 |
3.53e-13 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 71.67 E-value: 3.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 99 RKSGSAAphqLPDNETDCGwapFDKNNyqqlLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLG 178
Cdd:PRK11663 39 RKSFNAA---MPEMLADLG---LSRSD----IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 179 yfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVST-CWGLSFVVP 257
Cdd:PRK11663 109 -----SSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHyGWRYGMMIA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 258 GAIVAAMGIVCFLFLIEHPndvrcsSTLVTHSKGyengtnrlrlqkqilkSEKNKPLDPEMQclllSDGKGSIHpnhvvi 337
Cdd:PRK11663 184 GIIAIVVGLFLCWRLRDKP------QAMGLPSVG----------------EWRHDALELAQQ----QEGAGLSR------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 338 lpgdggsgtAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVI 417
Cdd:PRK11663 232 ---------KEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWG 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768020997 418 SDRLEKraSTCGLMLLLAAptLYIFSTVSKMGLEATIAMLLLSGAL------VSGPYTLITTAvsADLGTHKSLKGNA 489
Cdd:PRK11663 303 SDKLFN--GNRGPMNLIFA--AGILLSVGSLWLMPFASYVMQAACFftigffVFGPQMLIGMA--AAECSHKEAAGAA 374
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
99-276 |
6.93e-13 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 70.13 E-value: 6.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 99 RKSGSAAphqLPDNETDCGwapFDKNNyqqlLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLG 178
Cdd:cd17488 19 RKSFNAA---MPAMLADLG---LDKSD----IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 179 yfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVST-CWGLSFVVP 257
Cdd:cd17488 89 -----SSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTyGWRAGMYVP 163
|
170
....*....|....*....
gi 768020997 258 GAIVAAMGIVCFLFLIEHP 276
Cdd:cd17488 164 GIIAILMGIVLCWRLRDRP 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
128-475 |
3.20e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 65.33 E-value: 3.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 128 QLLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSV 207
Cdd:cd17328 34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF-----APNFWQLLLFRALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 208 VTCLGNWFGKGRRGLIMGVWNSHTSVGNILG----SLIAGYWVStcWGLSFVVPGAIVAAMGIVCFLFLIEHP-NDVRCS 282
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGyvvgGLVAQATGG--WRWAFRVTGVLGVLLAILLLLFVREPPrGAAEGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 283 STLVTHSKGYENGTnrlrlqKQILKSeknkpldPEMQCLLLsdgkgsihpnhvvilpgdggsGTAAISFTGalkipgvie 362
Cdd:cd17328 187 VMAKSTATSFLADL------KALAKN-------PSFILSTL---------------------GFTAVSFVT--------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 363 fslcllfaklvsYTFLFWLPLYITNVDHLDAKKAGELSTLFD----VGGIFGGILAGVISDRLEKRAST-----CGLMLL 433
Cdd:cd17328 224 ------------GALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKTPRadplvCAVGLL 291
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 768020997 434 LAAPTLYIFSTVSKMGLEATIAMLLLSGALVSGPYTLITTAV 475
Cdd:cd17328 292 AAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAIL 333
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
130-475 |
9.00e-11 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 64.30 E-value: 9.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 130 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVT 209
Cdd:PRK09556 66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 210 CLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLS----FVVPGAIVAAMGIVCFLFLIEHPNdvrcsstl 285
Cdd:PRK09556 146 TITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHvigmFIFPSIIALIIGFIGLRYGSDSPE-------- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 286 vthskgyENGTNRLrlqkQILKSEKNKPLDPEMQCLLLSdgKGSIHPNHVvilpgdggsgtaaisftgaLKIPGVieFSL 365
Cdd:PRK09556 218 -------ELGWGKA----EEIFGEPISEEDKETESTDMT--KWQIFVEYV-------------------LKNPVI--WLL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 366 CL--LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR---ASTCGLMLLLAAPTLY 440
Cdd:PRK09556 264 CFanIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRralVACIALALIIFTLGVY 343
|
330 340 350
....*....|....*....|....*....|....*
gi 768020997 441 IFSTVSKMGLeatiAMLLLSGALVSGPYTLITTAV 475
Cdd:PRK09556 344 QHATSEYMYL----ASLFALGFLVFGPQLLIGVAA 374
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
140-471 |
9.22e-10 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 60.88 E-value: 9.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 140 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfYNIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 219
Cdd:PRK11273 75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 220 RGLIMGVWN-SHTSVGNILGSL-IAGYWVSTCWGLSFVVPGAivAAMGIVCFLFLIEHPNDVRCSSTLVTHSK-----GY 292
Cdd:PRK11273 154 RGGIVSVWNcAHNVGGGLPPLLfLLGMAWFNDWHAALYMPAF--AAILVALFAFAMMRDTPQSCGLPPIEEYKndypdDY 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 293 ENGTNRLRLQKQILkseknkpldpeMQCLLlsdgkgsihPNHVVILpgdggsgtaaISFTGAlkipgviefslcllFAKL 372
Cdd:PRK11273 232 NEKHEQELTAKQIF-----------MQYVL---------PNKLLWY----------IAIANV--------------FVYL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 373 VSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGL-MLLLAAPTL-YIFSTVSKM 448
Cdd:PRK11273 268 LRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgnRGATGVFfMTLVTIATIvYWLNPAGNP 347
|
330 340
....*....|....*....|...
gi 768020997 449 GLEatIAMLLLSGALVSGPYTLI 471
Cdd:PRK11273 348 TVD--MACMIVIGFLIYGPVMLI 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
140-543 |
1.77e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 1.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 140 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 219
Cdd:cd17325 43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 220 RGLIMGVWNSHTSVGNILGSLIAGYWVSTcwgLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstlvthskgyengtnrl 299
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGLLADA---LGYRAPFLVCAALALLALVLAL-------------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 300 rlqkqILKSEKNKPldpemqclllsdgkgsihPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYtflf 379
Cdd:cd17325 169 -----LLLPEPRPP------------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF---- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 380 wLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRaSTCGLMLLLAAPTLYIFSTVSkmgleaTIAMLLL 459
Cdd:cd17325 222 -LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT------SFWLLLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 460 SGALVSGPYTLITTAVSADLG--THKSLKGNAHAL-STVTAIIDGTGSVGAALGPLLAgllspsGWSNVFYML-MFADAC 535
Cdd:cd17325 294 LLALLGLGLGLVFPATLALLAdiVPPEGRGTAMGLfNTAFSLGMVLGPLLGGFLYDAF------GFATPFLAAaALLLLA 367
|
....*...
gi 768020997 536 ALLFLIRL 543
Cdd:cd17325 368 AVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
130-489 |
4.69e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.33 E-value: 4.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 130 LGALDYSFLCAYAVGMYLSGIIGERLPIRyyltFGMLASGAFTALfGLGYFYNIHSFGFYVVTQVI----NGLVQTTGWP 205
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYK----RGLLLGLLLMAL-GLLLFALAPSYPLLLLALFLlglgLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 206 SVVTClgnwfGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstl 285
Cdd:COG0738 120 YVAAL-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 286 vthskgyengtnRLRLQKQILKSEKNKPldpemqclllsdgkgsihpnhvvilpgdggsgtAAISFTGALKIPGVIEFSL 365
Cdd:COG0738 183 ------------RSKLPEIEEEEEEAAG---------------------------------SAASLKSLLKNPRLLLGGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 366 CLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYIFSTV 445
Cdd:COG0738 218 AIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLA 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 768020997 446 SkmGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNA 489
Cdd:COG0738 297 P--GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSA 338
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
118-476 |
4.20e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 55.32 E-value: 4.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 118 WAPFDKNNYQ----QLLGALDYSFLcAYAVGMYLSGIIGERLPIRYYLTFGMLASGAftALFGLGYFYNI-HSFGFYVVT 192
Cdd:cd17475 18 LAPFLQEDLHlslaQVGLLLSALNL-GVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYpVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 193 QVINGLVQTTGWPSVVTclgnWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLF 271
Cdd:cd17475 95 GAGYGSVQPGGGRAIMR----WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYgWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 272 LIEHPndvrcsstlvthskgyengtnrlrlqkqilksekNKPLDPEMQCLLLSDGKGSIhpnhvvilpgdGGSGTAAISF 351
Cdd:cd17475 171 YREPP----------------------------------AASAATESASTLLRSLKEVL-----------RNRDVWLIAI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 352 TGALkipgviefsLCllfakLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE--KRASTCG 429
Cdd:cd17475 206 AGAL---------LV-----APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggRRRPVLV 271
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 768020997 430 LMLLLAAPTLYIFSTVSKMGLEATIAMLL-LSGALVSGPYTLITTAVS 476
Cdd:cd17475 272 ITAAIAAAALLVLSLLSPGTPLWLLVLLLiLLGLFAIGWNGLYLTLVA 319
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
137-280 |
1.55e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 53.79 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 137 FLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFG 216
Cdd:cd17327 50 FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768020997 217 KGRRGLIMGVWNSHTSVGNILGSLIAgYWVSTC--------WGLSFVVPGAIVAAMGIVCFLFLIEHPNDVR 280
Cdd:cd17327 125 REEQAKRIAFFYAAAGLGSIFGGLLA-YGVFKIlgvgglagWRWLFIIEGLITIIIGLVIFFWLPDNPSKAW 195
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
130-421 |
1.57e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 130 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGL----VQTTGWP 205
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT-----PSIYLFVVLMFLAGLgagiLDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 206 SVVTclgnwFGKGRRGLIMGVWNSHTSVGNILGSLIAGY--WVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSs 283
Cdd:cd17333 108 FVGA-----LFEESSATRLNVLHGFFGLGALIGPLIATSllTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNP- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 284 tlvthskgyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgDGGSGTAAISFTGALKIPGVIEF 363
Cdd:cd17333 182 ---------------------------------------------------------QQSVGAFSASASRLLRNPSIILG 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 768020997 364 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL 421
Cdd:cd17333 205 ALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI 262
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
136-274 |
2.85e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 2.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 136 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 215
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELF 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 216 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVpGAIVAAMGIVCFLFLIE 274
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALgWRWIFLI-NAPLGLLALVLRLRLPE 190
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
140-476 |
3.52e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.55 E-value: 3.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 140 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 219
Cdd:cd17324 46 GYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 220 RGLIMGVWNSHTSVGNILGSLIAGyWVSTCWGLSFVVpgAIVAAMGIVCFLFLIehpndvrcsstlvthskgyengtnrl 299
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAF--LAIAVLALLAALLLW-------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 300 rlqkqilkseknkpldpemqcLLLSDGKgsihpnhvvilPGDGGSGTAAISFTGALKIPGVIE---FSLCLLFAKLVSYT 376
Cdd:cd17324 172 ---------------------RLLPSLP-----------PKKPGSLGLLSSLLLLLRNPRLRLaylITFLLFGGFFALYT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 377 FLfwlPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAptlYIFSTVSKMGLEATIAM 456
Cdd:cd17324 220 YL---APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA---LLLLTLLGPSPLLLLVG 293
|
330 340
....*....|....*....|
gi 768020997 457 LLLSGALVSGPYTLITTAVS 476
Cdd:cd17324 294 LVLWGLGFFAAHSALQTRVL 313
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
364-477 |
4.95e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 4.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 364 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAsTCGLMLLLAAPTLYIFS 443
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK-TLVIGLILSGILALPLF 261
|
90 100 110
....*....|....*....|....*....|....
gi 768020997 444 tvskMGLEATIAMLLLSGALVSGPYTLITTAVSA 477
Cdd:cd17316 262 ----YLLSGSPTLLLLLLFILSFFVGGVWGALYA 291
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
140-459 |
6.35e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.80 E-value: 6.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 140 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTG---WPSVVTclgNWFG 216
Cdd:COG2807 65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGnvlLPGLIK---RWFP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 217 KgRRGLIMGVWNSHTSVGNILGSLIAGYWV-STCWGLSFVVpGAIVAAMGIVCFLFLIEHPndvrcsstlvthskgyeng 295
Cdd:COG2807 137 D-RVGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAV-WALLALLALLLWLPLLRRR------------------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 296 tnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSY 375
Cdd:COG2807 196 -------------------------------------------PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 376 TFLFWLPLYITNVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR---------ASTCGLMLLLAAPT--LYIFST 444
Cdd:COG2807 233 AVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplllllglLGLAGLLGLLLAPGslPWLWAV 311
|
330
....*....|....*
gi 768020997 445 VSKMGLEATIAMLLL 459
Cdd:COG2807 312 LLGLGQGGLFPLALT 326
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
121-468 |
1.47e-06 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 50.90 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 121 FDKNNYQQ--LLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfynIHSFGFYVVTQVINGL 198
Cdd:TIGR00894 67 KNPNFKWSgaLQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA---GGGIALVVFCRVIQGL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 199 vqttGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGY------WVSTCWGLSFVVPGAIVAAMGIVCFLFL 272
Cdd:TIGR00894 144 ----AQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPisgwlcESWGGWPMIFYVFGIVGCAWSLLWFVFP 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 273 IEHPNDVRCSStlvthskgyengtnrLRLQKQILKSeknkpldpemqclllsdgkgsihpnhvviLPGDGGSGTAAISFT 352
Cdd:TIGR00894 220 ADDPSIHPCIS---------------KFEKKYINSS-----------------------------LQGQKGSTRQSLPIK 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 353 GALKIPGVIEFSLClLFAKLVSYTFLF-WLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISD------RLEKRA 425
Cdd:TIGR00894 256 AIPKSLPVWAIWFA-IFGHFWLYTILPtYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADflksskTLSLTA 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 768020997 426 ST---CGLMLLLAAPTLYIFSTVSKmGLEATIAMLLLSGALVSGPY 468
Cdd:TIGR00894 335 ARkifNGIGGLGPGIFAYALPYLSA-AFYLTIIILTLANAVSSGPL 379
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
142-469 |
2.20e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.05 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 142 AVGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHSFGFYvvtQVINGLVQTTGWPSVVTCLGNWFGKGRRG 221
Cdd:TIGR00895 66 AFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLIL---RFLAGLGLGGLMPNLNALVSEYAPKRFRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 222 LIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEhpndvrcsSTLVTHSKGYENGTNRLr 300
Cdd:TIGR00895 141 TAVGLMFCGYPIGAAVGGFLAGWLIPVFgWRSLFYVGGIAPLLLLLLLMRFLPE--------SIDFLVSKRPETVRRIV- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 301 lqkqilkseknKPLDPEMQCLLLSdgkgsihpnHVVILPGDGGSGTAAIS--FTGALkipGVIEFSL-CLLFAKLVSYTF 377
Cdd:TIGR00895 212 -----------NAIAPQMQAEAQS---------ALPEQKSTQGTKRSVFKalFQGKT---ARITVLLwLLYFMLLVGVYF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 378 LF-WLPlYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAStcGLMLLLAAPTLYI-FSTVSKMGLEATia 455
Cdd:TIGR00895 269 LTnWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT--ALLLLLGAVFAVLvGSTLFSPTLLLL-- 343
|
330
....*....|....
gi 768020997 456 MLLLSGALVSGPYT 469
Cdd:TIGR00895 344 LGAIAGFFVNGGQS 357
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
147-471 |
1.67e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 147 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVvTCLGNWFGKGRRGLIMGV 226
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEG-ARLASQAAGGRRGLAMSI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 227 WNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstlvthskgyengtnrlRLQKQIL 306
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR--------------------------PLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 307 KSEKNKPLDPEmqclllsdgKGSIHPNHVVILpgdggsgtAAISFTGALKIPGVIEFSLCLLFAKLVSYTFlfwlplyit 386
Cdd:cd17478 178 KKAAAKSSARS---------TLKGVWRALLLL--------LIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF--------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 387 nvdhldakkAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTvskmGLEATIAMLLLSGALVSG 466
Cdd:cd17478 232 ---------AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT----PGIWSYILLVLAGFLLFA 298
|
....*
gi 768020997 467 PYTLI 471
Cdd:cd17478 299 SFPVT 303
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
364-484 |
3.14e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 364 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFS 443
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 768020997 444 TVSKMGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKS 484
Cdd:cd17321 254 LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA 294
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
125-239 |
7.06e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 7.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 125 NYQQLLGALDYSFLCA-YAVGMYLSGIIGERLPIRYYLTFGMLasGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTG 203
Cdd:pfam07690 231 GLSALLAGLLLGLGGLlGAIGRLLLGRLSDRLGRRRRLLLALL--LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
|
90 100 110
....*....|....*....|....*....|....*.
gi 768020997 204 WPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGS 239
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
142-271 |
8.04e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 8.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 142 AVGMYLSG-IIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRR 220
Cdd:cd17474 248 ALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGF-----VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 768020997 221 GLIMGVWNSHTSVGNILGSLIAGYWVSTcWGLS--FVVPGAIVAAMGIVCFLF 271
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSapFLVGAAIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
140-271 |
1.27e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 140 AYAVGMYLSGIIGERLPIR----YYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 215
Cdd:cd06173 252 AFGVGALLGALLLGRLSKRrrrgRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 768020997 216 GKGRRGLIMGVWNSHTSVGNILGSLIAGyWVSTCWGLS--FVVPGAIVAAMGIVCFLF 271
Cdd:cd06173 327 PDELRGRVFSVYNALNSGAMPLGALLAG-LLADALGLSavFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
121-271 |
4.85e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 42.61 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 121 FDKNNYQQllGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHsFGFYVVTQVINGLVQ 200
Cdd:cd17318 51 FDWSEKTQ--GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLL--TPLAARGG-YGALIVLRILQGLAQ 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768020997 201 TTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIvaamGIVCFLF 271
Cdd:cd17318 126 GVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLgWPSIFYIFGGL----GLLWCLL 193
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
140-273 |
2.72e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 140 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFglgYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCL------GN 213
Cdd:COG2211 276 AALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDE 352
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768020997 214 W-FGKGRRGLIMGVWNSHTSVGNILGSLIAGyWVSTCWGLSFVVPGAIVAAMGIVCFLFLI 273
Cdd:COG2211 353 WkTGRRREGLYFGIFTFAIKLGQALAGALAG-LLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
137-237 |
3.33e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 137 FLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFG 216
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-----AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
90 100
....*....|....*....|.
gi 768020997 217 KGRRGLIMGVWNSHTSVGNIL 237
Cdd:COG2814 327 PEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
372-479 |
3.83e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.97 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 372 LVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLE 451
Cdd:cd17367 237 LAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSP 316
|
90 100
....*....|....*....|....*...
gi 768020997 452 ATIAMLLLSGALVSGPYTLITTAVSADL 479
Cdd:cd17367 317 YTAFALVLVGLVFLSGYTSINAVVKAEL 344
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
375-541 |
4.21e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 4.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 375 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRastcglmlllaaptlYIFSTVSKMGLEATI 454
Cdd:cd17318 216 YTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSR---------------GILSTTTVRKLFTSI 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 455 AMLLLSGALVSGPY---------TLITTAVSADLGTHKSLKGNAHALS-----TVTAIIDGTGSVG-----AALGPLLAG 515
Cdd:cd17318 281 GFLGPGVFLIALGYlgsnatlavVFLTLSVGLSGACYSGFLVNHLDLApnyagTLMGITNTAATIAgiispLIVGAIVKN 360
|
170 180
....*....|....*....|....*..
gi 768020997 516 LLSPSGWSNVFYMLMFADA-CALLFLI 541
Cdd:cd17318 361 DQTIGQWRIVFFISAAIYIlGAIFYLI 387
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
353-489 |
5.05e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.48 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 353 GALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE-KRASTCGLM 431
Cdd:cd17503 173 RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGpRLLLLAGLL 252
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 768020997 432 LLLAAptLYIFSTVS-KMGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNA 489
Cdd:cd17503 253 LLALG--TLLLAFLTpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATA 309
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
142-276 |
5.98e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 5.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 142 AVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRG 221
Cdd:cd17474 48 AVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERA 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 768020997 222 LIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAmGIVCFLFLIEHP 276
Cdd:cd17474 123 KAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPV-AFLAILFLLPEP 176
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
363-477 |
7.47e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 363 FSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYI 441
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFgRRRVLLIGLLLFALGLLLLL 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 768020997 442 FSTvskmGLEATIAMLLLSGALVSGPYTLITTAVSA 477
Cdd:pfam07690 81 FAS----SLWLLLVLRVLQGLGAGALFPAALALIAD 112
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
145-270 |
7.99e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 7.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 145 MYLSGIIGERLPIRYYLTFGMLASGAFTALFglgyfYNIHSFGFYVVTQVINGLvqttgWPSVVTCLG----NWFGKGRR 220
Cdd:cd17471 252 MLLAGLLAKRFGKRRLLLAGFLAGVLFYLGL-----ALATSLWQLIALQLLNAI-----FIGITAGLGisyfQDLMPGQP 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 768020997 221 GLIMGVWNSHTSVGNILGSLIAGYWVSTcWGL--SFVVPgAIVAAMGIVCFL 270
Cdd:cd17471 322 GLATTLYSNASRIGSLLGGLLAGVIAQY-FGYraVFLVC-AVLALLALVLLL 371
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
358-473 |
9.29e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 38.75 E-value: 9.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768020997 358 PGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMlLLAAP 437
Cdd:PRK03699 205 IGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLA-GLALV 283
|
90 100 110
....*....|....*....|....*....|....*.
gi 768020997 438 TLYIFSTVSKMGLEATIAMLLlsGALVSGPYTLITT 473
Cdd:PRK03699 284 LMYLFVNTDDPSHLLYAILGL--GFFSSAIYTTIIT 317
|
|
| |
